TDR Targets

Basic information

Technical information

TDR Targets ID: 429581
Name: (4S,5R)-4-(2-methylpropoxy)-6-oxa-1-azabicycl o[3.2.1]octan-7-one
MW: 199.247 | Formula: C10H17NO3
H donors: 0 H acceptors: 1 LogP: 1.35 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(CO[C@H]1CCN2C[C@H]1OC2=O)C
InChi: 1S/C10H17NO3/c1-7(2)6-13-8-3-4-11-5-9(8)14-10(11)12/h7-9H,3-6H2,1-2H3/t8-,9+/m0/s1
InChiKey: YOGVFFRGTMXMRZ-DTWKUNHWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4S,5R)-4-isobutoxy-6-oxa-1-azabicyclo[3.2.1]octan-7-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin V	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References
Homo sapiens	cathepsin H	Starlite/ChEMBL	References
Homo sapiens	cathepsin C	Starlite/ChEMBL	References
Homo sapiens	cathepsin F	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_130494	All targets in OG5_130494
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium berghei	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	dipeptidyl aminopeptidase 1	Get druggable targets OG5_130494	All targets in OG5_130494
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Babesia bovis	cathepsin C precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin C precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	preprocathepsin c precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cathepsin C, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Babesia bovis	preprocathepsin c precursor, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	cathepsin c precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium knowlesi	dipeptidyl aminopeptidase 2, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Get druggable targets OG5_130494	All targets in OG5_130494
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	hypothetical protein	Get druggable targets OG5_130494	All targets in OG5_130494
Plasmodium berghei	dipeptidyl aminopeptidase 2	Get druggable targets OG5_130494	All targets in OG5_130494
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	Homo sapiens P3ECSL-related	Get druggable targets OG5_130494	All targets in OG5_130494
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Get druggable targets OG5_130494	All targets in OG5_130494
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPC1	Get druggable targets OG5_130494	All targets in OG5_130494
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Dipeptidyl-peptidase I precursor	Get druggable targets OG5_130494	All targets in OG5_130494
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	dipeptidyl aminopeptidase 1, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Theileria parva	cathepsin C, putative	Get druggable targets OG5_130494	All targets in OG5_130494
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	dipeptidyl aminopeptidase 2	Get druggable targets OG5_130494	All targets in OG5_130494

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	cysteine proteinase falcipain 2b	cathepsin H	335 aa	340 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin V	334 aa	357 aa	29.7 %
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	cathepsin C	141 aa	152 aa	22.4 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cathepsin B-like cysteine proteinase	0.0196	0.6076	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3698	0.6086
Loa Loa (eye worm)	hypothetical protein	0.0196	0.6076	1
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.0672	0.1818
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3698	0.6086
Entamoeba histolytica	cysteine proteinase, putative	0.0154	0.3698	1
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5
Brugia malayi	Cathepsin L-like precursor	0.01	0.0672	0.1107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3698	0.5599
Onchocerca volvulus		0.0154	0.3698	1
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3698	0.6086
Echinococcus multilocularis	cathepsin L cysteine protease	0.0154	0.3698	0.6086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3698	0.6086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0265	1	1
Brugia malayi	Cathepsin L-like precursor	0.01	0.0672	0.1107
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Onchocerca volvulus		0.0154	0.3698	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3698	0.6086
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3698	0.6086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.0672	0.133
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3698	0.6086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0265	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0196	0.6076	0.6076
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0265	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0154	0.3698	0.3698
Entamoeba histolytica	cysteine proteinase, putative	0.0154	0.3698	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0265	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Brugia malayi	Papain family cysteine protease containing protein	0.0154	0.3698	0.6086
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0122	0.1917	0.1917
Onchocerca volvulus		0.0154	0.3698	1
Echinococcus granulosus	cathepsin b	0.0196	0.6076	1
Echinococcus granulosus	cathepsin l1	0.0154	0.3698	0.6086
Onchocerca volvulus		0.0154	0.3698	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0154	0.3698	0.6086
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0196	0.6076	0.6076
Onchocerca volvulus	Cathepsin F homolog	0.0154	0.3698	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0154	0.3698	0.6086
Plasmodium vivax	vivapain-2	0.0154	0.3698	0.3698
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3698	0.6086
Onchocerca volvulus		0.0154	0.3698	1
Loa Loa (eye worm)	fibroinase	0.0154	0.3698	0.5599
Trypanosoma cruzi	cysteine peptidase, putative	0.0154	0.3698	0.6086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0154	0.3698	0.5599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.0672	0.133
Schistosoma mansoni	cathepsin F (C01 family)	0.0154	0.3698	0.3698
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0265	1	1
Loa Loa (eye worm)	ctsf protein	0.0154	0.3698	0.5599
Brugia malayi	Cathepsin L-like cysteine proteinase	0.01	0.0672	0.1107
Toxoplasma gondii	cathepsin CPC1	0.0265	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5
Toxoplasma gondii	cathepsin CPL	0.0154	0.3698	0.2204
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0154	0.3698	0.6086
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0154	0.3698	0.5599
Plasmodium vivax	vivapain-2	0.0154	0.3698	0.3698
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0122	0.1917	0.1917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Brugia malayi	Cathepsin L-like precursor	0.0154	0.3698	0.6086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0196	0.6076	0.6076
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0154	0.3698	0.6086
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5
Onchocerca volvulus		0.0154	0.3698	1
Echinococcus multilocularis	cathepsin b	0.0196	0.6076	1
Echinococcus multilocularis	cysteine protease	0.0154	0.3698	0.6086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.3698	1
Echinococcus multilocularis	cathepsin b	0.0196	0.6076	1
Echinococcus granulosus	cathepsin l1	0.01	0.0672	0.1107
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.01	0.0672	0.1107
Onchocerca volvulus		0.0154	0.3698	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0154	0.3698	0.3698
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0178	0.5057	1
Echinococcus granulosus	cathepsin b	0.0196	0.6076	1
Schistosoma mansoni	cathepsin F (C01 family)	0.01	0.0672	0.0672
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0265	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0154	0.3698	0.7312
Onchocerca volvulus	Cathepsin L homolog	0.0154	0.3698	1
Loa Loa (eye worm)	cysteine protease	0.0154	0.3698	0.5599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Entamoeba histolytica	cysteine protease, putative	0.0154	0.3698	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0196	0.6076	0.6076
Leishmania major	cysteine peptidase A (CPA)	0.0154	0.3698	0.5
Echinococcus multilocularis	cysteine protease	0.0154	0.3698	0.6086
Brugia malayi	cathepsin L-like precursor	0.01	0.0672	0.1107
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0196	0.6076	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0154	0.3698	0.3698
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0154	0.3698	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0154	0.3698	0.6086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0154	0.3698	0.7312
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0154	0.3698	0.3698
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0154	0.3698	0.6086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0154	0.3698	0.7312
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5
Leishmania major	cathepsin L-like protease	0.0154	0.3698	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of thrombin	ChEMBL.	17196818
Activity (binding)		Inhibition of trypsin	ChEMBL.	17196818
Activity (binding)	0	Inhibition of thrombin	ChEMBL.	17196818
Activity (binding)	0	Inhibition of trypsin	ChEMBL.	17196818
IC50 (binding)	= 0.008 uM	Inhibition of human recombinant cathepsin B	ChEMBL.	17196818
IC50 (binding)	= 0.008 uM	Inhibition of human recombinant cathepsin B	ChEMBL.	17196818
IC50 (binding)	= 0.191 uM	Inhibition of human recombinant cathepsin C	ChEMBL.	17196818
IC50 (binding)	= 0.191 uM	Inhibition of human recombinant cathepsin C	ChEMBL.	17196818
IC50 (binding)	= 0.23 uM	Inhibition of human recombinant cathepsin L	ChEMBL.	17196818
IC50 (binding)	= 0.23 uM	Inhibition of human recombinant cathepsin L	ChEMBL.	17196818
IC50 (binding)	= 0.298 uM	Inhibition of human recombinant cathepsin S	ChEMBL.	17196818
IC50 (binding)	= 0.298 uM	Inhibition of human recombinant cathepsin S	ChEMBL.	17196818
IC50 (binding)	= 0.894 uM	Inhibition of human recombinant cathepsin V	ChEMBL.	17196818
IC50 (binding)	= 0.894 uM	Inhibition of human recombinant cathepsin V	ChEMBL.	17196818
IC50 (binding)	= 1.102 uM	Inhibition of human recombinant cathepsin X	ChEMBL.	17196818
IC50 (binding)	= 1.102 uM	Inhibition of human recombinant cathepsin X	ChEMBL.	17196818
IC50 (binding)	= 1.267 uM	Inhibition of human recombinant cathepsin K	ChEMBL.	17196818
IC50 (binding)	= 1.267 uM	Inhibition of human recombinant cathepsin K	ChEMBL.	17196818
IC50 (binding)	= 1.826 uM	Inhibition of human recombinant cathepsin F	ChEMBL.	17196818
IC50 (binding)	= 1.826 uM	Inhibition of human recombinant cathepsin F	ChEMBL.	17196818
IC50 (binding)	> 10 uM	Inhibition of human recombinant cathepsin H	ChEMBL.	17196818
IC50 (binding)	> 10 uM	Inhibition of human recombinant cathepsin H	ChEMBL.	17196818

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL230478
PubChem: 24901101

Bibliographic References

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Detailed information for compound 429581