Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Rattus norvegicus | Melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | FAD binding domain containing protein | 0.0727 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0727 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0644 | 0.7709 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0727 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0727 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0727 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0727 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0727 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0727 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0449 | 0.2291 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0449 | 0.2291 | 0.2291 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0727 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0644 | 0.7709 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0727 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0727 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0727 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0727 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0727 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0727 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0727 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0727 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0727 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0727 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0727 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0727 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0727 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antagonist activity at rat MCH1 receptor expressed in HEK293 cells by FLIPR calcium mobility assay | ChEMBL. | 17668922 | |
IC50 (functional) | 0 | Antagonist activity at rat MCH1 receptor expressed in HEK293 cells by FLIPR calcium mobility assay | ChEMBL. | 17668922 |
Ki (binding) | = 43 nM | Displacement of [3H]T226296 from rat recombinant MCH1 receptor | ChEMBL. | 17668922 |
Ki (binding) | = 43 nM | Displacement of [3H]T226296 from rat recombinant MCH1 receptor | ChEMBL. | 17668922 |
Ki (binding) | = 1000 nM | Displacement of [3H]spiperone from human recombinant dopamine D2 receptor | ChEMBL. | 17668922 |
Ki (binding) | = 1000 nM | Displacement of [3H]spiperone from human recombinant dopamine D2 receptor | ChEMBL. | 17668922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.