Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0136 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0136 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0136 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0136 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0136 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0136 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0136 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0067 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0084 | 0.2407 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0136 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.012 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0136 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0136 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0136 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0136 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0136 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0068 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0136 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0136 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0136 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0136 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.012 | 0.7743 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0136 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0067 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0136 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0136 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0084 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5400 nM | Antagonist activity at rat MCH1 receptor expressed in HEK293 cells by FLIPR calcium mobility assay | ChEMBL. | 17668922 |
IC50 (functional) | = 5400 nM | Antagonist activity at rat MCH1 receptor expressed in HEK293 cells by FLIPR calcium mobility assay | ChEMBL. | 17668922 |
Ki (binding) | Displacement of [3H]spiperone from human recombinant dopamine D2 receptor | ChEMBL. | 17668922 | |
Ki (binding) | 0 | Displacement of [3H]spiperone from human recombinant dopamine D2 receptor | ChEMBL. | 17668922 |
Ki (binding) | = 65 nM | Displacement of [3H]T226296 from rat recombinant MCH1 receptor | ChEMBL. | 17668922 |
Ki (binding) | = 65 nM | Displacement of [3H]T226296 from rat recombinant MCH1 receptor | ChEMBL. | 17668922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.