Detailed information for compound 432750

Basic information

Technical information
  • TDR Targets ID: 432750
  • Name: 1H-indol-4-yl-(3,4,5-trimethoxyphenyl)methano ne
  • MW: 311.332 | Formula: C18H17NO4
  • H donors: 1 H acceptors: 1 LogP: 3.3 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)c1cccc2c1cc[nH]2
  • InChi: 1S/C18H17NO4/c1-21-15-9-11(10-16(22-2)18(15)23-3)17(20)13-5-4-6-14-12(13)7-8-19-14/h4-10,19H,1-3H3
  • InChiKey: CLUMHWYRLGICLP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0055 0.0248 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0126 0.0951 0.2909
Loa Loa (eye worm) phosphatidylinositol 3 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0068 0.0379 0.1079
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0126 0.0951 0.2909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Schistosoma mansoni hypothetical protein 0.0055 0.0248 0.2609
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0071 0.0408 0.0408
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0126 0.0951 0.2711
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0126 0.0951 0.0951
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0168 0.1765
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0071 0.0408 0.4286
Entamoeba histolytica hypothetical protein 0.0115 0.0842 0.8852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Plasmodium falciparum tubulin beta chain 0.003 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0071 0.0408 0.4286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0071 0.0408 0.0408
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0126 0.0951 0.2909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0408 0.4286
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0126 0.0951 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0408 0.4286
Loa Loa (eye worm) hypothetical protein 0.0071 0.0408 0.4286
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0055 0.0248 0.0248
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0126 0.0951 0.2711
Toxoplasma gondii target of rapamycin (TOR), putative 0.0126 0.0951 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0126 0.0951 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0126 0.0951 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0115 0.0842 0.2575
Schistosoma mansoni fkbp-rapamycin associated protein 0.0071 0.0408 0.4286
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0115 0.0842 0.8852
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0126 0.0951 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0248 0.2609
Loa Loa (eye worm) phosphatidylinositol 3 0.0126 0.0951 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0488 0.5131
Leishmania major hypothetical protein, conserved 0.0384 0.3509 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0408 0.4286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0126 0.0951 0.2711
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0126 0.0951 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0068 0.0379 0.1159
Echinococcus granulosus serine protein kinase ATM 0.0115 0.0842 0.0842
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0091 0.0602 0.1842
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1039 1 1
Toxoplasma gondii FATC domain-containing protein 0.0115 0.0842 0.8852
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0126 0.0951 0.2909
Giardia lamblia GTOR 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0115 0.0842 0.8852
Trypanosoma cruzi hypothetical protein, conserved 0.036 0.3269 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0488 0.5131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0126 0.0951 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0079 0.0488 0.5131
Loa Loa (eye worm) hypothetical protein 0.0055 0.0248 0.2609
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0126 0.0951 0.2711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0126 0.0951 0.2711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0408 0.4286
Echinococcus multilocularis serine protein kinase ATM 0.0115 0.0842 0.0842
Plasmodium vivax tubulin beta chain, putative 0.003 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Brugia malayi FAT domain containing protein 0.0055 0.0248 0.2609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0115 0.0842 0.8852
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0126 0.0951 0.0951
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Entamoeba histolytica protein kinase rad3, putative 0.0071 0.0408 0.4286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0408 0.4286
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0408 0.4286
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0408 0.4286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0168 0.1765
Trypanosoma cruzi target of rapamycin kinase 3 0.0126 0.0951 0.2909
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0079 0.0488 0.5131
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0488 0.5131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0126 0.0951 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0126 0.0951 0.0951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0602 0.633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.0951 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0115 0.0842 0.8852
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0071 0.0408 0.1247
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0126 0.0951 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 74 % Displacement of [3H]colchicine from tubulin at 5 uM ChEMBL. 17685504
Activity (binding) = 74 % Displacement of [3H]colchicine from tubulin at 5 uM ChEMBL. 17685504
IC50 (functional) = 46.4 nM Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 46.4 nM Growth inhibition of human HT29 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 49.1 nM Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 49.1 nM Growth inhibition of human MKN45 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 50.7 nM Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 50.7 nM Growth inhibition of human KB cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 51.4 nM Growth inhibition of human KB-vin10 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 53.8 nM Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 53.8 nM Growth inhibition of human H460 cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 54.4 nM Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (functional) = 54.4 nM Growth inhibition of human TSGH cells after 72 hrs by methylene blue dye assay ChEMBL. 17685504
IC50 (binding) = 2 uM Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins ChEMBL. 17685504
IC50 (binding) = 2 uM Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins ChEMBL. 17685504

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17685504

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.