Detailed information for compound 433344

Basic information

Technical information
  • TDR Targets ID: 433344
  • Name: 6-(3-chloropropyl)-2,3-dimethoxyindeno[1,2-c] isoquinoline-5,11-dione
  • MW: 383.825 | Formula: C21H18ClNO4
  • H donors: 0 H acceptors: 2 LogP: 3.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClCCCn1c2c3ccccc3C(=O)c2c2c(c1=O)cc(c(c2)OC)OC
  • InChi: 1S/C21H18ClNO4/c1-26-16-10-14-15(11-17(16)27-2)21(25)23(9-5-8-22)19-12-6-3-4-7-13(12)20(24)18(14)19/h3-4,6-7,10-11H,5,8-9H2,1-2H3
  • InChiKey: RBNJUOSLYWNDIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-(3-chloropropyl)-2,3-dimethoxy-indeno[1,2-c]isoquinoline-5,11-dione
  • 6-(3-chloropropyl)-2,3-dimethoxy-indeno[1,2-c]isoquinoline-5,11-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Alpha-tubulin 0.0105 0.0389 0.1042
Trichomonas vaginalis tubulin gamma chain, putative 0.0057 0.0131 0.336
Schistosoma mansoni tubulin subunit epsilon 0.0057 0.0131 0.1696
Plasmodium vivax tubulin alpha chain, putative 0.0105 0.0389 0.1042
Trichomonas vaginalis tubulin epsilon chain, putative 0.0105 0.0389 1
Schistosoma mansoni hypothetical protein 0.0043 0.0056 0.0651
Echinococcus granulosus tubulin alpha 3 chain 0.0105 0.0389 0.5192
Brugia malayi Tubulin gamma chain 0.0057 0.0131 0.0181
Echinococcus granulosus geminin 0.0168 0.0721 1
Echinococcus granulosus tubulin alpha chain 0.0105 0.0389 0.5192
Brugia malayi RNA binding protein 0.0067 0.0184 0.0255
Echinococcus multilocularis tubulin alpha 0.0057 0.0131 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0086 0.1066
Echinococcus multilocularis beta tubulin 0.0057 0.0131 0.0234
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0065 0.1446
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0377 0.9685
Trichomonas vaginalis tubulin beta chain, putative 0.0105 0.0389 1
Echinococcus multilocularis tubulin epsilon chain 0.0057 0.0131 0.0234
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Echinococcus multilocularis tubulin alpha chain 0.0105 0.0389 0.0832
Plasmodium falciparum telomerase reverse transcriptase 0.0523 0.2608 1
Loa Loa (eye worm) alpha-tubulin 0.0105 0.0389 1
Trypanosoma brucei alpha tubulin 0.0105 0.0389 0.149
Echinococcus multilocularis tubulin alpha chain 0.0105 0.0389 0.0832
Brugia malayi Tubulin beta-1 chain 0.0057 0.0131 0.0181
Loa Loa (eye worm) hypothetical protein 0.0054 0.0118 0.2842
Schistosoma mansoni alpha tubulin 0.0105 0.0389 0.5327
Echinococcus granulosus Tubulin alpha 1 chain 0.0105 0.0389 0.5192
Echinococcus multilocularis Tubulin beta 2C chain 0.0057 0.0131 0.0234
Trichomonas vaginalis tubulin alpha chain, putative 0.0057 0.0131 0.336
Echinococcus granulosus Tubulin beta 2C chain 0.0057 0.0131 0.1457
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0523 0.2608 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0086 0.2002
Brugia malayi TAR-binding protein 0.0067 0.0184 0.0255
Echinococcus multilocularis peroxisome assembly protein 26 0.0105 0.0389 0.0832
Trichomonas vaginalis tubulin epsilon chain, putative 0.0057 0.0131 0.336
Echinococcus multilocularis tubulin alpha chain 0.0105 0.0389 0.0832
Schistosoma mansoni hypothetical protein 0.0038 0.003 0.0279
Echinococcus multilocularis beta tubulin 0.0057 0.0131 0.0234
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0612 0.1351
Echinococcus multilocularis tubulin alpha chain 0.0105 0.0389 0.0832
Echinococcus multilocularis protein patched 0.0044 0.0065 0.0081
Echinococcus granulosus expressed conserved protein 0.0097 0.0344 0.4549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0086 0.1066
Schistosoma mansoni tubulin subunit gamma 0.0057 0.0131 0.1696
Giardia lamblia Telomerase catalytic subunit 0.0523 0.2608 1
Toxoplasma gondii beta tubulin 0.0057 0.0131 0.0151
Echinococcus multilocularis Tubulin beta 2C chain 0.0057 0.0131 0.0234
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0059 0.0226
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0105 0.0386 0.5287
Loa Loa (eye worm) tubulin beta-1 chain 0.0057 0.0131 0.3184
Echinococcus multilocularis tubulin subunit TubB 0.0105 0.0389 0.0832
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0065 0.0081
Loa Loa (eye worm) tubulin gamma chain 0.0057 0.0131 0.3184
Leishmania major telomerase reverse transcriptase, putative 0.0523 0.2608 1
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0184 0.2453
Toxoplasma gondii RNA-directed DNA polymerase 0.0523 0.2608 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0057 0.0131 0.3184
Echinococcus multilocularis protein dispatched 1 0.005 0.0098 0.0158
Echinococcus granulosus Tubulin beta 2C chain 0.0057 0.0131 0.1457
Loa Loa (eye worm) tubulin beta chain 0.0057 0.0131 0.3184
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0601 0.2304
Echinococcus multilocularis geminin 0.0168 0.0721 0.1603
Echinococcus multilocularis hypothetical protein 0.0105 0.0389 0.0832
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0184 0.2453
Echinococcus granulosus tubulin alpha chain 0.0105 0.0389 0.5192
Loa Loa (eye worm) beta-tubulin 0.0057 0.0131 0.3184
Trichomonas vaginalis tubulin beta chain, putative 0.0105 0.0389 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0377 0.0806
Toxoplasma gondii alpha tubulin TUBA1 0.0105 0.0389 0.1177
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.1459 0.5363
Echinococcus granulosus tar DNA binding protein 0.0067 0.0184 0.2236
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0601 0.1899
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0377 0.5029
Brugia malayi hypothetical protein 0.0038 0.003 0.0041
Echinococcus granulosus tubulin alpha 0.0057 0.0131 0.1457
Echinococcus granulosus beta tubulin 0.0057 0.0131 0.1457
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0105 0.0389 1
Toxoplasma gondii alpha-tubulin I, putative 0.0105 0.0389 0.1177
Brugia malayi Tubulin alpha-2 chain 0.0105 0.0389 0.0538
Brugia malayi Tubulin alpha-2 chain 0.0105 0.0389 0.0538
Giardia lamblia Alpha-tubulin 0.0105 0.0389 0.1042
Echinococcus multilocularis tubulin alpha 3 chain 0.0105 0.0389 0.0832
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0065 0.0505
Echinococcus granulosus beta tubulin 0.0057 0.0131 0.1457
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Plasmodium vivax telomerase reverse transcriptase, putative 0.0523 0.2608 1
Trypanosoma cruzi epsilon tubulin, putative 0.0057 0.0131 0.0281
Trichomonas vaginalis tubulin gamma chain, putative 0.0057 0.0131 0.336
Echinococcus granulosus tubulin alpha 1C chain 0.0105 0.0389 0.5192
Schistosoma mansoni alpha tubulin 0.0105 0.0389 0.5327
Trypanosoma cruzi epsilon tubulin, putative 0.0057 0.0131 0.0281
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0612 0.843
Schistosoma mansoni tubulin subunit beta 0.0057 0.0131 0.1696
Trichomonas vaginalis tubulin gamma chain, putative 0.0057 0.0131 0.336
Trypanosoma brucei epsilon tubulin 0.0057 0.0131 0.0501
Echinococcus multilocularis tubulin beta 1 chain 0.0057 0.0131 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1459 0.5494
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0081 0.0258 0.6551
Trypanosoma brucei beta tubulin 0.0057 0.0131 0.0501
Echinococcus granulosus tubulin beta 4A class IVa 0.0057 0.0131 0.1457
Toxoplasma gondii beta-tubulin, putative 0.0057 0.0131 0.0151
Echinococcus granulosus Tubulin beta 2C chain 0.0057 0.0131 0.1457
Schistosoma mansoni tubulin subunit alpha 0.0105 0.0389 0.5327
Loa Loa (eye worm) hypothetical protein 0.0103 0.0377 0.9702
Schistosoma mansoni tubulin subunit alpha 0.0105 0.0389 0.5327
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0184 0.2453
Trichomonas vaginalis tubulin beta chain, putative 0.0105 0.0389 1
Brugia malayi beta-tubulin, identical 0.0057 0.0131 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0086 0.1066
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0184 0.0358
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0184 0.0255
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.1459 0.5494
Schistosoma mansoni tubulin subunit beta 0.0057 0.0131 0.1696
Schistosoma mansoni patched 1 0.0044 0.0065 0.077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0086 0.0809
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.1446
Trichomonas vaginalis tubulin beta chain, putative 0.0105 0.0389 1
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Echinococcus multilocularis Tubulin beta 2C chain 0.0057 0.0131 0.0234
Mycobacterium ulcerans hypothetical protein 0.0162 0.0688 0.5
Loa Loa (eye worm) tubulin alpha 2 0.0081 0.0258 0.6551
Trichomonas vaginalis tubulin alpha chain, putative 0.0057 0.0131 0.336
Trypanosoma brucei alpha tubulin 0.0105 0.0389 0.149
Trichomonas vaginalis tubulin epsilon chain, putative 0.0057 0.0131 0.336
Entamoeba histolytica tubulin gamma chain 0.0057 0.0131 0.2806
Trypanosoma brucei tubulin gamma chain 0.0057 0.0131 0.0501
Schistosoma mansoni tubulin subunit beta 0.0057 0.0131 0.1696
Echinococcus multilocularis tubulin alpha chain 0.0105 0.0389 0.0832
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0057 0.0131 0.0234
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0184 0.4604
Brugia malayi Tubulin alpha chain 0.0105 0.0389 0.0538
Echinococcus granulosus tubulin alpha 3 chain 0.0105 0.0389 0.5192
Echinococcus multilocularis tubulin alpha 1C chain 0.0105 0.0389 0.0832
Echinococcus granulosus tubulin beta 1 chain 0.0057 0.0131 0.1457
Trypanosoma brucei beta tubulin 0.0057 0.0131 0.0501
Trypanosoma brucei beta tubulin 0.0057 0.0131 0.0501
Echinococcus granulosus tubulin alpha chain 0.0105 0.0389 0.5192
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0057 0.0131 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0086 0.0119
Plasmodium vivax tubulin alpha chain, putative 0.0105 0.0389 0.1042
Plasmodium falciparum alpha tubulin 1 0.0105 0.0389 0.1042
Echinococcus multilocularis tubulin alpha 1C chain 0.0105 0.0389 0.0832
Brugia malayi tubulin alpha chain - mouse 0.0105 0.0389 0.0538
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0601 0.2127
Echinococcus multilocularis tubulin gamma 1 chain 0.0057 0.0131 0.0234
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0849 0.4339 1
Loa Loa (eye worm) tubulin alpha 2 0.0049 0.0088 0.2056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0086 0.013
Loa Loa (eye worm) tubulin alpha chain 0.0105 0.0389 1
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Brugia malayi Telomerase reverse transcriptase 0.1392 0.7222 1
Trypanosoma cruzi beta tubulin, putative 0.0057 0.0131 0.0281
Entamoeba histolytica tubulin family protein 0.0057 0.0131 0.2806
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0109 0.0197
Loa Loa (eye worm) tubulin alpha 2 0.0081 0.0258 0.6551
Echinococcus granulosus tubulin subunit beta 0.0057 0.0131 0.1457
Echinococcus multilocularis Tubulin beta 2C chain 0.0057 0.0131 0.0234
Schistosoma mansoni hypothetical protein 0.0043 0.0056 0.0651
Schistosoma mansoni hypothetical protein 0.0168 0.0721 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0688 0.5
Brugia malayi tubulin alpha-2 chain 0.0105 0.0389 0.0538
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.003 0.0279
Trypanosoma cruzi tubulin gamma chain 0.0057 0.0131 0.0281
Loa Loa (eye worm) BEN-1 protein 0.0057 0.0131 0.3184
Trichomonas vaginalis tubulin beta chain, putative 0.0057 0.0131 0.336
Echinococcus granulosus Tubulin alpha 1 chain 0.0105 0.0389 0.5192
Plasmodium falciparum alpha tubulin 2 0.0105 0.0389 0.1042
Echinococcus granulosus tubulin alpha chain 0.0105 0.0389 0.5192
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0184 0.2453
Schistosoma mansoni tubulin subunit alpha 0.0105 0.0389 0.5327
Schistosoma mansoni tubulin subunit beta 0.0057 0.0131 0.1696
Echinococcus multilocularis expressed conserved protein 0.0097 0.0344 0.0729
Echinococcus multilocularis tubulin subunit beta 0.0057 0.0131 0.0234
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0523 0.2608 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0184 0.2453
Trypanosoma brucei telomerase reverse transcriptase 0.0523 0.2608 1
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Trypanosoma brucei epsilon tubulin 0.0057 0.0131 0.0501
Echinococcus granulosus Tubulin beta 2C chain 0.0057 0.0131 0.1457
Trypanosoma brucei epsilon tubulin 0.0057 0.0131 0.0501
Trypanosoma brucei beta tubulin 0.0057 0.0131 0.0501
Loa Loa (eye worm) tubulin beta-2A chain 0.0057 0.0131 0.3184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0093 0.0129
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0081 0.0258 0.664
Loa Loa (eye worm) alpha-tubulin 0.0105 0.0389 1
Schistosoma mansoni hypothetical protein 0.0168 0.0721 1
Entamoeba histolytica tubulin family protein 0.0057 0.0131 0.2806
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0086 0.0809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0086 0.013
Schistosoma mansoni tubulin subunit beta 0.0057 0.0131 0.1696
Loa Loa (eye worm) hypothetical protein 0.005 0.0093 0.2203
Loa Loa (eye worm) hypothetical protein 0.0073 0.0218 0.5505
Loa Loa (eye worm) RNA binding protein 0.0067 0.0184 0.4604
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0065 0.0505
Trypanosoma brucei beta tubulin 0.0057 0.0131 0.0501
Toxoplasma gondii beta-1 tubulin, putative 0.0057 0.0131 0.0151
Echinococcus multilocularis Tubulin alpha 1 chain 0.0105 0.0389 0.0832
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0377 0.0522
Echinococcus granulosus Tubulin alpha 1 chain 0.0105 0.0389 0.5192
Echinococcus multilocularis Tubulin alpha 1 chain 0.0105 0.0389 0.0832
Entamoeba histolytica tubulin alpha-1 chain 0.0105 0.0389 1
Brugia malayi alpha-tubulin 0.0105 0.0389 0.0538
Echinococcus multilocularis Tubulin alpha 1 chain 0.0105 0.0389 0.0832
Loa Loa (eye worm) tubulin alpha chain 0.0105 0.0389 1
Entamoeba histolytica tubulin alpha chain, putative 0.0105 0.0389 1
Trypanosoma brucei alpha tubulin 0.0105 0.0389 0.149
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.1459 0.5596
Loa Loa (eye worm) hypothetical protein 0.0081 0.0258 0.6551
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0073 0.0218 0.5621
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0093 0.2203
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0065 0.1667
Echinococcus granulosus tubulin alpha 1C chain 0.0105 0.0389 0.5192
Trypanosoma brucei alpha tubulin 0.0105 0.0389 0.149
Schistosoma mansoni hypothetical protein 0.0043 0.0056 0.0651
Brugia malayi CHE-14 protein 0.0044 0.0065 0.009
Echinococcus multilocularis tubulin alpha 3 chain 0.0105 0.0389 0.0832
Schistosoma mansoni hypothetical protein 0.0043 0.0056 0.0651
Trichomonas vaginalis tubulin epsilon chain, putative 0.0105 0.0389 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0073 0.0218 0.5505
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.001 0.0014
Echinococcus granulosus peroxisome assembly protein 26 0.0105 0.0389 0.5192
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0093 0.0129
Echinococcus granulosus tubulin gamma 1 chain 0.0057 0.0131 0.1457
Echinococcus granulosus tubulin alpha chain 0.0105 0.0389 0.5192
Schistosoma mansoni tubulin subunit beta 0.0057 0.0131 0.1696
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Trichomonas vaginalis tubulin, putative 0.0057 0.0131 0.336
Echinococcus granulosus tubulin subunit TubB 0.0105 0.0389 0.5192
Loa Loa (eye worm) hypothetical protein 0.0105 0.0389 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0057 0.0131 0.0234
Schistosoma mansoni alpha tubulin 0.0105 0.0389 0.5327
Loa Loa (eye worm) BEN-1 protein 0.0057 0.0131 0.3184
Leishmania major alpha tubulin 0.0105 0.0389 0.1042
Trichomonas vaginalis tubulin beta chain, putative 0.0105 0.0389 1
Echinococcus granulosus alpha tubulin 0.0105 0.0389 0.5192
Trypanosoma cruzi alpha tubulin, putative 0.0105 0.0389 0.1293
Loa Loa (eye worm) tubulin alpha-2 chain 0.0105 0.0389 1
Echinococcus granulosus tubulin epsilon chain 0.0057 0.0131 0.1457
Echinococcus granulosus Tubulin beta 2C chain 0.0057 0.0131 0.1457
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0184 0.4604
Trichomonas vaginalis tubulin beta chain, putative 0.0105 0.0389 1
Leishmania major alpha tubulin 0.0105 0.0389 0.1042

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 2.46 uM Cytotoxicity against human HCT116 cells ChEMBL. 17676830
GI50 (functional) = 2.46 uM Cytotoxicity against human HCT116 cells ChEMBL. 17676830
GI50 (functional) = 4.47 uM Cytotoxicity against human HOP62 cells ChEMBL. 17676830
GI50 (functional) = 4.47 uM Cytotoxicity against human HOP62 cells ChEMBL. 17676830
GI50 (functional) = 10.7 uM Cytotoxicity against human OVCAR3 cells ChEMBL. 17676830
GI50 (functional) = 10.7 uM Cytotoxicity against human OVCAR3 cells ChEMBL. 17676830
GI50 (functional) = 12.3 uM Cytotoxicity against human UACC62 cells ChEMBL. 17676830
GI50 (functional) = 12.3 uM Cytotoxicity against human UACC62 cells ChEMBL. 17676830
GI50 (functional) = 14.1 uM Cytotoxicity against human SF539 cells ChEMBL. 17676830
GI50 (functional) = 14.1 uM Cytotoxicity against human SF539 cells ChEMBL. 17676830
GI50 (functional) > 100 uM Cytotoxicity against human SN12C cells ChEMBL. 17676830
GI50 (functional) > 100 uM Cytotoxicity against human MDA-MB-435 cells ChEMBL. 17676830
GI50 (functional) > 100 uM Cytotoxicity against human DU145 cells ChEMBL. 17676830
GI50 (functional) > 100 uM Cytotoxicity against human SN12C cells ChEMBL. 17676830
GI50 (functional) > 100 uM Cytotoxicity against human MDA-MB-435 cells ChEMBL. 17676830
GI50 (functional) > 100 uM Cytotoxicity against human DU145 cells ChEMBL. 17676830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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