Detailed information for compound 43756

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.349 | Formula: C17H18N4O4
  • H donors: 4 H acceptors: 5 LogP: 0.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1cnc2c1ccnc2Nc1ccccc1
  • InChi: 1S/C17H18N4O4/c22-8-12-14(23)15(24)17(25-12)21-9-19-13-11(21)6-7-18-16(13)20-10-4-2-1-3-5-10/h1-7,9,12,14-15,17,22-24H,8H2,(H,18,20)
  • InChiKey: KPNMTRMMPYUFBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0314 0.1126
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0266 0.0641
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Brugia malayi Sugar transporter family protein 0.0014 0.0134 0.0479
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0134 0.0479
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0532 0.2418
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.004 0.0145
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0332 0.1511
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0486 0.2211
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.007 0.025
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0332 0.395
Brugia malayi hypothetical protein 0.0037 0.0661 0.2368
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0661 0.3006
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0541 0.8107
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.004 0.0184
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0532 0.2418
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.004 0.0145
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0541 0.1973
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0332 0.0201
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0134 0.0479
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0637 0.0779
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0532 0.0404
Trypanosoma brucei glucose transporter 2A 0.0032 0.0541 0.8107
Onchocerca volvulus 0.0022 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3681 0.3595
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.0184
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0532 0.0404
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0314 0.1126
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0134 0.0479
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0314 0.1126
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0314 0.1429
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0637 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.004 0.0184
Plasmodium falciparum protein kinase 7 0.029 0.6589 0.6542
Entamoeba histolytica protein kinase, putative 0.0031 0.0532 0.6069
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0184
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0134 0.0608
Schistosoma mansoni coup transcription factor 0.0022 0.0314 0.1429
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.025
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3681 0.5495
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0541 0.1973
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0532 0.1905
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0314 0.1126
Schistosoma mansoni glucose transport protein 0.0103 0.22 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0314 0.1126
Brugia malayi nuclear receptor NHR-88 0.001 0.004 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0314 0.1126
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.22 0.3201
Brugia malayi Nuclear hormone receptor E75 0.001 0.004 0.0145
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0332 0.395
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0314 1
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0332 0.1511
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0314 0.1126
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0314 0.1429
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Entamoeba histolytica protein kinase, putative 0.0031 0.0532 0.6069
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0532 0.0404
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0332 0.0961
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0541 0.1973
Onchocerca volvulus 0.0014 0.0134 0.341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0314 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0314 0.1126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0314 0.1429
Trypanosoma cruzi hexose transporter 0.0032 0.0541 0.8107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.007 0.0317
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0314 0.1429
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.004 0.0145
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0532 0.0617
Brugia malayi steroid hormone receptor 0.0022 0.0314 0.1126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.004 0.0184
Onchocerca volvulus 0.0014 0.0134 0.341
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0332 0.3046
Brugia malayi ecdysone receptor 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0314 0.1126
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0314 0.1126
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Onchocerca volvulus 0.0014 0.0134 0.341
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.22 1
Brugia malayi major facilitator superfamily protein 0.0014 0.0134 0.0479
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0134 0.0479
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0314 0.1429
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0517 0.235
Echinococcus granulosus General substrate transporter 0.0088 0.1862 0.8463
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0332 0.1511
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0203 0.1383
Loa Loa (eye worm) hypothetical protein 0.0031 0.0532 0.1905
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0532 0.7919
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0517 0.235
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0517 0.1855
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0314 0.1126
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.007 0.0317
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0517 0.5615
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0184
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0031 0.0517 0.1852
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0532 0.0404
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0184
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0541 0.1973
Onchocerca volvulus 0.0014 0.0134 0.341
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0314 0.1429
Schistosoma mansoni zinc finger protein 0.001 0.004 0.0184
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.004 0.0184
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Onchocerca volvulus 0.0014 0.0134 0.341
Loa Loa (eye worm) sugar transporter 0.0014 0.0134 0.0479
Loa Loa (eye worm) DR-78 0.001 0.004 0.0145
Brugia malayi tailless protein 0.001 0.004 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3681 0.3595
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0314 0.1126
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.004 0.0184
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Brugia malayi hypothetical protein 0.0014 0.0134 0.0479
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0314 0.1429
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0134 0.0608
Onchocerca volvulus 0.0014 0.0134 0.341
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0332 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0532 0.0404
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.007 0.0317
Mycobacterium ulcerans sugar transporter 0.0014 0.0134 0.2954
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0134 0.2954
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0314 0.1429
Echinococcus multilocularis General substrate transporter 0.0088 0.1862 0.8463
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi nuclear receptor NHR-88 0.0022 0.0314 0.1126
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0314 0.1429
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0541 0.1973
Plasmodium vivax hexose transporter 0.0103 0.22 0.2094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.004 0.0184
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0541 0.1973
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0314 0.1429
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.025
Brugia malayi conserved hypotetical protein 0.001 0.004 0.0145
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0252 1
Schistosoma mansoni nuclear receptor 0.001 0.004 0.0184
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0532 0.0404
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0517 0.235
Schistosoma mansoni protein kinase 0.0031 0.0532 0.2418
Leishmania major glucose transporter, lmgt1 0.0032 0.0541 0.8107
Entamoeba histolytica hypothetical protein 0.0037 0.0661 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0517 0.235
Brugia malayi Cam kinase protein 1 0.0031 0.0532 0.1905
Loa Loa (eye worm) hypothetical protein 0.0031 0.0517 0.1852
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.2793 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0637 1
Brugia malayi nuclear receptor NHR-67 0.001 0.004 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Schistosoma mansoni protein kinase 0.0031 0.0532 0.2418
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Brugia malayi hypothetical protein 0.0014 0.0134 0.0479
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Onchocerca volvulus 0.0014 0.0134 0.341
Leishmania major protein kinase, putative 0.0031 0.0532 0.7919
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0486 0.2211
Schistosoma mansoni nuclear receptor 0.001 0.004 0.0184
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi ecdysteroid receptor 0.0022 0.0314 0.1126
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0532 0.1905
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.004 0.0145
Plasmodium falciparum hexose transporter 0.0103 0.22 0.2094
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0092 0.0329
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.22 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0314 0.1429
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0541 0.8107
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0332 0.1511
Onchocerca volvulus 0.0014 0.0134 0.341
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0541 0.1973
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0314 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.22 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0314 0.1429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0314 0.1126
Onchocerca volvulus 0.0014 0.0134 0.341
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0134 0.5
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0532 0.0404
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.007 0.0317
Schistosoma mansoni protein kinase 0.0031 0.0532 0.2418
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0252 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0541 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Schistosoma mansoni hypothetical protein 0.0103 0.22 1
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.2793 1
Toxoplasma gondii protein kinase, putative 0.029 0.6589 1
Trypanosoma brucei glucose transporter 1E 0.0032 0.0541 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0637 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0314 0.1429
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0541 0.8107
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.004 0.0145
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0637 1
Schistosoma mansoni glucose transport protein 0.0103 0.22 1
Brugia malayi MH2 domain containing protein 0.0128 0.2793 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.0184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0661 0.3006
Brugia malayi major facilitator superfamily protein 0.0014 0.0134 0.0479
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0314 0.1429
Schistosoma mansoni glucose transporter 0.0014 0.0134 0.0608
Brugia malayi nuclear receptor RXR 0.001 0.004 0.0145
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.004 0.0184
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0332 0.0308
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0661 0.3006
Onchocerca volvulus 0.0014 0.0134 0.341
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0314 0.1126
Leishmania major glucose transporter, lmgt3 0.0032 0.0541 0.8107
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.004 0.0184
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0532 0.0404
Brugia malayi Sugar transporter family protein 0.0103 0.22 0.7878
Onchocerca volvulus Putative transporter 0.0014 0.0134 0.341
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0051 0.5
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0134 0.0608
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0314 0.1126
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0517 1
Loa Loa (eye worm) sugar transporter 0.0103 0.22 0.7878
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0314 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0314 0.1429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0314 0.1429
Brugia malayi nuclear receptor RXR 0.0012 0.007 0.025
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0532 0.1927
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0314 0.1429
Brugia malayi Sugar transporter family protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0637 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0134 0.2954
Leishmania major glucose transporter, lmgt2 0.0032 0.0541 0.8107
Brugia malayi Nuclear hormone receptor E75 0.001 0.004 0.0145
Brugia malayi hypothetical protein 0.001 0.004 0.0145
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0314 0.1126
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0134 0.2954
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0532 0.0404
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0332 0.119
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.004 0.0184
Brugia malayi nuclear hormone receptor 0.001 0.004 0.0145
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0332 0.395
Loa Loa (eye worm) hypothetical protein 0.0025 0.0382 0.1367
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.025
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0517 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0314 0.1429
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0532 0.1905
Loa Loa (eye worm) hypothetical protein 0.0023 0.0332 0.119
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0517 0.1852
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0314 0.1126
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.004 0.0184
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0532 0.0617
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0637 0.051
Schistosoma mansoni glucose transport protein 0.0103 0.22 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0314 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0314 0.1126
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0314 0.1429
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0332 1
Onchocerca volvulus 0.0014 0.0134 0.341
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0532 0.2418
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0314 0.1429
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0134 0.0608
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0332 1
Brugia malayi hypothetical protein 0.0014 0.0134 0.0479
Loa Loa (eye worm) hypothetical protein 0.0022 0.0314 0.1126
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0134 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0314 0.1126
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.004 0.0145
Brugia malayi hypothetical protein 0.0012 0.007 0.025
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0541 0.8107
Brugia malayi nuclear hormone receptor 0.0022 0.0314 0.1126
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Schistosoma mansoni sugar transporter 0.0014 0.0134 0.0608
Schistosoma mansoni hypothetical protein 0.0037 0.0661 0.3006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus granulosus solute carrier family 22 0.0014 0.0134 0.0608
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0332 0.0201
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Brugia malayi hypothetical protein 0.0012 0.007 0.025
Brugia malayi hypothetical protein 0.001 0.004 0.0145
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0332 0.5182
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0541 0.8107
Trypanosoma brucei glucose transporter, putative 0.0032 0.0541 0.8107
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0314 0.1429
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0532 0.0617
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0479
Echinococcus multilocularis solute carrier family 22 0.0014 0.0134 0.0608
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0145
Onchocerca volvulus 0.0014 0.0134 0.341
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0517 0.1852
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0637 0.051
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0314 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0314 0.1429

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 9 mg kg-1 Dose required to produce an acute inflammatory response of the algal poly saccharide carrageenan into the pleural cavity of rat. ChEMBL. 3941408
Inhibition (functional) = 4 % Compound was tested for inhibition of human sternal marrow cell (D98) growth at a concentration of 100 uM ChEMBL. 3941408
Inhibition (functional) = 10 % Inhibition of lymphocyte-mediated cytolysis at a concentratioon of 100 uM in [51Cr]- labelled EL4 leukemia cells ChEMBL. 3941408
Inhibition (functional) = 18 % Compound was tested for inhibition of mouse connective tissue cell (L) growth at a concentration of 100 uM ChEMBL. 3941408

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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