Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serotonin transporter | 0.0146 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0106 | 0.6251 | 0.6251 |
Echinococcus multilocularis | serotonin transporter | 0.0146 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.0047 | 0.0795 | 0.0795 |
Brugia malayi | hypothetical protein | 0.0112 | 0.6839 | 0.6477 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0059 | 0.193 | 0.193 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146 | 1 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.005 | 0.1062 | 0.029 |
Onchocerca volvulus | 0.0146 | 1 | 0.5 | |
Echinococcus granulosus | shaker cognate | 0.0059 | 0.193 | 0.1233 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0146 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0106 | 0.6251 | 0.5927 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0146 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0108 | 0.6447 | 0.604 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0059 | 0.193 | 0.1006 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0059 | 0.193 | 0.1006 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0059 | 0.193 | 0.1006 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.6839 | 0.6477 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0108 | 0.6447 | 0.604 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.005 | 0.1062 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0146 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0108 | 0.6447 | 0.604 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0098 | 0.5544 | 0.5544 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0095 | 0.5224 | 0.4677 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0108 | 0.6447 | 0.614 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0108 | 0.6447 | 0.6447 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.6447 | 0.604 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0106 | 0.6251 | 0.5822 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0095 | 0.5224 | 0.4677 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0108 | 0.6447 | 0.614 |
Echinococcus multilocularis | sodium channel protein | 0.005 | 0.1062 | 0.1062 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.005 | 0.1062 | 0.029 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0059 | 0.193 | 0.1233 |
Echinococcus multilocularis | shaker cognate | 0.0059 | 0.193 | 0.193 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.7 nM | Binding affinity to rat SERT | ChEMBL. | 17107798 |
Ki (binding) | = 5.7 nM | Binding affinity to rat SERT | ChEMBL. | 17107798 |
Ki (binding) | = 7.2 nM | Binding affinity to human SERT | ChEMBL. | 17107798 |
Ki (binding) | = 7.2 nM | Binding affinity to human SERT | ChEMBL. | 17107798 |
Ki (binding) | = 1108 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17107798 |
Ki (binding) | = 1108 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17107798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.