Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0146 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0146 | 1 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0048 | 0.1003 | 0.0272 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0146 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0103 | 0.6088 | 0.5668 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.0045 | 0.0751 | 0.0751 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0103 | 0.6088 | 0.5668 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.6088 | 0.5668 |
Echinococcus multilocularis | sodium channel protein | 0.0048 | 0.1003 | 0.1003 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0048 | 0.1003 | 0.0272 |
Onchocerca volvulus | 0.0146 | 1 | 0.5 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0146 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0101 | 0.5903 | 0.5463 |
Echinococcus granulosus | serotonin transporter | 0.0146 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0101 | 0.5903 | 0.557 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0103 | 0.6088 | 0.6088 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0057 | 0.1822 | 0.1158 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.4933 | 0.4389 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0103 | 0.6088 | 0.5668 |
Echinococcus multilocularis | shaker cognate | 0.0057 | 0.1822 | 0.1822 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0057 | 0.1822 | 0.0944 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0057 | 0.1822 | 0.0944 |
Brugia malayi | hypothetical protein | 0.0107 | 0.6458 | 0.6078 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0057 | 0.1822 | 0.0944 |
Echinococcus granulosus | shaker cognate | 0.0057 | 0.1822 | 0.1158 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0101 | 0.5903 | 0.5903 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0146 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0094 | 0.5236 | 0.5236 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0103 | 0.6088 | 0.577 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0048 | 0.1003 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0091 | 0.4933 | 0.4389 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146 | 1 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0103 | 0.6088 | 0.577 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0057 | 0.1822 | 0.1822 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.6458 | 0.6078 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 25 nM | Binding affinity to rat SERT | ChEMBL. | 17107798 |
Ki (binding) | = 25 nM | Binding affinity to rat SERT | ChEMBL. | 17107798 |
Ki (binding) | = 33 nM | Binding affinity to human SERT | ChEMBL. | 17107798 |
Ki (binding) | = 33 nM | Binding affinity to human SERT | ChEMBL. | 17107798 |
Ki (binding) | = 1440 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17107798 |
Ki (binding) | = 1440 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17107798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.