Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0146 | 1 | 1 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0047 | 0.0978 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0101 | 0.5938 | 0.5514 |
Loa Loa (eye worm) | serotonin transporter b | 0.0146 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0101 | 0.5938 | 0.5514 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.63 | 0.5913 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0101 | 0.5938 | 0.5617 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0089 | 0.4812 | 0.427 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0092 | 0.5107 | 0.5107 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0101 | 0.5938 | 0.5617 |
Brugia malayi | Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog | 0.0089 | 0.4812 | 0.427 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0101 | 0.5938 | 0.5938 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5938 | 0.5514 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0099 | 0.5758 | 0.5315 |
Echinococcus multilocularis | shaker cognate | 0.0056 | 0.1777 | 0.1777 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0047 | 0.0978 | 0.0265 |
Echinococcus multilocularis | sodium channel protein | 0.0047 | 0.0978 | 0.0978 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0056 | 0.1777 | 0.1128 |
Echinococcus granulosus | serotonin transporter | 0.0146 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0099 | 0.5758 | 0.5758 |
Echinococcus multilocularis | potassium voltage gated channel subfamily D | 0.0044 | 0.0732 | 0.0732 |
Brugia malayi | hypothetical protein | 0.0105 | 0.63 | 0.5913 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0056 | 0.1777 | 0.1777 |
Echinococcus multilocularis | serotonin transporter | 0.0146 | 1 | 1 |
Echinococcus granulosus | sodium channel protein | 0.0047 | 0.0978 | 0.0265 |
Onchocerca volvulus | 0.0146 | 1 | 0.5 | |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0099 | 0.5758 | 0.5423 |
Echinococcus granulosus | shaker cognate | 0.0056 | 0.1777 | 0.1128 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0146 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0056 | 0.1777 | 0.0918 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0056 | 0.1777 | 0.0918 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0146 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog | 0.0056 | 0.1777 | 0.0918 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0146 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0101 | 0.5938 | 0.5514 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 15 nM | Binding affinity to rat SERT | ChEMBL. | 17107798 |
Ki (binding) | = 15 nM | Binding affinity to rat SERT | ChEMBL. | 17107798 |
Ki (binding) | = 42 nM | Binding affinity to human SERT | ChEMBL. | 17107798 |
Ki (binding) | = 42 nM | Binding affinity to human SERT | ChEMBL. | 17107798 |
Ki (binding) | = 267 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17107798 |
Ki (binding) | = 267 nM | Binding affinity to human histamine H3 receptor | ChEMBL. | 17107798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.