TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 522.715 | Formula: C33H46O5
H donors: 0 H acceptors: 3 LogP: 8.31 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@]1(C)[C@@H](CC[C@]2([C@H]1CC[C@]1([C@H]2CC(=O)/C/1=C(\C=C\C=C(\C=C\C=C(C)C)/C)/C)C)C)OC(=O)C
InChi: 1S/C33H46O5/c1-21(2)12-10-13-22(3)14-11-15-23(4)29-25(35)20-27-31(6)19-17-28(38-24(5)34)33(8,30(36)37-9)26(31)16-18-32(27,29)7/h10-15,26-28H,16-20H2,1-9H3/b13-10+,15-11+,22-14+,29-23+/t26-,27+,28-,31+,32+,33-/m1/s1
InChiKey: GRNXZFQSLPDVMF-XKDOUPOMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0028	0.0061	0.0371
Onchocerca volvulus		0.0102	0.0389	1
Loa Loa (eye worm)	uncoordinated protein 58	0.0102	0.0389	0.0389
Echinococcus multilocularis	TWiK family of potassium channels protein 7	0.0102	0.0389	0.0389
Leishmania major	potassium channel subunit-like protein	0.0102	0.0389	1
Onchocerca volvulus		0.0102	0.0389	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0004	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0099	0.2544
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog	0.0102	0.0389	0.9952
Plasmodium falciparum	potassium channel	0.0102	0.0389	1
Loa Loa (eye worm)	hypothetical protein	0.1047	0.4568	0.4568
Mycobacterium leprae	Probable lipase LipE	0.0025	0.0048	0.5
Onchocerca volvulus		0.0102	0.0389	1
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0048	0.088
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0107	0.041	0.7374
Echinococcus multilocularis	twik family of potassium channels	0.0102	0.0389	0.0389
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0107	0.041	0.7374
Toxoplasma gondii	ion channel protein	0.0102	0.0389	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Mycobacterium ulcerans	transmembrane cation transporter	0.0102	0.0389	1
Schistosoma mansoni	calcium-activated potassium channel	0.2276	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Echinococcus granulosus	Two pore potassium channel protein sup 9	0.0102	0.0389	0.0389
Echinococcus granulosus	potassium channel subfamily K	0.0102	0.0389	0.0389
Onchocerca volvulus		0.0102	0.0389	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0136	0.0539	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Loa Loa (eye worm)	beta-lactamase	0.0025	0.0048	0.0048
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0114	0.0114
Echinococcus granulosus	twik family of potassium channels	0.0102	0.0389	0.0389
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0025	0.0048	0.0048
Onchocerca volvulus		0.0102	0.0389	1
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0068	0.0068
Onchocerca volvulus	Papilin homolog	0.0032	0.0081	0.0974
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Echinococcus granulosus	potassium channel subfamily K 8	0.0102	0.0389	0.0389
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 12	0.0102	0.0389	0.9952
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 35	0.0102	0.0389	0.9952
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0048	0.088
Brugia malayi	beta-lactamase	0.0025	0.0048	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 17	0.0102	0.0389	0.9952
Leishmania major	calcium/potassium channel (CAKC), putative	0.0102	0.0389	1
Trypanosoma cruzi	ion transport protein, putative	0.0102	0.0389	1
Echinococcus granulosus	lamin	0.0028	0.0061	0.0061
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0025	0.0048	0.0048
Brugia malayi	latrophilin 2 splice variant baaae	0.0023	0.0042	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	beta-lactamase family protein	0.0025	0.0048	0.1236
Onchocerca volvulus		0.0102	0.0389	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0133	0.3143
Leishmania major	hypothetical protein, conserved	0.0102	0.0389	1
Mycobacterium leprae	conserved hypothetical protein	0.0025	0.0048	0.5
Echinococcus multilocularis	geminin	0.0174	0.0706	0.0706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Leishmania major	ion transport protein-like protein	0.0102	0.0389	1
Brugia malayi	hypothetical protein	0.0102	0.0389	0.9952
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39B	0.0102	0.0389	0.9952
Echinococcus granulosus	tumor protein p63	0.0608	0.2626	0.2626
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0004	0.0107
Echinococcus granulosus	intermediate filament protein	0.0028	0.0061	0.0061
Leishmania major	cathepsin L-like protease	0.0044	0.0133	0.3143
Trypanosoma brucei	calcium-activated potassium channel, putative	0.0102	0.0389	1
Loa Loa (eye worm)	hypothetical protein	0.2276	1	1
Echinococcus multilocularis	tumor protein p63	0.0608	0.2626	0.2626
Echinococcus multilocularis	small conductance calcium activated potassium	0.2276	1	1
Echinococcus multilocularis	a disintegrin and metalloproteinase with	0.0043	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0061	0.1559
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Schistosoma mansoni	hypothetical protein	0.2276	1	1
Echinococcus granulosus	calcium activated potassium channel variant	0.0102	0.0389	0.0389
Mycobacterium ulcerans	ion transport protein	0.0102	0.0389	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0078	0.0078
Echinococcus multilocularis	Two pore potassium channel protein sup 9	0.0102	0.0389	0.0389
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 39A	0.0102	0.0389	0.9952
Leishmania major	hypothetical protein, conserved	0.0025	0.0048	0.088
Schistosoma mansoni	calcium-activated potassium channel	0.1765	0.7742	0.7742
Schistosoma mansoni	hypothetical protein	0.0102	0.0389	0.0389
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0158	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0015	0.0015
Schistosoma mansoni	ADAMTS5 peptidase (M12 family)	0.0043	0.0128	0.0128
Echinococcus multilocularis	lamin dm0	0.0028	0.0061	0.0061
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Echinococcus granulosus	microtubule associated protein 2	0.0475	0.2038	0.2038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	hypothetical protein	0.0102	0.0389	0.9952
Giardia lamblia	Hypothetical protein	0.0102	0.0389	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0136	0.0539	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0102	0.0389	1
Trypanosoma brucei	calcium/potassium channel (CAKC), putative	0.0102	0.0389	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0099	0.0099
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0025	0.0048	0.0048
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0034	0.009	0.2314
Brugia malayi	beta-lactamase family protein	0.0025	0.0048	0.1236
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0007
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0025	0.0048	0.0048
Schistosoma mansoni	lamin	0.0028	0.0061	0.0061
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0029	0.0068	0.0068
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0133	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Toxoplasma gondii	ABC1 family protein	0.0025	0.0048	0.088
Brugia malayi	ADAMTS-like protease	0.0031	0.0077	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Echinococcus granulosus	a disintegrin and metalloproteinase with	0.0043	0.0128	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Echinococcus granulosus	potassium channel subfamily K 8	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0081	0.0081
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0099	0.0099
Trypanosoma cruzi	hypothetical protein, conserved	0.0102	0.0389	1
Loa Loa (eye worm)	hypothetical protein	0.0409	0.1747	0.1747
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 28	0.0102	0.0389	0.9952
Loa Loa (eye worm)	TWK-28 protein	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0059	0.0059
Onchocerca volvulus		0.0102	0.0389	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Onchocerca volvulus		0.0089	0.0332	0.8333
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Leishmania major	cathepsin L-like protease	0.0044	0.0133	0.3143
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Echinococcus granulosus	twik family of potassium channels	0.0102	0.0389	0.0389
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 7	0.0102	0.0389	0.9952
Trypanosoma cruzi	hypothetical protein, conserved	0.0102	0.0389	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog	0.0102	0.0389	0.9952
Trypanosoma cruzi	ion transport protein, putative	0.0102	0.0389	1
Schistosoma mansoni	microtubule-associated protein tau	0.0475	0.2038	0.2038
Leishmania major	hypothetical protein, conserved	0.0102	0.0389	1
Leishmania major	cathepsin L-like protease	0.0044	0.0133	0.3143
Loa Loa (eye worm)	angiogenesis inhibito	0.0016	0.0009	0.0009
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 45	0.0102	0.0389	0.9952
Echinococcus multilocularis	lamin	0.0028	0.0061	0.0061
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0034	0.009	0.009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Echinococcus granulosus	lamin dm0	0.0028	0.0061	0.0061
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0099	0.0099
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0034	0.009	0.2314
Echinococcus multilocularis	potassium channel subfamily K 8	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Trypanosoma cruzi	major cysteine proteinase, putative	0.0035	0.0091	0.2031
Schistosoma mansoni	hypothetical protein	0.0023	0.0042	0.0042
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 13	0.0102	0.0389	0.9952
Brugia malayi	intermediate filament protein	0.0028	0.0061	0.1559
Brugia malayi	angiogenesis inhibito	0.0031	0.0077	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	hypothetical protein	0.0029	0.0068	0.1749
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0099	0.0099
Echinococcus multilocularis	microtubule associated protein 2	0.0475	0.2038	0.2038
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Echinococcus granulosus	geminin	0.0174	0.0706	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Plasmodium falciparum	potassium channel	0.0102	0.0389	1
Trypanosoma cruzi	calcium/potassium channel (CAKC), putative	0.0102	0.0389	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 24	0.0102	0.0389	0.9952
Loa Loa (eye worm)	TWK-7 protein	0.0102	0.0389	0.0389
Onchocerca volvulus		0.0028	0.0061	0.0371
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0102	0.0389	0.9952
Echinococcus granulosus	adam	0.0029	0.0068	0.0068
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Echinococcus multilocularis	musashi	0.0028	0.0061	0.0061
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.004	0.0116	0.2692
Toxoplasma gondii	ion channel protein	0.0102	0.0389	1
Schistosoma mansoni	hypothetical protein	0.0174	0.0706	0.0706
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0102	0.0389	0.6941
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0102	0.0391	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0099	0.0099
Echinococcus multilocularis	calcium activated potassium channel variant	0.0102	0.0389	0.0389
Echinococcus multilocularis	twik family of potassium channels	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0332	0.0332
Trypanosoma cruzi	hypothetical protein, conserved	0.0025	0.0048	0.088
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0102	0.0389	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.009	0.009
Plasmodium vivax	potassium channel, putative	0.0102	0.0389	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Onchocerca volvulus		0.0102	0.0389	1
Trypanosoma cruzi	calcium-activated potassium channel, putative	0.0102	0.0389	1
Plasmodium vivax	potassium channel, putative	0.0102	0.0389	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.0133	0.3143
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0099	0.0099
Echinococcus granulosus	TWiK family of potassium channels protein 7	0.0102	0.0389	0.0389
Loa Loa (eye worm)	large conductance calcium-activated potassium channel alpha subunit ai	0.0102	0.0389	0.0389
Loa Loa (eye worm)	S-phase kinase-associated protein 1A	0.0102	0.0389	0.0389
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 21	0.0102	0.0389	0.9952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0133	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Schistosoma mansoni	calcium-activated potassium channel	0.0102	0.0389	0.0389
Echinococcus multilocularis	adam	0.0029	0.0068	0.0068
Echinococcus multilocularis	potassium channel subfamily K 8	0.0102	0.0389	0.0389
Schistosoma mansoni	calcium-activated potassium channel	0.0102	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0061	0.0061
Entamoeba histolytica	calcium-gated potassium channel protein, putative	0.0102	0.0389	1
Echinococcus multilocularis	potassium channel subfamily K	0.0102	0.0389	0.0389
Mycobacterium tuberculosis	Possible transmembrane cation transporter	0.0102	0.0389	0.5771
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0042	0.0042
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0061	0.0061
Trypanosoma brucei	hypothetical protein, conserved	0.0025	0.0048	0.088
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0025	0.0048	0.1236
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0133	0.3143
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Brugia malayi	hypothetical protein	0.0017	0.0015	0.0395
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 5	0.0102	0.0389	0.9952
Schistosoma mansoni	twik family of potassium channels-related	0.0102	0.0389	0.0389
Echinococcus granulosus	beta LACTamase domain containing family member	0.0025	0.0048	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Schistosoma mansoni	cellular tumor antigen P53	0.0089	0.0332	0.0332
Brugia malayi	hypothetical protein	0.0036	0.0099	0.2529
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0389	0.0389
Schistosoma mansoni	lamin	0.0028	0.0061	0.0061
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0102	0.0389	0.9952
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Schistosoma mansoni	hypothetical protein	0.0174	0.0706	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0718	0.3113	0.3113
Brugia malayi	Twik (KCNK-like) family of potasium channels, alpha subunit 40	0.0102	0.0389	0.9952
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0061	0.0061

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Inhibition of VEGF-induced migration in human HUVEC cells	ChEMBL.	18492609
Activity (functional)	0	Inhibition of VEGF-induced tubular formation in human HUVEC cells	ChEMBL.	18492609
IC50 (functional)	= 0.064 uM	Growth inhibition of HUVEC cells after 72 hrs	ChEMBL.	17524651
IC50 (functional)	= 0.064 uM	Growth inhibition of HUVEC cells after 72 hrs	ChEMBL.	17524651
IC50 (functional)	= 3.1 uM	Growth inhibition of KB3-1 cells after 72 hrs	ChEMBL.	17524651
IC50 (functional)	= 3.2 uM	Growth inhibition of Neuro2A cells after 72 hrs	ChEMBL.	17524651
IC50 (functional)	= 9 uM	Growth inhibition of K562 cells after 72 hrs	ChEMBL.	17524651
IC50 (functional)	= 9 uM	Growth inhibition of K562 cells after 72 hrs	ChEMBL.	17524651
Ratio IC50 (functional)	= 48	Selectivity index, ratio of IC50 for KB3-1 cells to IC50 for HUVEC cells	ChEMBL.	17524651
Ratio IC50 (functional)	= 48	Selectivity index, IC50 for human HUVEC cells over IC50 for human KB3-1 cells	ChEMBL.	18492609
Ratio IC50 (functional)	= 50	Selectivity index, ratio of IC50 for Neuro2A cells to IC50 for HUVEC cells	ChEMBL.	17524651
Ratio IC50 (functional)	= 141	Selectivity index, ratio of IC50 for K562 cells to IC50 for HUVEC cells	ChEMBL.	17524651

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	17524651

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 445399