Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0017 | 0.003 | 0.003 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0703 | 0.4112 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Onchocerca volvulus | 0.0468 | 0.6067 | 1 | |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0762 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0017 | 0.003 | 0.003 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0067 | 0.0703 | 0.1583 |
Giardia lamblia | Hypothetical protein | 0.0017 | 0.003 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0166 | 0.0166 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0334 | 0.428 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0334 | 0.428 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0166 | 0.0136 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0139 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0762 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0697 | 0.9122 | 0.9122 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0139 | 0.1667 | 1 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0139 | 0.1667 | 0.1526 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0762 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0067 | 0.0703 | 0.4112 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0017 | 0.003 | 0.003 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Schistosoma mansoni | alpha-glucosidase | 0.0697 | 0.9122 | 0.9108 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0166 | 0.0166 |
Trypanosoma brucei | glucosidase, putative | 0.0067 | 0.0703 | 0.4112 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0762 | 1 | 1 |
Brugia malayi | translation initiation factor 4E | 0.0139 | 0.1667 | 0.1667 |
Schistosoma mansoni | alpha-glucosidase | 0.0697 | 0.9122 | 0.9108 |
Giardia lamblia | hypothetical protein | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0159 | 0.0159 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Giardia lamblia | Translation elongation factor | 0.0017 | 0.003 | 0.5 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0625 | 0.8168 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0139 | 0.1667 | 0.1641 |
Giardia lamblia | Hypothetical protein | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0166 | 0.0166 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.912 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0139 | 0.1667 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0703 | 0.0703 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0017 | 0.003 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0067 | 0.0703 | 0.4112 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0067 | 0.0703 | 0.0547 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0067 | 0.0703 | 0.4112 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.9108 |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0.003 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0703 | 0.4112 |
Leishmania major | glycosyl hydrolase-like protein | 0.0067 | 0.0703 | 0.4112 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0139 | 0.1667 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0067 | 0.0703 | 0.0675 |
Onchocerca volvulus | 0.0027 | 0.0166 | 0.0224 | |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0139 | 0.1667 | 1 |
Echinococcus granulosus | lamin | 0.0027 | 0.0166 | 0.0136 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0017 | 0.003 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0697 | 0.9122 | 0.9122 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0017 | 0.003 | 0.003 |
Schistosoma mansoni | alpha glucosidase | 0.0067 | 0.0703 | 0.0547 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 1 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0139 | 0.1667 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0166 | 0.0136 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0762 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0166 | 0.0166 |
Onchocerca volvulus | 0.0027 | 0.0166 | 0.0224 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.9108 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0067 | 0.0703 | 0.1114 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0017 | 0.003 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (ADMET) | = 130 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (ADMET) | = 130 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 160 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 160 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.