Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0139 | 0.1667 | 0.1641 |
Giardia lamblia | Hypothetical protein | 0.0017 | 0.003 | 0.5 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0625 | 0.8168 | 0.5 |
Giardia lamblia | Translation elongation factor | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0166 | 0.0166 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0017 | 0.003 | 0.003 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0762 | 1 | 1 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0139 | 0.1667 | 0.1526 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0139 | 0.1667 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0159 | 0.0159 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Giardia lamblia | hypothetical protein | 0.0017 | 0.003 | 0.5 |
Brugia malayi | translation initiation factor 4E | 0.0139 | 0.1667 | 0.1667 |
Schistosoma mansoni | alpha-glucosidase | 0.0697 | 0.9122 | 0.9108 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0762 | 1 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0067 | 0.0703 | 0.4112 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0166 | 0.0166 |
Schistosoma mansoni | alpha-glucosidase | 0.0697 | 0.9122 | 0.9108 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 0.3851 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0334 | 0.428 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0697 | 0.9122 | 0.9122 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0762 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0166 | 0.0136 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0139 | 0.1667 | 0.1667 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0334 | 0.428 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0017 | 0.003 | 0.003 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0166 | 0.0166 |
Giardia lamblia | Hypothetical protein | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0017 | 0.003 | 0.003 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0762 | 1 | 1 |
Onchocerca volvulus | 0.0468 | 0.6067 | 1 | |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0139 | 0.1667 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0067 | 0.0703 | 0.4112 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.9108 |
Onchocerca volvulus | 0.0027 | 0.0166 | 0.0224 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0762 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0017 | 0.003 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Onchocerca volvulus | Uncharacterized family 31 glucosidase KIAA1161 homolog | 0.0067 | 0.0703 | 0.1114 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0697 | 0.9122 | 0.9122 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0017 | 0.003 | 0.5 |
Echinococcus granulosus | lamin | 0.0027 | 0.0166 | 0.0136 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0139 | 0.1667 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0166 | 0.0136 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0139 | 0.1667 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0067 | 0.0703 | 0.0547 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0017 | 0.003 | 0.003 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0067 | 0.0703 | 0.0703 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0067 | 0.0703 | 0.4112 |
Leishmania major | glycosyl hydrolase-like protein | 0.0067 | 0.0703 | 0.4112 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Plasmodium vivax | hypothetical protein, conserved | 0.0017 | 0.003 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.0166 | 0.0224 | |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0067 | 0.0703 | 0.0675 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0139 | 0.1667 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0067 | 0.0703 | 0.1583 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0139 | 0.1667 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0067 | 0.0703 | 0.4112 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0017 | 0.003 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0067 | 0.0703 | 0.4112 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0067 | 0.0703 | 0.1583 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0703 | 0.0703 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0139 | 0.1667 | 0.1526 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.912 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0067 | 0.0703 | 0.1583 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0697 | 0.9122 | 0.9108 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0067 | 0.0703 | 0.4112 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0067 | 0.0703 | 0.0547 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (ADMET) | = 135 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (ADMET) | = 135 uM | Antiproliferative activity against human HFL1 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 320 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
ED50 (functional) | = 320 uM | Antiproliferative activity against human T24 cells after 96 hrs by crystal violet method | ChEMBL. | 17512203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.