Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanocortin 4 receptor | Starlite/ChEMBL | References |
Homo sapiens | melanocortin 5 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melanocortin 5 receptor | 325 aa | 311 aa | 20.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | EGF-like domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.2063 | 0.2063 |
Onchocerca volvulus | 0.0197 | 0.0669 | 1 | |
Giardia lamblia | High cysteine protein | 0.0064 | 0.0068 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1074 | 0.4634 | 0.4634 |
Echinococcus multilocularis | peroxidasin | 0.0197 | 0.0669 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | Cadherin domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Onchocerca volvulus | Dual oxidase homolog | 0.0197 | 0.0669 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0064 | 0.0068 | 0.0068 |
Toxoplasma gondii | hypothetical protein | 0.0505 | 0.2063 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0197 | 0.0669 | 1 | |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0275 | 0.1023 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Schistosoma mansoni | peroxidasin | 0.0197 | 0.0669 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.2063 | 0.2063 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0525 | 0.1002 |
Brugia malayi | notch-like transmembrane receptor | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0505 | 0.2063 | 0.2063 |
Brugia malayi | EGF-like domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | EGF-like domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1074 | 0.4634 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Leishmania major | carbonic anhydrase-like protein | 0.1074 | 0.4634 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0064 | 0.0068 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0525 | 0.1002 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0505 | 0.2063 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0296 | 0.1117 | 0.5 |
Brugia malayi | Delta serrate ligand family protein | 0.0064 | 0.0068 | 0.0068 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1074 | 0.4634 | 0.5 |
Brugia malayi | EGF-like domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | Peroxidasin | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Echinococcus granulosus | geminin | 0.0165 | 0.0525 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1074 | 0.4634 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1074 | 0.4634 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0505 | 0.2063 | 0.2063 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0505 | 0.2063 | 0.2063 |
Brugia malayi | EGF-like domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | Notch2 | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | EGF-like domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1074 | 0.4634 | 0.4634 |
Loa Loa (eye worm) | notch protein | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1074 | 0.4634 | 0.4634 |
Loa Loa (eye worm) | hypothetical protein | 0.2262 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1074 | 0.4634 | 0.4634 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.2262 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0505 | 0.2063 | 0.437 |
Plasmodium falciparum | carbonic anhydrase | 0.0505 | 0.2063 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0505 | 0.2063 | 0.2063 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0306 | 0.0306 |
Brugia malayi | Cadherin domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.0669 | 0.0669 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1074 | 0.4634 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Echinococcus granulosus | carbonic anhydrase | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0306 | 0.0306 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0505 | 0.2063 | 0.437 |
Echinococcus granulosus | carbonic anhydrase II | 0.1074 | 0.4634 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0505 | 0.2063 | 0.2063 |
Echinococcus granulosus | peroxidasin | 0.0197 | 0.0669 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Echinococcus multilocularis | carbonic anhydrase | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Onchocerca volvulus | Peroxidase homolog | 0.0197 | 0.0669 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Schistosoma mansoni | peroxidasin | 0.0197 | 0.0669 | 0.1317 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1074 | 0.4634 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0296 | 0.1117 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0197 | 0.0669 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Echinococcus multilocularis | carbonic anhydrase | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.2262 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0197 | 0.0669 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0669 | 0.0669 |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.0669 | 0.0669 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0505 | 0.2063 | 0.437 |
Onchocerca volvulus | Peroxidasin homolog | 0.0197 | 0.0669 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Onchocerca volvulus | Peroxidasin homolog | 0.0197 | 0.0669 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0197 | 0.0669 | 0.0669 |
Schistosoma mansoni | carbonic anhydrase | 0.0505 | 0.2063 | 0.437 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0525 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0505 | 0.2063 | 0.2063 |
Brugia malayi | EGF-like domain containing protein | 0.0064 | 0.0068 | 0.0068 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0197 | 0.0669 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0197 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0068 | 0.0068 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.5 uM | Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells | ChEMBL. | 17618123 |
Ki (binding) | = 3.5 uM | Displacement of [125I]NDP-MSH from MC1 receptor in mouse B16 cells | ChEMBL. | 17618123 |
Ki (binding) | = 4.7 uM | Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 4.7 uM | Displacement of [125I]NDP-MSH from human recombinant MC4 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 8.7 uM | Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 8.7 uM | Displacement of [125I]NDP-MSH from human recombinant MC5 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 22 uM | Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Ki (binding) | = 22 uM | Displacement of [125I]NDP-MSH from human recombinant MC3 receptor expressed in Sf9 cells | ChEMBL. | 17618123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.