Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.014 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0506 | 0.2791 | 0.2791 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0367 | 0.1737 | 0.1737 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.014 | 0 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0939 | 0.6095 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0367 | 0.1737 | 0.6223 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0506 | 0.2791 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0214 | 0.0568 | 0.2036 |
Trypanosoma brucei | prolyl endopeptidase | 0.0367 | 0.1737 | 0.6223 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0939 | 0.6095 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0367 | 0.1737 | 0.1737 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0506 | 0.2791 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0939 | 0.6095 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.1737 | 0.1737 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0214 | 0.0568 | 0.2036 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0506 | 0.2791 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.1726 | 0.1726 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.014 | 0 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.014 | 0 | 0.5 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0939 | 0.6095 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0939 | 0.6095 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1451 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.014 | 0 | 0.5 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0506 | 0.2791 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1451 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0506 | 0.2791 | 1 |
Brugia malayi | hypothetical protein | 0.0366 | 0.1726 | 0.1726 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0939 | 0.6095 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0214 | 0.0568 | 0.2036 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0506 | 0.2791 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.014 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0214 | 0.0568 | 0.5 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0214 | 0.0568 | 0.2036 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1451 | 1 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0939 | 0.6095 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.014 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0506 | 0.2791 | 0.2791 |
Trypanosoma cruzi | oligopeptidase b | 0.0214 | 0.0568 | 0.2036 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1451 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0367 | 0.1737 | 0.5258 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0506 | 0.2791 | 0.2791 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0367 | 0.1737 | 0.1737 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0367 | 0.1737 | 0.1737 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0214 | 0.0568 | 0.2036 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0506 | 0.2791 | 0.2791 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0228 | 0.0672 | 0.0189 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1451 | 1 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0214 | 0.0568 | 0.2036 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0939 | 0.6095 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0367 | 0.1737 | 0.6223 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0367 | 0.1737 | 0.1737 |
Entamoeba histolytica | hypothetical protein, conserved | 0.014 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.014 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.