Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 5 | 260 aa | 307 aa | 28.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0705 | 0.3941 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.014 | 0.0161 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0705 | 0.3941 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0178 | 0.0415 | 0.0926 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1611 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.014 | 0.0161 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0256 | 0.0938 | 0.079 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.014 | 0.0161 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0551 | 0.2907 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1611 | 1 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0551 | 0.2907 | 1 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0705 | 0.3941 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0256 | 0.0938 | 0.079 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0178 | 0.0415 | 0.0926 |
Loa Loa (eye worm) | hypothetical protein | 0.0256 | 0.0938 | 0.079 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0705 | 0.3941 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0551 | 0.2907 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 0.1969 | 0.1837 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.014 | 0.0161 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0178 | 0.0415 | 0.1053 |
Trypanosoma brucei | prolyl endopeptidase | 0.0256 | 0.0938 | 0.2831 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0551 | 0.2907 | 0.2791 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0551 | 0.2907 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.014 | 0.0161 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.014 | 0.0161 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0705 | 0.3941 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0256 | 0.0938 | 0.079 |
Trichomonas vaginalis | conserved hypothetical protein | 0.014 | 0.0161 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0256 | 0.0938 | 0.2831 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.014 | 0.0161 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0256 | 0.0938 | 0.079 |
Brugia malayi | hypothetical protein | 0.041 | 0.1969 | 0.1837 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0551 | 0.2907 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0178 | 0.0415 | 0.1053 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0551 | 0.2907 | 0.2791 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1611 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0705 | 0.3941 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0256 | 0.0938 | 0.079 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0178 | 0.0415 | 0.0926 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0256 | 0.0938 | 0.2099 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0178 | 0.0415 | 0.0926 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.014 | 0.0161 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0551 | 0.2907 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.0178 | 0.0415 | 0.0926 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0705 | 0.3941 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1611 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.0178 | 0.0415 | 0.0926 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1611 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.014 | 0.0161 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0705 | 0.3941 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0256 | 0.0938 | 0.2831 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0551 | 0.2907 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.014 | 0.0161 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0551 | 0.2907 | 1 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0178 | 0.0415 | 0.0926 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0178 | 0.0415 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.