Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Toxoplasma gondii | cathepsin B | 0.027 | 0.2743 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0147 | 0.0778 | 0.0778 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0168 | 0.1114 | 0.1114 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0265 | 0.2662 | 0.2662 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0184 | 0.1378 | 0.1378 |
Plasmodium vivax | vivapain-2 | 0.0265 | 0.2662 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0131 | 0.0536 | 0.0536 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0265 | 0.2662 | 0.2662 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0131 | 0.0536 | 0.0536 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0128 | 0.0478 | 0.0478 |
Giardia lamblia | Cathepsin B precursor | 0.027 | 0.2743 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0265 | 0.2662 | 0.2662 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Leishmania major | cysteine peptidase A (CPA) | 0.0265 | 0.2662 | 0.9704 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0265 | 0.2662 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0265 | 0.2662 | 0.2662 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Brugia malayi | Trypsin family protein | 0.0131 | 0.0536 | 0.0536 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Onchocerca volvulus | 0.0184 | 0.1378 | 0.5175 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0147 | 0.0778 | 0.2838 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0265 | 0.2662 | 0.2662 |
Brugia malayi | Cathepsin L-like precursor | 0.0265 | 0.2662 | 0.2662 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0265 | 0.2662 | 0.2662 |
Plasmodium vivax | vivapain-3 | 0.0147 | 0.0778 | 0.2924 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0727 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0147 | 0.0778 | 0.2924 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0168 | 0.1114 | 0.1114 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0147 | 0.0778 | 0.0778 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.027 | 0.2743 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0147 | 0.0778 | 0.2924 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0184 | 0.1378 | 0.1378 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Brugia malayi | cathepsin L-like precursor | 0.0184 | 0.1378 | 0.1378 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.027 | 0.2743 | 0.2743 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Echinococcus granulosus | cathepsin L | 0.0147 | 0.0778 | 0.0778 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0265 | 0.2662 | 1 |
Onchocerca volvulus | 0.0265 | 0.2662 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Loa Loa (eye worm) | fibroinase | 0.0265 | 0.2662 | 0.2662 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0147 | 0.0778 | 0.0778 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Echinococcus granulosus | cathepsin b | 0.0727 | 1 | 1 |
Onchocerca volvulus | 0.0131 | 0.0536 | 0.2012 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0727 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0147 | 0.0778 | 0.0778 |
Echinococcus multilocularis | cathepsin b | 0.0727 | 1 | 1 |
Plasmodium vivax | unspecified product | 0.0147 | 0.0778 | 0.2924 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0168 | 0.1114 | 0.1114 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Plasmodium vivax | vivapain-1 | 0.0147 | 0.0778 | 0.2924 |
Echinococcus granulosus | cathepsin b | 0.0727 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0184 | 0.1378 | 0.5022 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Onchocerca volvulus | 0.0265 | 0.2662 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0147 | 0.0778 | 0.0778 |
Onchocerca volvulus | Cathepsin L homolog | 0.0265 | 0.2662 | 1 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0265 | 0.2662 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0727 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0147 | 0.0778 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0265 | 0.2662 | 0.2662 |
Onchocerca volvulus | Cathepsin F homolog | 0.0265 | 0.2662 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0265 | 0.2662 | 0.2662 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Onchocerca volvulus | 0.0265 | 0.2662 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0147 | 0.0778 | 0.0778 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0265 | 0.2662 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0265 | 0.2662 | 0.2662 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 0.0778 | 0.2838 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0147 | 0.0778 | 0.2838 |
Onchocerca volvulus | 0.0265 | 0.2662 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.027 | 0.2743 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0265 | 0.2662 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0265 | 0.2662 | 0.2662 |
Echinococcus granulosus | cathepsin l1 | 0.0265 | 0.2662 | 0.2662 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0265 | 0.2662 | 0.2662 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0168 | 0.1114 | 0.1114 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0265 | 0.2662 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2662 | 0.2662 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0265 | 0.2662 | 0.2662 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0265 | 0.2662 | 0.2662 |
Brugia malayi | Cathepsin L-like precursor | 0.0265 | 0.2662 | 0.2662 |
Echinococcus granulosus | cysteine protease | 0.0147 | 0.0778 | 0.0778 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0184 | 0.1378 | 0.5022 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1378 | 0.1378 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0536 | 0.0536 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0184 | 0.1378 | 0.5175 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Loa Loa (eye worm) | ctsf protein | 0.0265 | 0.2662 | 0.2662 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0265 | 0.2662 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0147 | 0.0778 | 0.2838 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0168 | 0.1114 | 0.1114 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1378 | 0.1378 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0128 | 0.0478 | 0.0478 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0265 | 0.2662 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0265 | 0.2662 | 0.2662 |
Giardia lamblia | Cathepsin B precursor | 0.027 | 0.2743 | 1 |
Onchocerca volvulus | 0.0265 | 0.2662 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.0265 | 0.2662 | 0.2662 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0147 | 0.0778 | 0.2924 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0147 | 0.0778 | 0.2924 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0265 | 0.2662 | 0.2662 |
Onchocerca volvulus | 0.0265 | 0.2662 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.027 | 0.2743 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1378 | 0.1378 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0478 | 0.0478 |
Brugia malayi | Cathepsin L-like precursor | 0.0184 | 0.1378 | 0.1378 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0265 | 0.2662 | 0.2662 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0147 | 0.0778 | 0.2924 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0265 | 0.2662 | 0.2662 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0168 | 0.1114 | 0.4186 |
Entamoeba histolytica | cysteine protease, putative | 0.0265 | 0.2662 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0147 | 0.0778 | 0.0778 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.027 | 0.2743 | 0.2743 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0727 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0147 | 0.0778 | 0.0778 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0727 | 1 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0147 | 0.0778 | 0.0778 |
Plasmodium vivax | vivapain-2 | 0.0265 | 0.2662 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0727 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0265 | 0.2662 | 0.9704 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Loa Loa (eye worm) | hypothetical protein | 0.0727 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Loa Loa (eye worm) | cathepsin B | 0.027 | 0.2743 | 0.2743 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0536 | 0.0536 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0147 | 0.0778 | 0.2924 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0184 | 0.1378 | 0.1378 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0147 | 0.0778 | 0.0778 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0147 | 0.0778 | 0.0778 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma cruzi | cysteine protease, putative | 0.0147 | 0.0778 | 0.0778 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Onchocerca volvulus | 0.0265 | 0.2662 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0265 | 0.2662 | 0.9704 |
Toxoplasma gondii | cathepsin CPL | 0.0265 | 0.2662 | 0.9704 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Brugia malayi | Cathepsin L-like precursor | 0.0265 | 0.2662 | 0.2662 |
Entamoeba histolytica | cysteine protease, putative | 0.0147 | 0.0778 | 0.2924 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.027 | 0.2743 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0184 | 0.1378 | 0.1378 |
Echinococcus multilocularis | cysteine protease | 0.0265 | 0.2662 | 0.2662 |
Brugia malayi | Cathepsin L-like precursor | 0.0265 | 0.2662 | 0.2662 |
Brugia malayi | Cathepsin L-like precursor | 0.0184 | 0.1378 | 0.1378 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0097 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0265 | 0.2662 | 0.9704 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0097 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 10 % | Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO cells | ChEMBL. | 17915849 |
Activity (binding) | < 10 % | Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO cells | ChEMBL. | 17915849 |
Activity (binding) | = 46.1 % | Displacement of [3H]-CP-55940 from human CB2 receptor expressed in CHO cells | ChEMBL. | 17915849 |
Activity (binding) | = 46.1 % | Displacement of [3H]-CP-55940 from human CB2 receptor expressed in CHO cells | ChEMBL. | 17915849 |
Ki (binding) | 0 | Inhibition of human CB2 receptor expressed in CHO cells | ChEMBL. | 17915849 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.