Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0034 | 0.0358 | 0.4303 |
Entamoeba histolytica | hypothetical protein | 0.0065 | 0.0831 | 1 |
Loa Loa (eye worm) | MBOAT family protein | 0.0065 | 0.0831 | 0.0831 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0216 | 0.3152 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0193 | 0.0193 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0065 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0045 | 0.0535 | 0.0535 |
Loa Loa (eye worm) | MBOAT family protein | 0.0065 | 0.0831 | 0.0831 |
Leishmania major | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0831 | 0.0831 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hhat protein | 0.0065 | 0.0831 | 0.0831 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0831 | 0.0831 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0065 | 0.0831 | 0.0831 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0065 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0051 | 0.0622 | 0.0622 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0065 | 0.0831 | 1 |
Echinococcus multilocularis | lysophospholipid acyltransferase 7 | 0.0065 | 0.0831 | 0.0831 |
Schistosoma mansoni | zinc finger protein | 0.0065 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0831 | 0.0831 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0065 | 0.0831 | 1 |
Echinococcus granulosus | geminin | 0.0095 | 0.1293 | 0.1293 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0065 | 0.0831 | 1 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0065 | 0.0831 | 0.0831 |
Echinococcus granulosus | GPCR family 2 | 0.0011 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0.0051 | 0.0619 | 0.2889 | |
Leishmania major | squalene monooxygenase-like protein | 0.0216 | 0.3152 | 1 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0065 | 0.0831 | 0.0831 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Schistosoma mansoni | protein kinase C mu | 0.0051 | 0.0622 | 0.0622 |
Brugia malayi | C1-like domain containing protein | 0.0051 | 0.0622 | 0.7479 |
Echinococcus multilocularis | Membrane bound O acyl transferase, MBOAT | 0.0065 | 0.0831 | 0.0831 |
Leishmania major | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0023 | 0.0193 | 0.2327 |
Brugia malayi | Hhat protein | 0.0065 | 0.0831 | 1 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0065 | 0.0831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0642 | 0.0642 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0065 | 0.0831 | 1 |
Echinococcus granulosus | membrane bound acyltransferase:hhat | 0.0065 | 0.0831 | 0.0831 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0065 | 0.0831 | 0.0831 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0051 | 0.0622 | 0.7479 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0663 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0003 | 0.0003 |
Brugia malayi | MBOAT family protein | 0.0065 | 0.0831 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0065 | 0.0831 | 1 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0663 | 1 | 1 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0216 | 0.3152 | 1 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0065 | 0.0831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0599 | 0.9007 | 0.9007 |
Trypanosoma cruzi | GUP1, putative | 0.0065 | 0.0831 | 0.2637 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0065 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0011 | 0.0003 | 0.0003 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0011 | 0.0003 | 0.0003 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0065 | 0.0831 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1293 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0193 | 0.0193 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0011 | 0.0003 | 0.0034 |
Loa Loa (eye worm) | MBOAT family protein | 0.0065 | 0.0831 | 0.0831 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0065 | 0.0831 | 1 |
Echinococcus granulosus | Membrane bound O acyl transferase MBOAT | 0.0065 | 0.0831 | 0.0831 |
Leishmania major | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Trichomonas vaginalis | porcupine, putative | 0.0065 | 0.0831 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Echinococcus multilocularis | GPCR, family 2 | 0.0011 | 0.0003 | 0.0003 |
Echinococcus granulosus | lysophospholipid acyltransferase 7 | 0.0065 | 0.0831 | 0.0831 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0065 | 0.0831 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0034 | 0.0358 | 0.4303 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0358 | 0.0358 |
Leishmania major | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0011 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0095 | 0.1293 | 0.1293 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0533 | 0.0533 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0619 | 0.0619 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0065 | 0.0831 | 0.0831 |
Brugia malayi | MBOAT family protein | 0.0065 | 0.0831 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0011 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0003 | 0.0003 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0065 | 0.0831 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0011 | 0.0003 | 0.0034 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0065 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0065 | 0.0831 | 0.0831 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0034 | 0.0358 | 0.0358 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.0065 | 0.0831 | 0.0831 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0065 | 0.0831 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0003 | 0.0003 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0003 | 0.0003 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0065 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | hhat protein | 0.0065 | 0.0831 | 0.0831 |
Brugia malayi | MBOAT family protein | 0.0065 | 0.0831 | 1 |
Echinococcus multilocularis | geminin | 0.0095 | 0.1293 | 0.1293 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0011 | 0.0003 | 0.0003 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0065 | 0.0831 | 1 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0065 | 0.0831 | 0.0831 |
Trypanosoma cruzi | GUP1, putative | 0.0065 | 0.0831 | 0.2637 |
Loa Loa (eye worm) | hypothetical protein | 0.0663 | 1 | 1 |
Echinococcus multilocularis | membrane bound acyltransferase:hhat | 0.0065 | 0.0831 | 0.0831 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0011 | 0.0003 | 0.0003 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0065 | 0.0831 | 0.0831 |
Onchocerca volvulus | 0.0052 | 0.0642 | 0.3673 | |
Onchocerca volvulus | 0.0065 | 0.0831 | 1 | |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0065 | 0.0831 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0831 | 0.0831 |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.0065 | 0.0831 | 0.0831 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0065 | 0.0831 | 0.0831 |
Toxoplasma gondii | hypothetical protein | 0.0065 | 0.0831 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0011 | 0 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0216 | 0.3152 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0065 | 0.0831 | 0.2637 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0065 | 0.0831 | 1 |
Brugia malayi | MBOAT family protein | 0.0065 | 0.0831 | 1 |
Brugia malayi | diacylglycerol acyltransferase | 0.0065 | 0.0831 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0065 | 0.0831 | 0.2637 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0533 | 0.0533 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0065 | 0.0831 | 0.0831 |
Brugia malayi | MBOAT family protein | 0.0065 | 0.0831 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
deltaTm (binding) | = 28.2 degrees C | Binding affinity to human telo21 G-quadraplex DNA assessed as change in thermal stability in tris-HCl buffer at pH 7.4 | ChEMBL. | 17574421 |
IC50 (binding) | = 0.7 umol/L | Inhibition of amplification in human telo21 G-quadraplex DNA by PCR stop assay | ChEMBL. | 17574421 |
IC50 (binding) | = 12.5 umol/L | Inhibition of telomerase expressed in MCF7 cells by TRAP assay | ChEMBL. | 17574421 |
Ki (binding) | = 3.52 10^-6/M | Binding affinity to human telo21 G-quadraplex DNA at 1 uM after 5 mins | ChEMBL. | 17574421 |
Tm (binding) | = 68.3 degrees C | Binding affinity to human telo21 G-quadraplex DNA assessed as thermal stability in tris-HCl buffer at pH 7.4 | ChEMBL. | 17574421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.