Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.5877 | 0.8611 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.6489 | 0.9719 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.1274 | 0.0279 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.1238 | 0.0215 | 0.025 |
Echinococcus multilocularis | adam 17 protease | 0.6489 | 0.9719 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.358 | 0.4454 | 0.3725 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.3064 | 0.352 | 0.2528 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.3064 | 0.352 | 0.2613 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.3064 | 0.352 | 1 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.358 | 0.4454 | 0.3605 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 212.4 nM | Inhibition of electric eel AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 212.4 nM | Inhibition of electric eel AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 216.2 nM | Inhibition of Wistar rat brain AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 216.2 nM | Inhibition of Wistar rat brain AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 231.5 nM | Inhibition of human serum AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
IC50 (binding) | = 231.5 nM | Inhibition of human serum AChE by Ellman colorimetric assay | ChEMBL. | 17888667 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.