Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.1151 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.1151 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1151 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.1151 | 1 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.1151 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0913 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.1151 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.1151 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.1151 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.1151 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.01 mg Kg-1 | Blockade of secondary conditioned avoidance response in ip dosed rat | ChEMBL. | 17869521 |
ED50 (functional) | = 0.07 mg Kg-1 | Blockade of conditioned avoidance response in ip dosed rat | ChEMBL. | 17869521 |
ED50 (ADMET) | = 0.88 mg Kg-1 | Cataleptic activity in ip dosed rat | ChEMBL. | 17869521 |
ED50 (functional) | = 1.71 mg Kg-1 | Reduction of amphetamine-induced hyperactivity in ip dosed mouse | ChEMBL. | 17869521 |
ED50 (functional) | = 1.71 mg Kg-1 | Reduction of amphetamine-induced hyperactivity in ip dosed mouse | ChEMBL. | 17869521 |
ED50 (functional) | = 4.33 mg Kg-1 | Effect on locomotor activity in ip dosed mouse assessed as motor deficit by rota rod test | ChEMBL. | 17869521 |
ED50 (functional) | = 4.33 mg Kg-1 | Effect on locomotor activity in ip dosed mouse assessed as motor deficit by rota rod test | ChEMBL. | 17869521 |
ED50 (functional) | = 5.6 mg Kg-1 | Blockade of unconditioned avoidance response in ip dosed rat | ChEMBL. | 17869521 |
ED50 (functional) | = 5.75 mg Kg-1 | Antagonism of amphetamine-induced toxicity in ip dosed mouse | ChEMBL. | 17869521 |
ED50 (functional) | = 5.75 mg Kg-1 | Antagonism of amphetamine-induced toxicity in ip dosed mouse | ChEMBL. | 17869521 |
ED50 (functional) | = 12.6 mg Kg-1 | Ratio of ED50 for cataleptic activity in rat to ED50 for conditioned avoidance response in rat | ChEMBL. | 17869521 |
Ki (binding) | = -9.192 | Displacement of [3H]SCH23390 from dopamine D1 receptor in rat brain | ChEMBL. | 17869521 |
Ki (binding) | = -8.029 | Displacement of [3H]ketanserin from 5HT2A receptor in rat brain | ChEMBL. | 17869521 |
Ki (binding) | = -5.647 | Displacement of [3H]spiperone from dopamine D2 receptor in rat brain | ChEMBL. | 17869521 |
Log Ki (binding) | = 5.647 | Displacement of [3H]spiperone from dopamine D2 receptor in rat brain | ChEMBL. | 17869521 |
Log Ki (binding) | = 8.029 | Displacement of [3H]ketanserin from 5HT2A receptor in rat brain | ChEMBL. | 17869521 |
Log Ki (binding) | = 9.192 | Displacement of [3H]SCH23390 from dopamine D1 receptor in rat brain | ChEMBL. | 17869521 |
Ratio Ki (binding) | = 1.42 | Selectivity ratio of pKi for rat brain 5HT2A receptor to pKi for rat brain dopamine D2 receptor | ChEMBL. | 17869521 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.