Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0146 | 0.2454 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0146 | 0.2454 | 0.5 |
Mycobacterium ulcerans | 2-nitropropane dioxygenase | 0.0278 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0146 | 0.2454 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.2454 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0146 | 0.2454 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0146 | 0.2454 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0146 | 0.2454 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0146 | 0.2454 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0146 | 0.2454 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.2454 | 0.5 |
Onchocerca volvulus | 0.0146 | 0.2454 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.2454 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0146 | 0.2454 | 0.5 |
Trichomonas vaginalis | 2-nitropropane dioxygenase precursor, putative | 0.0278 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0278 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0278 | 1 | 1 |
Mycobacterium tuberculosis | Possible alanine rich oxidoreductase | 0.0278 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | trans-2-enoyl-ACP reductase, FabK | 0.0278 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 8.34 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 17127059 |
Ki (binding) | = 9.3 nM | Binding affinity at human histamine H3 receptor | ChEMBL. | 17127059 |
Ki (binding) | = 9.3 nM | Binding affinity at human histamine H3 receptor | ChEMBL. | 17127059 |
Ki (binding) | = 107 nM | Binding affinity at human SERT | ChEMBL. | 17127059 |
Ki (binding) | = 107 nM | Binding affinity at human SERT | ChEMBL. | 17127059 |
Ki (binding) | = 120 nM | Binding affinity at rat SERT | ChEMBL. | 17127059 |
Ki (binding) | = 120 nM | Binding affinity at rat SERT | ChEMBL. | 17127059 |
pA2 (functional) | = 8.34 | Antagonist activity at human histamine H3 receptor | ChEMBL. | 17127059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.