Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0099 | 0.0044 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.033 | 0.0276 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0048 | 0.0962 | 0.145 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0283 | 0.633 | 1 |
Trichomonas vaginalis | glutaminase, putative | 0.0296 | 0.6634 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 0.0962 | 0.0912 |
Schistosoma mansoni | hypothetical protein | 0.0443 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0226 | 0.5031 | 0.7583 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.029 | 0.6488 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0182 | 0.0827 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0182 | 0.0827 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.2195 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.029 | 0.6488 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0296 | 0.6634 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0102 | 0.2195 | 0.3309 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.2195 | 0.3296 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.033 | 0.0498 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0067 | 0.139 | 0.139 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.006 | 0.1229 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.033 | 0.0479 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.033 | 0.1504 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0605 | 0.0605 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0608 | 0.4946 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0102 | 0.2195 | 0.2195 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.033 | 0.033 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 0.0962 | 0.4384 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.2195 | 0.3296 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0608 | 0.0608 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0605 | 0.0552 |
Trypanosoma brucei | polo-like protein kinase | 0.0102 | 0.2195 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.033 | 0.0498 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0608 | 0.0555 |
Schistosoma mansoni | glutaminase | 0.0296 | 0.6634 | 0.6634 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.2195 | 0.3296 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0605 | 0.0552 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.1012 | 0.1508 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0051 | 0.1012 | 0.1508 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.033 | 0.0498 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0102 | 0.2195 | 0.2151 |
Loa Loa (eye worm) | glutaminase 2 | 0.0296 | 0.6634 | 1 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.0182 | 0.0827 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0564 | 0.085 |
Onchocerca volvulus | 0.0257 | 0.5744 | 1 | |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.033 | 0.0509 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0283 | 0.633 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0608 | 0.096 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0102 | 0.2195 | 0.3029 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0962 | 0.145 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0608 | 0.0916 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0283 | 0.633 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0226 | 0.5031 | 0.7583 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3699 | 0.3699 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.033 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0608 | 0.0916 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0102 | 0.2195 | 0.3309 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0608 | 0.0555 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0564 | 0.085 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0608 | 0.0555 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.033 | 0.033 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0102 | 0.2195 | 0.2151 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.2195 | 0.3296 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 0.0962 | 0.0962 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0102 | 0.2195 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.033 | 0.1504 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Schistosoma mansoni | kinase | 0.0052 | 0.1043 | 0.1043 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.029 | 0.6488 | 0.9779 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0099 | 0.0044 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.2195 | 0.3296 |
Onchocerca volvulus | 0.0033 | 0.0608 | 0.0084 | |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.033 | 0.1504 |
Leishmania major | DNA polymerase eta, putative | 0.0034 | 0.0632 | 0.2879 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0608 | 0.0608 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.029 | 0.6488 | 1 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0283 | 0.633 | 0.9543 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0056 | 0.0056 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.033 | 0.0276 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0034 | 0.0632 | 0.5144 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.3699 | 0.3699 |
Echinococcus granulosus | geminin | 0.0168 | 0.3699 | 0.3664 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0283 | 0.633 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0443 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.3699 | 0.3664 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0142 | 0.3093 | 0.4605 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 0.0962 | 0.4384 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.029 | 0.6488 | 1 |
Giardia lamblia | Kinase, PLK | 0.0102 | 0.2195 | 0.3384 |
Brugia malayi | glutaminase DH11.1 | 0.0296 | 0.6634 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0565 | 0.0512 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0605 | 0.0605 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.2195 | 0.3296 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0099 | 0.0149 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.033 | 0.0479 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0034 | 0.0632 | 0.2879 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0182 | 0.0827 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 0.0962 | 0.4384 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.033 | 0.1504 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Mycobacterium ulcerans | glutaminase | 0.0296 | 0.6634 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.033 | 0.1504 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0608 | 0.0608 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.033 | 0.1504 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 0.0962 | 0.0912 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0142 | 0.3093 | 0.4663 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.033 | 0.0276 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0608 | 0.0608 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0102 | 0.2195 | 0.3296 |
Trichomonas vaginalis | set domain proteins, putative | 0.0257 | 0.5744 | 0.8656 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.033 | 0.0498 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0564 | 0.0564 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0102 | 0.2195 | 0.3149 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0096 | 0.0145 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.0182 | 0.0827 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0102 | 0.2195 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.