Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 0.1455 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0577 | 0.1455 | 0.1455 |
Onchocerca volvulus | 0.0577 | 0.1455 | 0.1455 | |
Echinococcus multilocularis | serotonin transporter | 0.3399 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Plasmodium vivax | amine transporter, putative | 0.0577 | 0.1455 | 0.5 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0577 | 0.1455 | 0.1455 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 0.1455 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.3399 | 1 | 1 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.146 | 0.413 | 0.413 |
Loa Loa (eye worm) | hypothetical protein | 0.3399 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | norepinephrine transporter | 0.3399 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.3399 | 1 | 1 |
Onchocerca volvulus | 0.3399 | 1 | 1 | |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0577 | 0.1455 | 0.1455 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0577 | 0.1455 | 0.1455 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 0.1455 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.3399 | 1 | 1 |
Onchocerca volvulus | 0.0577 | 0.1455 | 0.1455 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0577 | 0.1455 | 0.1455 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0577 | 0.1455 | 0.1455 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.3399 | 1 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0577 | 0.1455 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0577 | 0.1455 | 0.1455 |
Toxoplasma gondii | hypothetical protein | 0.0577 | 0.1455 | 1 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0577 | 0.1455 | 0.1455 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.3399 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0577 | 0.1455 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0577 | 0.1455 | 0.5 |
Brugia malayi | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 0.1455 |
Onchocerca volvulus | 0.0577 | 0.1455 | 0.1455 | |
Echinococcus granulosus | serotonin transporter | 0.3399 | 1 | 1 |
Trypanosoma cruzi | MFS transporter, putative | 0.0096 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0577 | 0.1455 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0577 | 0.1455 | 0.1455 |
Plasmodium falciparum | transporter, putative | 0.0577 | 0.1455 | 0.5 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0577 | 0.1455 | 0.1455 |
Brugia malayi | prostaglandin transporter | 0.146 | 0.413 | 0.413 |
Loa Loa (eye worm) | hypothetical protein | 0.3399 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0577 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | serotonin transporter b | 0.3399 | 1 | 1 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0577 | 0.1455 | 0.1455 |
Onchocerca volvulus | Putative organic anion transporter | 0.146 | 0.413 | 0.413 |
Loa Loa (eye worm) | hypothetical protein | 0.0577 | 0.1455 | 0.1455 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0577 | 0.1455 | 0.1455 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0577 | 0.1455 | 1 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0577 | 0.1455 | 0.1455 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19 ug ml-1 | Inhibition of type1 FAS in HepG2 cells | ChEMBL. | 17507223 |
IC50 (binding) | = 96.8 uM | Inhibition of FASN in human HepG2 cells | ChEMBL. | 21726077 |
MIC (functional) | 0 | Antimicrobial activity against Haemophilus influenzae IID983 | ChEMBL. | 17507223 |
MIC (functional) | 0 | Antimicrobial activity against Bacteroides fragilis GAI5560 | ChEMBL. | 17507223 |
MIC (functional) | > 128 ug ml-1 | Antimicrobial activity against Staphylococcus aureus | ChEMBL. | 17507223 |
MIC (functional) | > 128 ug ml-1 | Antimicrobial activity against Moraxella catarrhalis ATCC25238 | ChEMBL. | 17507223 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.