TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 318.369 | Formula: C20H18N2O2
H donors: 0 H acceptors: 2 LogP: 4.13 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(ncnc2cc1OC)C#CCCc1ccccc1
InChi: 1S/C20H18N2O2/c1-23-19-12-16-17(21-14-22-18(16)13-20(19)24-2)11-7-6-10-15-8-4-3-5-9-15/h3-5,8-9,12-14H,6,10H2,1-2H3
InChiKey: UJTHKWFURJCQDD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	cathepsin B-like cysteine proteinase	0.0149	0.036	0.036
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0268	0.0824	0.0824
Schistosoma mansoni	tyrosine kinase	0.0096	0.015	0.015
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.2608	1	1
Onchocerca volvulus		0.081	0.295	1
Schistosoma mansoni	protein-s-isoprenylcysteine o-methyltransferase	0.2608	1	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.036	0.036
Entamoeba histolytica	cysteine proteinase 2	0.0417	0.141	0.1089
Brugia malayi	Cathepsin L-like precursor	0.0542	0.19	0.19
Plasmodium vivax	vivapain-2	0.081	0.295	0.2687
Onchocerca volvulus		0.081	0.295	1
Brugia malayi	Cathepsin L-like precursor	0.0542	0.19	0.19
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.048	0.048
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0149	0.036	0.036
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0417	0.141	0.141
Brugia malayi	Cathepsin L-like precursor	0.0268	0.0824	0.0824
Trypanosoma cruzi	cysteine proteinase, putative	0.0417	0.141	0.1089
Entamoeba histolytica	cysteine proteinase, putative	0.081	0.295	0.2687
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Loa Loa (eye worm)	hypothetical protein	0.0149	0.036	0.036
Onchocerca volvulus		0.081	0.295	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.081	0.295	0.295
Echinococcus granulosus	cathepsin L	0.0149	0.036	0.036
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Schistosoma mansoni	cathepsin s	0.0268	0.0824	0.0824
Echinococcus multilocularis	cathepsin L	0.0149	0.036	0.036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Loa Loa (eye worm)	cysteine protease	0.081	0.295	0.295
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.2608	1	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.036	0.036
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0149	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0149	0.036	0.036
Brugia malayi	Papain family cysteine protease containing protein	0.0149	0.036	0.036
Brugia malayi	cathepsin L-like precursor	0.0542	0.19	0.19
Brugia malayi	fibroinase precursor	0.0149	0.036	0.036
Brugia malayi	Papain family cysteine protease containing protein	0.081	0.295	0.295
Plasmodium vivax	unspecified product	0.0417	0.141	0.1089
Trypanosoma cruzi	cruzipain precursor, putative	0.0268	0.0824	0.0481
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0542	0.19	0.1597
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Plasmodium falciparum	protein-S-isoprenylcysteine O-methyltransferase, putative	0.2608	1	1
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.2608	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.081	0.295	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Echinococcus multilocularis	cathepsin b	0.0149	0.036	0.036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0149	0.036	0.036
Brugia malayi	Papain family cysteine protease containing protein	0.0149	0.036	0.036
Trypanosoma cruzi	cysteine peptidase, putative	0.081	0.295	0.2687
Onchocerca volvulus		0.081	0.295	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0149	0.036	0.036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Echinococcus granulosus	cathepsin l1	0.081	0.295	0.295
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0149	0.036	0.036
Leishmania major	prenyl protein specific carboxyl methyltransferase, putative	0.2608	1	1
Brugia malayi	Cathepsin L-like precursor	0.081	0.295	0.295
Echinococcus granulosus	cysteine protease	0.0417	0.141	0.141
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.081	0.295	0.2687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.081	0.295	0.295
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0268	0.0824	0.0824
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Schistosoma mansoni	tyrosine kinase	0.0096	0.015	0.015
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.048	0.048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0417	0.141	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Plasmodium vivax	protein-S-isoprenylcysteine O-methyltransferase, putative	0.2608	1	1
Mycobacterium ulcerans	hypothetical protein	0.1139	0.4239	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Brugia malayi	Papain family cysteine protease containing protein	0.0149	0.036	0.036
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.081	0.295	0.295
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0417	0.141	0.1089
Loa Loa (eye worm)	protein-S isoprenylcysteine O-methyltransferase	0.2608	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0149	0.036	0.036
Brugia malayi	Cathepsin L-like precursor	0.081	0.295	0.295
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0149	0.036	0.036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Brugia malayi	Cathepsin L-like precursor	0.081	0.295	0.295
Echinococcus multilocularis	cathepsin b	0.0149	0.036	0.036
Echinococcus multilocularis		0.2608	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0149	0.036	0.036
Echinococcus granulosus	cathepsin L	0.0417	0.141	0.141
Schistosoma mansoni	cathepsin F (C01 family)	0.081	0.295	0.295
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.141	0.1089
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.141	0.1089
Brugia malayi	cathepsin L-like cysteine proteinase	0.0149	0.036	0.036
Schistosoma mansoni	cathepsin F (C01 family)	0.081	0.295	0.295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0417	0.141	0.1089
Entamoeba histolytica	cysteine proteinase 1, putative	0.0417	0.141	0.1089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Loa Loa (eye worm)	hypothetical protein	0.081	0.295	0.295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0542	0.19	0.1597
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Brugia malayi	cathepsin F-like cysteine proteinase	0.0149	0.036	0.036
Schistosoma mansoni	tyrosine kinase	0.0096	0.015	0.015
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.2608	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.0154	0.0154
Onchocerca volvulus		0.081	0.295	1
Loa Loa (eye worm)	hypothetical protein	0.0149	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0542	0.19	0.19
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Trypanosoma cruzi	cysteine peptidase, putative	0.0417	0.141	0.1089
Trypanosoma cruzi	cruzipain precursor, putative	0.081	0.295	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Brugia malayi	Papain family cysteine protease containing protein	0.0417	0.141	0.141
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Toxoplasma gondii	cathepsin CPL	0.081	0.295	0.2687
Echinococcus multilocularis	cathepsin L cysteine protease	0.081	0.295	0.295
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0149	0.036	0.036
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Trypanosoma cruzi	cysteine peptidase, putative	0.081	0.295	0.2687
Plasmodium vivax	vivapain-1	0.0417	0.141	0.1089
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0149	0.036	0.036
Brugia malayi	cathepsin F-like cysteine proteinase	0.0268	0.0824	0.0824
Onchocerca volvulus	Cathepsin L homolog	0.081	0.295	1
Echinococcus granulosus	cathepsin b	0.0149	0.036	0.036
Onchocerca volvulus	Cathepsin F homolog	0.081	0.295	1
Echinococcus granulosus	protein S isoprenylcysteine O methyltransferase	0.2608	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0149	0.036	0.036
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0149	0.036	0.036
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0542	0.19	0.19
Giardia lamblia	Isoprenylcysteine carboxyl methyltransferase	0.2608	1	1
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2608	1	1
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Toxoplasma gondii	isoprenylcysteine carboxyl methyltransferase (icmt) family protein	0.2608	1	1
Trypanosoma brucei	prenyl protein specific carboxyl methyltransferase	0.2608	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Schistosoma mansoni	tyrosine kinase	0.0097	0.0154	0.0154
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0149	0.036	0.036
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.048	0.048
Onchocerca volvulus		0.0542	0.19	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Echinococcus granulosus	cathepsin L cysteine proteinase	0.081	0.295	0.295
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0268	0.0824	0.0824
Schistosoma mansoni	cathepsin C	0.0149	0.036	0.036
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2608	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Plasmodium vivax	vivapain-2	0.081	0.295	0.2687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0417	0.141	0.1089
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.081	0.295	0.2687
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.141	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.0154	0.0154
Echinococcus granulosus	cathepsin L cysteine protease	0.0417	0.141	0.141
Schistosoma mansoni	tyrosine kinase	0.018	0.048	0.048
Loa Loa (eye worm)	ctsf protein	0.081	0.295	0.295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Trypanosoma cruzi	cysteine peptidase, putative	0.081	0.295	0.2687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Echinococcus multilocularis	cathepsin L	0.0417	0.141	0.141
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0417	0.141	0.1089
Schistosoma mansoni	tyrosine kinase	0.0097	0.0154	0.0154
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0417	0.141	0.1089
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0542	0.19	0.1597
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0149	0.036	0.036
Brugia malayi	cathepsin L precursor	0.0149	0.036	0.036
Echinococcus multilocularis	cysteine protease	0.081	0.295	0.295
Loa Loa (eye worm)	hypothetical protein	0.0268	0.0824	0.0824
Onchocerca volvulus	Cathepsin L homolog	0.081	0.295	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.081	0.295	0.295
Entamoeba histolytica	cysteine proteinase, putative	0.0417	0.141	0.1089
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.1139	0.4239	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0417	0.141	0.1089
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.048	0.048
Entamoeba histolytica	cysteine protease, putative	0.081	0.295	0.2687
Brugia malayi	Cathepsin L-like precursor	0.081	0.295	0.295
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0149	0.036	0.036
Loa Loa (eye worm)	hypothetical protein	0.0542	0.19	0.19
Onchocerca volvulus		0.081	0.295	1
Loa Loa (eye worm)	hypothetical protein	0.0268	0.0824	0.0824
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0542	0.19	0.19
Entamoeba histolytica	cysteine proteinase, putative	0.0542	0.19	0.1597
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.081	0.295	0.2687
Plasmodium falciparum	cysteine proteinase falcipain 3	0.081	0.295	0.2687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.081	0.295	0.2687
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.081	0.295	0.295
Echinococcus granulosus	cathepsin b	0.0149	0.036	0.036
Brugia malayi	Cathepsin L-like precursor	0.081	0.295	0.295
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0149	0.036	0.036
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0417	0.141	0.141
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0417	0.141	0.141
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Plasmodium vivax	vivapain-3	0.0417	0.141	0.1089
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.2608	1	1
Brugia malayi	Cathepsin L-like precursor	0.081	0.295	0.295
Loa Loa (eye worm)	fibroinase	0.081	0.295	0.295
Entamoeba histolytica	cysteine protease, putative	0.0417	0.141	0.1089
Loa Loa (eye worm)	cathepsin B	0.0149	0.036	0.036
Entamoeba histolytica	cysteine proteinase, putative	0.081	0.295	0.2687
Schistosoma mansoni	cathepsin F (C01 family)	0.0542	0.19	0.19
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.081	0.295	0.295
Brugia malayi	Papain family cysteine protease containing protein	0.0417	0.141	0.141
Echinococcus multilocularis	cysteine protease	0.081	0.295	0.295
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.081	0.295	0.2687
Trypanosoma cruzi	cysteine protease, putative	0.0417	0.141	0.1089
Echinococcus granulosus	cathepsin l1	0.0542	0.19	0.19
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.081	0.295	0.2687
Onchocerca volvulus		0.081	0.295	1
Trypanosoma cruzi	cysteine peptidase, putative	0.081	0.295	0.2687
Leishmania major	cathepsin L-like protease	0.081	0.295	0.2687
Leishmania major	cysteine peptidase A (CPA)	0.081	0.295	0.2687
Trypanosoma cruzi	cysteine peptidase, putative	0.0268	0.0824	0.0481
Plasmodium vivax	unspecified product	0.0268	0.0824	0.0481

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 14 nM	Inhibition of partially purified EGFR tyrosine kinase from human A431 cells	ChEMBL.	17869510
IC50 (binding)	= 14 nM	Inhibition of partially purified EGFR tyrosine kinase from human A431 cells	ChEMBL.	17869510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 459261