TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.59 | Formula: C29H33N3O4
H donors: 1 H acceptors: 4 LogP: 2.4 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1cc2c(ncnc2cc1OCC)C#C[C@](N1CCC(CC1)C(=O)O)(Cc1ccccc1)C
InChi: 1S/C29H33N3O4/c1-4-35-26-17-23-24(30-20-31-25(23)18-27(26)36-5-2)11-14-29(3,19-21-9-7-6-8-10-21)32-15-12-22(13-16-32)28(33)34/h6-10,17-18,20,22H,4-5,12-13,15-16,19H2,1-3H3,(H,33,34)/t29-/m0/s1
InChiKey: GRSVZOBWWBQUNG-LJAQVGFWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0096	0.0096	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.089	0.2101	0.1883
Echinococcus granulosus	cathepsin b	0.0164	0.0269	0.0269
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0596	0.1359	0.112
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Giardia lamblia	Isoprenylcysteine carboxyl methyltransferase	0.4019	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Loa Loa (eye worm)	cysteine protease	0.089	0.2101	0.2101
Schistosoma mansoni	cathepsin F (C01 family)	0.089	0.2101	0.2101
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0269	0.0269
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0164	0.0269	0.0269
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Schistosoma mansoni	cathepsin F (C01 family)	0.089	0.2101	0.2101
Echinococcus granulosus	cathepsin L	0.0459	0.1012	0.1012
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0164	0.0269	0.0269
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.4019	1	1
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.089	0.2101	0.2101
Echinococcus multilocularis	cathepsin b	0.0164	0.0269	0.0269
Loa Loa (eye worm)	protein-S isoprenylcysteine O-methyltransferase	0.4019	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Schistosoma mansoni	cathepsin B (C01 family)	0.0164	0.0269	0.0269
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Brugia malayi	cathepsin L-like cysteine proteinase	0.0164	0.0269	0.0269
Trypanosoma cruzi	cysteine proteinase, putative	0.0459	0.1012	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.0309	0.0309
Mycobacterium ulcerans	hypothetical protein	0.1755	0.4284	0.5
Echinococcus granulosus	cathepsin b	0.0164	0.0269	0.0269
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.4019	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0459	0.1012	0.0763
Schistosoma mansoni	tyrosine kinase	0.0097	0.0099	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Plasmodium vivax	unspecified product	0.0294	0.0597	0.0337
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Brugia malayi	Papain family cysteine protease containing protein	0.0459	0.1012	0.1012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Schistosoma mansoni	tyrosine kinase	0.0096	0.0096	0.0096
Echinococcus multilocularis	cysteine protease	0.089	0.2101	0.2101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Echinococcus granulosus	cysteine protease	0.0459	0.1012	0.1012
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.4019	1	1
Brugia malayi	Cathepsin L-like precursor	0.089	0.2101	0.2101
Echinococcus granulosus	cathepsin l cysteine peptidase	0.089	0.2101	0.2101
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0269	0.0269
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Trypanosoma cruzi	cysteine peptidase, putative	0.089	0.2101	0.1883
Onchocerca volvulus	Cathepsin L homolog	0.089	0.2101	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0164	0.0269	0.0269
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.089	0.2101	0.1883
Brugia malayi	Papain family cysteine protease containing protein	0.0164	0.0269	0.0269
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0269	0.0269
Onchocerca volvulus		0.089	0.2101	1
Echinococcus granulosus	cathepsin l1	0.089	0.2101	0.2101
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.4019	1	1
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.4019	1	1
Onchocerca volvulus		0.0596	0.1359	0.6323
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0459	0.1012	0.0763
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0164	0.0269	0.0269
Brugia malayi	Cathepsin L-like precursor	0.0596	0.1359	0.1359
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0294	0.0597	0.0597
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0459	0.1012	0.0763
Plasmodium vivax	unspecified product	0.0459	0.1012	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0164	0.0269	0.0269
Plasmodium falciparum	protein-S-isoprenylcysteine O-methyltransferase, putative	0.4019	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Brugia malayi	Papain family cysteine protease containing protein	0.0164	0.0269	0.0269
Schistosoma mansoni	cathepsin S (C01 family)	0.0164	0.0269	0.0269
Echinococcus multilocularis	cathepsin b	0.0164	0.0269	0.0269
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0164	0.0269	0.0269
Plasmodium vivax	vivapain-2	0.089	0.2101	0.1883
Loa Loa (eye worm)	fibroinase	0.089	0.2101	0.2101
Brugia malayi	fibroinase precursor	0.0164	0.0269	0.0269
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0597	0.0597
Brugia malayi	Papain family cysteine protease containing protein	0.0164	0.0269	0.0269
Loa Loa (eye worm)	cathepsin B	0.0164	0.0269	0.0269
Entamoeba histolytica	cysteine proteinase, putative	0.0459	0.1012	0.0763
Loa Loa (eye worm)	hypothetical protein	0.089	0.2101	0.2101
Onchocerca volvulus		0.089	0.2101	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0294	0.0597	0.0597
Entamoeba histolytica	cysteine proteinase 1, putative	0.0459	0.1012	0.0763
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0164	0.0269	0.0269
Entamoeba histolytica	cysteine protease, putative	0.089	0.2101	0.1883
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.0309	0.0309
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0459	0.1012	0.0763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0596	0.1359	0.112
Schistosoma mansoni	protein-s-isoprenylcysteine o-methyltransferase	0.4019	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Onchocerca volvulus		0.089	0.2101	1
Loa Loa (eye worm)	hypothetical protein	0.0596	0.1359	0.1359
Echinococcus granulosus	cathepsin L cysteine protease	0.0459	0.1012	0.1012
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0597	0.0597
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.0099	0.0099
Plasmodium vivax	protein-S-isoprenylcysteine O-methyltransferase, putative	0.4019	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.089	0.2101	0.2101
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0164	0.0269	0.0269
Trypanosoma cruzi	cysteine peptidase, putative	0.0294	0.0597	0.0337
Schistosoma mansoni	cathepsin s	0.0294	0.0597	0.0597
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Onchocerca volvulus		0.089	0.2101	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Echinococcus granulosus	cathepsin l1	0.0596	0.1359	0.1359
Trypanosoma cruzi	cysteine peptidase, putative	0.0459	0.1012	0.0763
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Brugia malayi	Cathepsin L-like precursor	0.089	0.2101	0.2101
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.089	0.2101	0.2101
Brugia malayi	Papain family cysteine protease containing protein	0.0459	0.1012	0.1012
Onchocerca volvulus		0.089	0.2101	1
Brugia malayi	Cathepsin L-like precursor	0.089	0.2101	0.2101
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Brugia malayi	Cathepsin L-like precursor	0.0596	0.1359	0.1359
Entamoeba histolytica	cysteine proteinase, putative	0.089	0.2101	0.1883
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.4019	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0459	0.1012	0.1012
Toxoplasma gondii	cathepsin CPL	0.089	0.2101	0.1883
Plasmodium falciparum	cysteine proteinase falcipain 3	0.089	0.2101	0.1883
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Entamoeba histolytica	cysteine proteinase, putative	0.0459	0.1012	0.0763
Plasmodium vivax	vivapain-3	0.0459	0.1012	0.0763
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Brugia malayi	Cathepsin L-like precursor	0.089	0.2101	0.2101
Brugia malayi	Cathepsin L-like precursor	0.089	0.2101	0.2101
Brugia malayi	cathepsin L precursor	0.0164	0.0269	0.0269
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.089	0.2101	0.2101
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Loa Loa (eye worm)	hypothetical protein	0.009	0.0082	0.0082
Brugia malayi	cathepsin L-like precursor	0.0596	0.1359	0.1359
Entamoeba histolytica	cysteine proteinase, putative	0.0596	0.1359	0.112
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.0309	0.0309
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Onchocerca volvulus		0.089	0.2101	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0294	0.0597	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0596	0.1359	0.1359
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0164	0.0269	0.0269
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0459	0.1012	0.1012
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.089	0.2101	0.1883
Trypanosoma cruzi	cysteine peptidase, putative	0.089	0.2101	0.1883
Echinococcus multilocularis	cathepsin L	0.0164	0.0269	0.0269
Brugia malayi	Cathepsin L-like precursor	0.0294	0.0597	0.0597
Echinococcus multilocularis	cathepsin L cysteine protease	0.089	0.2101	0.2101
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.1755	0.4284	0.5
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0596	0.1359	0.1359
Entamoeba histolytica	cysteine proteinase, putative	0.0459	0.1012	0.0763
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0164	0.0269	0.0269
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.0099	0.0099
Entamoeba histolytica	cysteine proteinase 2	0.0459	0.1012	0.0763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Trypanosoma cruzi	cysteine peptidase, putative	0.089	0.2101	0.1883
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Echinococcus multilocularis	cathepsin L	0.0459	0.1012	0.1012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0459	0.1012	0.0763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.0309	0.0309
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Schistosoma mansoni	tyrosine kinase	0.0097	0.0099	0.0099
Echinococcus granulosus	cathepsin L cysteine proteinase	0.089	0.2101	0.2101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Loa Loa (eye worm)	ctsf protein	0.089	0.2101	0.2101
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0459	0.1012	0.0763
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Entamoeba histolytica	cysteine proteinase, putative	0.089	0.2101	0.1883
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.089	0.2101	0.1883
Echinococcus granulosus	protein S isoprenylcysteine O methyltransferase	0.4019	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0164	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0294	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0269	0.0269
Onchocerca volvulus	Cathepsin L homolog	0.0164	0.0269	0.093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0596	0.1359	0.112
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0269	0.0269
Echinococcus granulosus	cathepsin L	0.0164	0.0269	0.0269
Schistosoma mansoni	tyrosine kinase	0.018	0.0309	0.0309
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0164	0.0269	0.0269
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.4019	1	1
Toxoplasma gondii	isoprenylcysteine carboxyl methyltransferase (icmt) family protein	0.4019	1	1
Onchocerca volvulus	Cathepsin F homolog	0.089	0.2101	1
Onchocerca volvulus	Cathepsin L homolog	0.089	0.2101	1
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Entamoeba histolytica	cysteine protease, putative	0.0459	0.1012	0.0763
Leishmania major	prenyl protein specific carboxyl methyltransferase, putative	0.4019	1	1
Schistosoma mansoni	tyrosine kinase	0.0096	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0269	0.0269
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0596	0.1359	0.1359
Schistosoma mansoni	cathepsin C	0.0164	0.0269	0.0269
Leishmania major	cathepsin L-like protease	0.089	0.2101	0.1883
Echinococcus multilocularis		0.4019	1	1
Onchocerca volvulus		0.0164	0.0269	0.093
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Brugia malayi	cathepsin B-like cysteine proteinase	0.0164	0.0269	0.0269
Brugia malayi	cathepsin F-like cysteine proteinase	0.0294	0.0597	0.0597
Trypanosoma brucei	prenyl protein specific carboxyl methyltransferase	0.4019	1	1
Brugia malayi	Phospholipase A2 family protein	0.009	0.0082	0.0082
Onchocerca volvulus		0.089	0.2101	1
Trypanosoma cruzi	cysteine protease, putative	0.0459	0.1012	0.0763
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0164	0.0269	0.0269
Plasmodium vivax	vivapain-1	0.0459	0.1012	0.0763
Trypanosoma cruzi	cruzipain precursor, putative	0.089	0.2101	0.1883
Loa Loa (eye worm)	hypothetical protein	0.009	0.0082	0.0082
Leishmania major	cysteine peptidase A (CPA)	0.089	0.2101	0.1883
Entamoeba histolytica	cysteine proteinase, putative	0.0459	0.1012	0.0763
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0459	0.1012	0.1012
Brugia malayi	Papain family cysteine protease containing protein	0.089	0.2101	0.2101
Echinococcus multilocularis	cathepsin L cysteine protease	0.089	0.2101	0.2101
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.089	0.2101	0.1883
Plasmodium vivax	vivapain-2	0.089	0.2101	0.1883
Brugia malayi	Cathepsin L-like precursor	0.089	0.2101	0.2101
Schistosoma mansoni	cathepsin F (C01 family)	0.0596	0.1359	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0269	0.0269
Trypanosoma cruzi	cysteine peptidase, putative	0.089	0.2101	0.1883
Trypanosoma cruzi	cysteine proteinase, putative	0.0459	0.1012	0.0763
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.0099	0.0099
Echinococcus multilocularis	cysteine protease	0.089	0.2101	0.2101

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.2 nM	Inhibition of partially purified EGFR tyrosine kinase from human A431 cells	ChEMBL.	17869510
IC50 (binding)	= 4.2 nM	Inhibition of partially purified EGFR tyrosine kinase from human A431 cells	ChEMBL.	17869510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 459284