TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 251.321 | Formula: C14H21NO3
H donors: 2 H acceptors: 2 LogP: 1.62 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCN1CCOC(C1)c1ccc(c(c1)O)CO
InChi: 1S/C14H21NO3/c1-2-5-15-6-7-18-14(9-15)11-3-4-12(10-16)13(17)8-11/h3-4,8,14,16-17H,2,5-7,9-10H2,1H3
InChiKey: VQDBZBRRFKOERX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dopamine receptor D3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	dopamine receptor D3	400 aa	392 aa	19.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0415	0.4198
Echinococcus granulosus	muscleblind protein	0.0146	0.2874	0.341
Brugia malayi	6-phosphofructokinase	0.0123	0.2368	0.2491
Leishmania major	ATP-dependent phosphofructokinase	0.0123	0.2368	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Loa Loa (eye worm)	hypothetical protein	0.0449	0.9503	0.9503
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0531	0.0531
Trypanosoma brucei	glucosidase, putative	0.0041	0.0582	0.2417
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0415	0.4198
Schistosoma mansoni	NAD dehydrogenase	0.0039	0.0551	0.0539
Mycobacterium ulcerans	6-phosphofructokinase	0.0123	0.2368	0.1922
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0015	0.0024	0.0046
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0033	0.0415	0.0445
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0313	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0381	0.0381
Echinococcus granulosus	GPCR family 2	0.0018	0.0081	0.0081
Schistosoma mansoni	lamin	0.0026	0.0267	0.0254
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0123	0.2368	1
Schistosoma mansoni	fad oxidoreductase	0.0039	0.0551	0.0539
Echinococcus multilocularis	Protein lozenge	0.0056	0.0923	0.1085
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0184	0.3702	0.4397
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0024	0.0024
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Brugia malayi	hypothetical protein	0.0449	0.9503	1
Echinococcus multilocularis	peregrin	0.0028	0.0313	0.0358
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.004	0.0556	0.0647
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0514	0.0597
Brugia malayi	bZIP transcription factor family protein	0.0187	0.3781	0.3979
Brugia malayi	6-phosphofructokinase	0.0123	0.2368	0.2491
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.1187	0.5148
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0514	0.0501
Brugia malayi	phosphofructokinase	0.0123	0.2368	0.2491
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0033	0.0415	0.06
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.2874	0.341
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0015	0.0024	0.0046
Schistosoma mansoni	cpg binding protein	0.0059	0.0985	0.0974
Brugia malayi	jmjC domain containing protein	0.0038	0.0514	0.054
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0187	0.3781	0.4491
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0039	0.0551	0.9825
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1187	0.0672
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0081	0.0081
Echinococcus granulosus	geminin	0.0165	0.3301	0.3919
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0039	0.0551	0.058
Brugia malayi	jmjC domain containing protein	0.0093	0.1726	0.1816
Loa Loa (eye worm)	6-phosphofructokinase	0.0123	0.2368	0.2368
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0551	0.0551
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0415	0.0664
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.0582	0.0947
Leishmania major	alpha glucosidase II subunit, putative	0.0041	0.0582	0.2417
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0041	0.0582	0.0947
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.004	0.0556	0.2305
Schistosoma mansoni	hypothetical protein	0.0038	0.0531	0.0519
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0514	0.0514
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0039	0.0551	0.0642
Echinococcus granulosus	lysosomal alpha glucosidase	0.0184	0.3702	0.4397
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0042	0.0602	0.0981
Echinococcus granulosus	lamin	0.0026	0.0267	0.0302
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0041	0.0582	0.1584
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0039	0.0551	0.9825
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0267	0.0267
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.006	0.0198
Echinococcus granulosus	lamin dm0	0.0026	0.0267	0.0302
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.1187	0.1399
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.1187	0.1399
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0602	0.2502
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.006	0.0198
Schistosoma mansoni	alpha glucosidase	0.0041	0.0582	0.057
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0267	0.0281
Schistosoma mansoni	hypothetical protein	0.0018	0.0081	0.0068
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0039	0.0551	0.2287
Brugia malayi	polk-prov protein	0.0032	0.0381	0.0401
Schistosoma mansoni	lozenge	0.0056	0.0923	0.0911
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0039	0.0551	0.0551
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.1726	0.2042
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0039	0.0551	0.2287
Onchocerca volvulus		0.0449	0.9503	1
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0039	0.0551	0.0912
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0033	0.0415	0.0664
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0081	0.0081
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0081	0.0081
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0023	0.0199	0.0186
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0017	0.0071	0.0069
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0039	0.0551	0.1404
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.0582	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0267	0.0267
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0556	1
Toxoplasma gondii	6-phosphofructokinase	0.0033	0.0415	0.06
Echinococcus granulosus	dnaJ subfamily B	0.0399	0.8404	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.004	0.0556	0.2305
Entamoeba histolytica	phosphofructokinase, putative	0.0123	0.2368	0.3988
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0313	0.0358
Entamoeba histolytica	phosphofructokinase, putative	0.0123	0.2368	0.3988
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0041	0.0582	0.0947
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0041	0.0582	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0449	0.9503	0.9503
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0015	0.0013	0.0013
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0582	0.2417
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0381	0.1562
Onchocerca volvulus		0.0026	0.0267	0.0256
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0033	0.0415	0.0681
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0123	0.2368	0.3549
Brugia malayi	F/Y-rich N-terminus family protein	0.0026	0.0269	0.0283
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1187	0.0672
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1187	0.0672
Schistosoma mansoni	lamin	0.0026	0.0267	0.0254
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0919	0.0967
Loa Loa (eye worm)	6-phosphofructokinase	0.0123	0.2368	0.2368
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0056	0.0916	0.0916
Toxoplasma gondii	hypothetical protein	0.0039	0.0551	0.1404
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0582	0.2417
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0039	0.0551	0.0539
Brugia malayi	intermediate filament protein	0.0026	0.0267	0.0281
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0184	0.3702	0.3896
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Schistosoma mansoni	hypothetical protein	0.0152	0.3015	0.3006
Schistosoma mansoni	6-phosphofructokinase	0.0123	0.2368	0.2358
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0039	0.0551	0.2287
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0039	0.0551	0.2287
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1187	0.1175
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.1726	0.2042
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0015	0.0024	0.0018
Leishmania major	hypothetical protein, conserved	0.0039	0.0551	0.2287
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0415	0.0664
Loa Loa (eye worm)	runx1	0.0056	0.0923	0.0923
Echinococcus granulosus	neutral alpha glucosidase AB	0.0041	0.0582	0.0678
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.2368	0.3977
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.1187	0.4985
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0159	0.0621
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.2733	0.2309
Echinococcus granulosus	peregrin	0.0028	0.0313	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2874	0.2874
Loa Loa (eye worm)	histone methyltransferase	0.0017	0.0071	0.0071
Brugia malayi	RE18450p	0.0039	0.0551	0.058
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0041	0.0582	0.0947
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0184	0.3702	0.4397
Trichomonas vaginalis	DNA polymerase eta, putative	0.0042	0.0602	0.0981
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.2368	0.3977
Giardia lamblia	PHD finger protein 15	0.0028	0.0313	0.0268
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.006	0.0198
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1308	0.1297
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.2733	0.2309
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0415	0.0664
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0602	0.2502
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.5917	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0514	0.0501
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0081	0.0085
Treponema pallidum	exodeoxyribonuclease (exoA)	0.004	0.0556	0.0256
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0602	0.0053
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Echinococcus multilocularis	jun protein	0.0187	0.3781	0.4491
Echinococcus granulosus	6 phosphofructokinase	0.0123	0.2368	0.2806
Echinococcus granulosus	intermediate filament protein	0.0026	0.0267	0.0302
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0919	0.0919
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0033	0.0415	0.4198
Echinococcus multilocularis	6 phosphofructokinase	0.0123	0.2368	0.2806
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0159	0.0621
Schistosoma mansoni	hypothetical protein	0.0018	0.0081	0.0068
Schistosoma mansoni	hypothetical protein	0.0028	0.0313	0.0301
Echinococcus multilocularis	musashi	0.0026	0.0267	0.0302
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.004	0.0556	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0919	0.0919
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0015	0.0024	0.0046
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0187	0.3781	0.4491
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0013	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2874	0.2874
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0081	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0551	0.0551
Onchocerca volvulus		0.0026	0.0267	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0013	0.0013
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0039	0.0551	0.0912
Echinococcus multilocularis	lamin	0.0026	0.0267	0.0302
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.2368	0.3977
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0039	0.0551	0.2287
Schistosoma mansoni	hypothetical protein	0.0018	0.0081	0.0068
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0472	1	1
Schistosoma mansoni	hypothetical protein	0.0399	0.8404	0.8402
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Loa Loa (eye worm)	phosphofructokinase	0.0123	0.2368	0.2368
Schistosoma mansoni	hypothetical protein	0.0018	0.0081	0.0068
Plasmodium vivax	6-phosphofructokinase, putative	0.0033	0.0415	0.4198
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0556	0.0903
Schistosoma mansoni	alpha-glucosidase	0.0158	0.3144	0.3135
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.004	0.0556	0.2305
Schistosoma mansoni	hypothetical protein	0.0165	0.3301	0.3293
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1187	0.1175
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0039	0.0551	0.2287
Onchocerca volvulus	Putative fad oxidoreductase	0.0039	0.0551	0.0557
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0556	0.0648
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.2733	0.298
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0551	0.0551
Echinococcus multilocularis	dnaJ subfamily B	0.0399	0.8404	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0313	0.0358
Trypanosoma brucei	unspecified product	0.0035	0.0456	0.1881
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0039	0.0551	0.2287
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0456	0.1881
Loa Loa (eye worm)	hypothetical protein	0.0182	0.3669	0.3669
Onchocerca volvulus		0.0147	0.2903	0.3037
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.004	0.0556	0.0689
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0123	0.2368	1
Leishmania major	glycosyl hydrolase-like protein	0.0015	0.0024	0.0046
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0444	0.0514
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.004	0.0556	0.0595
Echinococcus multilocularis	geminin	0.0165	0.3301	0.3919
Onchocerca volvulus	Alhambra homolog	0.0028	0.0313	0.0305
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0582	0.0947
Onchocerca volvulus		0.0056	0.0916	0.0941
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0123	0.2368	0.1922
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0081	0.0081
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Leishmania major	hypothetical protein, conserved	0.0039	0.0551	0.2287
Entamoeba histolytica	phosphofructokinase, putative	0.0123	0.2368	0.3988
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0313	0.0313
Schistosoma mansoni	cpg binding protein	0.0056	0.0916	0.0904
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.1187	0.1286
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0039	0.0551	0.2287
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0472	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0381	0.1562
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Toxoplasma gondii	phosphofructokinase PFKII	0.0033	0.0415	0.06
Echinococcus granulosus	dna polymerase kappa	0.0042	0.0602	0.0702
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0582	0.0947
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0582	0.0947
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0602	0.0053
Giardia lamblia	Fructose-bisphosphate aldolase	0.0285	0.5917	1
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0267	0.0254
Echinococcus multilocularis	cpg binding protein	0.0059	0.0985	0.1159
Brugia malayi	Muscleblind-like protein	0.0146	0.2874	0.3024
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0556	0.0648
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0017	0.0071	0.0069
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0081	0.0081
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.004	0.0556	0.0919
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0039	0.0551	0.0682
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0531	0.0559
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0039	0.0551	0.0557
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0433	0.9141	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.004	0.0556	0.2305
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0582	0.0947
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0106	0.201	1
Brugia malayi	hypothetical protein	0.0147	0.2903	0.3055
Schistosoma mansoni	ap endonuclease	0.004	0.0556	0.0544
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.0602	0.0702
Brugia malayi	exodeoxyribonuclease III family protein	0.004	0.0556	0.0585
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0041	0.0582	0.0582
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0159	0.016
Brugia malayi	PHD-finger family protein	0.0028	0.0313	0.033
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0041	0.0582	0.0964
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0039	0.0551	0.2287
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0013	0.0014
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Echinococcus granulosus	jun protein	0.0187	0.3781	0.4491
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0119	0.2287	0.2277
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0039	0.0551	0.0557
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.5917	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0285	0.5917	1
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0039	0.0551	0.0642
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0159	0.0621
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0415	0.0664
Schistosoma mansoni	ap endonuclease	0.004	0.0556	0.0544
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0039	0.0551	0.2287
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0039	0.0551	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0974	0.0974
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0039	0.0551	0.2287
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.004	0.0556	1
Onchocerca volvulus		0.0106	0.2011	0.2097
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0039	0.0551	0.0642
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0015	0.0024	0.0025
Schistosoma mansoni	6-phosphofructokinase	0.0123	0.2368	0.2358
Schistosoma mansoni	d-amino acid oxidase	0.0472	1	1
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0039	0.0551	0.2287
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0267	0.0267
Schistosoma mansoni	fad oxidoreductase	0.0039	0.0551	0.0539
Brugia malayi	CXXC zinc finger family protein	0.0056	0.0916	0.0964
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0919	0.0967
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0415	0.0664
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0039	0.0551	0.0539
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0602	0.2502
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0184	0.3702	0.3702
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.004	0.0556	0.0004
Schistosoma mansoni	hypothetical protein	0.0165	0.3301	0.3293
Brugia malayi	cDNA sequence BC016226	0.0039	0.0551	0.058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0081	0.0081
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0039	0.0551	0.059
Trichomonas vaginalis	alpha-glucosidase, putative	0.0041	0.0582	0.0947
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0039	0.0551	0.0642
Echinococcus multilocularis	muscleblind protein	0.0146	0.2874	0.341
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0039	0.0551	0.2287
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0081	0.0085
Echinococcus multilocularis	lamin dm0	0.0026	0.0267	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0757	0.0757
Trichomonas vaginalis	phosphofructokinase, putative	0.0123	0.2368	0.3977
Schistosoma mansoni	cpg binding protein	0.0059	0.0985	0.0974
Schistosoma mansoni	alpha-glucosidase	0.0158	0.3144	0.3135
Echinococcus granulosus	cpg binding protein	0.0059	0.0985	0.1159
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0039	0.0551	0.058
Brugia malayi	Bromodomain containing protein	0.0028	0.0313	0.033
Schistosoma mansoni	jun-related protein	0.0152	0.3015	0.3006
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0123	0.2368	0.258
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.004	0.0556	0.5
Toxoplasma gondii	exonuclease III APE	0.004	0.0556	0.1429
Trichomonas vaginalis	ap endonuclease, putative	0.004	0.0556	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0313	0.0313
Trichomonas vaginalis	phosphofructokinase, putative	0.0033	0.0415	0.0664
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0041	0.0582	0.0612
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.5917	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.004	0.0556	0.0647

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 5900 nM	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL.	17976986
EC50 (functional)	> 5900 nM	Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation	ChEMBL.	17976986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 461848