Detailed information for compound 461848

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 251.321 | Formula: C14H21NO3
  • H donors: 2 H acceptors: 2 LogP: 1.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCOC(C1)c1ccc(c(c1)O)CO
  • InChi: 1S/C14H21NO3/c1-2-5-15-6-7-18-14(9-15)11-3-4-12(10-16)13(17)8-11/h3-4,8,14,16-17H,2,5-7,9-10H2,1H3
  • InChiKey: VQDBZBRRFKOERX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Protein lozenge 0.0056 0.0923 0.1085
Echinococcus multilocularis geminin 0.0165 0.3301 0.3919
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0582 0.0612
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0081
Toxoplasma gondii exonuclease III APE 0.004 0.0556 0.1429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0551 0.0551
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0556 0.0256
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0415 0.0664
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0313 0.0313
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.8404 1
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0602 0.2502
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.006 0.0198
Chlamydia trachomatis D-amino acid dehydrogenase 0.0039 0.0551 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0602 0.0053
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0039 0.0551 0.0682
Schistosoma mansoni jun-related protein 0.0152 0.3015 0.3006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0556 0.2305
Onchocerca volvulus 0.0026 0.0267 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Schistosoma mansoni fad oxidoreductase 0.0039 0.0551 0.0539
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0556 0.2305
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0313 0.0301
Brugia malayi 6-phosphofructokinase 0.0123 0.2368 0.2491
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.3702 0.4397
Loa Loa (eye worm) hypothetical protein 0.0049 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0974 0.0974
Brugia malayi bZIP transcription factor family protein 0.0187 0.3781 0.3979
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0081 0.0085
Schistosoma mansoni cpg binding protein 0.0059 0.0985 0.0974
Loa Loa (eye worm) hypothetical protein 0.0032 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0018 0.0081 0.0068
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.2368 0.258
Schistosoma mansoni hypothetical protein 0.0018 0.0081 0.0068
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0039 0.0551 0.0642
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0039 0.0551 0.2287
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0039 0.0551 0.0551
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0039 0.0551 0.0642
Onchocerca volvulus 0.0056 0.0916 0.0941
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0081 0.0081
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0582 0.0678
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0919 0.0967
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0381 0.1562
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.2368 0.3549
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0039 0.0551 0.2287
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0556 0.0919
Echinococcus granulosus lamin 0.0026 0.0267 0.0302
Echinococcus granulosus jumonji domain containing protein 0.004 0.0556 0.0648
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0602 0.0702
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2874 0.341
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0024 0.0025
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.3702 0.3896
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0556 0.5
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0039 0.0551 0.2287
Schistosoma mansoni cpg binding protein 0.0056 0.0916 0.0904
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.2368 0.2358
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.2368 1
Brugia malayi polk-prov protein 0.0032 0.0381 0.0401
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0556 0.0648
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1726 0.2042
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0514 0.0514
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0039 0.0551 0.2287
Schistosoma mansoni alpha glucosidase 0.0041 0.0582 0.057
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0039 0.0551 0.1404
Echinococcus granulosus muscleblind protein 0.0146 0.2874 0.341
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0039 0.0551 0.0539
Echinococcus multilocularis musashi 0.0026 0.0267 0.0302
Loa Loa (eye worm) runx1 0.0056 0.0923 0.0923
Echinococcus multilocularis cpg binding protein 0.0059 0.0985 0.1159
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0456 0.1881
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0582 0.0947
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0556 0.0689
Leishmania major hypothetical protein, conserved 0.0039 0.0551 0.2287
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.2368 0.2358
Trypanosoma brucei glucosidase, putative 0.0041 0.0582 0.2417
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0472 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0556 0.2305
Brugia malayi Bromodomain containing protein 0.0028 0.0313 0.033
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0024 0.0046
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.5917 1
Schistosoma mansoni lamin 0.0026 0.0267 0.0254
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0531 0.0559
Onchocerca volvulus 0.0026 0.0267 0.0256
Trypanosoma brucei unspecified product 0.0035 0.0456 0.1881
Echinococcus multilocularis muscleblind protein 0.0146 0.2874 0.341
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2368 0.3977
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0024 0.0018
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.2368 0.2368
Schistosoma mansoni NAD dehydrogenase 0.0039 0.0551 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0582 0.0964
Leishmania major DNA polymerase kappa, putative 0.0021 0.0159 0.0621
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0159 0.016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0551 0.0551
Schistosoma mansoni ap endonuclease 0.004 0.0556 0.0544
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Echinococcus multilocularis lamin dm0 0.0026 0.0267 0.0302
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0556 0.0585
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0415 0.4198
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.2368 0.3988
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2368 0.3977
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0415 0.4198
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0514 0.0597
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0039 0.0551 0.9825
Brugia malayi hypothetical protein 0.0147 0.2903 0.3055
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0081 0.0085
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0013 0.0013
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0039 0.0551 0.0642
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0081 0.0081
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.2368 0.1922
Loa Loa (eye worm) hypothetical protein 0.0038 0.0531 0.0531
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1726 0.2042
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.1187 0.1399
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0556 0.0903
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.2368 0.1922
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0313 0.0358
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1187 0.0672
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2368 0.3977
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0919 0.0919
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0039 0.0551 0.0557
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0602 0.0981
Echinococcus multilocularis GPCR, family 2 0.0018 0.0081 0.0081
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0267 0.0267
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0269 0.0283
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0039 0.0551 0.2287
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0039 0.0551 0.058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0556 0.2305
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0071 0.0071
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0081 0.0081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0582 0.0947
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0602 0.0981
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0039 0.0551 0.2287
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0039 0.0551 0.058
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0039 0.0551 0.0642
Echinococcus granulosus jun protein 0.0187 0.3781 0.4491
Leishmania major hypothetical protein, conserved 0.0039 0.0551 0.2287
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0556 0.0595
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0556 0.0556
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0039 0.0551 0.059
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.2733 0.2309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1187 0.0672
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0267 0.0267
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0415 0.0445
Echinococcus granulosus dnaJ subfamily B 0.0399 0.8404 1
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0039 0.0551 0.2287
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0582 0.0964
Treponema pallidum fructose-bisphosphate aldolase 0.0285 0.5917 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0285 0.5917 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0256 0.0256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Loa Loa (eye worm) hypothetical protein 0.0146 0.2874 0.2874
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0582 0.0947
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0582 0.0582
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0187 0.3781 0.4491
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.2287 0.2277
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.1187 0.4985
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0039 0.0551 0.0912
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.2733 0.2309
Brugia malayi cDNA sequence BC016226 0.0039 0.0551 0.058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Schistosoma mansoni lozenge 0.0056 0.0923 0.0911
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.006 0.0198
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0415 0.06
Schistosoma mansoni cpg binding protein 0.0059 0.0985 0.0974
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1308 0.1297
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.1187 0.5148
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0415 0.0664
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1187 0.1175
Brugia malayi jmjC domain containing protein 0.0093 0.1726 0.1816
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0013
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0039 0.0551 0.0539
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0602 0.0053
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.2368 0.2806
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.006 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0582 0.2417
Onchocerca volvulus Putative fad oxidoreductase 0.0039 0.0551 0.0557
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0582 0.0947
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0013 0.0014
Toxoplasma gondii hypothetical protein 0.0039 0.0551 0.1404
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0415 0.0664
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0313 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.2368 0.2806
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0582 0.0947
Loa Loa (eye worm) hypothetical protein 0.0039 0.0551 0.0551
Onchocerca volvulus Alhambra homolog 0.0028 0.0313 0.0305
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.1187 0.1175
Schistosoma mansoni hypothetical protein 0.0165 0.3301 0.3293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0582 0.0678
Loa Loa (eye worm) hypothetical protein 0.0026 0.0267 0.0267
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0039 0.0551 0.2287
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0582 0.0947
Brugia malayi CXXC zinc finger family protein 0.0056 0.0916 0.0964
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0582 0.0947
Echinococcus granulosus lamin dm0 0.0026 0.0267 0.0302
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0415 0.0664
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.3702 0.4397
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0415 0.0681
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0013 0.0014
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.2368 0.3988
Brugia malayi 6-phosphofructokinase 0.0123 0.2368 0.2491
Loa Loa (eye worm) hypothetical protein 0.0449 0.9503 0.9503
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0039 0.0551 0.0912
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0039 0.0551 0.2287
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Schistosoma mansoni hypothetical protein 0.0038 0.0531 0.0519
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0039 0.0551 0.0557
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.2733 0.298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0514 0.0501
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0582 0.0947
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.1187 0.0672
Onchocerca volvulus 0.0106 0.2011 0.2097
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0071 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0919 0.0967
Schistosoma mansoni alpha-glucosidase 0.0158 0.3144 0.3135
Echinococcus granulosus peregrin 0.0028 0.0313 0.0358
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0081 0.0081
Brugia malayi phosphofructokinase 0.0123 0.2368 0.2491
Echinococcus granulosus intermediate filament protein 0.0026 0.0267 0.0302
Brugia malayi RE18450p 0.0039 0.0551 0.058
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0582 0.0947
Schistosoma mansoni hypothetical protein 0.0152 0.3015 0.3006
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0285 0.5917 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0071 0.0069
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.2368 1
Schistosoma mansoni alpha-glucosidase 0.0158 0.3144 0.3135
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.2368 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0582 0.1584
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0039 0.0551 0.2287
Loa Loa (eye worm) hypothetical protein 0.0146 0.2874 0.2874
Echinococcus multilocularis lamin 0.0026 0.0267 0.0302
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0556 0.0647
Echinococcus granulosus dna polymerase kappa 0.0042 0.0602 0.0702
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.2368 0.3988
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.2368 0.3977
Loa Loa (eye worm) phosphofructokinase 0.0123 0.2368 0.2368
Brugia malayi hypothetical protein 0.0449 0.9503 1
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0415 0.06
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0159 0.0621
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0582 0.2417
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0415 0.0664
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0199 0.0186
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0916 0.0916
Schistosoma mansoni hypothetical protein 0.0028 0.0313 0.0301
Loa Loa (eye worm) hypothetical protein 0.0182 0.3669 0.3669
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0514 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0381 0.1562
Schistosoma mansoni fad oxidoreductase 0.0039 0.0551 0.0539
Echinococcus granulosus cpg binding protein 0.0059 0.0985 0.1159
Brugia malayi jmjC domain containing protein 0.0038 0.0514 0.054
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0024 0.0046
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0556 0.0647
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.3702 0.4397
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.3702 0.3702
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0556 1
Onchocerca volvulus 0.0147 0.2903 0.3037
Schistosoma mansoni hypothetical protein 0.0165 0.3301 0.3293
Echinococcus multilocularis jun protein 0.0187 0.3781 0.4491
Schistosoma mansoni d-amino acid oxidase 0.0472 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.1187 0.1399
Brugia malayi Muscleblind-like protein 0.0146 0.2874 0.3024
Echinococcus granulosus geminin 0.0165 0.3301 0.3919
Onchocerca volvulus 0.0449 0.9503 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0444 0.0514
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0415 0.4198
Schistosoma mansoni hypothetical protein 0.0399 0.8404 0.8402
Loa Loa (eye worm) hypothetical protein 0.0056 0.0919 0.0919
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0415 0.0664
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0582 0.2417
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0018 0.0081 0.0068
Schistosoma mansoni ap endonuclease 0.004 0.0556 0.0544
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0285 0.5917 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0267 0.0254
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.2368 0.2368
Loa Loa (eye worm) hypothetical protein 0.0449 0.9503 0.9503
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0472 1 1
Echinococcus multilocularis peregrin 0.0028 0.0313 0.0358
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0433 0.9141 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0267 0.0281
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0039 0.0551 0.9825
Brugia malayi intermediate filament protein 0.0026 0.0267 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0159 0.0621
Schistosoma mansoni lamin 0.0026 0.0267 0.0254
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0039 0.0551 0.2287
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0024 0.0046
Schistosoma mansoni hypothetical protein 0.0018 0.0081 0.0068
Echinococcus granulosus GPCR family 2 0.0018 0.0081 0.0081
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0602 0.2502
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0556 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0602 0.2502
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0415 0.06
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0039 0.0551 0.2287
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0039 0.0551 0.2287
Brugia malayi PHD-finger family protein 0.0028 0.0313 0.033
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0415 0.0664
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0187 0.3781 0.4491
Giardia lamblia PHD finger protein 15 0.0028 0.0313 0.0268
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0024 0.0046
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0556 0.0903
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0415 0.4198
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.1187 0.1286
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0556 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.201 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0313 0.0313

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 5900 nM Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation ChEMBL. 17976986
EC50 (functional) > 5900 nM Agonist activity at human recombinant dopamine D3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulation ChEMBL. 17976986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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