TDR Targets

Basic information

Technical information

TDR Targets ID: 49278
Name: 3-(3-fluorophenyl)pyridine
MW: 173.186 | Formula: C11H8FN
H donors: 0 H acceptors: 1 LogP: 2.58 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)c1cccnc1
InChi: 1S/C11H8FN/c12-11-5-1-3-9(7-11)10-4-2-6-13-8-10/h1-8H
InChiKey: VAEHVGQVESGORT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	p70 ribosomal S6 kinase beta	0.001	0.0218	0.0281
Schistosoma mansoni	nuclear hormone receptor	0.0008	0.0046	0.005
Echinococcus multilocularis	serine:threonine protein kinase N2	0.001	0.0218	0.0255
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0218	0.024
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0218	0.024
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0136	1	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0008	0.0046	0.0059
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0046	0.0059
Brugia malayi	Steroid receptor seven-up type 2	0.0008	0.0046	0.0059
Trypanosoma brucei	Emopamil binding protein, putative	0.0136	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0218	0.024
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0787	0.0864
Entamoeba histolytica	protein kinase, putative	0.001	0.0218	0.5
Echinococcus multilocularis	serine:threonine protein kinase N2	0.001	0.0218	0.0255
Brugia malayi	Protein kinase domain containing protein	0.001	0.0218	0.0281
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.001	0.0218	0.0262
Schistosoma mansoni	serine/threonine protein kinase	0.001	0.0218	0.024
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0018	0.0787	0.0921
Loa Loa (eye worm)	AGC/PKN protein kinase	0.001	0.0218	0.0262
Brugia malayi	Protein kinase domain containing protein	0.001	0.0218	0.0281
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.001	0.0218	0.0262
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.001	0.0218	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0046	0.0059
Echinococcus granulosus	FTZ F1 alpha	0.0008	0.0046	0.0053
Brugia malayi	steroid hormone receptor	0.0008	0.0046	0.0059
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.001	0.0218	0.0255
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0008	0.0046	0.0053
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0008	0.0046	0.005
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0008	0.0046	0.0055
Echinococcus granulosus	NDR protein kinase	0.001	0.0218	0.0255
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0008	0.0046	0.005
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0008	0.0046	0.0059
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0008	0.0046	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0008	0.0046	0.0055
Echinococcus multilocularis	protein kinase c iota type	0.0117	0.8542	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0008	0.0046	0.0053
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0008	0.0046	0.0055
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0018	0.0787	0.0945
Brugia malayi	Protein kinase domain containing protein	0.001	0.0218	0.0281
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0136	1	0.5
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0136	1	0.5
Schistosoma mansoni	atypical protein kinase C	0.0124	0.9111	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0008	0.0046	0.005
Brugia malayi	ecdysteroid receptor	0.0008	0.0046	0.0059
Echinococcus granulosus	serine:threonine protein kinase N2	0.001	0.0218	0.0255
Schistosoma mansoni	serine/threonine kinase	0.001	0.0218	0.024
Echinococcus multilocularis	serine:threonine protein kinase 38	0.001	0.0218	0.0255
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Entamoeba histolytica	protein kinase, putative	0.001	0.0218	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0008	0.0046	0.0053
Trypanosoma cruzi	Emopamil binding protein, putative	0.0136	1	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0008	0.0046	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Trypanosoma cruzi	Emopamil binding protein, putative	0.0136	1	0.5
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.001	0.0218	0.0255
Toxoplasma gondii	AGC kinase	0.001	0.0218	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0008	0.0046	0.0045
Echinococcus granulosus	protein kinase C gamma type	0.001	0.0218	0.0255
Echinococcus granulosus	protein kinase c iota type	0.0117	0.8542	1
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0046	0.005
Echinococcus granulosus	Protein kinase C brain isozyme	0.0018	0.0787	0.0921
Echinococcus multilocularis	protein kinase c epsilon type	0.0018	0.0787	0.0921
Echinococcus multilocularis	FTZ F1 alpha	0.0008	0.0046	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0008	0.0046	0.0055
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0008	0.0046	0.0055
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0046	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0046	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Brugia malayi	protein kinase C II.	0.0018	0.0787	0.1015
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0046	0.0053
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.001	0.0218	0.0255
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0008	0.0046	0.0053
Schistosoma mansoni	retinoic acid receptor RXR	0.0008	0.0046	0.005
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.001	0.0218	0.0262
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0008	0.0046	0.0053
Loa Loa (eye worm)	STE/STE11/MEKK2 protein kinase	0.0008	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Entamoeba histolytica	protein kinase, putative	0.001	0.0218	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0008	0.0046	0.0045
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0008	0.0046	0.0053
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0008	0.0046	0.0053
Schistosoma mansoni	RAR-like nuclear receptor	0.0008	0.0046	0.005
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0114	0.8324	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0008	0.0046	0.0055
Brugia malayi	nuclear receptor NHR-88	0.0008	0.0046	0.0059
Loa Loa (eye worm)	AGC/NDR protein kinase	0.001	0.0218	0.0262
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0008	0.0046	0.005
Brugia malayi	protein kinase C3,putative	0.0107	0.7755	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0008	0.0046	0.0053
Onchocerca volvulus		0.0008	0.0046	0.0045
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0008	0.0046	0.0059
Brugia malayi	Hr1 repeat family protein	0.001	0.0218	0.0281
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0008	0.0046	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Loa Loa (eye worm)	steroid hormone receptor	0.0008	0.0046	0.0055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0008	0.0046	0.0055
Entamoeba histolytica	protein kinase, putative	0.001	0.0218	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0008	0.0046	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0787	0.0864
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0008	0.0046	0.0059
Echinococcus granulosus	protein kinase c epsilon type	0.0018	0.0787	0.0921
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0008	0.0046	0.005
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.001	0.0218	0.0255
Schistosoma mansoni	thyroid hormone receptor	0.0008	0.0046	0.005
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.001	0.0218	0.0262
Brugia malayi	nuclear hormone receptor	0.0008	0.0046	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0008	0.0046	0.0059
Brugia malayi	photoreceptor-specific nuclear receptor	0.0008	0.0046	0.0059
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0008	0.0046	0.0059
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0008	0.0046	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0008	0.0046	0.0053
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0008	0.0046	0.0059
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0008	0.0046	0.0059
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0008	0.0046	0.005
Loa Loa (eye worm)	hypothetical protein	0.001	0.0218	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0046	0.0055
Schistosoma mansoni	coup transcription factor	0.0008	0.0046	0.005
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0008	0.0046	0.005
Brugia malayi	Protein kinase domain containing protein	0.0008	0.0001	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0008	0.0046	0.0059
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.001	0.0218	0.0255
Loa Loa (eye worm)	AGC/AKT protein kinase	0.001	0.0218	0.0262
Echinococcus multilocularis	serine threonine protein kinase	0.001	0.0218	0.0255
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0008	0.0046	0.0053
Onchocerca volvulus		0.0136	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0008	0.0046	0.0059
Echinococcus multilocularis	ecdysone induced protein 78C	0.0008	0.0046	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.0787	0.0864
Trichomonas vaginalis	AGC family protein kinase	0.001	0.0218	1

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (binding)	0 uM kg-1	Dopamine receptor activation in limbic system of reserpinized rat	ChEMBL.	6796690
ED50 (binding)	0 uM kg-1	Dopamine receptor activation in striatum of reserpinized rat	ChEMBL.	6796690

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 12937919

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 49278