Detailed information for compound 49539

Basic information

Technical information
  • TDR Targets ID: 49539
  • Name: 6-[4-(methylamino)phenyl]-N-(2H-tetrazol-5-yl )pyridine-2-carboxamide
  • MW: 295.299 | Formula: C14H13N7O
  • H donors: 3 H acceptors: 5 LogP: 1.55 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccc(cc1)c1cccc(n1)C(=O)Nc1n[nH]nn1
  • InChi: 1S/C14H13N7O/c1-15-10-7-5-9(6-8-10)11-3-2-4-12(16-11)13(22)17-14-18-20-21-19-14/h2-8,15H,1H3,(H2,17,18,19,20,21,22)
  • InChiKey: OGPWRZRZAFAWGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[4-(methylamino)phenyl]-N-(2H-tetrazol-5-yl)-2-pyridinecarboxamide
  • 6-[4-(methylamino)phenyl]-N-(2H-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide
  • 6-[4-(methylamino)phenyl]-N-(2H-tetrazol-5-yl)picolinamide
  • 6-(4-methylaminophenyl)-N-(2H-tetrazol-5-yl)pyridine-2-carboxamide
  • 6-(4-methylaminophenyl)-N-(2H-tetrazol-5-yl)-2-pyridinecarboxamide
  • 6-(4-methylaminophenyl)-N-(2H-tetrazol-5-yl)picolinamide
  • 6-(4-methylaminophenyl)-N-(2H-1,2,3,4-tetrazol-5-yl)pyridine-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0417 0.0361
Echinococcus granulosus flap endonuclease 1 0.0026 0.0292 0.0237
Loa Loa (eye worm) hypothetical protein 0.0451 1 1
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0349 0.7672 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0273 0.0273
Entamoeba histolytica phosphoglycerate mutase family protein, putative 0.0266 0.5777 0.7485
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0057 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0273 0.0217
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein 0.0192 0.4092 0.4058
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0273 0.9184
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0292 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0273 0.9184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0744 0.0692
Loa Loa (eye worm) hypothetical protein 0.0045 0.0722 0.0669
Giardia lamblia Hypothetical protein 0.0266 0.5777 0.7485
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0744 0.0692
Echinococcus granulosus dna polymerase kappa 0.0019 0.0137 0.0081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.0081
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0137 0.0081
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0137 0.0081
Trypanosoma brucei 6-phosphofructo-2-kinase 2 0.0443 0.9826 0.9826
Mycobacterium ulcerans hypothetical protein 0.0266 0.5777 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0192 0.4092 0.4058
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0451 1 1
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0192 0.4092 0.4058
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0057 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.052 0.0466
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0722 0.0669
Echinococcus granulosus dna polymerase eta 0.0045 0.0722 0.0669
Entamoeba histolytica hypothetical protein 0.0036 0.052 0.0508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.0081
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0057 0.0057
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0099 0.1964 0.2425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Leishmania major 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0443 0.9826 0.9825
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0057 0.0057
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0722 0.2799
Plasmodium falciparum flap endonuclease 1 0.0026 0.0292 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0477 0.0422
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0137 0.0137
Echinococcus multilocularis dna polymerase eta 0.0045 0.0722 0.0669
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0451 1 1
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0451 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0137 0.0137
Trypanosoma brucei 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0192 0.4092 0.4092
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0838 0.3289
Echinococcus multilocularis geminin 0.017 0.3583 0.3546
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0417 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0838 0.3289
Echinococcus multilocularis 6 phosphofructo 2 kinase:fructose 2 0.0451 1 1
Mycobacterium ulcerans fructose-2,6-bisphosphatase GpmB 0.0266 0.5777 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0744 0.0692
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0137 0.0081
Leishmania major DNA polymerase eta, putative 0.0045 0.0722 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0273 0.9184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0744 0.0692
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0057 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2434 0.2391
Schistosoma mansoni hypothetical protein 0.0036 0.052 0.0466
Trypanosoma cruzi 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative 0.0451 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0001
Schistosoma mansoni hypothetical protein 0.0034 0.0477 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0477 0.1767
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.052 0.0466
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0744 0.0692
Giardia lamblia Hypothetical protein 0.0266 0.5777 0.7485
Loa Loa (eye worm) hypothetical protein 0.0443 0.9826 0.9825
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0137 0.0081
Entamoeba histolytica hypothetical protein 0.0036 0.052 0.0508
Leishmania major DNA polymerase kappa, putative 0.0019 0.0137 0.0081
Brugia malayi Flap endonuclease-1 0.0026 0.0292 0.0991
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0137 0.034
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2434 0.2391
Brugia malayi hypothetical protein 0.0025 0.0273 0.091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0744 0.0692
Entamoeba histolytica hypothetical protein 0.0036 0.052 0.0508
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0137 0.0081
Schistosoma mansoni flap endonuclease-1 0.0024 0.0235 0.0179
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.052 0.0466
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.0081
Entamoeba histolytica hypothetical protein 0.0099 0.1964 0.2425
Loa Loa (eye worm) hypothetical protein 0.0259 0.5603 0.5578
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0137 1
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0443 0.9826 0.9825
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0001
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0292 0.0237
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0744 0.0692
Brugia malayi isocitrate dehydrogenase 0.0016 0.0057 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.005 0.0838 0.0786
Schistosoma mansoni hypothetical protein 0.017 0.3583 0.3546
Brugia malayi hypothetical protein 0.0016 0.0068 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0744 0.0692
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0292 0.0205
Giardia lamblia DNA repair protein RAD52 0.0349 0.7672 1
Leishmania major DNA polymerase eta, putative 0.0032 0.0417 0.0361
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0292 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0137 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0036 0.052 0.0508
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0292 0.6539
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0057 0.0002
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0137 0.0081
Brugia malayi hypothetical protein 0.0036 0.052 0.195
Trypanosoma brucei unspecified product 0.0019 0.0137 0.0137
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0292 0.0236
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0292 0.0205
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0722 0.0722
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0137 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0057 0.0001
Schistosoma mansoni DNA polymerase eta 0.0045 0.0722 0.0669
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0273 0.0217
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0838 0.0786
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0273 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0137 0.0137
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0137 0.0081
Onchocerca volvulus 0.0451 1 0.5
Trypanosoma cruzi 6-phosphofructo-2-kinase 1 0.0443 0.9826 0.9825
Echinococcus granulosus geminin 0.017 0.3583 0.3546
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0292 0.0292
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0744 0.2892
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0292 0.0237
Schistosoma mansoni 6-phosphofructokinase 0.0451 1 1
Leishmania major hypothetical protein, conserved 0.0025 0.0273 0.0217
Schistosoma mansoni hypothetical protein 0.017 0.3583 0.3546
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0292 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0137 0.0081
Brugia malayi MH2 domain containing protein 0.012 0.2434 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0273 0.6006

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) ND 0 % Antiallergic activity against passive cutaneous anaphylaxis (PCA) in male Sprague-Dawley rats (10 mg/kg oral administration) ChEMBL. 6137568
Inhibition (functional) = 29 % Inhibition of passive cutaneous anaphylaxis in male Sprague-Dawley rats following 0.3 mg/kg p.o. administration; Not significant. ChEMBL. 6137568
Inhibition (functional) = 71 % Inhibition of passive cutaneous anaphylaxis in male Sprague-Dawley rats following 1 mg/kg p.o. administration; Not significant. ChEMBL. 6137568
Inhibition (functional) = 83 % Antiallergic activity against passive cutaneous anaphylaxis(PCA) in male Sprague-Dawley rats after 3.0 mg/kg oral administration;not statistically significant ChEMBL. 6137568

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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