Detailed information for compound 500352

Basic information

Technical information
  • TDR Targets ID: 500352
  • Name: (1R)-1-pyridin-3-yl-2-[2-[4-[2-(trifluorometh yl)-1,3-thiazol-4-yl]phenoxy]ethylamino]ethan ol
  • MW: 409.425 | Formula: C19H18F3N3O2S
  • H donors: 2 H acceptors: 3 LogP: 2.85 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](c1cccnc1)CNCCOc1ccc(cc1)c1csc(n1)C(F)(F)F
  • InChi: 1S/C19H18F3N3O2S/c20-19(21,22)18-25-16(12-28-18)13-3-5-15(6-4-13)27-9-8-24-11-17(26)14-2-1-7-23-10-14/h1-7,10,12,17,24,26H,8-9,11H2/t17-/m0/s1
  • InChiKey: KSSIJUJWXZXKGL-KRWDZBQOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (1R)-1-(3-pyridyl)-2-[2-[4-[2-(trifluoromethyl)thiazol-4-yl]phenoxy]ethylamino]ethanol
  • (1R)-1-(3-pyridyl)-2-[2-[4-[2-(trifluoromethyl)-4-thiazolyl]phenoxy]ethylamino]ethanol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 3 Starlite/ChEMBL References
Homo sapiens adrenoceptor beta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0532 0.0527
Brugia malayi conserved hypotetical protein 0.0011 0.0016 0.0011
Trichomonas vaginalis ABC transporter, putative 0.001 0.0005 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0071 0.0071
Entamoeba histolytica P-glycoprotein-2 0.001 0.0005 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Trichomonas vaginalis ABC transporter, putative 0.001 0.0005 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0071 0.0071
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0129 0.5103 0.5103
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0071 0.0066
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0532 0.0532
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0244 1 1
Brugia malayi hypothetical protein 0.0012 0.0071 0.0066
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0532 0.0532
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0016 0.0016
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Brugia malayi nuclear receptor NHR-88 0.0023 0.0532 0.0527
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0016 0.0016
Brugia malayi ecdysteroid receptor 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0532 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0532 0.0527
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0532 1
Brugia malayi hypothetical protein 0.0011 0.0016 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0532 0.0532
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0005 0.5
Entamoeba histolytica P-glycoprotein-2, putative 0.001 0.0005 0.5
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001 0.0005 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0532 0.0527
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0532 0.0532
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0005 0.0005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0005 0.0005
Onchocerca volvulus 0.0011 0.0016 0.0212
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0016 0.0016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0532 0.0532
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0532 0.0527
Trichomonas vaginalis ABC transporter, putative 0.001 0.0005 0.5
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0005 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0532 0.0527
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0016 0.0212
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0011 0.0016 0.0212
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0005 0.0005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Brugia malayi hypothetical protein 0.0011 0.0016 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0532 0.0527
Entamoeba histolytica P-glycoprotein-2 0.001 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0244 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0532 0.0532
Loa Loa (eye worm) multidrug resistance protein 3 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0532 0.0532
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0071 0.0066
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0005 0.5
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.001 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.001 0.0005 0.0005
Schistosoma mansoni peptidylglycine monooxygenase 0.0129 0.5103 0.51
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0532 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0532 0.0532
Trichomonas vaginalis taga, putative 0.001 0.0005 0.5
Plasmodium falciparum multidrug resistance protein 1 0.001 0.0005 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0071 0.0066
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0005 0.0005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0005 0.0005
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.001 0.0005 0.5
Brugia malayi nuclear hormone receptor 0.0023 0.0532 0.0527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0532 0.0532
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0071 0.0071
Entamoeba histolytica P-glycoprotein-5 0.001 0.0005 0.5
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0005 0.0005
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0005 0.0005
Onchocerca volvulus 0.0011 0.0016 0.0212
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0532 0.0532
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0532 0.0532
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0016 0.0011
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0532 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0532 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0532 0.0527
Brugia malayi nuclear receptor RXR 0.0011 0.0016 0.0011
Plasmodium vivax multidrug resistance protein 1, putative 0.001 0.0005 0.5
Brugia malayi nuclear receptor RXR 0.0012 0.0071 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Brugia malayi hypothetical protein 0.0012 0.0071 0.0066
Brugia malayi nuclear hormone receptor 0.0011 0.0016 0.0011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0016 0.0016
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0016 0.0016
Brugia malayi nuclear receptor NHR-67 0.0011 0.0016 0.0011
Onchocerca volvulus 0.0023 0.0532 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0005 0.0005
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.001 0.0005 0.5
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0016 0.0011
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0129 0.5103 0.51
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0532 0.0532
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0244 1 1
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0244 1 1
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0532 0.0532
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0011
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0016 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0064 0.2288 0.2284
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0005 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Schistosoma mansoni nuclear receptor 0.0011 0.0016 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0532 0.0527
Schistosoma mansoni zinc finger protein 0.0011 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0532 0.0532
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Schistosoma mansoni dopamine-beta-monooxygenase 0.0129 0.5103 0.51
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0532 0.0532
Leishmania major p-glycoprotein 0.001 0.0005 0.5
Entamoeba histolytica P-glycoprotein-1 0.001 0.0005 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0532 0.0527
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Brugia malayi steroid hormone receptor 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0532 0.0527
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Brugia malayi tailless protein 0.0011 0.0016 0.0011
Trichomonas vaginalis abcb9, putative 0.001 0.0005 0.5
Entamoeba histolytica P-glyco protein 6, putative 0.001 0.0005 0.5
Schistosoma mansoni nuclear receptor 0.0011 0.0016 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0016 0.0011
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0071 0.0066
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0532 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0005 0.5
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0005 0.5
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0016 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0532 0.0527
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0016 0.0011
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0005 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0532 0.0527
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0532 0.0532
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0016 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0532 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0532 0.0532
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0532 0.0527
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0532 0.0532
Schistosoma mansoni coup transcription factor 0.0023 0.0532 0.0527
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0005 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0532 0.0527
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.001 0.0005 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0005 0.0005
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0005 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0016 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0532 0.0532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0532 0.0532
Brugia malayi ecdysone receptor 0.0011 0.0016 0.0011
Loa Loa (eye worm) DR-78 0.0011 0.0016 0.0016
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0005 0.0005
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0005 0.5
Trichomonas vaginalis ABC transporter, putative 0.001 0.0005 0.5
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Trichomonas vaginalis abcb9, putative 0.001 0.0005 0.5
Entamoeba histolytica P-glycoprotein 5, putative 0.001 0.0005 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0005 0.5
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0005 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0532 0.0532
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0005 0.5
Brugia malayi nuclear receptor NHR-88 0.0011 0.0016 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0532 0.0527
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0016 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Trichomonas vaginalis abcb9, putative 0.001 0.0005 0.5
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0532 0.0532
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0532 0.0527
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0066 0.237 0.2367
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0532 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0532 0.0527
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0071 0.0071

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.2 uM Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP production ChEMBL. 17632003
EC50 (functional) = 0.2 uM Agonist activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP production ChEMBL. 17632003
Intrinsic activity (binding) < 6 % Intrinsic activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP production at 30 uM relative to isoproterenol ChEMBL. 17632003
Intrinsic activity (binding) < 6 % Intrinsic activity at human adrenergic beta1 receptor expressed in CHO cells assessed as cAMP production at 30 uM relative to isoproterenol ChEMBL. 17632003
Intrinsic activity (binding) = 9 % Intrinsic activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP production at 30 uM relative to isoproterenol ChEMBL. 17632003
Intrinsic activity (binding) = 9 % Intrinsic activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP production at 30 uM relative to isoproterenol ChEMBL. 17632003
Intrinsic activity (binding) = 150 % Intrinsic activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP production relative to isoproterenol ChEMBL. 17632003
Intrinsic activity (binding) = 150 % Intrinsic activity at human adrenergic beta3 receptor expressed in CHO cells assessed as cAMP production relative to isoproterenol ChEMBL. 17632003
Ki (binding) 0 Displacement of [125I]iodocyanopindolol from human adrenergic beta2 receptor expressed in CHO cells ChEMBL. 17632003
Ki (binding) = 0.1 uM Displacement of [125I]iodocyanopindolol from human adrenergic beta1 receptor expressed in CHO cells ChEMBL. 17632003
Ki (binding) = 0.1 uM Displacement of [125I]iodocyanopindolol from human adrenergic beta1 receptor expressed in CHO cells ChEMBL. 17632003

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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