Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.2549 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0012 | 0.0346 | 0.0346 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0346 | 0.0346 |
Onchocerca volvulus | 0.0012 | 0.0346 | 0.068 | |
Loa Loa (eye worm) | serotonin transporter b | 0.0073 | 0.475 | 0.475 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0099 | 0.6631 | 0.6631 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | serotonin transporter | 0.0073 | 0.475 | 0.4895 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0346 | 0.0346 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.2549 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.6434 | 0.6434 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0073 | 0.475 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.475 | 0.475 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.2549 | 0.2627 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0346 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0012 | 0.0346 | 0.0357 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0012 | 0.0346 | 0.0346 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 1 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.2291 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0073 | 0.475 | 0.475 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0012 | 0.0346 | 0.0346 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.2291 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0099 | 0.6631 | 0.6631 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0346 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0012 | 0.0346 | 0.0346 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0099 | 0.6631 | 0.6833 |
Onchocerca volvulus | 0.0073 | 0.475 | 0.9337 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.2549 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0073 | 0.475 | 0.475 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0141 | 0.9704 | 1 |
Echinococcus granulosus | jun protein | 0.0099 | 0.6631 | 0.6833 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Schistosoma mansoni | jun-related protein | 0.008 | 0.5285 | 0.5285 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.2291 | 0.5 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0012 | 0.0346 | 0.0357 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.2549 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Onchocerca volvulus | 0.0078 | 0.5088 | 1 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0073 | 0.475 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0346 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0012 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0346 | 0.0346 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.2549 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0346 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.475 | 0.475 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0073 | 0.475 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.475 | 0.475 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0346 | 0.0346 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0012 | 0.0346 | 0.5 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0012 | 0.0346 | 0.0346 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0012 | 0.0346 | 0.0346 |
Onchocerca volvulus | 0.0012 | 0.0346 | 0.068 | |
Echinococcus multilocularis | serotonin transporter | 0.0073 | 0.475 | 0.475 |
Onchocerca volvulus | 0.0012 | 0.0346 | 0.068 | |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.5285 | 0.5285 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0012 | 0.0346 | 0.0346 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0073 | 0.475 | 0.475 |
Brugia malayi | hypothetical protein | 0.0078 | 0.5088 | 0.5088 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0012 | 0.0346 | 0.0357 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0012 | 0.0346 | 0.0346 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0012 | 0.0346 | 0.0357 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0012 | 0.0346 | 0.0357 |
Echinococcus multilocularis | jun protein | 0.0099 | 0.6631 | 0.6631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.