TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.556 | Formula: C27H33NO3
H donors: 2 H acceptors: 3 LogP: 2.25 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CC23[C@H](O)C(=C)[C@H]4C[C@H]2C2[C@@]5([C@H]1[C@@](C)(CCC5)CN2Cc1ccccc1)[C@@H]3[C@H]4O
InChi: 1S/C27H33NO3/c1-15-17-11-18-23-26-10-6-9-25(2,14-28(23)13-16-7-4-3-5-8-16)21(26)19(29)12-27(18,24(15)31)22(26)20(17)30/h3-5,7-8,17-18,20-24,30-31H,1,6,9-14H2,2H3/t17-,18+,20+,21-,22+,23?,24-,25+,26+,27?/m1/s1
InChiKey: TYQJDMABNTVIES-LDZRSVAVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0015	0.0015	0.0024
Echinococcus multilocularis	geminin	0.0175	0.5627	0.8933
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0015	0.0015	0.0024
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0025	0.0339	0.0538
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.1209	0.1209
Echinococcus granulosus	neuropeptide FF receptor 2	0.0015	0.0015	0.0024
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0339	0.0884
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0124	0.3836	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0015	0.0024
Brugia malayi	Melatonin receptor type 1A	0.0015	0.0015	0.004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0015	0.0024
Entamoeba histolytica	rodhanase-like domain containing protein	0.0124	0.3836	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Onchocerca volvulus		0.0124	0.3836	1
Echinococcus granulosus	FTZ F1 alpha	0.0025	0.0339	0.0538
Trichomonas vaginalis	cdc25b, putative	0.0124	0.3836	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0124	0.3836	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0015	0.0015	0.0024
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0025	0.0339	0.0884
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0015	0.0015	0.0015
Echinococcus multilocularis	Ankyrin	0.0015	0.0004	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0015	0.0015	0.004
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0025	0.0339	0.0884
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.1449	0.3777
Loa Loa (eye worm)	melatonin receptor type 1A	0.0015	0.0015	0.0028
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0025	0.0339	0.0538
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0124	0.3836	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0015	0.0015
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0015	0.0015	0.0024
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0015	0.0028
Echinococcus multilocularis	sex peptide receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	g-protein coupled receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0015	0.0015	0.0024
Trichomonas vaginalis	m-phase inducer phosphatase, putative	0.0124	0.3836	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	neuropeptides capa receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	neuropeptide s receptor	0.0015	0.0015	0.0024
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	amine GPCR	0.0015	0.0015	0.0015
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.1209	0.1209
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0076	0.215	0.3414
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Brugia malayi	steroid hormone receptor	0.0025	0.0339	0.0884
Brugia malayi	hypothetical protein	0.0077	0.218	0.5683
Brugia malayi	mbt repeat family protein	0.0049	0.1209	0.3152
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0025	0.0339	0.0884
Brugia malayi	nuclear hormone receptor	0.0025	0.0339	0.0884
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Brugia malayi	G-protein coupled receptor	0.0015	0.0015	0.004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0015	0.0024
Loa Loa (eye worm)	MBCTL1	0.0056	0.1449	0.377
Echinococcus multilocularis	neuropeptide receptor A26	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	somatostatin receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0098	0.2919	0.4634
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0015	0.0024
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0015	0.0015	0.004
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	G protein coupled receptor 139	0.0015	0.0015	0.0024
Echinococcus multilocularis	jun protein	0.0098	0.2919	0.4634
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0025	0.0339	0.0884
Loa Loa (eye worm)	TYRA-2 protein	0.0015	0.0015	0.0028
Schistosoma mansoni	amine GPCR	0.0015	0.0015	0.0015
Schistosoma mansoni	opsin-like receptor	0.0015	0.0015	0.0015
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Brugia malayi	photoreceptor-specific nuclear receptor	0.0025	0.0339	0.0884
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0015	0.0015
Echinococcus multilocularis	m phase inducer phosphatase(cdc25)	0.0124	0.3836	0.6089
Echinococcus multilocularis	serotonin receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1209	0.3145
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	ecdysone induced protein 78C	0.0025	0.0339	0.0538
Schistosoma mansoni	hypothetical protein	0.008	0.2274	0.2274
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0015	0.0024
Onchocerca volvulus		0.0077	0.218	0.5666
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0015	0.0015
Brugia malayi	AKH receptor	0.0015	0.0015	0.004
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0025	0.0339	0.0873
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0025	0.0339	0.0339
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0025	0.0339	0.0847
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0195	0.6299	1
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0015	0.0015	0.0028
Echinococcus granulosus	m phase inducer phosphatasecdc25	0.0124	0.3836	0.6089
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.1209	0.192
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0015	0.0015	0.0028
Brugia malayi	RE15519p	0.0015	0.0015	0.004
Echinococcus granulosus	somatostatin receptor	0.0015	0.0015	0.0024
Brugia malayi	ORL1-like opioid receptor	0.0015	0.0015	0.004
Echinococcus multilocularis	orexin receptor type 2	0.0015	0.0015	0.0024
Brugia malayi	Dopamine receptor	0.0015	0.0015	0.004
Loa Loa (eye worm)	hypothetical protein	0.0056	0.1449	0.377
Brugia malayi	Steroid receptor seven-up type 2	0.0025	0.0339	0.0884
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0015	0.0015	0.0015
Onchocerca volvulus		0.0124	0.3836	1
Echinococcus granulosus	neuropeptide Y receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Schistosoma mansoni	amine GPCR	0.0015	0.0015	0.0015
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0015	0.0015
Brugia malayi	putative neuropeptide receptor NPR1	0.0015	0.0015	0.004
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Schistosoma mansoni	coup transcription factor	0.0025	0.0339	0.0339
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.1449	0.23
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0025	0.0339	0.0884
Brugia malayi	G protein-coupled receptor F59B2.13	0.0015	0.0015	0.004
Entamoeba histolytica	rodhanase-like domain containing protein	0.0124	0.3836	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0025	0.0339	0.0339
Brugia malayi	ecdysteroid receptor	0.0025	0.0339	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Onchocerca volvulus	Bile acid receptor homolog	0.0025	0.0339	0.0847
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0015	0.0015	0.0015
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0015	0.0015	0.0015
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0025	0.0339	0.0538
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0025	0.0339	0.0884
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0195	0.6299	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0025	0.0339	0.0538
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0025	0.0339	0.0873
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0015	0.0015
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0025	0.0339	0.0538
Schistosoma mansoni	histamine h1 receptor	0.0015	0.0015	0.0015
Brugia malayi	Dopamine receptor protein 1	0.0015	0.0015	0.004
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0025	0.0339	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0025	0.0339	0.0884
Schistosoma mansoni	biogenic amine receptor	0.0015	0.0015	0.0015
Schistosoma mansoni	jun-related protein	0.008	0.2274	0.2274
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0015	0.0015	0.0028
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0015	0.0024
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	thyroid hormone receptor	0.0025	0.0339	0.0339
Brugia malayi	bZIP transcription factor family protein	0.0098	0.2919	0.7609
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.1449	0.23
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0015	0.0015	0.0015
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0124	0.3836	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0015	0.0024
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Echinococcus multilocularis	FTZ F1 alpha	0.0025	0.0339	0.0538
Echinococcus granulosus	G protein coupled receptor 139	0.0015	0.0015	0.0024
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0025	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0076	0.215	0.3414
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0025	0.0339	0.0884
Loa Loa (eye worm)	hypothetical protein	0.0115	0.3495	0.9112
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0015	0.0028
Echinococcus multilocularis	dro:myosuppressin receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	Ankyrin	0.0015	0.0004	0.0007
Brugia malayi	neuropeptide F receptor	0.0015	0.0015	0.004
Echinococcus multilocularis	neuropeptide receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0025	0.0339	0.0538
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.1209	0.192
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0025	0.0339	0.0538
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0015	0.0015	0.0024
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0015	0.0015	0.0024
Brugia malayi	follicle stimulating hormone receptor	0.0015	0.0015	0.004
Schistosoma mansoni	thyroid hormone receptor	0.0025	0.0339	0.0339
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0025	0.0339	0.0884
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0015	0.0015	0.004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0015	0.0015
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0025	0.0339	0.0538
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Schistosoma mansoni	neuropeptide receptor	0.0015	0.0015	0.0015
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0015	0.0015	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0015	0.0015	0.0024
Schistosoma mansoni	opsin-like receptor	0.0015	0.0015	0.0015
Trichomonas vaginalis	cdc25b, putative	0.0124	0.3836	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	RAR-like nuclear receptor	0.0025	0.0339	0.0339
Onchocerca volvulus		0.0049	0.1209	0.3125
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	m-phase inducer phosphatase(cdc25)	0.0124	0.3836	0.3836
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0015	0.0015	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Echinococcus granulosus	fmrfamide receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Brugia malayi	sulfakinin receptor protein	0.0015	0.0015	0.004
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Brugia malayi	larval opioid receptor	0.0015	0.0015	0.004
Brugia malayi	G protein-coupled receptor	0.0015	0.0015	0.004
Schistosoma mansoni	neuropeptide F-like receptor	0.0015	0.0015	0.0015
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0025	0.0339	0.0873
Schistosoma mansoni	myosin xvIII	0.0015	0.0015	0.0015
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0025	0.0339	0.0538
Brugia malayi	G-protein coupled receptor	0.0015	0.0015	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Echinococcus granulosus	serotonin receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0015	0.0024
Onchocerca volvulus		0.0124	0.3836	1
Echinococcus granulosus	neuropeptide receptor A26	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0015	0.0015	0.0024
Onchocerca volvulus		0.0124	0.3836	1
Brugia malayi	neuropeptide F receptor	0.0015	0.0015	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0025	0.0339	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	hypothetical protein	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0124	0.3836	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Echinococcus multilocularis	fmrfamide receptor	0.0015	0.0015	0.0024
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0339	0.0339
Onchocerca volvulus	Protein ultraspiracle homolog	0.0025	0.0339	0.0847
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.1209	0.192
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0015	0.0015	0.0024
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	jun protein	0.0098	0.2919	0.4634
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0025	0.0339	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	neuropeptide receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.1449	0.23
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Schistosoma mansoni	retinoic acid receptor RXR	0.0025	0.0339	0.0339
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.1209	0.3125
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0025	0.0339	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	adenoreceptor	0.0015	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0025	0.0339	0.0884
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0015	0.0015	0.0015
Echinococcus granulosus	allatostatin A receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0025	0.0339	0.0873
Echinococcus multilocularis	g-protein coupled receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Echinococcus granulosus	neuropeptide s receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	biogenic amine 5HT receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.1449	0.23
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0015	0.0015
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.1209	0.192
Schistosoma mansoni	amine GPCR	0.0015	0.0015	0.0015
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0015	0.0015	0.0024
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0015	0.0015	0.0015
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.1209	0.3145
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0025	0.0339	0.0873
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Loa Loa (eye worm)	neuropeptide F receptor	0.0015	0.0015	0.0028
Brugia malayi	Rhodanese-like domain containing protein	0.0124	0.3836	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0015	0.0015	0.0015
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0015	0.0015	0.0024
Echinococcus granulosus	sex peptide receptor	0.0015	0.0015	0.0024
Schistosoma mansoni	hypothetical protein	0.0175	0.5627	0.5627
Trichomonas vaginalis	mitotic inducer phosphatase CDC25, putative	0.0124	0.3836	0.5
Brugia malayi	putative neuropeptide receptor	0.0015	0.0015	0.004
Echinococcus granulosus	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0115	0.3495	0.9112
Brugia malayi	nuclear receptor NHR-88	0.0025	0.0339	0.0884
Echinococcus granulosus	ecdysone induced protein 78C	0.0025	0.0339	0.0538
Echinococcus multilocularis	neuropeptides capa receptor	0.0015	0.0015	0.0024
Brugia malayi	Serotonin receptor	0.0015	0.0015	0.004
Loa Loa (eye worm)	steroid hormone receptor	0.0025	0.0339	0.0873
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0015	0.0015	0.0028
Brugia malayi	GnHR receptor homolog	0.0015	0.0015	0.004
Schistosoma mansoni	hypothetical protein	0.0015	0.0015	0.0015
Schistosoma mansoni	amine GPCR	0.0015	0.0015	0.0015
Echinococcus granulosus	orexin receptor type 2	0.0015	0.0015	0.0024
Echinococcus granulosus	7tm_1 domain containing protein	0.0015	0.0015	0.0024
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0015	0.0015	0.0015
Brugia malayi	mbt repeat family protein	0.0049	0.1209	0.3152
Schistosoma mansoni	growth hormone secretagogue receptor	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	geminin	0.0175	0.5627	0.8933
Trichomonas vaginalis	cdc25c, putative	0.0124	0.3836	0.5
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.1449	0.1449
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0015	0.0015	0.0015
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0025	0.0339	0.0339
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.1209	0.1209
Schistosoma mansoni	hypothetical protein	0.0175	0.5627	0.5627
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0015	0.0015	0.0015
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0025	0.0339	0.0339
Loa Loa (eye worm)	G-protein coupled receptor	0.0015	0.0015	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0025	0.0339	0.0884
Echinococcus multilocularis	g protein coupled receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0015	0.0015	0.0015
Echinococcus granulosus	g protein coupled receptor	0.0015	0.0015	0.0024
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0025	0.0339	0.0538
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0025	0.0339	0.0339
Entamoeba histolytica	rodhanase-like domain containing protein	0.0124	0.3836	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0015	0.0024
Schistosoma mansoni	nuclear hormone receptor	0.0025	0.0339	0.0339
Brugia malayi	hypothetical protein	0.0015	0.0015	0.004
Brugia malayi	Serotonin receptor	0.0015	0.0015	0.004
Echinococcus granulosus	tm gpcr rhodopsin	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0025	0.0339	0.0538
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0015	0.0015	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0098	0.2919	0.4634
Echinococcus multilocularis	serotonin receptor	0.0015	0.0015	0.0024
Echinococcus multilocularis	allatostatin A receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0025	0.0339	0.0884
Schistosoma mansoni	opsin-like receptor	0.0015	0.0015	0.0015
Echinococcus multilocularis	neuropeptide Y receptor	0.0015	0.0015	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0025	0.0339	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0339	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2824	0.7361
Brugia malayi	Dopamine receptor protein 2	0.0015	0.0015	0.004
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0015	0.0028
Onchocerca volvulus		0.0025	0.0339	0.0847
Brugia malayi	Rhodanese-like domain containing protein	0.0124	0.3836	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0025	0.0339	0.0884
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0015	0.0015	0.0024
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0015	0.0015	0.0024

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	> 20 uM	Antiproliferative activity against human A549 cells by sulforhodamine B assay	ChEMBL.	25770782
IC50 (functional)	= 1.01 umol/ml	Growth inhibition of human A172 cells after 6 days	ChEMBL.	18044843

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 503881