TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 486.583 | Formula: C27H39N2O4P
H donors: 3 H acceptors: 4 LogP: 4.13 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(C(=O)N[C@@H](C(C)(C)C)C(=O)NC)CP(=O)(Cc1ccc(cc1)Cc1ccccc1)O
InChi: 1S/C27H39N2O4P/c1-6-10-23(25(30)29-24(26(31)28-5)27(2,3)4)19-34(32,33)18-22-15-13-21(14-16-22)17-20-11-8-7-9-12-20/h7-9,11-16,23-24H,6,10,17-19H2,1-5H3,(H,28,31)(H,29,30)(H,32,33)/t23?,24-/m1/s1
InChiKey: SGQUQTNEKICYNL-XMMISQBUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	matrix metallopeptidase 1 (interstitial collagenase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Matrixin family protein	matrix metallopeptidase 1 (interstitial collagenase)	403 aa	401 aa	27.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	beta tubulin	0.009	0.1294	0.9214
Trichomonas vaginalis	tubulin beta chain, putative	0.0093	0.1364	1
Trypanosoma brucei	alpha tubulin	0.0093	0.1364	1
Echinococcus granulosus	tubulin alpha chain	0.0093	0.1364	0.1364
Plasmodium vivax	tubulin beta chain, putative	0.009	0.1294	0.949
Giardia lamblia	Alpha-tubulin	0.0093	0.1364	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0093	0.1364	0.1364
Echinococcus granulosus	muscleblind protein	0.012	0.2079	0.2079
Onchocerca volvulus		0.024	0.524	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0093	0.1364	0.1364
Echinococcus granulosus	tubulin alpha chain	0.0093	0.1364	0.1364
Plasmodium vivax	tubulin alpha chain, putative	0.0093	0.1364	1
Echinococcus multilocularis	serotonin transporter	0.024	0.524	0.524
Trypanosoma brucei	alpha tubulin	0.0093	0.1364	1
Onchocerca volvulus		0.0075	0.0891	0.1701
Trichomonas vaginalis	tubulin beta chain, putative	0.0093	0.1364	1
Brugia malayi	alpha-tubulin	0.0093	0.1364	0.2603
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0055	0.0367	0.07
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.1294	0.1294
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.009	0.1294	0.1294
Onchocerca volvulus	Matrilysin homolog	0.0053	0.0313	0.0597
Loa Loa (eye worm)	alpha-tubulin	0.0093	0.1364	0.2603
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.024	0.524	0.612
Brugia malayi	Matrixin family protein	0.0053	0.0313	0.0597
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Plasmodium falciparum	tubulin gamma chain	0.0059	0.0479	0.3512
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0191	0.3961	0.3961
Schistosoma mansoni	hypothetical protein	0.0366	0.8562	1
Echinococcus granulosus	serotonin transporter	0.024	0.524	0.524
Trichomonas vaginalis	tubulin beta chain, putative	0.0093	0.1364	1
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Treponema pallidum	sodium- and chloride- dependent transporter	0.024	0.524	0.5
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0064	0.0614	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0691	0.1318
Loa Loa (eye worm)	tubulin beta-2A chain	0.009	0.1294	0.247
Toxoplasma gondii	beta tubulin	0.009	0.1294	0.949
Echinococcus multilocularis	tubulin alpha	0.0059	0.0479	0.0479
Wolbachia endosymbiont of Brugia malayi	leucyl aminopeptidase	0.007	0.0771	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.1294	0.1294
Schistosoma mansoni	tubulin subunit beta	0.009	0.1294	0.1512
Echinococcus multilocularis	tubulin beta 1 chain	0.009	0.1294	0.1294
Echinococcus multilocularis	tubulin gamma 1 chain	0.0059	0.0479	0.0479
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.1294	0.1294
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Entamoeba histolytica	tubulin gamma chain	0.0059	0.0479	0.1123
Schistosoma mansoni	alpha tubulin	0.0093	0.1364	0.1593
Mycobacterium ulcerans	leucyl aminopeptidase	0.007	0.0771	1
Brugia malayi	Muscleblind-like protein	0.012	0.2079	0.3969
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0093	0.1364	0.1364
Brugia malayi	Matrixin family protein	0.0053	0.0313	0.0597
Plasmodium falciparum	kinesin-5	0.0055	0.0367	0.2691
Echinococcus multilocularis	leucine aminopeptidase protein	0.007	0.0771	0.0771
Toxoplasma gondii	leucyl aminopeptidase LAP	0.007	0.0771	0.5656
Trypanosoma brucei	metallo-peptidase, Clan MF, Family M17	0.007	0.0771	0.3305
Echinococcus multilocularis	beta tubulin	0.009	0.1294	0.1294
Loa Loa (eye worm)	matrixin family protein	0.0117	0.1999	0.3814
Plasmodium vivax	kinesin-5	0.0055	0.0367	0.2691
Loa Loa (eye worm)	serotonin transporter b	0.024	0.524	1
Brugia malayi	Matrixin family protein	0.0127	0.2275	0.4343
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0313	0.0597
Echinococcus multilocularis	muscleblind protein 1	0.012	0.2079	0.2079
Echinococcus multilocularis	tubulin alpha chain	0.0093	0.1364	0.1364
Plasmodium falciparum	tubulin beta chain	0.009	0.1294	0.949
Trichomonas vaginalis	tubulin gamma chain, putative	0.009	0.1294	0.9214
Echinococcus granulosus	tubulin alpha 1C chain	0.0093	0.1364	0.1364
Leishmania major	alpha tubulin	0.0093	0.1364	1
Echinococcus granulosus	alpha tubulin	0.0093	0.1364	0.1364
Echinococcus multilocularis	kinesin family 1	0.0421	1	1
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Trichomonas vaginalis	tubulin beta chain, putative	0.0093	0.1364	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0093	0.1364	0.1364
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0487	0.0929
Echinococcus multilocularis	muscleblind protein	0.012	0.2079	0.2079
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0093	0.1364	0.2603
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0059	0.0487	0.0086
Loa Loa (eye worm)	hypothetical protein	0.012	0.2079	0.3969
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Schistosoma mansoni	tubulin subunit gamma	0.0059	0.0479	0.0559
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0093	0.1364	1
Schistosoma mansoni	alpha tubulin	0.0093	0.1364	0.1593
Schistosoma mansoni	tubulin subunit alpha	0.0093	0.1364	0.1593
Loa Loa (eye worm)	hypothetical protein	0.012	0.2079	0.3969
Echinococcus granulosus	tubulin gamma 1 chain	0.0059	0.0479	0.0479
Loa Loa (eye worm)	matrixin family protein	0.0127	0.2275	0.4343
Toxoplasma gondii	beta-1 tubulin, putative	0.009	0.1294	0.949
Loa Loa (eye worm)	alpha-tubulin	0.0093	0.1364	0.2603
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Entamoeba histolytica	tubulin family protein	0.009	0.1294	0.9302
Echinococcus granulosus	tubulin alpha 3 chain	0.0093	0.1364	0.1364
Giardia lamblia	Gamma tubulin	0.0059	0.0479	0.1123
Echinococcus granulosus	Tubulin alpha 1 chain	0.0093	0.1364	0.1364
Schistosoma mansoni	tubulin subunit alpha	0.0093	0.1364	0.1593
Echinococcus granulosus	tubulin alpha chain	0.0093	0.1364	0.1364
Trichomonas vaginalis	tubulin, putative	0.009	0.1294	0.9214
Loa Loa (eye worm)	BEN-1 protein	0.009	0.1294	0.247
Loa Loa (eye worm)	hypothetical protein	0.024	0.524	1
Schistosoma mansoni	kinesin eg-5	0.0055	0.0367	0.0429
Brugia malayi	Matrixin family protein	0.0053	0.0313	0.0597
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Schistosoma mansoni	tubulin subunit beta	0.009	0.1294	0.1512
Loa Loa (eye worm)	tubulin beta-1 chain	0.009	0.1294	0.247
Brugia malayi	tubulin alpha chain - mouse	0.0093	0.1364	0.2603
Entamoeba histolytica	tubulin family protein	0.009	0.1294	0.9302
Entamoeba histolytica	tubulin alpha chain, putative	0.0093	0.1364	1
Onchocerca volvulus		0.0053	0.0313	0.0597
Brugia malayi	Kinesin motor domain containing protein	0.0055	0.0367	0.07
Plasmodium vivax	tubulin epsilon chain, putative	0.0059	0.0479	0.3512
Echinococcus multilocularis	tubulin alpha chain	0.0093	0.1364	0.1364
Trichomonas vaginalis	tubulin beta chain, putative	0.0093	0.1364	1
Trypanosoma brucei	beta tubulin	0.009	0.1294	0.9214
Trichomonas vaginalis	tubulin epsilon chain, putative	0.009	0.1294	0.9214
Echinococcus multilocularis	beta tubulin	0.009	0.1294	0.1294
Echinococcus multilocularis	tubulin epsilon chain	0.0059	0.0479	0.0479
Leishmania major	cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17	0.007	0.0771	0.3305
Schistosoma mansoni	tubulin subunit alpha	0.0093	0.1364	0.1593
Echinococcus multilocularis	tubulin alpha 1C chain	0.0093	0.1364	0.1364
Plasmodium vivax	M17 leucyl aminopeptidase, putative	0.007	0.0771	0.5656
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.1294	0.1294
Echinococcus multilocularis	hypothetical protein	0.0093	0.1364	0.1364
Loa Loa (eye worm)	tubulin beta-4 chain	0.009	0.1294	0.247
Schistosoma mansoni	tubulin subunit epsilon	0.0059	0.0479	0.0559
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0059	0.0487	0.0929
Schistosoma mansoni	tubulin subunit beta	0.009	0.1294	0.1512
Giardia lamblia	Beta tubulin	0.009	0.1294	0.9302
Loa Loa (eye worm)	tubulin alpha chain	0.0093	0.1364	0.2603
Echinococcus multilocularis	tubulin alpha chain	0.0093	0.1364	0.1364
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0093	0.1364	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.009	0.1294	0.9214
Trichomonas vaginalis	tubulin alpha chain, putative	0.009	0.1294	0.9214
Echinococcus granulosus	tubulin alpha	0.0059	0.0479	0.0479
Schistosoma mansoni	tubulin subunit beta	0.009	0.1294	0.1512
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1364	0.2603
Leishmania major	alpha tubulin	0.0093	0.1364	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0093	0.1364	0.1364
Echinococcus granulosus	tubulin beta 4A class IVa	0.009	0.1294	0.1294
Trypanosoma brucei	beta tubulin	0.009	0.1294	0.9214
Plasmodium vivax	tubulin alpha chain, putative	0.0093	0.1364	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.024	0.524	1
Giardia lamblia	Beta tubulin	0.009	0.1294	0.9302
Trichomonas vaginalis	tubulin beta chain, putative	0.0093	0.1364	1
Leishmania major	alpha tubulin	0.0093	0.1364	1
Trypanosoma cruzi	metallo-peptidase, Clan MF, Family M17, putative	0.007	0.0771	0.3305
Trypanosoma cruzi	cytosolic leucyl aminopeptidase, putative	0.007	0.0771	0.3305
Echinococcus granulosus	peroxisome assembly protein 26	0.0093	0.1364	0.1364
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.1294	0.1294
Echinococcus granulosus	tubulin alpha 3 chain	0.0093	0.1364	0.1364
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.1294	0.1294
Echinococcus multilocularis	peroxisome assembly protein 26	0.0093	0.1364	0.1364
Echinococcus multilocularis	tubulin alpha chain	0.0093	0.1364	0.1364
Echinococcus granulosus	tubulin epsilon chain	0.0059	0.0479	0.0479
Plasmodium vivax	tubulin gamma chain, putative	0.0059	0.0479	0.3512
Toxoplasma gondii	alpha tubulin TUBA1	0.0093	0.1364	1
Brugia malayi	Matrixin family protein	0.0053	0.0313	0.0597
Brugia malayi	beta-tubulin, identical	0.009	0.1294	0.247
Brugia malayi	Tubulin alpha chain	0.0093	0.1364	0.2603
Loa Loa (eye worm)	beta-tubulin	0.009	0.1294	0.247
Schistosoma mansoni	alpha tubulin	0.0093	0.1364	0.1593
Mycobacterium tuberculosis	Probable aminopeptidase PepB	0.007	0.0771	1
Plasmodium falciparum	alpha tubulin 2	0.0093	0.1364	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0093	0.1364	1
Loa Loa (eye worm)	tubulin alpha 2	0.0067	0.0691	0.1318
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0053	0.0313	0.0365
Brugia malayi	Tubulin gamma chain	0.0059	0.0479	0.0914
Trypanosoma cruzi	alpha tubulin, putative	0.0093	0.1364	1
Mycobacterium leprae	Probable cytosol aminopeptidase PepB	0.007	0.0771	1
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0191	0.3961	0.3961
Schistosoma mansoni	sodium/chloride dependent transporter	0.024	0.524	0.612
Brugia malayi	tubulin alpha-2 chain	0.0093	0.1364	0.2603
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0614	0.1173
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0059	0.0479	0.3512
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Loa Loa (eye worm)	tubulin gamma chain	0.0059	0.0479	0.0914
Echinococcus granulosus	tubulin subunit TubB	0.0093	0.1364	0.1364
Echinococcus granulosus	Tubulin beta 2C chain	0.009	0.1294	0.1294
Leishmania major	alpha tubulin	0.0093	0.1364	1
Loa Loa (eye worm)	tubulin alpha chain	0.0093	0.1364	0.2603
Trypanosoma cruzi	beta tubulin, putative	0.009	0.1294	0.9214
Trypanosoma brucei	alpha tubulin	0.0093	0.1364	1
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Echinococcus granulosus	leucine aminopeptidase protein	0.007	0.0771	0.0771
Echinococcus multilocularis	tubulin alpha 3 chain	0.0093	0.1364	0.1364
Echinococcus multilocularis	tubulin alpha 3 chain	0.0093	0.1364	0.1364
Brugia malayi	Tubulin beta-1 chain	0.009	0.1294	0.247
Trypanosoma brucei	beta tubulin	0.009	0.1294	0.9214
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Entamoeba histolytica	tubulin alpha-1 chain	0.0093	0.1364	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0093	0.1364	0.1364
Loa Loa (eye worm)	BEN-1 protein	0.009	0.1294	0.247
Echinococcus granulosus	tubulin alpha chain	0.0093	0.1364	0.1364
Plasmodium falciparum	alpha tubulin 1	0.0093	0.1364	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0059	0.0479	0.3512
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0117	0.1999	0.3814
Leishmania major	alpha tubulin	0.0093	0.1364	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.009	0.1294	0.1294
Plasmodium falciparum	M17 leucyl aminopeptidase	0.007	0.0771	0.5656
Echinococcus granulosus	beta tubulin	0.009	0.1294	0.1294
Leishmania major	alpha tubulin	0.0093	0.1364	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.024	0.524	1
Echinococcus multilocularis	tubulin subunit beta	0.009	0.1294	0.1294
Giardia lamblia	Beta tubulin	0.009	0.1294	0.9302
Toxoplasma gondii	beta-tubulin, putative	0.009	0.1294	0.949
Loa Loa (eye worm)	matrix metalloproteinase	0.0053	0.0313	0.0597
Schistosoma mansoni	hypothetical protein	0.0075	0.0891	0.1041
Toxoplasma gondii	kinesin motor domain-containing protein	0.0055	0.0367	0.2691
Schistosoma mansoni	tubulin subunit beta	0.009	0.1294	0.1512
Loa Loa (eye worm)	tubulin beta chain	0.009	0.1294	0.247
Loa Loa (eye worm)	solute carrier family 6 member 4	0.024	0.524	1
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Toxoplasma gondii	alpha-tubulin I, putative	0.0093	0.1364	1
Leishmania major	alpha tubulin	0.0093	0.1364	1
Brugia malayi	Tubulin alpha-2 chain	0.0093	0.1364	0.2603
Leishmania major	alpha tubulin	0.0093	0.1364	1
Chlamydia trachomatis	cytosol aminopeptidase	0.007	0.0771	1
Echinococcus multilocularis	tubulin alpha chain	0.0093	0.1364	0.1364
Echinococcus granulosus	beta tubulin	0.009	0.1294	0.1294
Leishmania major	alpha tubulin	0.0093	0.1364	1
Loa Loa (eye worm)	norepinephrine transporter	0.024	0.524	1
Trypanosoma brucei	alpha tubulin	0.0093	0.1364	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0313	0.0597
Giardia lamblia	Alpha-tubulin	0.0093	0.1364	1
Leishmania major	alpha tubulin	0.0093	0.1364	1
Echinococcus granulosus	tubulin alpha chain	0.0093	0.1364	0.1364
Loa Loa (eye worm)	tubulin alpha 2	0.0067	0.0691	0.1318
Onchocerca volvulus	Matrilysin homolog	0.0117	0.1999	0.3814
Loa Loa (eye worm)	hypothetical protein	0.024	0.524	1
Leishmania major	alpha tubulin	0.0093	0.1364	1
Trichomonas vaginalis	tubulin beta chain, putative	0.009	0.1294	0.9214
Brugia malayi	Tubulin alpha-2 chain	0.0093	0.1364	0.2603
Leishmania major	alpha tubulin	0.0093	0.1364	1
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Schistosoma mansoni	tubulin subunit beta	0.009	0.1294	0.1512
Echinococcus granulosus	tubulin subunit beta	0.009	0.1294	0.1294
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0067	0.0691	0.2393
Echinococcus granulosus	Tubulin alpha 1 chain	0.0093	0.1364	0.1364
Leishmania major	beta tubulin	0.009	0.1294	0.9214
Echinococcus multilocularis	tubulin subunit TubB	0.0093	0.1364	0.1364
Brugia malayi	Hemopexin family protein	0.0075	0.0891	0.1701
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0067	0.0691	0.1318
Echinococcus granulosus	tubulin beta 1 chain	0.009	0.1294	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0313	0.0597

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.47	Inhibition of MMP1 (unknown origin)	ChEMBL.	17275314
log(1/IC50) (binding)	= 6.47	Inhibition of MMP1 (unknown origin)	ChEMBL.	17275314

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 503974