Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Plasmodium falciparum | thymidylate kinase | 0.0219 | 0.3664 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.018 | 0.028 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Schistosoma mansoni | thymidylate kinase | 0.0219 | 0.3664 | 0.3548 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0219 | 0.3664 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.018 | 0.028 |
Brugia malayi | protein kinase C II. | 0.006 | 0.0651 | 0.1014 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.2197 | 0.2054 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.083 | 0.0734 |
Leishmania major | thymidine kinase, putative | 0.0511 | 0.9224 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.2197 | 0.2054 |
Schistosoma mansoni | NADH-ubiquinone oxidoreductase | 0.0069 | 0.083 | 0.0662 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.072 | 0.055 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.018 | 0.0261 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0125 | 0.1897 | 0.1749 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.072 | 0.1122 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0035 | 0.018 | 0.0261 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.2089 | 0.1944 |
Toxoplasma gondii | thymidylate kinase | 0.0219 | 0.3664 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.072 | 0.1045 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.006 | 0.0651 | 0.0479 |
Brugia malayi | protein kinase C3,putative | 0.0364 | 0.6419 | 1 |
Loa Loa (eye worm) | thymidylate kinase | 0.0219 | 0.3664 | 0.5318 |
Echinococcus granulosus | protein kinase c epsilon type | 0.006 | 0.0651 | 0.0479 |
Schistosoma mansoni | thyroid hormone receptor | 0.0136 | 0.2089 | 0.1944 |
Giardia lamblia | CDC8 | 0.0219 | 0.3664 | 0.3376 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0035 | 0.018 | 0.0261 |
Entamoeba histolytica | thymidine kinase, putative | 0.0511 | 0.9224 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0219 | 0.3664 | 0.3853 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0511 | 0.9224 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.072 | 0.055 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0069 | 0.083 | 0.0719 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.072 | 0.055 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0219 | 0.3664 | 0.3863 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Schistosoma mansoni | serine/threonine protein kinase | 0.006 | 0.0651 | 0.0479 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0141 | 0.2197 | 0.2054 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.018 | 0.028 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.072 | 0.1122 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.072 | 0.1045 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0035 | 0.018 | 0.028 |
Brugia malayi | thymidylate kinase | 0.0219 | 0.3664 | 0.5709 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.072 | 0.055 |
Echinococcus multilocularis | thymidylate kinase | 0.0219 | 0.3664 | 0.3548 |
Echinococcus granulosus | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0069 | 0.083 | 0.0662 |
Schistosoma mansoni | hypothetical protein | 0.0219 | 0.3664 | 0.3548 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0552 | 1 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0511 | 0.9224 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.0219 | 0.3664 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.072 | 0.055 |
Echinococcus multilocularis | NADH ubiquinone oxidoreductase 42 kDa subunit | 0.0069 | 0.083 | 0.0662 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.2197 | 0.2054 |
Trypanosoma brucei | thymidine kinase | 0.0511 | 0.9224 | 1 |
Brugia malayi | Hr1 repeat family protein | 0.0035 | 0.018 | 0.028 |
Loa Loa (eye worm) | deoxynucleoside kinase | 0.0069 | 0.083 | 0.1205 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0069 | 0.083 | 0.0719 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0141 | 0.2197 | 0.3423 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0219 | 0.3664 | 0.5 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0219 | 0.3664 | 0.3853 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Echinococcus granulosus | thymidine kinase | 0.0552 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0141 | 0.2197 | 0.3189 |
Echinococcus multilocularis | thymidine kinase | 0.0552 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.006 | 0.0651 | 0.0479 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0511 | 0.9224 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0511 | 0.9224 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.083 | 0.0734 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0493 | 0.0319 |
Brugia malayi | Deoxynucleoside kinase family protein | 0.0069 | 0.083 | 0.1294 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0219 | 0.3664 | 0.3853 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.072 | 0.055 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0388 | 0.689 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0069 | 0.083 | 0.0719 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.006 | 0.0651 | 0.0479 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0035 | 0.018 | 0.0261 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0219 | 0.3664 | 0.5 |
Giardia lamblia | Deoxynucleoside kinase | 0.0444 | 0.7955 | 0.8489 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0141 | 0.2197 | 0.2054 |
Plasmodium vivax | thymidylate kinase, putative | 0.0219 | 0.3664 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.072 | 0.055 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.2197 | 0.2054 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0035 | 0.018 | 0.0261 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0069 | 0.083 | 0.0719 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0035 | 0.018 | 0.0261 |
Leishmania major | thymidylate kinase-like protein | 0.0219 | 0.3664 | 0.312 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0552 | 1 | 1 |
Echinococcus granulosus | thymidylate kinase | 0.0219 | 0.3664 | 0.3548 |
Giardia lamblia | Thymidine kinase | 0.0511 | 0.9224 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0398 | 0.707 | 0.7017 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.083 | 0.0734 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.072 | 0.1045 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.083 | 0.0734 |
Schistosoma mansoni | thymidylate kinase | 0.0219 | 0.3664 | 0.3548 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.1897 | 0.1749 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0136 | 0.2089 | 0.1944 |
Schistosoma mansoni | serine/threonine protein kinase | 0.006 | 0.0651 | 0.0479 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0511 | 0.9224 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0398 | 0.707 | 0.7017 |
Chlamydia trachomatis | thymidylate kinase | 0.0219 | 0.3664 | 0.5 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0035 | 0.018 | 0.0261 |
Entamoeba histolytica | deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein | 0.0069 | 0.083 | 0.0719 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.006 | 0.0651 | 0.0944 |
Schistosoma mansoni | thymidine kinase | 0.0552 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0219 | 0.3664 | 0.312 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0069 | 0.083 | 0.0734 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0219 | 0.3664 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0141 | 0.2197 | 0.2054 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.006 | 0.0651 | 0.0479 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0219 | 0.3664 | 0.312 |
Schistosoma mansoni | atypical protein kinase C | 0.0423 | 0.7542 | 0.7497 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0035 | 0.018 | 0.0261 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0219 | 0.3664 | 0.5 |
Brugia malayi | RNA binding protein | 0.0063 | 0.072 | 0.1122 |
Trichomonas vaginalis | AGC family protein kinase | 0.0035 | 0.018 | 0.0016 |
Echinococcus multilocularis | thymidine kinase | 0.0552 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0125 | 0.1897 | 0.1749 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0219 | 0.3664 | 0.3863 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta blood pressure (functional) | = 0 mmHg | Difference in systolic blood pressure of SH rats observed prior to the first application and 2 hr after the fifth application at the oral dose of 25 mg/kg was expressed as Delta BP | ChEMBL. | 6492077 |
ED25 (functional) | = 3.5 mg kg-1 | Dose estimated to produce 25 mm Hg fall in mean systemic blood pressure of anesthetized cat at 10 min after administration | ChEMBL. | 6492077 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.