TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 569.03 | Formula: C23H29ClN6O7S
H donors: 4 H acceptors: 9 LogP: 3.68 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: [O-][Cl](=O)(=O)=O.C[S+](CC1OC(C(C1O)O)n1cnc2c1ncnc2N)CCCCc1c[nH]c2c1cccc2
InChi: 1S/C23H29N6O3S.ClHO4/c1-33(9-5-4-6-14-10-25-16-8-3-2-7-15(14)16)11-17-19(30)20(31)23(32-17)29-13-28-18-21(24)26-12-27-22(18)29;2-1(3,4)5/h2-3,7-8,10,12-13,17,19-20,23,25,30-31H,4-6,9,11H2,1H3,(H2,24,26,27);(H,2,3,4,5)/q+1;/p-1
InChiKey: FGPWZIMWVDXAEM-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nAChR subunit	0.0082	0.0867	0.0965
Brugia malayi	excitatory GABA receptor EXP-1A	0.0082	0.0867	0.0867
Onchocerca volvulus		0.0038	0.0259	0.1289
Schistosoma mansoni	acetylcholine receptor-related	0.0038	0.0259	0.0288
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3199	1
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0627	0.0697
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0092	0.5
Schistosoma mansoni	neurotransmitter gated ion channel	0.0038	0.0259	0.0288
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0867	0.0965
Schistosoma mansoni	nAChR subunit	0.0082	0.0867	0.0965
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0082	0.0867	0.0965
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0044	0.0346	0.0386
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0038	0.0259	0.0288
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Echinococcus granulosus	pikachurin	0.0027	0.0111	0.0123
Echinococcus multilocularis	nAChR subunit	0.0082	0.0867	0.0965
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0044	0.0346	0.0346
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0082	0.0867	0.0965
Schistosoma mansoni	nAChR subunit	0.0082	0.0867	0.0965
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0627	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Brugia malayi	TAR-binding protein	0.0065	0.0627	0.0627
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0867	0.0867
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0258	0.3295	0.3295
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.038	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	hypothetical protein	0.0038	0.0259	0.0259
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Echinococcus granulosus	nAChR subunit	0.0044	0.0346	0.0386
Schistosoma mansoni	neurotransmitter gated ion channel	0.0038	0.0259	0.0288
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0038	0.0259	0.0288
Schistosoma mansoni	nAChR subunit	0.0038	0.0259	0.0288
Schistosoma mansoni	nAChR subunit	0.0082	0.0867	0.0965
Schistosoma mansoni	nAChR subunit	0.0038	0.0259	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0038	0.0259	0.0259
Onchocerca volvulus		0.0044	0.0346	0.1724
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0082	0.0867	0.0965
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0082	0.0867	0.0867
Onchocerca volvulus		0.0082	0.0867	0.4314
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3199	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0082	0.0867	0.0867
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0262	0.0291
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0627	0.0627
Brugia malayi	Cation transporter family protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Onchocerca volvulus		0.0082	0.0867	0.4314
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0252	0.3199	0.3199
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0027	0.0111	0.0111
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0082	0.0867	0.0965
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0038	0.0259	0.0259
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3199	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.038	0.0423
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0867	0.0867
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0082	0.0867	0.0867
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0044	0.0346	0.0346
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0082	0.0867	0.0965
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0038	0.0259	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0082	0.0867	0.0867
Echinococcus granulosus	slit 2 protein	0.0027	0.0111	0.0123
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.038	0.0423
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.038	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0259	0.0259
Onchocerca volvulus		0.0082	0.0867	0.4314
Schistosoma mansoni	neurotransmitter gated ion channel	0.0044	0.0346	0.0386
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0038	0.0259	0.0259
Onchocerca volvulus		0.0082	0.0867	0.4314
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0082	0.0867	0.0965
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0082	0.0867	0.0965
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0038	0.0259	0.0288
Schistosoma mansoni	nAChR subunit	0.0082	0.0867	0.0965
Brugia malayi	hypothetical protein	0.0038	0.0262	0.0262
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Loa Loa (eye worm)	ACC-1 protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	ACC-1 protein	0.0082	0.0867	0.0867
Schistosoma mansoni	nAChR subunit	0.0082	0.0867	0.0965
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0044	0.0346	0.0346
Echinococcus granulosus	neurogenic locus notch protein	0.0027	0.0111	0.0123
Schistosoma mansoni	cell polarity protein	0.0027	0.0111	0.0123
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0082	0.0867	0.0867
Onchocerca volvulus		0.0044	0.0346	0.1724
Echinococcus granulosus	nAChR subunit	0.0082	0.0867	0.0965
Schistosoma mansoni	laminin gamma-3 chain	0.0027	0.0111	0.0123
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0044	0.0346	0.0386
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0259	0.0259
Loa Loa (eye worm)	LGC-31 protein	0.0082	0.0867	0.0867
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0092	0.5
Loa Loa (eye worm)	hypothetical protein	0.0415	0.5453	0.5453
Brugia malayi	laminin alpha chain	0.0027	0.0111	0.0111
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0092	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0867	0.0867
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3199	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0082	0.0867	0.0867
Echinococcus multilocularis	neurogenic locus notch protein	0.0027	0.0111	0.0123
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0082	0.0867	0.0867
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0627	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Brugia malayi	hypothetical protein	0.0038	0.0259	0.0259
Loa Loa (eye worm)	GABA receptor subunit	0.0044	0.0346	0.0346
Echinococcus granulosus	microtubule associated protein 2	0.0672	0.8985	1
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0627	0.0697
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.038	0.0423
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0111
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2131	0.1027
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.2131	0.1027
Entamoeba histolytica	hypothetical protein	0.0044	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0082	0.0867	0.0965
Schistosoma mansoni	slit	0.0027	0.0111	0.0123
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.0746	1	1
Echinococcus multilocularis	nAChR subunit	0.0044	0.0346	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3199	1
Echinococcus multilocularis	pikachurin	0.0027	0.0111	0.0123
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0082	0.0867	0.0965
Onchocerca volvulus		0.0038	0.0259	0.1289
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.2009	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0082	0.0867	0.0965
Brugia malayi	hypothetical protein	0.0026	0.0092	0.0092
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0262	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	Cation transporter family protein	0.0082	0.0867	0.0867
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0867	0.0867
Schistosoma mansoni	nAChR subunit	0.0082	0.0867	0.0965
Echinococcus multilocularis	glycine receptor subunit beta	0.0082	0.0867	0.0965
Brugia malayi	hypothetical protein	0.0038	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0082	0.0867	0.0965
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0092	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0627	0.0627
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0092	0.5
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0627	0.0627
Onchocerca volvulus	Putative nachr subunit	0.0082	0.0867	0.4314
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.038	0.0423
Leishmania major	hypothetical protein, conserved	0.0026	0.0092	0.5
Brugia malayi	hypothetical protein	0.0038	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Brugia malayi	RNA binding protein	0.0065	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0111
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0038	0.0259	0.0288
Trichomonas vaginalis	glucosylceramidase, putative	0.0252	0.3199	1
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0027	0.0111	0.0123
Echinococcus granulosus	expressed protein	0.0364	0.474	0.5275
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0082	0.0867	0.0867
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0627	0.0627
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.038	0.0423
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0627	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0346	0.0346
Brugia malayi	EGF-like domain containing protein	0.0027	0.0111	0.0111
Echinococcus granulosus	glycine receptor subunit beta	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Echinococcus multilocularis	microtubule associated protein 2	0.0672	0.8985	1
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0027	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0746	1	1
Echinococcus multilocularis	expressed protein	0.0364	0.474	0.5275
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0082	0.0867	0.0965
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0867	0.0867
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0746	1	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Onchocerca volvulus		0.0038	0.0259	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0092	0.5
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0082	0.0867	0.0867
Brugia malayi	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	Cation transporter family protein	0.0082	0.0867	0.0867
Schistosoma mansoni	microtubule-associated protein tau	0.0672	0.8985	1
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0082	0.0867	0.0965
Echinococcus granulosus	glycine receptor subunit beta	0.0082	0.0867	0.0965
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0252	0.3199	0.3199
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0038	0.0259	0.0288
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0082	0.0867	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3295	0.3295
Loa Loa (eye worm)	acetylcholine receptor protein	0.0038	0.0259	0.0259
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.038	0.038
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.038	0.038
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0082	0.0867	0.0965
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0221	0.2774	0.2774
Onchocerca volvulus		0.0082	0.0867	0.4314
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0044	0.0346	0.0346
Echinococcus multilocularis	slit 2 protein	0.0027	0.0111	0.0123
Schistosoma mansoni	hypothetical protein	0.0038	0.0262	0.0291
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0627	0.0697
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0627	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0038	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0111	0.0111
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0092	0.5
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0038	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Onchocerca volvulus		0.0082	0.0867	0.4314
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0038	0.0259	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0259	0.0259
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0262	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0867	0.0867
Loa Loa (eye worm)	abnormal epIthelia family member	0.0027	0.0111	0.0111

Activities

Activity type	Activity value	Assay description	Source	Reference
I50 (binding)	= 38 uM	Inhibitory activity against rabbit lung indole N-methyltransferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.	ChEMBL.	6620306
I50 (binding)	= 10000 uM	Inhibitory activity against catechol O-methyltransferase	ChEMBL.	6620306
Ki (binding)	= 12 uM	Inhibitory constant towards indole N-methyltransferase	ChEMBL.	6620306

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 151209

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 50518