TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 497.608 | Formula: C26H36FN7O2
H donors: 3 H acceptors: 5 LogP: 3.66 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C[C@@H]([C@H](NC(=O)Nc1cc(CC)cc(c1)c1nnnn1C)C)O)CCCc1ccc(cc1)F
InChi: 1S/C26H36FN7O2/c1-5-19-14-21(25-30-31-32-33(25)4)16-23(15-19)29-26(36)28-18(3)24(35)17-34(6-2)13-7-8-20-9-11-22(27)12-10-20/h9-12,14-16,18,24,35H,5-8,13,17H2,1-4H3,(H2,28,29,36)/t18-,24+/m1/s1
InChiKey: ZKBWRGSSTRYGHO-KOSHJBKYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	alpha tubulin	0.0021	0.0605	0.1335
Echinococcus granulosus	tubulin subunit beta	0.0053	0.2793	0.2709
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0021	0.0605	0.0496
Brugia malayi	tubulin alpha-2 chain	0.0021	0.0605	0.0605
Echinococcus multilocularis	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Brugia malayi	Tubulin gamma chain	0.0021	0.0605	0.0605
Leishmania major	beta tubulin	0.0053	0.2793	1
Leishmania major	beta tubulin	0.0053	0.2793	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.2161	0.7114
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0794	0.305
Schistosoma mansoni	inositol monophosphatase	0.0044	0.2161	0.5574
Schistosoma mansoni	tubulin subunit gamma	0.0021	0.0605	0.1335
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.2161	0.7739
Echinococcus granulosus	beta tubulin	0.0053	0.2793	0.2709
Echinococcus granulosus	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Onchocerca volvulus		0.0023	0.0794	1
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.2161	0.7114
Echinococcus multilocularis	tubulin alpha chain	0.0021	0.0605	0.0496
Schistosoma mansoni	tubulin subunit beta	0.0053	0.2793	0.7293
Loa Loa (eye worm)	hypothetical protein	0.0159	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0021	0.0605	0.2166
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0794	0.0794
Echinococcus multilocularis	tubulin subunit beta	0.0053	0.2793	0.2709
Leishmania major	beta tubulin	0.0053	0.2793	1
Brugia malayi	Tubulin alpha-2 chain	0.0021	0.0605	0.0605
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0394	0.0424
Toxoplasma gondii	beta tubulin	0.0053	0.2793	1
Brugia malayi	beta-tubulin, identical	0.0053	0.2793	0.2793
Echinococcus granulosus	tubulin alpha chain	0.0021	0.0605	0.0496
Schistosoma mansoni	alpha tubulin	0.0021	0.0605	0.1335
Echinococcus granulosus	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Echinococcus multilocularis	tubulin epsilon chain	0.0021	0.0605	0.0496
Schistosoma mansoni	tubulin subunit alpha	0.0021	0.0605	0.1335
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0794	0.0794
Echinococcus multilocularis	peroxisome assembly protein 26	0.0021	0.0605	0.0496
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.2161	0.7114
Echinococcus multilocularis	tubulin gamma 1 chain	0.0021	0.0605	0.0496
Brugia malayi	RNA binding protein	0.0067	0.3787	0.3787
Trypanosoma brucei	alpha tubulin	0.0021	0.0605	0.2166
Echinococcus multilocularis	beta tubulin	0.0053	0.2793	0.2709
Brugia malayi	Tubulin alpha-2 chain	0.0021	0.0605	0.0605
Echinococcus granulosus	tubulin subunit TubB	0.0021	0.0605	0.0496
Echinococcus granulosus	Tubulin alpha 1 chain	0.0021	0.0605	0.0496
Trichomonas vaginalis	tubulin gamma chain, putative	0.0053	0.2793	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0794	0.0864
Echinococcus granulosus	Tubulin alpha 1 chain	0.0021	0.0605	0.0496
Loa Loa (eye worm)	BEN-1 protein	0.0053	0.2793	0.2793
Leishmania major	beta tubulin	0.0053	0.2793	1
Loa Loa (eye worm)	alpha-tubulin	0.0021	0.0605	0.0605
Toxoplasma gondii	beta-1 tubulin, putative	0.0053	0.2793	1
Brugia malayi	Tubulin beta-1 chain	0.0053	0.2793	0.2793
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0044	0.2161	0.7114
Giardia lamblia	Beta tubulin	0.0053	0.2793	1
Plasmodium vivax	tubulin alpha chain, putative	0.0021	0.0605	0.0879
Schistosoma mansoni	tubulin subunit beta	0.0053	0.2793	0.7293
Trypanosoma brucei	beta tubulin	0.0053	0.2793	1
Schistosoma mansoni	tubulin subunit beta	0.0053	0.2793	0.7293
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0021	0.0605	0.0496
Trypanosoma brucei	epsilon tubulin	0.0021	0.0605	0.2166
Echinococcus granulosus	tubulin beta 4A class IVa	0.0053	0.2793	0.2709
Leishmania major	beta tubulin	0.0053	0.2793	1
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.1225	0.3463
Giardia lamblia	Beta tubulin	0.0053	0.2793	1
Brugia malayi	hypothetical protein	0.0019	0.0511	0.0511
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0794	0.0864
Echinococcus multilocularis	tubulin alpha chain	0.0021	0.0605	0.0496
Trypanosoma brucei	alpha tubulin	0.0021	0.0605	0.2166
Leishmania major	hypothetical protein, conserved	0.003	0.1225	0.2833
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0021	0.0605	0.0605
Echinococcus multilocularis	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0394	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.1225	0.4385
Plasmodium vivax	tubulin alpha chain, putative	0.0021	0.0605	0.0879
Plasmodium vivax	tubulin beta chain, putative	0.0053	0.2793	1
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.1225	0.2833
Trichomonas vaginalis	tubulin, putative	0.0053	0.2793	1
Echinococcus granulosus	tubulin epsilon chain	0.0021	0.0605	0.0496
Echinococcus granulosus	tubulin alpha 1C chain	0.0021	0.0605	0.0496
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.1852	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0053	0.2793	1
Schistosoma mansoni	tubulin subunit beta	0.0053	0.2793	0.7293
Plasmodium vivax	tubulin gamma chain, putative	0.0021	0.0605	0.0879
Echinococcus multilocularis	tubulin alpha 3 chain	0.0021	0.0605	0.0496
Echinococcus granulosus	tubulin gamma 1 chain	0.0021	0.0605	0.0496
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0044	0.2161	0.5
Loa Loa (eye worm)	hypothetical protein	0.003	0.1225	0.1225
Echinococcus granulosus	muscleblind protein	0.0159	1	1
Brugia malayi	TAR-binding protein	0.0067	0.3787	0.3787
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0044	0.2161	0.7114
Trichomonas vaginalis	tubulin alpha chain, putative	0.0021	0.0605	0.2166
Leishmania major	beta tubulin	0.0053	0.2793	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0021	0.0605	0.2166
Brugia malayi	Tubulin alpha chain	0.0021	0.0605	0.0605
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0794	0.2263
Loa Loa (eye worm)	tubulin alpha chain	0.0021	0.0605	0.0605
Echinococcus multilocularis	beta tubulin	0.0053	0.2793	0.2709
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0794	0.305
Leishmania major	beta tubulin	0.0053	0.2793	1
Loa Loa (eye worm)	BEN-1 protein	0.0053	0.2793	0.2793
Leishmania major	beta tubulin	0.0053	0.2793	1
Echinococcus granulosus	beta tubulin	0.0053	0.2793	0.2709
Echinococcus granulosus	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Echinococcus granulosus	tubulin alpha chain	0.0021	0.0605	0.0496
Echinococcus multilocularis	tubulin alpha 1C chain	0.0021	0.0605	0.0496
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.3787	1
Brugia malayi	alpha-tubulin	0.0021	0.0605	0.0605
Echinococcus granulosus	Tubulin alpha 1 chain	0.0021	0.0605	0.0496
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0794	0.2263
Brugia malayi	MH2 domain containing protein	0.0141	0.8745	0.8745
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0794	0.0864
Echinococcus granulosus	tubulin alpha 3 chain	0.0021	0.0605	0.0496
Echinococcus multilocularis	tubulin alpha 1C chain	0.0021	0.0605	0.0496
Leishmania major	beta tubulin	0.0053	0.2793	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0053	0.2793	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0021	0.0605	0.2166
Plasmodium falciparum	tubulin gamma chain	0.0021	0.0605	0.0879
Schistosoma mansoni	alpha tubulin	0.0021	0.0605	0.1335
Trichomonas vaginalis	tubulin beta chain, putative	0.0021	0.0605	0.2166
Trichomonas vaginalis	tubulin beta chain, putative	0.0021	0.0605	0.2166
Echinococcus granulosus	tubulin alpha chain	0.0021	0.0605	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0605	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Leishmania major	beta tubulin	0.0053	0.2793	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.1225	0.2833
Loa Loa (eye worm)	transcription factor SMAD2	0.0141	0.8745	0.8745
Loa Loa (eye worm)	RNA binding protein	0.0067	0.3787	0.3787
Echinococcus granulosus	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Trichomonas vaginalis	tubulin alpha chain, putative	0.0053	0.2793	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0021	0.0605	0.0496
Echinococcus multilocularis	tubulin subunit TubB	0.0021	0.0605	0.0496
Trypanosoma brucei	beta tubulin	0.0053	0.2793	1
Leishmania major	beta tubulin	0.0053	0.2793	1
Trypanosoma brucei	tubulin gamma chain	0.0021	0.0605	0.2166
Echinococcus multilocularis	tubulin alpha chain	0.0021	0.0605	0.0496
Echinococcus multilocularis	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Trichomonas vaginalis	tubulin gamma chain, putative	0.0021	0.0605	0.2166
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0794	0.2263
Leishmania major	beta tubulin	0.0053	0.2793	1
Plasmodium falciparum	alpha tubulin 1	0.0021	0.0605	0.0879
Loa Loa (eye worm)	beta-tubulin	0.0053	0.2793	0.2793
Echinococcus granulosus	alpha tubulin	0.0021	0.0605	0.0496
Trypanosoma brucei	alpha tubulin	0.0021	0.0605	0.2166
Entamoeba histolytica	tubulin family protein	0.0053	0.2793	1
Leishmania major	beta tubulin	0.0053	0.2793	1
Trypanosoma brucei	beta tubulin	0.0053	0.2793	1
Loa Loa (eye worm)	tubulin beta chain	0.0053	0.2793	0.2793
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.3787	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0021	0.0605	0.0496
Schistosoma mansoni	tubulin subunit epsilon	0.0021	0.0605	0.1335
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0021	0.0605	0.0496
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.3787	0.3787
Leishmania major	beta tubulin	0.0053	0.2793	1
Loa Loa (eye worm)	hypothetical protein	0.0159	1	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0794	0.0864
Echinococcus granulosus	tubulin alpha chain	0.0021	0.0605	0.0496
Loa Loa (eye worm)	MH2 domain-containing protein	0.0141	0.8745	0.8745
Trypanosoma brucei	alpha tubulin	0.0021	0.0605	0.2166
Trichomonas vaginalis	tubulin beta chain, putative	0.0021	0.0605	0.2166
Schistosoma mansoni	tubulin subunit alpha	0.0021	0.0605	0.1335
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.1225	0.3463
Trichomonas vaginalis	inositol monophosphatase, putative	0.0044	0.2161	0.7739
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.1225	0.3463
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0021	0.0605	0.2166
Echinococcus granulosus	tubulin beta 1 chain	0.0053	0.2793	0.2709
Entamoeba histolytica	tubulin family protein	0.0053	0.2793	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.2161	0.7739
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0794	0.0794
Echinococcus multilocularis	hypothetical protein	0.0021	0.0605	0.0496
Loa Loa (eye worm)	alpha-tubulin	0.0021	0.0605	0.0605
Echinococcus multilocularis	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0044	0.2161	1
Echinococcus multilocularis	tubulin alpha chain	0.0021	0.0605	0.0496
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.3787	0.3715
Echinococcus multilocularis	muscleblind protein	0.0159	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0021	0.0605	0.0879
Trypanosoma brucei	epsilon tubulin	0.0021	0.0605	0.2166
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0021	0.0605	0.2166
Toxoplasma gondii	beta-tubulin, putative	0.0053	0.2793	1
Trypanosoma brucei	beta tubulin	0.0021	0.0605	0.2166
Loa Loa (eye worm)	tubulin gamma chain	0.0021	0.0605	0.0605
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0053	0.2793	0.2709
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0794	0.0794
Echinococcus granulosus	inositol monophosphatase 1	0.0044	0.2161	0.207
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.3787	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0044	0.2161	0.207
Schistosoma mansoni	tubulin subunit alpha	0.0021	0.0605	0.1335
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.1225	0.2833
Loa Loa (eye worm)	tubulin alpha chain	0.0021	0.0605	0.0605
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0794	0.2263
Giardia lamblia	Beta tubulin	0.0053	0.2793	1
Echinococcus granulosus	tubulin alpha	0.0021	0.0605	0.0496
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.3787	0.3787
Loa Loa (eye worm)	tubulin beta-2A chain	0.0053	0.2793	0.2793
Plasmodium falciparum	alpha tubulin 2	0.0021	0.0605	0.0879
Brugia malayi	hypothetical protein	0.003	0.1225	0.1225
Echinococcus granulosus	tar DNA binding protein	0.0067	0.3787	0.3715
Echinococcus multilocularis	muscleblind protein 1	0.0159	1	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.2161	0.7739
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.3787	1
Leishmania major	beta tubulin	0.0053	0.2793	1
Schistosoma mansoni	tubulin subunit beta	0.0053	0.2793	0.7293
Echinococcus multilocularis	tubulin alpha chain	0.0021	0.0605	0.0496
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0794	0.2263
Loa Loa (eye worm)	inositol-1	0.0044	0.2161	0.2161
Plasmodium falciparum	tubulin epsilon chain, putative	0.0021	0.0605	0.0879
Echinococcus multilocularis	tubulin alpha	0.0021	0.0605	0.0496
Leishmania major	beta tubulin	0.0053	0.2793	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0053	0.2793	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0794	0.0794
Trypanosoma brucei	epsilon tubulin	0.0021	0.0605	0.2166
Echinococcus multilocularis	tubulin alpha 3 chain	0.0021	0.0605	0.0496
Trichomonas vaginalis	tubulin beta chain, putative	0.0021	0.0605	0.2166
Trypanosoma cruzi	beta tubulin, putative	0.0053	0.2793	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0053	0.2793	0.2793
Echinococcus multilocularis	tubulin beta 1 chain	0.0053	0.2793	0.2709
Echinococcus granulosus	Tubulin beta 2C chain	0.0053	0.2793	0.2709
Brugia malayi	tubulin alpha chain - mouse	0.0021	0.0605	0.0605
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0794	0.0864
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0794	0.2263
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.3787	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0053	0.2793	0.2793
Brugia malayi	Inositol-1	0.0044	0.2161	0.2161
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.1852	1
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.3787	0.3787
Echinococcus granulosus	tubulin alpha chain	0.0021	0.0605	0.0496
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0794	0.2263
Leishmania major	beta tubulin	0.0053	0.2793	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0794	0.0864
Echinococcus granulosus	tubulin alpha 1C chain	0.0021	0.0605	0.0496
Schistosoma mansoni	inositol monophosphatase	0.0044	0.2161	0.5574
Trichomonas vaginalis	tubulin gamma chain, putative	0.0021	0.0605	0.2166
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0794	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0394	0.0394
Plasmodium falciparum	tubulin beta chain	0.0053	0.2793	1
Trypanosoma brucei	beta tubulin	0.0053	0.2793	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0794	0.2263
Leishmania major	beta tubulin	0.0053	0.2793	1
Schistosoma mansoni	tubulin subunit beta	0.0053	0.2793	0.7293

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 55 %	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 0.3 nM	ChEMBL.	18160284
Activity (functional)	= 55 %	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 0.3 nM	ChEMBL.	18160284
IC50 (functional)	= 0.004 nM	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL.	18160284
IC50 (functional)	= 0.004 nM	Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil	ChEMBL.	18160284
IC50 (binding)	= 0.4 nM	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL.	18160284
IC50 (binding)	= 0.4 nM	Displacement of [125I] eotaxin from human CCR3 receptor in CHO cells	ChEMBL.	18160284

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL428062

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 506858