Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0036 | 0.0432 | 0.5489 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.076 | 0.076 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0.0432 | 0.1206 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0056 | 0.0077 |
Schistosoma mansoni | nuclear hormone receptor | 0.0017 | 0.0032 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0036 | 0.0432 | 0.0432 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0019 | 0.0075 | 0.0075 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0036 | 0.0432 | 0.1206 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.01 | 0.1758 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0222 | 0.1262 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0075 | 0.0075 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0017 | 0.0032 | 0.0043 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0742 | 0.0742 |
Entamoeba histolytica | protein kinase, putative | 0.01 | 0.1758 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0023 | 0.0153 | 0.0425 |
Brugia malayi | nuclear receptor NHR-67 | 0.0017 | 0.0032 | 0.0032 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0056 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0036 | 0.0432 | 0.0432 |
Onchocerca volvulus | 0.0017 | 0.0032 | 0.0402 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0053 | 0.079 | 0.2204 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0.0432 | 0.0594 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0133 | 0.2441 | 0.2441 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0222 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0036 | 0.0432 | 0.0594 |
Loa Loa (eye worm) | DR-78 | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0222 | 0.0222 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0.0432 | 0.0594 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0742 | 0.1019 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0036 | 0.0432 | 0.0432 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0036 | 0.0432 | 0.0594 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0036 | 0.0432 | 0.0594 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0255 | 0.4998 | 0.6864 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0036 | 0.0432 | 0.0594 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0036 | 0.0432 | 0.0432 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0039 | 0.0496 | 0.0682 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0056 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0036 | 0.0432 | 0.0432 |
Echinococcus multilocularis | dual specificity | 0.01 | 0.1758 | 0.2414 |
Echinococcus granulosus | tumor protein p63 | 0.0364 | 0.7282 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0172 | 0.3259 | 1 |
Echinococcus granulosus | dual specificity | 0.01 | 0.1758 | 0.2414 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0056 | 0.0321 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0032 | 0.0043 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0017 | 0.0032 | 0.0402 |
Entamoeba histolytica | protein kinase domain containing protein | 0.01 | 0.1758 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0017 | 0.0032 | 0.0032 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0036 | 0.0432 | 0.0432 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0036 | 0.0432 | 0.0432 |
Brugia malayi | nuclear receptor RXR | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0039 | 0.0496 | 0.1385 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0.0432 | 0.0594 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0036 | 0.0432 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0053 | 0.0787 | 0.2196 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0039 | 0.0496 | 0.0682 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.01 | 0.1758 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0036 | 0.0432 | 0.1206 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0133 | 0.2441 | 0.2441 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0036 | 0.0432 | 0.5489 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Brugia malayi | TAR-binding protein | 0.0133 | 0.2441 | 0.2441 |
Schistosoma mansoni | thyroid hormone receptor | 0.0036 | 0.0432 | 0.1206 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0056 | 0.0321 |
Brugia malayi | nuclear hormone receptor | 0.0036 | 0.0432 | 0.0432 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0222 | 0.1262 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0494 | 1 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.01 | 0.1758 | 0.1758 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | TAR-binding protein | 0.0133 | 0.2441 | 0.2441 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0056 | 0.0321 |
Brugia malayi | MH2 domain containing protein | 0.0133 | 0.2462 | 0.2462 |
Onchocerca volvulus | 0.0017 | 0.0032 | 0.0402 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2441 | 0.6809 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0017 | 0.0032 | 0.0402 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0017 | 0.0032 | 0.0043 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0036 | 0.0432 | 0.0594 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0058 | 0.0883 | 0.1212 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0036 | 0.0432 | 0.0594 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0017 | 0.0032 | 0.0032 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0222 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0742 | 0.2069 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0036 | 0.0432 | 0.1206 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0133 | 0.2462 | 0.2462 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0017 | 0.0032 | 0.0088 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0019 | 0.0075 | 0.0075 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0019 | 0.0075 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0222 | 1 |
Onchocerca volvulus | 0.0053 | 0.0787 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0036 | 0.0432 | 0.0432 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0017 | 0.0032 | 0.0043 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.076 | 0.2119 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0043 | 0.0563 | 0.0563 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0058 | 0.0883 | 0.1212 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.01 | 0.1758 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0036 | 0.0432 | 0.1206 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0056 | 0.0157 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0036 | 0.0432 | 0.0432 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0036 | 0.0432 | 0.0594 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0036 | 0.0432 | 0.0594 |
Brugia malayi | steroid hormone receptor | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0075 | 0.0075 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0036 | 0.0432 | 0.0432 |
Entamoeba histolytica | protein kinase, putative | 0.01 | 0.1758 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2441 | 0.6809 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0056 | 0.0077 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0.0432 | 0.0594 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0222 | 0.0222 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0017 | 0.0032 | 0.0088 |
Echinococcus multilocularis | tar DNA binding protein | 0.0133 | 0.2441 | 0.3353 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0036 | 0.0432 | 0.1206 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0017 | 0.0032 | 0.0043 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0017 | 0.0032 | 0.0043 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.01 | 0.1758 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0017 | 0.0032 | 0.0032 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0047 | 0.0656 | 0.0656 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0056 | 0.0173 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0056 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0222 | 0.1262 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0036 | 0.0432 | 0.0594 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2441 | 0.6809 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0017 | 0.0032 | 0.0043 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0036 | 0.0432 | 0.0594 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0036 | 0.0432 | 0.1206 |
Schistosoma mansoni | nuclear receptor | 0.0017 | 0.0032 | 0.0088 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0036 | 0.0432 | 0.0432 |
Brugia malayi | RNA binding protein | 0.0133 | 0.2441 | 0.2441 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0019 | 0.0075 | 0.0102 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0036 | 0.0432 | 0.0432 |
Echinococcus granulosus | tar DNA binding protein | 0.0133 | 0.2441 | 0.3353 |
Schistosoma mansoni | zinc finger protein | 0.0017 | 0.0032 | 0.0088 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0056 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0742 | 0.0742 |
Echinococcus granulosus | FTZ F1 alpha | 0.0036 | 0.0432 | 0.0594 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0742 | 0.2069 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0056 | 0.2542 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0056 | 0.2542 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0036 | 0.0432 | 0.1206 |
Entamoeba histolytica | hypothetical protein | 0.01 | 0.1758 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.4998 | 0.4998 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0056 | 0.0056 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0019 | 0.0075 | 0.0075 |
Schistosoma mansoni | nuclear receptor | 0.0017 | 0.0032 | 0.0088 |
Schistosoma mansoni | nuclear hormone receptor | 0.0017 | 0.0032 | 0.0088 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0056 | 0.0056 |
Brugia malayi | ecdysone receptor | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0036 | 0.0432 | 0.0432 |
Onchocerca volvulus | 0.0036 | 0.0432 | 0.5489 | |
Brugia malayi | nuclear hormone receptor | 0.0017 | 0.0032 | 0.0032 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0028 | 0.0028 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0017 | 0.0032 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0075 | 0.0075 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0056 | 0.2542 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0017 | 0.0032 | 0.0088 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1747 | 0.1747 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0036 | 0.0432 | 0.1206 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1747 | 0.1747 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0133 | 0.2462 | 0.2462 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2441 | 0.6809 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | coup transcription factor | 0.0036 | 0.0432 | 0.1206 |
Schistosoma mansoni | d-amino acid oxidase | 0.0187 | 0.3586 | 1 |
Brugia malayi | tailless protein | 0.0017 | 0.0032 | 0.0032 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0023 | 0.0153 | 0.0153 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0017 | 0.0032 | 0.0043 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0036 | 0.0432 | 0.5489 |
Onchocerca volvulus | 0.0052 | 0.076 | 0.965 | |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0056 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0036 | 0.0432 | 0.1206 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0017 | 0.0032 | 0.0032 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0742 | 0.1019 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0742 | 0.1019 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0036 | 0.0432 | 0.0432 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0036 | 0.0432 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Brugia malayi | nuclear receptor NHR-88 | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0075 | 0.0075 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0187 | 0.3586 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0018 | 0.006 | 0.006 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | glutamate receptor | 0.0047 | 0.0656 | 0.0656 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0222 | 0.1262 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0017 | 0.0032 | 0.0032 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0019 | 0.0075 | 0.0208 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0036 | 0.0432 | 0.0432 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0187 | 0.3586 | 1 |
Brugia malayi | hypothetical protein | 0.0255 | 0.4998 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.076 | 0.2119 |
Brugia malayi | nuclear receptor RXR | 0.0019 | 0.0075 | 0.0075 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0017 | 0.0032 | 0.0032 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0036 | 0.0432 | 0.0594 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0017 | 0.0032 | 0.0043 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0032 | 0.0043 |
Loa Loa (eye worm) | RNA binding protein | 0.0133 | 0.2441 | 0.2441 |
Schistosoma mansoni | serine/threonine protein kinase | 0.01 | 0.1758 | 0.4903 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0787 | 0.0787 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0056 | 0.0157 |
Schistosoma mansoni | tar DNA-binding protein | 0.0133 | 0.2441 | 0.6809 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0255 | 0.4998 | 0.6864 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0742 | 0.1019 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0222 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0075 | 0.0075 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0036 | 0.0432 | 0.1206 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0017 | 0.0032 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0432 | 0.0432 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0742 | 0.2069 |
Brugia malayi | conserved hypotetical protein | 0.0017 | 0.0032 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0075 | 0.0075 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0036 | 0.0432 | 0.0432 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0056 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0036 | 0.0432 | 0.0432 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0036 | 0.0432 | 0.0432 |
Echinococcus multilocularis | tumor protein p63 | 0.0364 | 0.7282 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0019 | 0.0075 | 0.0102 |
Brugia malayi | Protein kinase domain containing protein | 0.01 | 0.1758 | 0.1758 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0056 | 0.0157 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0032 | 0.0032 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0056 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.3586 | 0.3586 |
Brugia malayi | ecdysteroid receptor | 0.0036 | 0.0432 | 0.0432 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 26.2 nM | Antitumor activity against mouse P388 cells | ChEMBL. | 18197599 |
ED50 (functional) | = 26.2 nM | Antitumor activity against mouse P388 cells | ChEMBL. | 18197599 |
GI50 (functional) | = 45 nM | Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 26042639 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.