Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | endothelin converting enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2098 | 0.2098 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.3432 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.3432 | 0.3432 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.0719 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2098 | 0.2098 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.2002 | 0.2002 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0251 | 1 | 1 |
Plasmodium vivax | amine transporter, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2002 | 0.2002 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2002 | 0.2002 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.3432 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2098 | 0.2098 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2098 | 0.2098 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.3432 | 0.3432 |
Plasmodium falciparum | transporter, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0251 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.3432 | 0.3432 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.3432 | 0.3432 |
Plasmodium falciparum | amino acid transporter, putative | 0.0043 | 0 | 0.5 |
Brugia malayi | Peptidase family M13 containing protein | 0.0114 | 0.3432 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2098 | 0.2098 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0058 | 0.0719 | 0.0719 |
Loa Loa (eye worm) | serotonin transporter b | 0.0251 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0251 | 1 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0251 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0251 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.0719 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2002 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.3432 | 0.3432 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0058 | 0.0719 | 0.0719 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2098 | 0.2098 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0546 | 0.0546 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.3432 | 1 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.3432 | 0.5 |
Onchocerca volvulus | 0.0056 | 0.0669 | 0.0669 | |
Onchocerca volvulus | 0.0251 | 1 | 1 | |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.2002 | 0.2002 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0546 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 1 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.3432 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0546 | 0.0546 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0058 | 0.0719 | 0.0719 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 0.3432 | 0.3432 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0546 | 0.0546 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 160 nM | Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1). | ChEMBL. | 9554884 |
IC50 (binding) | = 160 nM | Inhibitory activity was assessed on CHO cells expressing recombinant human Endothelin-converting enzyme 1 (ECE-1). | ChEMBL. | 9554884 |
Inhibition (binding) | = 21 % | Inhibitory activity of the compound (10 microM) against rat neutral endopeptidase(NEP) | ChEMBL. | 9554884 |
Inhibition (binding) | = 21 % | Inhibitory activity of the compound (10 microM) against rat neutral endopeptidase(NEP) | ChEMBL. | 9554884 |
Selectivity (binding) | Ratio of inhibitory activities against endothelin converting enzyme-1(ECE-1) and Neutral Endo Peptidase (NEP); not determined | ChEMBL. | 9554884 | |
Selectivity (binding) | 0 | Ratio of inhibitory activities against endothelin converting enzyme-1(ECE-1) and Neutral Endo Peptidase (NEP); not determined | ChEMBL. | 9554884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.