Detailed information for compound 510086

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.439 | Formula: C25H21NO3
  • H donors: 1 H acceptors: 3 LogP: 4.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(Cc2cccc3c2cccc3)c(cn1[C@H](C(=O)O)C)c1ccccc1
  • InChi: 1S/C25H21NO3/c1-17(25(28)29)26-16-23(19-8-3-2-4-9-19)21(15-24(26)27)14-20-12-7-11-18-10-5-6-13-22(18)20/h2-13,15-17H,14H2,1H3,(H,28,29)/t17-/m0/s1
  • InChiKey: KMIWPDZUIBDHIR-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Brugia malayi transcriptional regulator, Sir2 family protein 0.0234 0.2858 0.5168
Plasmodium vivax aspartyl protease, putative 0.0285 0.3643 0.6591
Toxoplasma gondii aspartyl protease ASP1 0.0082 0.0559 0.1005
Echinococcus granulosus histone deacetylase 6 0.0225 0.273 0.4899
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.099 0.1721
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.006 0.0024
Schistosoma mansoni cathepsin D (A01 family) 0.0456 0.6219 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.2858 0.4595
Onchocerca volvulus 0.023 0.2799 1
Mycobacterium tuberculosis Conserved protein 0.011 0.099 0.0947
Toxoplasma gondii histone deacetylase SIR2 0.0048 0.0048 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.006 0.0097
Plasmodium falciparum plasmepsin VI 0.0082 0.0559 0.1005
Mycobacterium ulcerans beta-lactamase 0.011 0.099 0.3283
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0048 0.0077
Trypanosoma brucei hypothetical protein, conserved 0.011 0.099 0.1721
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0154 0.1654 0.2933
Loa Loa (eye worm) histone deacetylase 11 0.0142 0.1474 0.2662
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1654 0.2933
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.099 0.1721
Mycobacterium ulcerans lipase LipD 0.011 0.099 0.3283
Brugia malayi Pre-SET motif family protein 0.0202 0.2377 0.4297
Trichomonas vaginalis histone deacetylase, putative 0.041 0.5524 1
Onchocerca volvulus 0.011 0.099 0.3526
Plasmodium vivax aspartyl proteinase, putative 0.0082 0.0559 0.1005
Trypanosoma brucei Polypeptide deformylase 1 0.0091 0.0692 0.1177
Toxoplasma gondii histone deacetylase HDAC5 0.0142 0.1474 0.2662
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.099 0.1721
Trypanosoma cruzi histone deacetylase, putative 0.0225 0.273 0.4899
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0048 0.0077
Treponema pallidum fructose-bisphosphate aldolase 0.0319 0.4148 1
Loa Loa (eye worm) glutamate receptor 0.0047 0.0031 0.0047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.011 0.099 0.1785
Trichomonas vaginalis histone deacetylase, putative 0.041 0.5524 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0047 0.0031 0.0047
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0251 0.3114 0.5007
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0082 0.0062
Leishmania major histone deacetylase, putative 0.0225 0.273 0.4899
Trichomonas vaginalis histone deacetylase, putative 0.041 0.5524 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.099 0.0947
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0234 0.2858 0.5131
Leishmania major hypothetical protein, conserved 0.011 0.099 0.1721
Loa Loa (eye worm) hypothetical protein 0.0056 0.0169 0.0298
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0093 0.073 0.1246
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.099 0.1721
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.099 0.1721
Plasmodium vivax histone deacetylase 2, putative 0.0225 0.273 0.4938
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.099 0.0947
Echinococcus granulosus metabotropic glutamate receptor 5 0.0056 0.0169 0.0222
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.2858 0.4595
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.099 0.1785
Schistosoma mansoni histone deacetylase hda2 0.0142 0.1474 0.2371
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Echinococcus multilocularis histone deacetylase 6 0.0225 0.273 0.4899
Schistosoma mansoni chromatin regulatory protein sir2 0.0154 0.1654 0.2659
Mycobacterium tuberculosis Conserved protein 0.011 0.099 0.0947
Echinococcus granulosus histone deacetylase 6 0.0225 0.273 0.4899
Trypanosoma brucei histone deacetylase, putative 0.0225 0.273 0.4899
Echinococcus multilocularis histone deacetylase 0.0225 0.273 0.4899
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.0692 0.1177
Mycobacterium tuberculosis Conserved protein 0.011 0.099 0.0947
Giardia lamblia Fructose-bisphosphate aldolase 0.0319 0.4148 0.7486
Giardia lamblia Hypothetical protein 0.0234 0.2858 0.5131
Echinococcus multilocularis glutamate receptor NMDA 0.0077 0.0486 0.0801
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.006 0.0024
Giardia lamblia Histone deacetylase 0.041 0.5524 1
Schistosoma mansoni memapsin-2 (A01 family) 0.0045 0.0005 0.0008
Toxoplasma gondii histone deacetylase SIR2-like 0.0048 0.0048 0.0077
Echinococcus granulosus histone deacetylase 3 0.041 0.5524 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Echinococcus multilocularis histone deacetylase 8 0.0142 0.1474 0.2605
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0251 0.3114 0.5599
Plasmodium falciparum plasmepsin X 0.0285 0.3643 0.6591
Schistosoma mansoni histone deacetylase hda2 0.0225 0.273 0.439
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.099 0.1721
Echinococcus granulosus histone deacetylase 1 0.041 0.5524 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0082 0.0062
Plasmodium falciparum peptide deformylase 0.0238 0.2919 0.5279
Toxoplasma gondii aspartyl protease ASP3 0.0285 0.3643 0.6591
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.0692 0.1177
Loa Loa (eye worm) hypothetical protein 0.0106 0.0924 0.1666
Plasmodium vivax histone deacetylase, putative 0.0142 0.1474 0.2662
Leishmania major histone deacetylase, putative 0.0225 0.273 0.4899
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0154 0.1654 0.2933
Loa Loa (eye worm) sirtuin 4 0.0048 0.0048 0.0077
Echinococcus granulosus histone deacetylase 6 0.0225 0.273 0.4899
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0048 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.006 0.0097
Loa Loa (eye worm) hypothetical protein 0.011 0.099 0.1785
Brugia malayi histone deacetylase 11 0.0142 0.1474 0.2662
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0082 0.0559 0.1005
Onchocerca volvulus 0.011 0.099 0.3526
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.099 0.3283
Trypanosoma cruzi histone deacetylase, putative 0.0225 0.273 0.4899
Toxoplasma gondii histone deacetylase HDAC4 0.0142 0.1474 0.2662
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0048 0.0077
Brugia malayi beta-lactamase family protein 0.011 0.099 0.1785
Toxoplasma gondii ABC1 family protein 0.011 0.099 0.1785
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.099 0.1721
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.006 0.0024
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.099 0.3283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0234 0.2858 0.5131
Plasmodium falciparum plasmepsin I 0.0082 0.0559 0.1005
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.099 0.0947
Brugia malayi NAD-dependent deacetylase SIRT1 0.0154 0.1654 0.2988
Onchocerca volvulus 0.011 0.099 0.3526
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Loa Loa (eye worm) hypothetical protein 0.0142 0.1474 0.2662
Echinococcus multilocularis histone deacetylase 1 0.041 0.5524 1
Trypanosoma brucei histone deacetylase 2 0.0142 0.1474 0.2605
Loa Loa (eye worm) hypothetical protein 0.0154 0.1654 0.2988
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0234 0.2858 0.5131
Trypanosoma cruzi histone deacetylase 1, putative 0.041 0.5524 1
Echinococcus granulosus nmda type glutamate receptor 0.0092 0.0706 0.1202
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.1677 0.3564
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0238 0.2919 1
Chlamydia trachomatis peptide deformylase 0.0238 0.2919 0.5
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0082 0.0559 0.1005
Loa Loa (eye worm) hypothetical protein 0.011 0.099 0.1785
Brugia malayi transcriptional regulator, Sir2 family protein 0.0048 0.0048 0.0077
Schistosoma mansoni histone deacetylase 0.041 0.5524 0.8882
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0048 0.0077
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.1677 0.1638
Echinococcus multilocularis nmda type glutamate receptor 0.0092 0.0706 0.1202
Schistosoma mansoni histone deacetylase 0.041 0.5524 0.8882
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0048 0.0048 0.0077
Plasmodium falciparum histone deacetylase, putative 0.0225 0.273 0.4938
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.041 0.5524 1
Trypanosoma cruzi histone deacetylase, putative 0.0142 0.1474 0.2605
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0091 0.0692 0.1177
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0082 0.0062
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Trypanosoma cruzi Peptide deformylase 2, putative 0.0091 0.0692 0.1177
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0234 0.2858 0.5131
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.1677 0.5677
Plasmodium vivax aspartyl protease, putative 0.0285 0.3643 0.6591
Leishmania major polypeptide deformylase-like protein, putative 0.0091 0.0692 0.1177
Mycobacterium ulcerans peptide deformylase 0.0238 0.2919 1
Plasmodium falciparum plasmepsin IX 0.0285 0.3643 0.6591
Brugia malayi beta-lactamase 0.011 0.099 0.1785
Loa Loa (eye worm) hypothetical protein 0.0083 0.0574 0.1031
Entamoeba histolytica histone deacetylase, putative 0.041 0.5524 1
Mycobacterium tuberculosis Probable hydrolase 0.011 0.099 0.0947
Echinococcus multilocularis nmda type glutamate receptor 0.0088 0.0655 0.111
Trypanosoma cruzi histone deacetylase, putative 0.0225 0.273 0.4899
Trypanosoma brucei histone deacetylase 1 0.041 0.5524 1
Plasmodium vivax histone deacetylase 1, putative 0.041 0.5524 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0082 0.0062
Echinococcus multilocularis glutamate receptor 2 0.005 0.0082 0.0062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.099 0.1785
Leishmania major silent information regulator 2, putative 0.0234 0.2858 0.5131
Loa Loa (eye worm) beta-lactamase 0.011 0.099 0.1785
Echinococcus granulosus histone deacetylase 0.0225 0.273 0.4899
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.041 0.5524 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0251 0.3114 0.5599
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0238 0.2919 0.2885
Echinococcus multilocularis histone deacetylase 6 0.0225 0.273 0.4899
Mycobacterium ulcerans hypothetical protein 0.011 0.099 0.3283
Trypanosoma cruzi histone deacetylase 1, putative 0.041 0.5524 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0234 0.2858 0.5131
Plasmodium vivax peptide deformylase, putative 0.0238 0.2919 0.5279
Brugia malayi Histone deacetylase 1 0.041 0.5524 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0082 0.0062
Loa Loa (eye worm) histone deacetylase 3 0.041 0.5524 1
Plasmodium falciparum plasmepsin II 0.0082 0.0559 0.1005
Loa Loa (eye worm) transcriptional regulator 0.0048 0.0048 0.0077
Loa Loa (eye worm) histone deacetylase 1 0.041 0.5524 1
Loa Loa (eye worm) hypothetical protein 0.011 0.099 0.1785
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0082 0.0559 0.0934
Trichomonas vaginalis histone deacetylase, putative 0.041 0.5524 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.006 0.0101
Loa Loa (eye worm) transcriptional regulator 0.0234 0.2858 0.5168
Plasmodium vivax NAD-dependent deacetylase, putative 0.0048 0.0048 0.0077
Leishmania major histone deacetylase, putative 0.041 0.5524 1
Schistosoma mansoni glutamate receptor NMDA 0.0128 0.125 0.2009
Toxoplasma gondii histone deacetylase HDAC1 0.0225 0.273 0.4938
Brugia malayi histone deacetylase 3 (HD3) 0.041 0.5524 1
Schistosoma mansoni glutamate receptor NMDA 0.0093 0.073 0.1174
Onchocerca volvulus Histone deacetylase 10 homolog 0.0142 0.1474 0.5259
Echinococcus multilocularis histone deacetylase 7 0.0225 0.273 0.4899
Schistosoma mansoni chromatin regulatory protein sir2 0.0048 0.0048 0.0077
Plasmodium vivax histone deacetylase, putative 0.0225 0.273 0.4938
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.099 0.1592
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Plasmodium vivax hypothetical protein, conserved 0.011 0.099 0.1785
Trichomonas vaginalis esterase, putative 0.011 0.099 0.1721
Brugia malayi Histone deacetylase family protein 0.0225 0.273 0.4938
Schistosoma mansoni histone deacetylase 4 5 0.0225 0.273 0.439
Echinococcus multilocularis histone deacetylase 6 0.0225 0.273 0.4899
Schistosoma mansoni cathepsin D (A01 family) 0.0456 0.6219 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0234 0.2858 0.5131
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0234 0.2858 0.5131
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0045 0.0005 0.0008
Plasmodium falciparum histone deacetylase 1 0.041 0.5524 1
Schistosoma mansoni histone deacetylase 4 5 0.0225 0.273 0.439
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0234 0.2858 0.5131
Loa Loa (eye worm) hypothetical protein 0.041 0.5524 1
Trypanosoma brucei histone deacetylase 3 0.0225 0.273 0.4899
Brugia malayi histone deacetylase 1 (HD1) 0.041 0.5524 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0082 0.0559 0.0934
Loa Loa (eye worm) hypothetical protein 0.0083 0.0574 0.1031
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0082 0.0559 0.0934
Echinococcus multilocularis chromatin regulatory protein sir2 0.0234 0.2858 0.5131
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0559 0.0899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.006 0.0097
Echinococcus granulosus histone deacetylase 8 0.0142 0.1474 0.2605
Trypanosoma cruzi histone deacetylase, putative 0.0142 0.1474 0.2605
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.041 0.5524 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0048 0.0048 0.0077
Loa Loa (eye worm) histone deacetylase 7A 0.0225 0.273 0.4938
Loa Loa (eye worm) hypothetical protein 0.0082 0.0559 0.1005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.099 0.0947
Trypanosoma brucei histone deacetylase 4 0.0225 0.273 0.4899
Echinococcus granulosus glutamate receptor NMDA 0.0077 0.0486 0.0801
Brugia malayi Histone deacetylase family protein 0.0225 0.273 0.4938
Plasmodium falciparum histone deacetylase 2 0.0225 0.273 0.4938
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.099 0.1721
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1654 0.2933
Loa Loa (eye worm) histone deacetylase 0.0225 0.273 0.4938
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2377 0.4297
Trichomonas vaginalis histone deacetylase, putative 0.041 0.5524 1
Trypanosoma brucei Peptide deformylase 2 0.0091 0.0692 0.1177
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.099 0.0947
Plasmodium falciparum plasmepsin IV 0.0082 0.0559 0.1005
Loa Loa (eye worm) hypothetical protein 0.011 0.099 0.1785
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0234 0.2858 0.5131
Schistosoma mansoni histone deacetylase 1 2 3 0.0142 0.1474 0.2371
Echinococcus granulosus histone deacetylase 7 0.0225 0.273 0.4899
Toxoplasma gondii histone deacetylase HDAC2 0.041 0.5524 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.006 0.0024
Leishmania major histone deacetylase, putative 0.041 0.5524 1
Plasmodium vivax plasmepsin IV, putative 0.0082 0.0559 0.1005
Trichomonas vaginalis histone deacetylase, putative 0.041 0.5524 1
Toxoplasma gondii hypothetical protein 0.0238 0.2919 0.5279
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1654 0.2933
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1654 0.2933
Toxoplasma gondii histone deacetylase HDAC3 0.041 0.5524 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.099 0.1592
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0154 0.1654 0.2933
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.2858 0.4595
Echinococcus granulosus nmda type glutamate receptor 0.0088 0.0655 0.111
Echinococcus multilocularis histone deacetylase 3 0.041 0.5524 1
Trichomonas vaginalis set domain proteins, putative 0.023 0.2799 0.5024
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0082 0.0062
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0056 0.0169 0.0222
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.006 0.0101
Echinococcus granulosus glutamate NMDA receptor subunit 0.0093 0.073 0.1246
Brugia malayi beta-lactamase family protein 0.011 0.099 0.1785
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0238 0.2919 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.099 0.1721
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0082 0.0062
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.4148 0.7486
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0082 0.0062
Loa Loa (eye worm) hypothetical protein 0.011 0.099 0.1785
Echinococcus granulosus chromatin regulatory protein sir2 0.0234 0.2858 0.5131
Echinococcus granulosus glutamate receptor 2 0.005 0.0082 0.0062
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.099 0.0947

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 32 Inhibition of P pilus biogenesis in Escherichia coli HB101/pPAP5 assessed as agglutination of erythrocytes at 1.8 mM ChEMBL. 18499455

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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