Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Butyrylcholinesterase | 602 aa | 554 aa | 35.9 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Onchocerca volvulus | Putative nuclear protein | Butyrylcholinesterase | 602 aa | 573 aa | 41.4 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 551 aa | 30.1 % | |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 578 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 1.4 | Antioxidant activity assessed as trolox equivalents by ORAC-fluorescence assay | ChEMBL. | 18406135 |
IC50 (binding) | = 9.6 nM | Inhibition of electric eel AchE by Ellman's assay | ChEMBL. | 18406135 |
IC50 (binding) | = 9.6 nM | Inhibition of electric eel AchE by Ellman's assay | ChEMBL. | 18406135 |
IC50 (binding) | = 12.7 nM | Inhibition of equine BChE by Ellman's assay | ChEMBL. | 18406135 |
IC50 (binding) | = 12.7 nM | Inhibition of equine BChE by Ellman's assay | ChEMBL. | 18406135 |
IC50 (binding) | = 16.9 nM | Inhibition of eel AChE using acetylthiocholine iodide as substrate after 5 mins by Ellman's method | ChEMBL. | 22512543 |
IC50 (binding) | = 27.4 nM | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate after 5 mins by Ellman's method | ChEMBL. | 22512543 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.