Detailed information for compound 515460

Basic information

Technical information
  • TDR Targets ID: 515460
  • Name: 5,8-dichloro-N-[2-(4-chlorophenyl)ethyl]-6,7- dihydroxy-3,4-dihydro-1H-isoquinoline-2-carbo thioamide
  • MW: 431.764 | Formula: C18H17Cl3N2O2S
  • H donors: 3 H acceptors: 2 LogP: 4.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CCNC(=S)N1CCc2c(C1)c(Cl)c(c(c2Cl)O)O
  • InChi: 1S/C18H17Cl3N2O2S/c19-11-3-1-10(2-4-11)5-7-22-18(26)23-8-6-12-13(9-23)15(21)17(25)16(24)14(12)20/h1-4,24-25H,5-9H2,(H,22,26)
  • InChiKey: YZKRUTAMNGCIOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peregrin 0.0031 0.0571 0.0953
Plasmodium falciparum phd finger protein, putative 0.0031 0.0571 1
Brugia malayi jmjC domain containing protein 0.0102 0.3132 0.3132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0598 0.0598
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0571 0.9479
Loa Loa (eye worm) hypothetical protein 0.0087 0.2599 0.2595
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0404 0.0404
Schistosoma mansoni hypothetical protein 0.0031 0.0571 0.0571
Schistosoma mansoni glutaminase 0.0292 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.1038 0.1038
Echinococcus multilocularis dna polymerase eta 0.0084 0.2478 0.4138
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0571 0.0953
Giardia lamblia GTOR 0.0019 0.0143 0.0207
Leishmania major DNA polymerase eta, putative 0.0084 0.2478 0.7959
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0571 0.0953
Onchocerca volvulus 0.0033 0.0627 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Loa Loa (eye worm) hypothetical protein 0.0053 0.1375 0.1371
Leishmania major DNA polymerase kappa, putative 0.0064 0.1749 0.5539
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0171 0.1745
Echinococcus multilocularis chromobox protein 1 0.0075 0.2135 0.3566
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0143 0.0633
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0171 0.0091
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0143 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1211 0.1211
Leishmania major DNA polymerase eta, putative 0.0045 0.1064 0.3266
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.027 0.0627
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0598 0.0998
Trypanosoma brucei DNA polymerase IV, putative 0.0085 0.2521 0.8103
Schistosoma mansoni hypothetical protein 0.0181 0.5988 0.5988
Trypanosoma brucei polo-like protein kinase 0.0101 0.3092 1
Loa Loa (eye worm) glutaminase 0.0292 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.3092 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.2687 0.4488
Trichomonas vaginalis chromobox protein, putative 0.0045 0.1067 0.0938
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1113 0.3427
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.1067 0.0619
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Brugia malayi Heterochromatin protein 1 0.0075 0.2135 0.2135
Echinococcus multilocularis chromobox protein 1 0.0075 0.2135 0.3566
Echinococcus multilocularis dna polymerase kappa 0.0085 0.2521 0.421
Echinococcus granulosus dna polymerase kappa 0.0085 0.2521 0.421
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.1064 1
Brugia malayi Pre-SET motif family protein 0.0032 0.0598 0.0598
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1211 0.1207
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.1749 0.5539
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.1494 0.8385
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.3092 0.3142
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0404 0.0404
Entamoeba histolytica hypothetical protein 0.0027 0.0404 0.0884
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0834 0.1393
Plasmodium vivax SET domain protein, putative 0.0032 0.0598 1
Echinococcus multilocularis geminin 0.0181 0.5988 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Trypanosoma brucei unspecified product 0.0078 0.2266 0.7257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0404 0.0265
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0598 0.0998
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0143 0.0139
Schistosoma mansoni kinase 0.0051 0.1299 0.1299
Loa Loa (eye worm) hypothetical protein 0.0023 0.027 0.0265
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0598 0.5252
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0143 0.0207
Giardia lamblia Kinase, PLK 0.0101 0.3092 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0171 0.0286
Trypanosoma brucei DNA polymerase IV, putative 0.0085 0.2521 0.8103
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0171 0.0166
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0404 0.3285
Trypanosoma brucei unspecified product 0.0039 0.0858 0.2581
Onchocerca volvulus 0.0254 0.8596 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0073 0.208 0.208
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.2288 0.3822
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0404 0.1073
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.3132 0.523
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0807 0.0807
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0143 0.0207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1211 0.2023
Trypanosoma brucei unspecified product 0.0039 0.0858 0.2581
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1113 0.3427
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.1011 0.1689
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0513 0.0375
Trichomonas vaginalis CAMK family protein kinase 0.005 0.125 0.1123
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0085 0.2521 0.2412
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0143 0.0207
Echinococcus multilocularis jun protein 0.009 0.2687 0.4488
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.3092 0.3092
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0143 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1211 0.1211
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0171 0.1841
Echinococcus granulosus Ankyrin 0.0016 0.0005 0.0008
Mycobacterium ulcerans glutaminase 0.0292 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1113 0.3427
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.3092 0.3089
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0404 0.0675
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0571 0.0571
Brugia malayi bZIP transcription factor family protein 0.009 0.2687 0.2687
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.3092 0.5164
Onchocerca volvulus 0.0044 0.1038 0.0582
Loa Loa (eye worm) hypothetical protein 0.0033 0.0627 0.0623
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1211 0.2023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0143 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1108 0.341
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0171 0.0028
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0143 0.0207
Schistosoma mansoni hypothetical protein 0.0038 0.0834 0.0834
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0571 0.0566
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1211 0.1211
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0336 0.259
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0143 0.0239
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1211 0.2023
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.2288 0.3822
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Schistosoma mansoni DNA polymerase eta 0.0084 0.2478 0.2478
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0171 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0953 0.0821
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0145 0.0211
Echinococcus granulosus jumonji domain containing protein 0.0043 0.1011 0.1689
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0953 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0513 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.3092 0.3092
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0571 0.4979
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0143 0.0143
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.1494 0.2495
Onchocerca volvulus 0.0071 0.1991 0.177
Schistosoma mansoni jumonji domain containing protein 0.0081 0.2374 0.2374
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0571 0.4979
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.3092 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1211 0.1211
Brugia malayi jmjC domain containing protein 0.0038 0.0807 0.0807
Brugia malayi chromobox protein homolog 3 0.0042 0.0953 0.0953
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0171 0.0299
Echinococcus granulosus geminin 0.0181 0.5988 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0145 0.0211
Trichomonas vaginalis CAMK family protein kinase 0.005 0.125 0.1123
Brugia malayi polk-prov protein 0.0046 0.1108 0.1108
Schistosoma mansoni chromobox protein 0.0075 0.2135 0.2135
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.3092 1
Brugia malayi Pre-SET motif family protein 0.0223 0.7481 0.7481
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.2266 0.7257
Echinococcus multilocularis peregrin 0.0031 0.0571 0.0953
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0171 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.2478 0.2478
Mycobacterium ulcerans DNA polymerase IV 0.0085 0.2521 0.246
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.2687 0.4488
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0143 0.0239
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0598 0.0598
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0171 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1108 0.341
Schistosoma mansoni ap endonuclease 0.002 0.0171 0.0171
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0143 0.0239
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0171 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Brugia malayi hypothetical protein 0.0038 0.0834 0.0834
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0953 0.0476
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.1494 0.149
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.3132 0.523
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0555 0.0927
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0171 0.0299
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0143 0.0143
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0404 0.0675
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0807 0.1348
Loa Loa (eye worm) hypothetical protein 0.0084 0.2478 0.2474
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Echinococcus granulosus chromobox protein 1 0.0075 0.2135 0.3566
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.1749 0.5539
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0171 0.0094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0598 0.0998
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.3092 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0143 0.0139
Trichomonas vaginalis set domain proteins, putative 0.0253 0.8591 0.8571
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0598 0.0598
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0834 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0171 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1769 0.1765
Toxoplasma gondii exonuclease III APE 0.002 0.0171 0.0917
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0143 0.0143
Brugia malayi glutaminase DH11.1 0.0292 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0085 0.2521 0.246
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0143 0.0207
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.3092 0.5164
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.1749 1
Schistosoma mansoni chromobox protein 0.0075 0.2135 0.2135
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.1064 0.3266
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0081 0.0081
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0807 0.0807
Echinococcus granulosus jun protein 0.009 0.2687 0.4488
Brugia malayi Bromodomain containing protein 0.0031 0.0571 0.0571
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Echinococcus multilocularis Ankyrin 0.0016 0.0005 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0171 0.0299
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.1494 0.4581
Echinococcus granulosus chromobox protein 1 0.0075 0.2135 0.3566
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0834 0.1393
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0143 0.0207
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.1494 0.1494
Trichomonas vaginalis chromobox protein, putative 0.0075 0.2135 0.2021
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Loa Loa (eye worm) hypothetical protein 0.0042 0.0953 0.0949
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.1494 0.2495
Schistosoma mansoni ap endonuclease 0.002 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0046 0.1108 0.1103
Giardia lamblia PHD finger protein 15 0.0031 0.0571 0.1626
Brugia malayi PHD-finger family protein 0.0031 0.0571 0.0571
Schistosoma mansoni jun-related protein 0.0073 0.208 0.208
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.2478 0.7959
Brugia malayi Protein kinase domain containing protein 0.0016 0.0012 0.0012
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1211 0.2023
Loa Loa (eye worm) hypothetical protein 0.0032 0.0598 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0171 0.0299
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0807 0.1348
Trichomonas vaginalis chromobox protein, putative 0.0045 0.1067 0.0938
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0807 0.0803
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.7481 0.748
Giardia lamblia DINP protein human, muc B family 0.0064 0.1749 0.5539
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0404 0.1073
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Loa Loa (eye worm) hypothetical protein 0.0031 0.0571 0.0566
Echinococcus granulosus dna polymerase eta 0.0084 0.2478 0.4138
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0143 0.0207
Trichomonas vaginalis DNA polymerase eta, putative 0.0085 0.2521 0.2412
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0143 0.0207
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.1494 0.1494
Trypanosoma brucei DNA polymerase eta, putative 0.0084 0.2478 0.7959
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0143 0.0207
Trichomonas vaginalis chromobox protein, putative 0.0075 0.2135 0.2021
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.2135 0.2131
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.1494 0.1494
Brugia malayi hypothetical protein 0.0071 0.1991 0.1991
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0143 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Trichomonas vaginalis glutaminase, putative 0.0292 1 1
Schistosoma mansoni hypothetical protein 0.0181 0.5988 0.5988
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0171 0.0171

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 14 % Bronchorelaxing effect in leukotriene D4-contracted human lung small airways model assessed as remaining contraction at 10 uM relative to control ChEMBL. 18248995
Activity (functional) = 14 % Bronchorelaxing effect on LTD4-contracted small human lung airways assessed as remaining contraction at 10 uM after 1.5 hrs relative to control ChEMBL. 18065228
Activity (functional) = 32 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 6 hrs relative to control ChEMBL. 18248995
Activity (functional) = 44 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 4.5 hrs relative to control ChEMBL. 18248995
Activity (functional) = 57 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 3 hrs relative to control ChEMBL. 18248995
Activity (functional) = 79 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 1.5 hrs relative to control ChEMBL. 18248995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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