Detailed information for compound 515460

Basic information

Technical information
  • TDR Targets ID: 515460
  • Name: 5,8-dichloro-N-[2-(4-chlorophenyl)ethyl]-6,7- dihydroxy-3,4-dihydro-1H-isoquinoline-2-carbo thioamide
  • MW: 431.764 | Formula: C18H17Cl3N2O2S
  • H donors: 3 H acceptors: 2 LogP: 4.81 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CCNC(=S)N1CCc2c(C1)c(Cl)c(c(c2Cl)O)O
  • InChi: 1S/C18H17Cl3N2O2S/c19-11-3-1-10(2-4-11)5-7-22-18(26)23-8-6-12-13(9-23)15(21)17(25)16(24)14(12)20/h1-4,24-25H,5-9H2,(H,22,26)
  • InChiKey: YZKRUTAMNGCIOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0038 0.0834 0.0834
Echinococcus granulosus jumonji domain containing protein 0.0043 0.1011 0.1689
Trypanosoma brucei unspecified product 0.0078 0.2266 0.7257
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Plasmodium falciparum phd finger protein, putative 0.0031 0.0571 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0143 0.0239
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0171 0.0094
Loa Loa (eye worm) hypothetical protein 0.0084 0.2478 0.2474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0598 0.0598
Echinococcus multilocularis chromobox protein 1 0.0075 0.2135 0.3566
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0513 0.0375
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.2687 0.4488
Giardia lamblia GTOR 0.0019 0.0143 0.0207
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0807 0.1348
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1211 0.2023
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.3092 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Loa Loa (eye worm) hypothetical protein 0.0032 0.0598 0.0593
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.2687 0.4488
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.2288 0.3822
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0143 0.0207
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.1494 0.1494
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0143 0.0207
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.3132 0.523
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0171 0.0299
Leishmania major DNA polymerase kappa, putative 0.0064 0.1749 0.5539
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0143 0.0207
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.1494 0.149
Loa Loa (eye worm) glutaminase 0.0292 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0171 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Brugia malayi Bromodomain containing protein 0.0031 0.0571 0.0571
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.1064 0.3266
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0171 0.0299
Echinococcus multilocularis Ankyrin 0.0016 0.0005 0.0008
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.3092 0.3089
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0571 0.9479
Schistosoma mansoni kinase 0.0051 0.1299 0.1299
Schistosoma mansoni chromobox protein 0.0075 0.2135 0.2135
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0171 0.0299
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1769 0.1765
Schistosoma mansoni jun-related protein 0.0073 0.208 0.208
Schistosoma mansoni hypothetical protein 0.0073 0.208 0.208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1211 0.2023
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.3092 0.3092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0171 0.0299
Onchocerca volvulus 0.0044 0.1038 0.0582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1211 0.1211
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0807 0.0807
Mycobacterium ulcerans glutaminase 0.0292 1 1
Echinococcus granulosus Ankyrin 0.0016 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0046 0.1108 0.1103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0143 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1113 0.3427
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0143 0.0207
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1211 0.1211
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0404 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1108 0.341
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0807 0.0803
Trypanosoma brucei polo-like protein kinase 0.0101 0.3092 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0404 0.0404
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0171 0.0286
Trichomonas vaginalis chromobox protein, putative 0.0075 0.2135 0.2021
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0336 0.259
Echinococcus granulosus dna polymerase eta 0.0084 0.2478 0.4138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1211 0.1211
Schistosoma mansoni ap endonuclease 0.002 0.0171 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.3092 0.3092
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1113 0.3427
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0513 0.0375
Trichomonas vaginalis chromobox protein, putative 0.0045 0.1067 0.0938
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0807 0.0807
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Schistosoma mansoni ap endonuclease 0.002 0.0171 0.0171
Plasmodium vivax SET domain protein, putative 0.0032 0.0598 1
Echinococcus granulosus dna polymerase kappa 0.0085 0.2521 0.421
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.1494 0.4581
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0143 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0143 0.0143
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0085 0.2521 0.2412
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.2266 0.7257
Trypanosoma brucei DNA polymerase eta, putative 0.0084 0.2478 0.7959
Trichomonas vaginalis glutaminase, putative 0.0292 1 1
Brugia malayi jmjC domain containing protein 0.0102 0.3132 0.3132
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0143 0.0207
Echinococcus multilocularis geminin 0.0181 0.5988 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0143 0.0207
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0571 0.4979
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0143 0.0239
Mycobacterium ulcerans DNA polymerase IV 0.0085 0.2521 0.246
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Echinococcus granulosus jun protein 0.009 0.2687 0.4488
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0598 0.0998
Giardia lamblia PHD finger protein 15 0.0031 0.0571 0.1626
Brugia malayi Pre-SET motif family protein 0.0032 0.0598 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.1749 0.5539
Echinococcus multilocularis jun protein 0.009 0.2687 0.4488
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0143 0.0239
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0143 0.0143
Toxoplasma gondii exonuclease III APE 0.002 0.0171 0.0917
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0571 0.4979
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Giardia lamblia DINP protein human, muc B family 0.0064 0.1749 0.5539
Mycobacterium ulcerans DNA polymerase IV 0.0085 0.2521 0.246
Onchocerca volvulus 0.0254 0.8596 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.3092 1
Schistosoma mansoni DNA polymerase eta 0.0084 0.2478 0.2478
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0143 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Brugia malayi glutaminase DH11.1 0.0292 1 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0171 0.1841
Brugia malayi Pre-SET motif family protein 0.0223 0.7481 0.7481
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.1038 0.1038
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1113 0.3427
Leishmania major DNA polymerase eta, putative 0.0084 0.2478 0.7959
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0143 0.0207
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.1067 0.0619
Trypanosoma brucei DNA polymerase IV, putative 0.0085 0.2521 0.8103
Trichomonas vaginalis chromobox protein, putative 0.0075 0.2135 0.2021
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Entamoeba histolytica hypothetical protein 0.0038 0.0834 0.2343
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.3092 0.3142
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0171 0.0171
Trypanosoma brucei unspecified product 0.0039 0.0858 0.2581
Loa Loa (eye worm) hypothetical protein 0.0031 0.0571 0.0566
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.1108 0.341
Echinococcus multilocularis dna polymerase eta 0.0084 0.2478 0.4138
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.1064 1
Echinococcus granulosus chromobox protein 1 0.0075 0.2135 0.3566
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Schistosoma mansoni hypothetical protein 0.0031 0.0571 0.0571
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.3092 0.5164
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.3092 0.5164
Loa Loa (eye worm) hypothetical protein 0.0023 0.027 0.0265
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0171 0.0166
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0404 0.0675
Loa Loa (eye worm) hypothetical protein 0.0053 0.1375 0.1371
Trichomonas vaginalis CAMK family protein kinase 0.005 0.125 0.1123
Brugia malayi Heterochromatin protein 1 0.0075 0.2135 0.2135
Entamoeba histolytica hypothetical protein 0.0027 0.0404 0.0884
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0143 0.0143
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.1494 0.2495
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0143 0.0207
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0171 0.0028
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0953 0.0476
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0571 0.0566
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Brugia malayi ImpB/MucB/SamB family protein 0.0084 0.2478 0.2478
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0145 0.0211
Schistosoma mansoni hypothetical protein 0.0038 0.0834 0.0834
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.3132 0.523
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.1494 0.1494
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0081 0.0081
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0571 0.0953
Loa Loa (eye worm) hypothetical protein 0.0087 0.2599 0.2595
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0807 0.1348
Trichomonas vaginalis chromobox protein, putative 0.0045 0.1067 0.0938
Giardia lamblia Kinase, PLK 0.0101 0.3092 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Brugia malayi PHD-finger family protein 0.0031 0.0571 0.0571
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0598 0.0598
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0171 0.0028
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.1011 0.1689
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0143 0.0207
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1211 0.1207
Leishmania major DNA polymerase eta, putative 0.0045 0.1064 0.3266
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.1749 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.2478 0.7959
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0143 0.0239
Brugia malayi bZIP transcription factor family protein 0.009 0.2687 0.2687
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.1494 0.8385
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0834 0.0834
Schistosoma mansoni hypothetical protein 0.0181 0.5988 0.5988
Brugia malayi Protein kinase domain containing protein 0.0016 0.0012 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0143 0.0207
Schistosoma mansoni chromobox protein 0.0075 0.2135 0.2135
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.2135 0.2131
Schistosoma mansoni hypothetical protein 0.0181 0.5988 0.5988
Onchocerca volvulus 0.0033 0.0627 0.007
Trichomonas vaginalis DNA polymerase eta, putative 0.0085 0.2521 0.2412
Brugia malayi jmjC domain containing protein 0.0038 0.0807 0.0807
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1211 0.2023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Schistosoma mansoni jumonji domain containing protein 0.0081 0.2374 0.2374
Loa Loa (eye worm) hypothetical protein 0.0042 0.0953 0.0949
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0834 0.1393
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0598 0.5252
Brugia malayi chromobox protein homolog 3 0.0042 0.0953 0.0953
Trichomonas vaginalis set domain proteins, putative 0.0253 0.8591 0.8571
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0953 0.0821
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0404 0.3285
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0171 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.7481 0.748
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0953 0.0821
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0834 0.1393
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0571 0.0953
Loa Loa (eye worm) hypothetical protein 0.0033 0.0627 0.0623
Echinococcus granulosus chromobox protein 1 0.0075 0.2135 0.3566
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0143 0.0633
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0145 0.0211
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0598 0.0998
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0143 0.0207
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0404 0.1073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0404 0.0404
Trypanosoma brucei DNA polymerase IV, putative 0.0085 0.2521 0.8103
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0171 0.0286
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0598 0.0998
Echinococcus multilocularis peregrin 0.0031 0.0571 0.0953
Echinococcus multilocularis chromobox protein 1 0.0075 0.2135 0.3566
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0171 0.0091
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.2288 0.3822
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1211 0.2023
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0171 0.1745
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.2521 0.8103
Schistosoma mansoni glutaminase 0.0292 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1211 0.1211
Onchocerca volvulus 0.0071 0.1991 0.177
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0404 0.0675
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0171 0.0299
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.1494 0.2495
Echinococcus multilocularis dna polymerase kappa 0.0085 0.2521 0.421
Echinococcus granulosus peregrin 0.0031 0.0571 0.0953
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0555 0.0927
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.027 0.0627
Trypanosoma brucei unspecified product 0.0039 0.0858 0.2581
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.1494 0.1494
Brugia malayi polk-prov protein 0.0046 0.1108 0.1108
Echinococcus granulosus geminin 0.0181 0.5988 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.3092 0.2992
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0143 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0598 0.0598
Trichomonas vaginalis CAMK family protein kinase 0.005 0.125 0.1123
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0571 0.0571
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.3092 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.1749 0.5539
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.3092 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0404 0.0265
Brugia malayi hypothetical protein 0.0071 0.1991 0.1991

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 14 % Bronchorelaxing effect in leukotriene D4-contracted human lung small airways model assessed as remaining contraction at 10 uM relative to control ChEMBL. 18248995
Activity (functional) = 14 % Bronchorelaxing effect on LTD4-contracted small human lung airways assessed as remaining contraction at 10 uM after 1.5 hrs relative to control ChEMBL. 18065228
Activity (functional) = 32 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 6 hrs relative to control ChEMBL. 18248995
Activity (functional) = 44 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 4.5 hrs relative to control ChEMBL. 18248995
Activity (functional) = 57 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 3 hrs relative to control ChEMBL. 18248995
Activity (functional) = 79 % Bronchorelaxing effect in leukotriene D4-contracted small human lung small airways model assessed as remaining contraction at 10 uM after 1.5 hrs relative to control ChEMBL. 18248995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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