TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 282.38 | Formula: C18H22N2O
H donors: 1 H acceptors: 2 LogP: 3.68 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(=O)Nc1c2CC(C)CCc2nc2c1cccc2
InChi: 1S/C18H22N2O/c1-3-6-17(21)20-18-13-7-4-5-8-15(13)19-16-10-9-12(2)11-14(16)18/h4-5,7-8,12H,3,6,9-11H2,1-2H3,(H,19,20,21)
InChiKey: FCBKFXXXKHJQRX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0022	0.011	0.1279
Echinococcus multilocularis	geminin	0.0186	0.2791	0.806
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	Csnk2b protein	0.0037	0.0352	0.0352
Schistosoma mansoni	protein kinase	0.0068	0.086	0.2469
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0492	0.1404
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	calpain-7 (C02 family)	0.0022	0.011	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Trichomonas vaginalis	CMGC family protein kinase	0.0068	0.086	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0037	0.0352	0.4093
Echinococcus granulosus	casein kinase ii subunit beta	0.0037	0.0352	0.0999
Echinococcus granulosus	calpain 7 C02 family	0.0022	0.011	0.0299
Loa Loa (eye worm)	POT family protein	0.0166	0.2462	0.2462
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.0227	0.3462	1
Brugia malayi	larval opioid receptor	0.0016	0.0007	0.0007
Trypanosoma cruzi	tyrosyl-tRNA synthetase, putative	0.0018	0.0044	0.051
Echinococcus granulosus	calpain A	0.0062	0.0758	0.2174
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	Dopamine receptor protein 2	0.0016	0.0007	0.0007
Toxoplasma gondii	CMGC kinase, CK2 family	0.0068	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	calpain-7 (C02 family)	0.0022	0.011	0.0299
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0037	0.0352	0.4093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0492	0.1404
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0062	0.0758	0.2174
Brugia malayi	Dopamine receptor	0.0016	0.0007	0.0007
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0037	0.0352	1
Brugia malayi	Melatonin receptor type 1A	0.0016	0.0007	0.0007
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0037	0.0352	0.4093
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0007	0.0007
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0037	0.0352	0.4093
Brugia malayi	calpain 7	0.0022	0.011	0.011
Echinococcus granulosus	calpain A	0.0022	0.011	0.0299
Trypanosoma brucei	calpain-like protein, putative	0.0022	0.011	0.1279
Brugia malayi	Serotonin receptor	0.0016	0.0007	0.0007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0062	0.0758	0.2174
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Echinococcus multilocularis	GA binding protein alpha chain	0.0072	0.0928	0.2667
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0016	0.0007	0.0007
Brugia malayi	G-protein coupled receptor	0.0016	0.0007	0.0007
Entamoeba histolytica	tyrosyl-tRNA synthetase, putative	0.0018	0.0044	0.051
Echinococcus multilocularis	calpain family protein 1, d	0.0044	0.0458	0.1307
Echinococcus multilocularis	calpain	0.0022	0.011	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0037	0.0352	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0227	0.3462	0.3462
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0268	0.4143	0.4143
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.0227	0.3462	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0059	0.0714	0.2047
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	Fli-1 protein	0.0219	0.3339	0.3339
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	POT family protein	0.0166	0.2462	0.2462
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0052	0.06
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.0227	0.3462	1
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0068	0.086	0.086
Entamoeba histolytica	casein kinase, putative	0.0068	0.086	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0052	0.06
Trichomonas vaginalis	CMGC family protein kinase	0.0068	0.086	1
Brugia malayi	follicle stimulating hormone receptor	0.0268	0.4143	0.4143
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.086	1
Schistosoma mansoni	gabp alpha	0.0072	0.0928	0.2667
Trypanosoma cruzi	casein kinase II, putative	0.0068	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0348	0.0348
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0052	0.06
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Brugia malayi	ORL1-like opioid receptor	0.0016	0.0007	0.0007
Trichomonas vaginalis	CMGC family protein kinase	0.0068	0.086	1
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0052	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	G-protein coupled receptor	0.0016	0.0007	0.0007
Brugia malayi	AKH receptor	0.0016	0.0007	0.0007
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	calpain	0.0022	0.011	0.011
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0052	0.013
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Brugia malayi	G protein-coupled receptor F59B2.13	0.0016	0.0007	0.0007
Brugia malayi	Dopamine receptor protein 1	0.0016	0.0007	0.0007
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0227	0.3462	0.3462
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0016	0.0007	0.0007
Plasmodium vivax	calpain, putative	0.0022	0.011	0.0811
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0022	0.011	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0604	0.0604
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0059	0.0717	0.0717
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0061	0.0746	0.0746
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0492	0.1404
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0068	0.086	0.2469
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0052	0.0096
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0022	0.011	0.1279
Schistosoma mansoni	peptidylglycine monooxygenase	0.012	0.1719	0.4955
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	calpain family protein 1	0.0059	0.0714	0.0714
Echinococcus granulosus	casein kinase ii subunit alpha	0.0068	0.086	0.2469
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0492	0.0492
Brugia malayi	Casein kinase II, alpha chain	0.0068	0.086	0.086
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.012	0.1719	0.1719
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0022	0.011	0.0299
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0016	0.0007	0.0007
Leishmania major	hypothetical protein, conserved	0.0019	0.0056	0.0652
Trichomonas vaginalis	CMGC family protein kinase	0.0068	0.086	1
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0037	0.0352	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	casein kinase II beta subunit	0.0037	0.0352	0.0999
Giardia lamblia	Kinase, CMGC CK2	0.0068	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Echinococcus multilocularis	calpain A	0.0062	0.0758	0.2174
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0052	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0492	0.1404
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0062	0.0758	0.2174
Plasmodium vivax	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0037	0.0352	0.3775
Trichomonas vaginalis	CMGC family protein kinase	0.0068	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0052	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0056	0.0652
Toxoplasma gondii	exonuclease III APE	0.0019	0.0052	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	calpain (C02 family)	0.0022	0.011	0.0299
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0016	0.0007	0.0007
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Plasmodium falciparum	casein kinase II beta chain	0.0037	0.0352	0.3775
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0492	0.1404
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	calpain C (C02 family)	0.0022	0.011	0.0299
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0052	0.0096
Brugia malayi	putative neuropeptide receptor NPR1	0.0016	0.0007	0.0007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Echinococcus multilocularis	casein kinase ii subunit beta	0.0037	0.0352	0.0999
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.0007	0.0007
Echinococcus multilocularis	calpain 7 (C02 family)	0.0022	0.011	0.0299
Echinococcus granulosus	calpain	0.0022	0.011	0.0299
Brugia malayi	putative neuropeptide receptor	0.0016	0.0007	0.0007
Brugia malayi	sulfakinin receptor protein	0.0016	0.0007	0.0007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0068	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Plasmodium vivax	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Echinococcus granulosus	geminin	0.0186	0.2791	0.806
Trypanosoma brucei	calpain-like protein, putative	0.0022	0.011	0.1279
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0052	0.0096
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0052	0.0052
Trichomonas vaginalis	CMGC family protein kinase	0.0068	0.086	1
Brugia malayi	Csnk2b protein	0.0037	0.0352	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	ets-related	0.0219	0.3339	0.9644
Echinococcus multilocularis	calpain 5	0.0022	0.011	0.0299
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0016	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0052	0.0052
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0022	0.011	0.1279
Toxoplasma gondii	ck2 beta subunit	0.0037	0.0352	0.3775
Plasmodium vivax	unspecified product	0.0068	0.086	1
Echinococcus granulosus	calpain 5	0.0022	0.011	0.0299
Schistosoma mansoni	ap endonuclease	0.0019	0.0052	0.013
Plasmodium falciparum	casein kinase II beta chain	0.0037	0.0352	0.3775
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.0007	0.0007
Leishmania major	tyrosyl-tRNA synthetase, putative	0.0018	0.0044	0.051
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0062	0.0758	0.2174
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0068	0.086	1
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0037	0.0352	0.4093
Schistosoma mansoni	hypothetical protein	0.0186	0.2791	0.806
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Brugia malayi	Ets-domain containing protein	0.0072	0.0928	0.0928
Giardia lamblia	Casein kinase II beta chain	0.0037	0.0352	0.3775
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0052	0.06
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0186	0.2791	0.806
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0714	0.0714
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.0007	0.0007
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0052	0.06
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Echinococcus multilocularis	tyrosyl tRNA synthetase	0.0032	0.0276	0.0779
Trypanosoma brucei	calpain-like protein, putative	0.0022	0.011	0.1279
Trypanosoma brucei	calpain-like protein, putative	0.0022	0.011	0.1279
Brugia malayi	RE15519p	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Loa Loa (eye worm)	calpain family protein 1	0.0059	0.0714	0.0714
Brugia malayi	calpain family protein 1	0.0059	0.0714	0.0714
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0052	0.013
Onchocerca volvulus		0.0037	0.0348	0.9894
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	dopamine-beta-monooxygenase	0.012	0.1719	0.4955
Trichomonas vaginalis	CMGC family protein kinase	0.0068	0.086	1
Echinococcus multilocularis	hypothetical protein	0.0022	0.011	0.0299
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	fli-1 protein	0.0219	0.3339	0.3339
Brugia malayi	G protein-coupled receptor	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.012	0.1719	0.1719
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0756	0.0756
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0016	0.0007	0.0007
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0052	0.0096
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0052	0.0096
Echinococcus granulosus	GA binding protein alpha chain	0.0072	0.0928	0.2667
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0037	0.0352	0.4093
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0007	0.0007
Trypanosoma brucei	antigen, putative	0.0022	0.011	0.1279
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0022	0.011	0.1279
Schistosoma mansoni	ap endonuclease	0.0019	0.0052	0.013
Trypanosoma brucei	tyrosyl-tRNA synthetase, putative	0.0018	0.0044	0.051
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Brugia malayi	Serotonin receptor	0.0016	0.0007	0.0007
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0492	0.1404
Trypanosoma brucei	Casein kinase II	0.0068	0.086	1
Brugia malayi	Ets-domain containing protein	0.0072	0.0928	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0052	0.5
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0625	1	1
Brugia malayi	neuropeptide F receptor	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0072	0.0928	0.0928
Schistosoma mansoni	tyrosyl-tRNA synthetase	0.0032	0.0276	0.0779
Brugia malayi	neuropeptide F receptor	0.0016	0.0007	0.0007
Echinococcus granulosus	tyrosyl tRNA synthetase	0.0032	0.0276	0.0779
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Leishmania major	casein kinase II, putative	0.0068	0.086	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0037	0.0352	0.3775
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0007
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0492	0.1404
Brugia malayi	GnHR receptor homolog	0.0016	0.0007	0.0007
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0022	0.011	0.1279
Trypanosoma cruzi	hypothetical protein, conserved	0.0019	0.0056	0.0652
Entamoeba histolytica	protein kinase, putative	0.0016	0.0008	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0007	0.0007
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0022	0.011	0.1279
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0022	0.011	0.1279

Activities

Activity type	Activity value	Assay description	Source	Reference
HACU improvement (functional)	= -16 %	Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-6 M	ChEMBL.	No reference
HACU improvement (functional)	= -6 %	Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-7 M	ChEMBL.	No reference
HACU improvement (functional)	= 6 %	Effect on the uptake amount of [3H]-choline in the hippocampal synaptosomes of AF64A-treated rats at 10e-5 M	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL37443

Bibliographic References

No literature references available for this target.

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Detailed information for compound 51945