TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 370.469 | Formula: C19H22N4O2S
H donors: 1 H acceptors: 4 LogP: 3.68 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)c1nc(ncc1Sc1nccn1C)C(C)(C)C)O
InChi: 1S/C19H22N4O2S/c1-19(2,3)17-21-11-15(26-18-20-8-9-23(18)4)16(22-17)13-10-12(25-5)6-7-14(13)24/h6-11,24H,1-5H3
InChiKey: QQPSSVQBJFNYDY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Leishmania major	eukaryotic initiation factor 4a, putative	0.0076	0.4751	1
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.002	0.0731	0.1538
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.002	0.0731	0.1413
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0669	0.1408
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0731	0.0731
Echinococcus granulosus	serotonin receptor	0.0019	0.0669	0.0669
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0669	0.0669
Plasmodium falciparum	multidrug resistance protein 1	0.0064	0.3864	0.8105
Echinococcus multilocularis	geminin	0.0115	0.7508	0.7508
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Plasmodium vivax	ABC transporter B family member 3, putative	0.002	0.0731	0.1413
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.002	0.0731	0.1413
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0669	0.1408
Schistosoma mansoni	opsin-like receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0064	0.3864	0.3864
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0669	0.0669
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0669	0.1408
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.0669	0.0891
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0076	0.4751	1
Brugia malayi	GnHR receptor homolog	0.0019	0.0669	0.1408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.002	0.0731	0.0973
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.0669	0.1408
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Plasmodium vivax	multidrug resistance protein 2, putative	0.002	0.0731	0.1413
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.002	0.0731	0.1413
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0669	0.0669
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.002	0.0731	0.1413
Entamoeba histolytica	hypothetical protein	0.002	0.0731	0.0122
Brugia malayi	Dopamine receptor	0.0019	0.0669	0.1408
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0669	0.0669
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0064	0.3864	0.782
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.002	0.0731	0.1413
Trichomonas vaginalis	abcb9, putative	0.0064	0.3864	0.782
Entamoeba histolytica	P-glycoprotein-1	0.0064	0.3864	0.782
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.002	0.0731	0.5
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0064	0.3864	0.8132
Echinococcus granulosus	somatostatin receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	opsin-like receptor	0.0019	0.0669	0.0891
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0669	0.0669
Brugia malayi	ABC transporter	0.0019	0.0681	0.1433
Plasmodium vivax	ABC transporter B family member 4, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Schistosoma mansoni	multidrug resistance protein	0.0064	0.3864	0.5146
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0669	0.0669
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.002	0.0731	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Onchocerca volvulus		0.0019	0.0669	0.1408
Leishmania major	ABC-thiol transporter	0.002	0.0731	0.1413
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Onchocerca volvulus		0.0019	0.0669	0.1408
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Schistosoma mansoni	multidrug resistance protein	0.002	0.0731	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0064	0.3864	0.8105
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	smdr2	0.0064	0.3864	0.5146
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0064	0.3864	0.782
Trypanosoma brucei	multidrug resistance protein E	0.002	0.0731	0.1413
Schistosoma mansoni	amine GPCR	0.0019	0.0669	0.0891
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0669	0.0669
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	Serotonin receptor	0.0019	0.0669	0.1408
Schistosoma mansoni	multidrug resistance protein	0.002	0.0731	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0681	0.1433
Onchocerca volvulus		0.0019	0.0669	0.1408
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0731	0.0122
Brugia malayi	ABC transporter family protein	0.0064	0.3864	0.8132
Loa Loa (eye worm)	hypothetical protein	0.0063	0.3814	0.8027
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0064	0.3864	0.782
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0064	0.3864	0.5
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0731	0.0122
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0076	0.4751	1
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0076	0.4751	0.4751
Echinococcus granulosus	multidrug resistance protein 1	0.0064	0.3864	0.3864
Entamoeba histolytica	P-glycoprotein-5	0.0064	0.3864	0.782
Schistosoma mansoni	myosin xvIII	0.0019	0.0669	0.0891
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0731	0.0122
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0669	0.1408
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0669	0.1408
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.0669	0.0891
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0064	0.3864	0.782
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus granulosus	ATP binding cassette sub family B	0.0019	0.0681	0.0681
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Onchocerca volvulus		0.0019	0.0669	0.1408
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0669	0.0669
Leishmania major	p-glycoprotein e	0.002	0.0731	0.1413
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0064	0.3864	0.782
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.002	0.0731	0.1413
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0669	0.0669
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0045	0.2487	0.4437
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0669	0.0669
Onchocerca volvulus		0.0019	0.0669	0.1408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Echinococcus multilocularis	multidrug resistance associated protein 7	0.002	0.0731	0.0731
Toxoplasma gondii	ABC transporter family protein	0.002	0.0731	0.1413
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0669	0.1408
Schistosoma mansoni	smdr1	0.002	0.0731	0.0973
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0669	0.0669
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0024	0.1046	0.1046
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0669	0.0891
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0681	0.1433
Brugia malayi	hypothetical protein	0.002	0.0731	0.1538
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.002	0.0731	0.5
Brugia malayi	Uncoordinated protein 44	0.001	0.000000040358	0.000000084939
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.002	0.0731	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0669	0.1408
Brugia malayi	Death domain containing protein	0.001	0.000000040358	0.000000084939
Giardia lamblia	Multidrug resistance-associated protein 1	0.002	0.0731	0.0122
Echinococcus granulosus	multidrug resistance associated protein 1	0.002	0.0731	0.0731
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0669	0.0669
Trichomonas vaginalis	ABC transporter, putative	0.0064	0.3864	0.782
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0669	0.0669
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0076	0.4751	0.6328
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Onchocerca volvulus		0.0019	0.0669	0.1408
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0076	0.4751	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0064	0.3864	0.782
Brugia malayi	isocitrate dehydrogenase	0.0011	0.0069	0.0145
Brugia malayi	ABC transporter transmembrane region family protein	0.002	0.0731	0.1538
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0076	0.4751	1
Brugia malayi	Protein kinase domain containing protein	0.001	0.000000040358	0.000000084939
Onchocerca volvulus		0.0019	0.0669	0.1408
Trypanosoma brucei	p-glycoprotein	0.002	0.0731	0.1413
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.002	0.0731	0.1413
Trypanosoma cruzi	multidrug resistance protein E, putative	0.002	0.0731	0.1413
Schistosoma mansoni	hypothetical protein	0.0019	0.0669	0.0891
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0064	0.3864	0.782
Echinococcus granulosus	multidrug resistance associated protein 7	0.002	0.0731	0.0731
Echinococcus granulosus	sex peptide receptor	0.0019	0.0669	0.0669
Brugia malayi	neuropeptide F receptor	0.0019	0.0669	0.1408
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.002	0.0731	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0669	0.0669
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0669	0.1408
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.002	0.0731	0.1413
Schistosoma mansoni	amine GPCR	0.0019	0.0669	0.0891
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0669	0.0891
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0064	0.3864	0.8105
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	histamine h1 receptor	0.0019	0.0669	0.0891
Brugia malayi	G-protein coupled receptor	0.0019	0.0669	0.1408
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0669	0.0669
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0064	0.3864	0.3864
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.002	0.0731	0.1538
Plasmodium vivax	multidrug resistance protein 1, putative	0.0064	0.3864	0.8105
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0064	0.3864	0.3864
Giardia lamblia	ABC transporter, putative	0.002	0.0731	0.0122
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Onchocerca volvulus		0.0019	0.0669	0.1408
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0064	0.3864	0.3864
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.002	0.0731	0.1538
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0669	0.0669
Entamoeba histolytica	multidrug resistance protein, putative	0.002	0.0731	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0064	0.3864	0.8132
Brugia malayi	larval opioid receptor	0.0019	0.0669	0.1408
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0011	0.0069	0.0069
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0669	0.0669
Entamoeba histolytica	P-glycoprotein-2	0.0064	0.3864	0.782
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0669	0.0669
Onchocerca volvulus		0.0019	0.0669	0.1408
Echinococcus granulosus	geminin	0.0115	0.7508	0.7508
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0669	0.0669
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0669	0.0891
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0076	0.4751	0.4751
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0669	0.0669
Plasmodium vivax	RNA helicase-1, putative	0.0076	0.4751	1
Loa Loa (eye worm)	ABC transporter	0.002	0.0731	0.1538
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.0669	0.0891
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0669	0.0669
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0669	0.0669
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0731	0.0731
Brugia malayi	AKH receptor	0.0019	0.0669	0.1408
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.0669	0.0669
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	hypothetical protein	0.0019	0.0669	0.0891
Entamoeba histolytica	P-glycoprotein-2, putative	0.0064	0.3864	0.782
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0669	0.0669
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.0669	0.0891
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	RE15519p	0.0019	0.0669	0.1408
Onchocerca volvulus		0.0019	0.0669	0.1408
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.0669	0.0891
Schistosoma mansoni	multidrug resistance protein	0.0019	0.0681	0.0907
Echinococcus multilocularis		0.002	0.0731	0.0731
Brugia malayi	ABC transporter family protein	0.002	0.0731	0.1538
Loa Loa (eye worm)	ABC transporter	0.002	0.0731	0.1538
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.002	0.0731	0.1413
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0076	0.4751	1
Schistosoma mansoni	adenoreceptor	0.0019	0.0669	0.0891
Plasmodium falciparum	multidrug resistance-associated protein 1	0.002	0.0731	0.1413
Entamoeba histolytica	hypothetical protein	0.0024	0.1046	0.0897
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0669	0.0669
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0024	0.1046	0.1046
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0076	0.4751	1
Schistosoma mansoni	multidrug resistance protein	0.002	0.0731	0.0973
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0076	0.4751	1
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0669	0.0669
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0063	0.3814	0.3814
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0669	0.0891
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0064	0.3864	0.8105
Echinococcus multilocularis	isocitrate dehydrogenase	0.0011	0.0069	0.0069
Schistosoma mansoni	amine GPCR	0.0019	0.0669	0.0891
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0019	0.0669	0.1408
Trichomonas vaginalis	ABC transporter, putative	0.0064	0.3864	0.782
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Schistosoma mansoni	hypothetical protein	0.0115	0.7508	1
Plasmodium falciparum	ABC transporter B family member 4, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0669	0.1408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Brugia malayi	sulfakinin receptor protein	0.0019	0.0669	0.1408
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.0669	0.1408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0064	0.3864	0.8105
Echinococcus multilocularis	multidrug resistance protein 1	0.0064	0.3864	0.3864
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0669	0.0669
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0669	0.0891
Brugia malayi	multidrug resistance protein 3	0.0064	0.3864	0.8132
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	putative neuropeptide receptor	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0669	0.1408
Plasmodium falciparum	ABC transporter B family member 7, putative	0.002	0.0731	0.1413
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0669	0.0891
Brugia malayi	multidrug resistance related protein 1	0.002	0.0731	0.1538
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0669	0.0669
Leishmania major	p-glycoprotein	0.0064	0.3864	0.8105
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.002	0.0731	0.1413
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0669	0.0669
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.001	0.000000040358	0.000000040358
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0669	0.0669
Echinococcus multilocularis	serotonin receptor	0.0019	0.0669	0.0669
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	G protein-coupled receptor	0.0019	0.0669	0.1408
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Trichomonas vaginalis	abcb9, putative	0.0064	0.3864	0.782
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0669	0.0669
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0669	0.1408
Schistosoma mansoni	opsin-like receptor	0.0019	0.0669	0.0891
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0731	0.0731
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0669	0.0891
Onchocerca volvulus		0.0064	0.3864	0.8132
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0669	0.0891
Schistosoma mansoni	multidrug resistance protein	0.002	0.0731	0.0973
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0064	0.3864	0.782
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0011	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	multidrug resistance protein	0.0064	0.3864	0.5146
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Entamoeba histolytica	P-glycoprotein-2	0.0064	0.3864	0.782
Treponema pallidum	ATP-dependent RNA helicase	0.0076	0.4751	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Schistosoma mansoni	hypothetical protein	0.0024	0.1046	0.1393
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0064	0.3864	0.782
Giardia lamblia	MRP-like ABC transporter	0.002	0.0731	0.0122
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0011	0.0069	0.0069
Echinococcus multilocularis	ATP binding cassette sub family B	0.002	0.0731	0.0731
Echinococcus granulosus	Ankyrin	0.001	0.0006	0.0006
Echinococcus multilocularis	serotonin receptor	0.0019	0.0669	0.0669
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	eukaryotic initiation factor 4A	0.0076	0.4751	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.002	0.0731	0.1413
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0669	0.0891
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.002	0.0731	0.1413
Brugia malayi	ABC transporter transmembrane region family protein	0.002	0.0731	0.1538
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0076	0.4751	0.4751
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0669	0.1408
Entamoeba histolytica	P-glyco protein 6, putative	0.0064	0.3864	0.782
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0669	0.0669
Plasmodium falciparum	ABC transporter B family member 6, putative	0.002	0.0731	0.1413
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.002	0.0731	0.1538
Loa Loa (eye worm)	multidrug resistance protein 3	0.0064	0.3864	0.8132
Schistosoma mansoni	hypothetical protein	0.0115	0.7508	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.0669	0.0891
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0064	0.3864	0.3864
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0669	0.0669
Onchocerca volvulus		0.0019	0.0669	0.1408
Echinococcus multilocularis	Ankyrin	0.001	0.0006	0.0006
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Schistosoma mansoni	multidrug resistance protein	0.0064	0.3864	0.5146
Toxoplasma gondii	ABC transporter, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0011	0.0069	0.0092
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0669	0.0891
Entamoeba histolytica	ABC transporter, putative	0.002	0.0731	0.0122
Entamoeba histolytica	P-glycoprotein 6, putative	0.002	0.0731	0.0122
Echinococcus multilocularis	multidrug resistance protein 1	0.0045	0.2487	0.2487
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0669	0.0669
Loa Loa (eye worm)	ABC transporter	0.002	0.0731	0.1538
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0669	0.0669
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0011	0.0069	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4751	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0669	0.1408
Echinococcus multilocularis	ATP binding cassette sub family B	0.0063	0.3814	0.3814
Onchocerca volvulus		0.0019	0.0669	0.1408
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0064	0.3864	0.3864
Brugia malayi	hypothetical protein	0.0024	0.1046	0.2201
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0076	0.4751	1
Schistosoma mansoni	transcription factor LCR-F1	0.0024	0.1046	0.1393
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0064	0.3864	0.8132
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0064	0.3864	0.3864
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.0669	0.0891
Onchocerca volvulus		0.0019	0.0669	0.1408
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.002	0.0731	0.1413
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0669	0.0669
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.002	0.0731	0.1413
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0064	0.3864	0.782
Plasmodium vivax	ABC transporter B family member 6, putative	0.002	0.0731	0.1413
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Schistosoma mansoni	amine GPCR	0.0019	0.0669	0.0891
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0076	0.4751	1
Trichomonas vaginalis	abcb9, putative	0.0064	0.3864	0.782
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.002	0.0731	0.1538
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Onchocerca volvulus		0.0019	0.0669	0.1408
Trichomonas vaginalis	ABC transporter, putative	0.0064	0.3864	0.782
Echinococcus granulosus	ATP binding cassette sub family B	0.002	0.0731	0.0731
Echinococcus granulosus	multidrug resistance protein 1	0.0064	0.3864	0.3864
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0019	0.0681	0.0907
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0064	0.3864	0.782
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0669	0.0669
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	hypothetical protein	0.0019	0.0669	0.0891
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0669	0.1408
Brugia malayi	ABC transporter family protein	0.002	0.0731	0.1538
Entamoeba histolytica	hypothetical protein	0.0024	0.1046	0.0897
Echinococcus multilocularis	multidrug resistance associated protein 1	0.002	0.0731	0.0731
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Onchocerca volvulus		0.0019	0.0669	0.1408
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0669	0.1408
Plasmodium vivax	ABC transporter B family member 7, putative	0.002	0.0731	0.1413
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0669	0.0891
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.0669	0.0891
Brugia malayi	Serotonin receptor	0.0019	0.0669	0.1408
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0076	0.4751	0.6328
Entamoeba histolytica	hypothetical protein	0.0024	0.1046	0.0897
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.001	0.0006	0.0008
Entamoeba histolytica	P-glycoprotein 5, putative	0.0064	0.3864	0.782
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0669	0.0669
Brugia malayi	ABC transporter	0.002	0.0731	0.1538
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0669	0.0669
Brugia malayi	Isocitrate dehydrogenase	0.0011	0.0069	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0669	0.0669
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.002	0.0731	0.1413
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0669	0.0669
Echinococcus multilocularis	multidrug resistance protein 1	0.0064	0.3864	0.3864
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.002	0.0731	0.1413
Brugia malayi	P-glycoprotein-like protein	0.002	0.0731	0.1538
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.002	0.0731	0.5
Leishmania major	pentamidine resistance protein 1	0.002	0.0731	0.1413
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0669	0.1408
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0064	0.3864	0.782
Brugia malayi	neuropeptide F receptor	0.0019	0.0669	0.1408
Leishmania major	eukaryotic initiation factor 4a, putative	0.0076	0.4751	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0076	0.4751	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0064	0.3864	0.782
Trichomonas vaginalis	taga, putative	0.0064	0.3864	0.782
Plasmodium falciparum	multidrug resistance-associated protein 2	0.002	0.0731	0.1413
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.001	0.000000040358	0.000000040358
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0669	0.1408
Echinococcus granulosus	hypothetical protein	0.0019	0.0669	0.0669
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0064	0.3864	0.782
Brugia malayi	ABC transporter family protein	0.002	0.0731	0.1538
Plasmodium falciparum	multidrug resistance protein 2	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0011	0.0069	0.0069
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0669	0.0891
Echinococcus granulosus	ATP binding cassette sub family B	0.002	0.0731	0.0731
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.0669	0.0669
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0019	0.0669	0.1408
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0669	0.0891
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0669	0.0669
Schistosoma mansoni	multidrug resistance protein	0.002	0.0731	0.0973
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0669	0.0669
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0076	0.4751	0.4751
Giardia lamblia	Multidrug resistance-associated protein 1	0.002	0.0731	0.0122
Echinococcus granulosus	multidrug resistance protein 1	0.0045	0.2487	0.2487
Entamoeba histolytica	hypothetical protein	0.0024	0.1046	0.0897
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Onchocerca volvulus		0.0019	0.0669	0.1408
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.002	0.0731	0.1413
Brugia malayi	hypothetical protein	0.0019	0.0669	0.1408
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0064	0.3864	0.3864
Schistosoma mansoni	hypothetical protein	0.0019	0.0669	0.0891
Plasmodium vivax	ABC transporter B family member 5, putative	0.002	0.0731	0.1413
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.002	0.0731	0.0122
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0669	0.1408
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.002	0.0731	0.5
Brugia malayi	ABC transporter transmembrane region family protein	0.0019	0.0681	0.1433
Entamoeba histolytica	ATP-binding cassette protein, putative	0.002	0.0731	0.0122
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Trichomonas vaginalis	ABC transporter, putative	0.0064	0.3864	0.782
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.002	0.0731	0.5
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.002	0.0731	0.1413
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.015	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0064	0.3864	0.3864
Brugia malayi	G-protein coupled receptor	0.0019	0.0669	0.1408
Schistosoma mansoni	ankyrin 23/unc44	0.001	0.000000040358	0.000000053754
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0669	0.0669
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0076	0.4751	1
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0669	0.0669
Entamoeba histolytica	P-glycoprotein 6, putative	0.002	0.0731	0.0122
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0669	0.0669
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0669	0.0669
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0669	0.0669
Plasmodium falciparum	ABC transporter B family member 3, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0669	0.1408
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0064	0.3864	0.782
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0076	0.4751	1
Echinococcus granulosus	multidrug resistance protein 1	0.0064	0.3864	0.3864
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.002	0.0731	0.1413
Echinococcus granulosus	multidrug resistance protein 1	0.0045	0.2487	0.2487
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0669	0.0669
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0011	0.0069	0.0145
Onchocerca volvulus		0.0019	0.0669	0.1408
Plasmodium falciparum	ABC transporter B family member 5, putative	0.002	0.0731	0.1413
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0669	0.1408
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.002	0.0731	0.1413
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0669	0.0669
Schistosoma mansoni	amine GPCR	0.0019	0.0669	0.0891
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.002	0.0731	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0669	0.0669

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	= 115.56 mg/ml	Cytotoxicity against dog MDCK cells	ChEMBL.	18160286

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 519650