Detailed information for compound 519663

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 650.919 | Formula: C25H24ClIN6O3S
  • H donors: 3 H acceptors: 6 LogP: 4.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(C(=O)[C@H]1S[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I)c1ccccc1
  • InChi: 1S/C25H24ClIN6O3S/c1-2-32(16-9-4-3-5-10-16)23(36)20-18(34)19(35)24(37-20)33-13-29-17-21(30-25(26)31-22(17)33)28-12-14-7-6-8-15(27)11-14/h3-11,13,18-20,24,34-35H,2,12H2,1H3,(H,28,30,31)/t18-,19+,20-,24+/m0/s1
  • InChiKey: REMDNJBPGYCGTO-CMCWBKRRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine A1 receptor Starlite/ChEMBL References
Homo sapiens adenosine A3 receptor Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Brugia malayi hypothetical protein adenosine A1 receptor 326 aa 305 aa 21.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.001 0.000000040358 0.000000084939
Schistosoma mansoni opsin-like receptor 0.0023 0.0865 0.1152
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.008 0.4751 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0011 0.0069 0.0092
Onchocerca volvulus 0.0023 0.0865 0.182
Trichomonas vaginalis ABC transporter, putative 0.0067 0.3864 0.782
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0731 0.1413
Echinococcus granulosus multidrug resistance protein 1 0.0067 0.3864 0.3864
Giardia lamblia MRP-like ABC transporter 0.0021 0.0731 0.0122
Echinococcus multilocularis Ankyrin 0.001 0.0006 0.0006
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0021 0.0731 0.1413
Echinococcus granulosus hypothetical protein 0.0023 0.0865 0.0865
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0865 0.0865
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0865 0.0865
Schistosoma mansoni hypothetical protein 0.0023 0.0865 0.1152
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.008 0.4751 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Schistosoma mansoni neuropeptide receptor 0.0023 0.0865 0.1152
Schistosoma mansoni hypothetical protein 0.0023 0.0865 0.1152
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.008 0.4751 1
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0021 0.0731 0.1413
Loa Loa (eye worm) hypothetical protein 0.0021 0.0731 0.1538
Plasmodium vivax ABC transporter B family member 3, putative 0.0021 0.0731 0.1413
Toxoplasma gondii ABC transporter, putative 0.0021 0.0731 0.1413
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0865 0.0865
Plasmodium vivax multidrug resistance protein 1, putative 0.0067 0.3864 0.8105
Plasmodium vivax multidrug resistance protein 2, putative 0.0021 0.0731 0.1413
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0067 0.3864 0.8132
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0865 0.182
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0865 0.1152
Echinococcus granulosus sex peptide receptor 0.0023 0.0865 0.0865
Trichomonas vaginalis abcb9, putative 0.0067 0.3864 0.782
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0865 0.182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Brugia malayi multidrug resistance protein 3 0.0067 0.3864 0.8132
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0865 0.0865
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0021 0.0731 0.5
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0021 0.0731 0.1413
Echinococcus granulosus ATP binding cassette sub family B 0.0021 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0021 0.0731 0.1413
Onchocerca volvulus 0.0023 0.0865 0.182
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0865 0.1152
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.002 0.0681 0.1433
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0865 0.1152
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0865 0.0865
Echinococcus granulosus multidrug resistance protein 1 0.0067 0.3864 0.3864
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus eukaryotic initiation factor 4A 0.008 0.4751 0.4751
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0865 0.0865
Plasmodium falciparum ABC transporter B family member 4, putative 0.0021 0.0731 0.1413
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0731 0.1413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni hypothetical protein 0.012 0.7508 1
Loa Loa (eye worm) ABC transporter 0.0021 0.0731 0.1538
Entamoeba histolytica ABC transporter, putative 0.0021 0.0731 0.0122
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.008 0.4751 1
Schistosoma mansoni amine GPCR 0.0023 0.0865 0.1152
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0865 0.0865
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0731 0.0122
Echinococcus multilocularis serotonin receptor 0.0023 0.0865 0.0865
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0865 0.0865
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0865 0.0865
Entamoeba histolytica P-glycoprotein-2 0.0067 0.3864 0.782
Schistosoma mansoni multidrug resistance protein 0.0021 0.0731 0.0973
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0865 0.1152
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0731 0.0122
Echinococcus multilocularis isocitrate dehydrogenase 0.0011 0.0069 0.0069
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0067 0.3864 0.782
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0021 0.0731 0.1413
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0021 0.0731 0.1413
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0026 0.1046 0.1046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0026 0.1046 0.1046
Echinococcus granulosus eukaryotic initiation factor 4A III 0.008 0.4751 0.4751
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0865 0.1152
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0865 0.182
Schistosoma mansoni smdr1 0.0021 0.0731 0.0973
Echinococcus granulosus multidrug resistance protein 1 0.0067 0.3864 0.3864
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0865 0.0865
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Treponema pallidum ATP-dependent RNA helicase 0.008 0.4751 0.5
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0021 0.0731 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0067 0.3864 0.3864
Echinococcus granulosus g protein coupled receptor 0.0023 0.0865 0.0865
Brugia malayi isocitrate dehydrogenase 0.0011 0.0069 0.0145
Brugia malayi hypothetical protein 0.0021 0.0731 0.1538
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0066 0.3814 0.8027
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.008 0.4751 1
Brugia malayi neuropeptide F receptor 0.0023 0.0865 0.182
Schistosoma mansoni opsin-like receptor 0.0023 0.0865 0.1152
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0067 0.3864 0.782
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0731 0.0122
Brugia malayi sulfakinin receptor protein 0.0023 0.0865 0.182
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0865 0.0865
Schistosoma mansoni amine GPCR 0.0023 0.0865 0.1152
Echinococcus granulosus neuropeptide receptor 0.0023 0.0865 0.0865
Echinococcus granulosus g protein coupled receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0865 0.0865
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Trypanosoma cruzi multidrug resistance protein E, putative 0.0021 0.0731 0.1413
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0865 0.0865
Plasmodium vivax ABC transporter B family member 4, putative 0.0021 0.0731 0.1413
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0021 0.0731 0.5
Brugia malayi G-protein coupled receptor 0.0023 0.0865 0.182
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0865 0.1152
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0865 0.0865
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0865 0.0865
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0865 0.0865
Plasmodium vivax ABC transporter B family member 5, putative 0.0021 0.0731 0.1413
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Echinococcus multilocularis geminin 0.012 0.7508 0.7508
Loa Loa (eye worm) hypothetical protein 0.0067 0.3864 0.8132
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0731 0.0731
Plasmodium vivax ABC transporter B family member 7, putative 0.0021 0.0731 0.1413
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0865 0.1152
Onchocerca volvulus 0.0023 0.0865 0.182
Onchocerca volvulus 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Toxoplasma gondii ABC transporter family protein 0.0021 0.0731 0.1413
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0021 0.0731 0.1413
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0865 0.182
Leishmania major eukaryotic initiation factor 4a, putative 0.008 0.4751 1
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0865 0.0865
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.001 0.0006 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0865 0.182
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0021 0.0731 0.1538
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0731 0.0122
Trichomonas vaginalis taga, putative 0.0067 0.3864 0.782
Onchocerca volvulus 0.0023 0.0865 0.182
Entamoeba histolytica P-glycoprotein 5, putative 0.0067 0.3864 0.782
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0067 0.3864 0.3864
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0731 0.0122
Plasmodium falciparum ABC transporter B family member 6, putative 0.0021 0.0731 0.1413
Onchocerca volvulus 0.0023 0.0865 0.182
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0865 0.0865
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0021 0.0731 0.1413
Plasmodium falciparum ABC transporter B family member 5, putative 0.0021 0.0731 0.1413
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Brugia malayi Serotonin receptor 0.0023 0.0865 0.182
Onchocerca volvulus 0.0023 0.0865 0.182
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0731 0.0122
Plasmodium falciparum multidrug resistance protein 2 0.0021 0.0731 0.1413
Onchocerca volvulus 0.0023 0.0865 0.182
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0865 0.182
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.008 0.4751 1
Brugia malayi P-glycoprotein-like protein 0.0021 0.0731 0.1538
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0865 0.182
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0865 0.0865
Echinococcus multilocularis multidrug resistance protein 1 0.0067 0.3864 0.3864
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Entamoeba histolytica P-glycoprotein 6, putative 0.0021 0.0731 0.0122
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0865 0.0865
Plasmodium falciparum ABC transporter B family member 7, putative 0.0021 0.0731 0.1413
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0865 0.0865
Plasmodium falciparum eukaryotic initiation factor 4A 0.008 0.4751 1
Brugia malayi Dopamine receptor protein 1 0.0023 0.0865 0.182
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0865 0.182
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0865 0.0865
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Trichomonas vaginalis ABC transporter, putative 0.0067 0.3864 0.782
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0066 0.3814 0.3814
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0067 0.3864 0.782
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0865 0.0865
Schistosoma mansoni multidrug resistance protein 0.0067 0.3864 0.5146
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0067 0.3864 0.782
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0067 0.3864 0.3864
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0865 0.0865
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.008 0.4751 1
Schistosoma mansoni neuropeptide receptor 0.0023 0.0865 0.1152
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0021 0.0731 0.1413
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0731 0.1413
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Schistosoma mansoni multidrug resistance protein 0.0021 0.0731 0.0973
Echinococcus multilocularis serotonin receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0067 0.3864 0.782
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0865 0.0865
Brugia malayi G protein-coupled receptor 0.0023 0.0865 0.182
Trichomonas vaginalis ABC transporter, putative 0.0067 0.3864 0.782
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0021 0.0731 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0865 0.0865
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni myosin xvIII 0.0023 0.0865 0.1152
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0865 0.0865
Schistosoma mansoni opsin-like receptor 0.0023 0.0865 0.1152
Leishmania major ABC-thiol transporter 0.0021 0.0731 0.1413
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0731 0.1413
Brugia malayi RE15519p 0.0023 0.0865 0.182
Onchocerca volvulus 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Brugia malayi larval opioid receptor 0.0023 0.0865 0.182
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0865 0.182
Echinococcus granulosus ATP binding cassette sub family B 0.0021 0.0731 0.0731
Trichomonas vaginalis ABC transporter, putative 0.0067 0.3864 0.782
Loa Loa (eye worm) multidrug resistance protein 3 0.0067 0.3864 0.8132
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0067 0.3864 0.782
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Brugia malayi Melatonin receptor type 1A 0.0023 0.0865 0.182
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.001 0.000000040358 0.000000040358
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0021 0.0731 0.1538
Echinococcus granulosus multidrug resistance protein 1 0.0047 0.2487 0.2487
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Onchocerca volvulus 0.0023 0.0865 0.182
Schistosoma mansoni neuropeptide receptor 0.0023 0.0865 0.1152
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0865 0.0865
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0865 0.1152
Plasmodium falciparum ABC transporter B family member 3, putative 0.0021 0.0731 0.1413
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0021 0.0731 0.1413
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0731 0.1413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus somatostatin receptor 0.0023 0.0865 0.0865
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0731 0.0122
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0067 0.3864 0.782
Onchocerca volvulus 0.0023 0.0865 0.182
Schistosoma mansoni multidrug resistance protein 0.0021 0.0731 0.0973
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0865 0.0865
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0021 0.0731 0.1413
Brugia malayi ORL1-like opioid receptor 0.0023 0.0865 0.182
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Brugia malayi putative neuropeptide receptor 0.0023 0.0865 0.182
Schistosoma mansoni hypothetical protein 0.0026 0.1046 0.1393
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Entamoeba histolytica hypothetical protein 0.0026 0.1046 0.0897
Brugia malayi ABC transporter 0.002 0.0681 0.1433
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0731 0.1413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0731 0.1413
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0731 0.1413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Onchocerca volvulus 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0731 0.0731
Schistosoma mansoni adenoreceptor 0.0023 0.0865 0.1152
Brugia malayi Serotonin receptor 0.0023 0.0865 0.182
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0067 0.3864 0.8105
Onchocerca volvulus 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0865 0.182
Echinococcus granulosus serotonin receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni multidrug resistance protein 0.0021 0.0731 0.0973
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.008 0.4751 0.6328
Schistosoma mansoni hypothetical protein 0.0023 0.0865 0.1152
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0731 0.1538
Onchocerca volvulus 0.0023 0.0865 0.182
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0067 0.3864 0.3864
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0067 0.3864 0.8105
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0021 0.0731 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0865 0.0865
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0067 0.3864 0.782
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0865 0.0865
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0067 0.3864 0.782
Brugia malayi multidrug resistance related protein 1 0.0021 0.0731 0.1538
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0067 0.3864 0.782
Onchocerca volvulus 0.0023 0.0865 0.182
Brugia malayi ABC transporter family protein 0.0021 0.0731 0.1538
Brugia malayi Death domain containing protein 0.001 0.000000040358 0.000000084939
Schistosoma mansoni multidrug resistance protein 0.0021 0.0731 0.0973
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0865 0.182
Plasmodium vivax ABC transporter B family member 6, putative 0.0021 0.0731 0.1413
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0865 0.182
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0067 0.3864 0.3864
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.008 0.4751 1
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.008 0.4751 0.4751
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Echinococcus multilocularis multidrug resistance protein 1 0.0067 0.3864 0.3864
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0731 0.0731
Schistosoma mansoni amine GPCR 0.0023 0.0865 0.1152
Brugia malayi ABC transporter family protein 0.0021 0.0731 0.1538
Giardia lamblia Translation initiation factor eIF-4A, putative 0.008 0.4751 1
Brugia malayi hypothetical protein 0.0026 0.1046 0.2201
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0012
Schistosoma mansoni multidrug resistance protein 0.0067 0.3864 0.5146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0731 0.1538
Echinococcus granulosus g protein coupled receptor 0.0023 0.0865 0.0865
Plasmodium falciparum multidrug resistance-associated protein 2 0.0021 0.0731 0.1413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0865 0.0865
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0069 0.0069
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0865 0.1152
Echinococcus multilocularis somatostatin receptor 0.0023 0.0865 0.0865
Brugia malayi Dopamine receptor 0.0023 0.0865 0.182
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0865 0.182
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0067 0.3864 0.782
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0731 0.1538
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0865 0.1152
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0067 0.3864 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Onchocerca volvulus 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0157 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.3864 0.8132
Loa Loa (eye worm) ABC transporter 0.0021 0.0731 0.1538
Trypanosoma brucei p-glycoprotein 0.0021 0.0731 0.1413
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0865 0.0865
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0865 0.0865
Leishmania major p-glycoprotein e 0.0021 0.0731 0.1413
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0865 0.0865
Trichomonas vaginalis abcb9, putative 0.0067 0.3864 0.782
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0021 0.0731 0.1413
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0011 0.0069 0.0069
Brugia malayi ABC transporter family protein 0.0021 0.0731 0.1538
Echinococcus multilocularis sex peptide receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0865 0.1152
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0731 0.1538
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Onchocerca volvulus 0.0023 0.0865 0.182
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0865 0.182
Brugia malayi G-protein coupled receptor 0.0023 0.0865 0.182
Entamoeba histolytica hypothetical protein 0.0026 0.1046 0.0897
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0865 0.1152
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Schistosoma mansoni multidrug resistance protein 0.002 0.0681 0.0907
Plasmodium vivax RNA helicase-1, putative 0.008 0.4751 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0865 0.1152
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0865 0.0865
Echinococcus granulosus multidrug resistance protein 1 0.0047 0.2487 0.2487
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0865 0.1152
Echinococcus multilocularis multidrug resistance protein 1 0.0047 0.2487 0.2487
Brugia malayi Isocitrate dehydrogenase 0.0011 0.0069 0.0145
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0865 0.0865
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0021 0.0731 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus allatostatin A receptor 0.0023 0.0865 0.0865
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.002 0.0681 0.0907
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Brugia malayi AKH receptor 0.0023 0.0865 0.182
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.008 0.4751 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0865 0.0865
Echinococcus granulosus Ankyrin 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus neuropeptide receptor 0.0023 0.0865 0.0865
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0067 0.3864 0.3864
Leishmania major eukaryotic initiation factor 4a, putative 0.008 0.4751 1
Schistosoma mansoni multidrug resistance protein 0.0067 0.3864 0.5146
Schistosoma mansoni biogenic amine receptor 0.0023 0.0865 0.1152
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0865 0.182
Giardia lamblia ABC transporter, putative 0.0021 0.0731 0.0122
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0067 0.3864 0.3864
Schistosoma mansoni biogenic amine receptor 0.0023 0.0865 0.1152
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0021 0.0731 0.1413
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0865 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Brugia malayi neuropeptide F receptor 0.0023 0.0865 0.182
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0731 0.0731
Schistosoma mansoni ankyrin 23/unc44 0.001 0.000000040358 0.000000053754
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0731 0.1413
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0067 0.3864 0.8105
Entamoeba histolytica hypothetical protein 0.0021 0.0731 0.0122
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0021 0.0731 0.1413
Schistosoma mansoni amine GPCR 0.0023 0.0865 0.1152
Schistosoma mansoni neuropeptide receptor 0.0023 0.0865 0.1152
Entamoeba histolytica P-glycoprotein-2 0.0067 0.3864 0.782
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0865 0.0865
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0067 0.3864 0.3864
Echinococcus granulosus geminin 0.012 0.7508 0.7508
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0865 0.0865
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0865 0.1152
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0731 0.0731
Brugia malayi GnHR receptor homolog 0.0023 0.0865 0.182
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0865 0.0865
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0067 0.3864 0.782
Schistosoma mansoni biogenic amine receptor 0.0023 0.0865 0.1152
Trichomonas vaginalis abcb9, putative 0.0067 0.3864 0.782
Plasmodium falciparum multidrug resistance-associated protein 1 0.0021 0.0731 0.1413
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0865 0.1152
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0865 0.0865
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0865 0.0865
Loa Loa (eye worm) ABC transporter 0.0021 0.0731 0.1538
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0067 0.3864 0.8105
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Echinococcus multilocularis eukaryotic initiation factor 4A 0.008 0.4751 0.4751
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0021 0.0731 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0681 0.1433
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0865 0.182
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0011 0.0069 0.0069
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0067 0.3864 0.3864
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0865 0.0865
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.001 0.000000040358 0.000000040358
Brugia malayi ABC transporter family protein 0.0067 0.3864 0.8132
Entamoeba histolytica hypothetical protein 0.0026 0.1046 0.0897
Onchocerca volvulus 0.0067 0.3864 0.8132
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0865 0.0865
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0069 0.0069
Leishmania major pentamidine resistance protein 1 0.0021 0.0731 0.1413
Echinococcus granulosus fmrfamide receptor 0.0023 0.0865 0.0865
Trypanosoma brucei multidrug resistance protein E 0.0021 0.0731 0.1413
Entamoeba histolytica P-glycoprotein 6, putative 0.0021 0.0731 0.0122
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0021 0.0731 0.5
Entamoeba histolytica P-glycoprotein-2, putative 0.0067 0.3864 0.782
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0021 0.0731 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Leishmania major p-glycoprotein 0.0067 0.3864 0.8105
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0865 0.1152
Echinococcus multilocularis 0.0021 0.0731 0.0731
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0731 0.0122
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0731 0.1413
Schistosoma mansoni hypothetical protein 0.012 0.7508 1
Entamoeba histolytica P-glycoprotein-1 0.0067 0.3864 0.782
Schistosoma mansoni amine GPCR 0.0023 0.0865 0.1152
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0731 0.0731
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus ATP binding cassette sub family B 0.002 0.0681 0.0681
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0865 0.0865
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0067 0.3864 0.782
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0067 0.3864 0.782
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Brugia malayi Uncoordinated protein 44 0.001 0.000000040358 0.000000084939
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0865 0.182
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0865 0.1152
Brugia malayi eukaryotic initiation factor 4A 0.008 0.4751 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0865 0.1152
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Echinococcus granulosus orexin receptor type 2 0.0023 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0023 0.0865 0.182
Brugia malayi Dopamine receptor protein 2 0.0023 0.0865 0.182
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0021 0.0731 0.1413
Brugia malayi ABC transporter 0.0021 0.0731 0.1538
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0731 0.0731
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0865 0.0865
Plasmodium falciparum multidrug resistance protein 1 0.0067 0.3864 0.8105
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0865 0.182
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.008 0.4751 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0865 0.0865
Echinococcus multilocularis ATP binding cassette sub family B 0.0066 0.3814 0.3814
Schistosoma mansoni hypothetical protein 0.0023 0.0865 0.1152
Schistosoma mansoni smdr2 0.0067 0.3864 0.5146
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0865 0.0865
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0021 0.0731 0.0973
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.008 0.4751 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0011 0.0069 0.0145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0865 0.1152
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0865 0.182
Entamoeba histolytica P-glyco protein 6, putative 0.0067 0.3864 0.782
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0067 0.3864 0.782
Brugia malayi ABC transporter transmembrane region family protein 0.002 0.0681 0.1433
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0865 0.1152
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0865 0.0865
Entamoeba histolytica hypothetical protein 0.0026 0.1046 0.0897
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.008 0.4751 0.6328
Schistosoma mansoni transcription factor LCR-F1 0.0026 0.1046 0.1393
Schistosoma mansoni histamine h1 receptor 0.0023 0.0865 0.1152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0011 0.0069 0.0069
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0865 0.0865
Entamoeba histolytica P-glycoprotein-5 0.0067 0.3864 0.782
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0865 0.182
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0865 0.0865
Brugia malayi hypothetical protein 0.0023 0.0865 0.182
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0047 0.2487 0.4437
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0021 0.0731 0.1413
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0865 0.0865
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0865 0.0865

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) >= 10 uM Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells ChEMBL. 18255292
IC50 (binding) >= 10 uM Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells ChEMBL. 18255292
IC50 (binding) >= 10 uM Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells ChEMBL. 18255292
IC50 (binding) >= 10 uM Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells ChEMBL. 18255292
Inhibition (binding) = 8 % Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells at 10 uM ChEMBL. 18255292
Inhibition (binding) = 8 % Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells at 10 uM ChEMBL. 18255292
Inhibition (binding) = 18 % Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells at 10 uM ChEMBL. 18255292
Inhibition (binding) = 18 % Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells at 10 uM ChEMBL. 18255292
Ki (binding) = 398 nM Displacement of [3H]ABMECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 18255292
Ki (binding) = 398 nM Displacement of [3H]ABMECA from human adenosine A3 receptor expressed in CHO cells ChEMBL. 18255292

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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