Detailed information for compound 542935

Basic information

Technical information
  • TDR Targets ID: 542935
  • Name: magnesium; disodium; (1E)-2-[6-[[amino-[(E)-[ amino-(4-chloroanilino)methylene]amino]methyl ene]amino]hexyl]-1-[amino-(4-chloroanilino)me thylene]guanidine; 2-aminobutanedioate; butan edioate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-ox o-3H-purin-9-yl)tetrahydrofuran-2-yl]methyl d ihydrogen phosphate; hydron; (2R,3S,4R,5R)-2, 3,4,5,6-pentahydroxyhexanoic acid; pyridine-3 -carboxamide
  • MW: 1822.67 | Formula: C62H91Cl2MgN18Na2O35P
  • H donors: 26 H acceptors: 35 LogP: -12.71 Rotable bonds: 37
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1[nH]cnc2=O)COP(=O)(O)O.NC(=O)c1cccnc1.NC(=NCCCCCC/N=C(/N=C(/Nc1ccc(cc1)Cl)\N)\N)/N=C(/Nc1ccc(cc1)Cl)\N.[O-]C(=O)CC(C(=O)[O-])N.[O-]C(=O)CC(C(=O)[O-])N.[O-]C(=O)CCC(=O)[O-].OC[C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O.OC[C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O.[NaH+].[NaH+].[MgH2+2].[H+].[H+]
  • InChi: 1S/C22H30Cl2N10.C10H13N4O8P.C6H6N2O.2C6H12O7.2C4H7NO4.C4H6O4.Mg.2Na/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;7-6(9)5-2-1-3-8-4-5;2*7-1-2(8)3(9)4(10)5(11)6(12)13;2*5-2(4(8)9)1-3(6)7;5-3(6)1-2-4(7)8;;;/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-4H,(H2,7,9);2*2-5,7-11H,1H2,(H,12,13);2*2H,1,5H2,(H,6,7)(H,8,9);1-2H2,(H,5,6)(H,7,8);;;/q;;;;;;;;+2;2*+1/p-4/t;4-,6-,7-,10-;;2*2-,3-,4+,5-;;;;;;/m.1.11....../s1
  • InChiKey: APZRQYXXDGMUIF-BYSABFAXSA-J  


Substructure search Similarity search

Network

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Synonyms

  • magnesium; disodium; 2-[amino-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylene]amino]methylene]amino]hexylimino]methyl]-1-(4-chlorophenyl)guanidine; 2-aminobutanedioate; butanedioate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)-2-tetrahydrofuranyl]methyl dihydrogen phosphate; hydron; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; 3-pyridinecarboxamide
  • magnesium; disodium; (1E)-2-[6-[[azanyl-[(E)-[azanyl-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]-1-[azanyl-[(4-chlorophenyl)amino]methylidene]guanidine; 2-azanylbutanedioate; butanedioate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate; hydron; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; pyridine-3-carboxamide
  • magnesium; disodium; (1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylene]amino]methylene]amino]hexyl]-1-[amino-(4-chloroanilino)methylene]guanidine; 2-aminosuccinate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-keto-3H-purin-9-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate; hydron; nicotinamide; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; succinate
  • magnesium; disodium; (1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine; 2-aminobutanedioate; butanedioate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate; hydron; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; pyridine-3-carboxamide
  • Anticataracticum
  • magnesium; disodium; (1E)-2-[6-[[amino-[[amino-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]-1-[amino-[(4-chlorophenyl)amino]methylidene]guanidine; 2-aminobutanedioate; butanedioate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate; hydron; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; pyridine-3-carboxamide
  • magnesium; disodium; (1E)-2-[6-[[amino-[[amino-[(4-chlorophenyl)amino]methylene]amino]methylene]amino]hexyl]-1-[amino-[(4-chlorophenyl)amino]methylene]guanidine; 2-aminobutanedioate; butanedioate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate; hydron; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; pyridine-3-carboxamide
  • magnesium; disodium; (1E)-2-[6-[[amino-[[amino-[(4-chlorophenyl)amino]methylene]amino]methylene]amino]hexyl]-1-[amino-[(4-chlorophenyl)amino]methylene]guanidine; 2-aminobutanedioate; butanedioate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)-2-tetrahydrofuranyl]methyl dihydrogen phosphate; hydron; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; 3-pyridinecarboxamide
  • magnesium; disodium; (1E)-2-[6-[[amino-[[amino-[(4-chlorophenyl)amino]methylene]amino]methylene]amino]hexyl]-1-[amino-[(4-chlorophenyl)amino]methylene]guanidine; 2-aminosuccinate; [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-keto-3H-purin-9-yl)tetrahydrofuran-2-yl]methyl dihydrogen phosphate; hydron; nicotinamide; (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid; succinate
  • 138240-73-0

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica Ran family GTPase 0.0021 0.023 0.0582
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1088 0.1286
Echinococcus multilocularis pyruvate kinase 0.0017 0.0147 0.0147
Echinococcus granulosus solute carrier family 22 0.0015 0.0096 0.0096
Echinococcus multilocularis Protein lozenge 0.0054 0.0884 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0502 0.1052
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1099 0.1099
Loa Loa (eye worm) beta-lactamase 0.0035 0.0502 0.0593
Echinococcus multilocularis solute carrier family 22 0.0015 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0593
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0539 0.051
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0157 0.0159
Echinococcus granulosus importin subunit beta 1 0.0029 0.0385 0.0385
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0096 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0119 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.023 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0096 0.05
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0205 0.3956 0.3956
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0119 0.0119
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0385 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0096 0.05
Echinococcus multilocularis pyruvate kinase 0.0034 0.0477 0.0477
Echinococcus granulosus General substrate transporter 0.009 0.1618 0.1618
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0119 0.0119
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0096 0.0113
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0494 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0502 0.0847
Brugia malayi beta-lactamase family protein 0.0035 0.0502 0.0593
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Trypanosoma brucei glucose transporter 1E 0.0032 0.0455 0.093
Echinococcus granulosus tar DNA binding protein 0.0064 0.1088 0.1088
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.1916 0.1916
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0494 0.0494
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0447 0.0617
Echinococcus granulosus solute carrier family 22 0.0015 0.0096 0.0096
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0199 0.0216
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0477 0.0989
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0539 0.051
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0455 0.2374
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0494 0.0458
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0447 0.0404
Leishmania major glucose transporter, lmgt3 0.0032 0.0455 0.093
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0271 0.0201
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0446 0.0528
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0502 0.262
Loa Loa (eye worm) hypothetical protein 0.0032 0.0446 0.0528
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Schistosoma mansoni hypothetical protein 0.0016 0.0119 0.0119
Onchocerca volvulus 0.0015 0.0096 0.0113
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0447 0.0617
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0494 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0455 0.093
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Plasmodium vivax hexose transporter 0.0105 0.1916 0.2094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0813 0.0962
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0446 0.0909
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0205 0.3956 1
Brugia malayi major facilitator superfamily protein 0.0015 0.0096 0.0113
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0502 0.1052
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0502 0.0593
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0494 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0271 0.0152
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0311 0.0248
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.023 0.0155
Loa Loa (eye worm) runx1 0.0054 0.0884 0.1046
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0539 0.0779
Mycobacterium tuberculosis Probable oxidoreductase 0.0252 0.489 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.4502 0.4502
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0446 0.0446
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0455 0.093
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.1099 0.2599
Brugia malayi Cam kinase protein 1 0.0032 0.0446 0.0528
Loa Loa (eye worm) hypothetical protein 0.0016 0.0119 0.0141
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0494 0.0494
Plasmodium falciparum glutathione reductase 0.0099 0.1806 0.1968
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.1099 0.2092
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.1099 0.1099
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0096 0.05
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.023 0.023
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0119 0.0141
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1088 0.1088
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0271 0.0453
Echinococcus multilocularis pyruvate kinase 0.0017 0.0147 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni hypothetical protein 0.0034 0.0492 0.0492
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0311 0.0248
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0477 0.0593
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0447 0.0617
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.4379 0.8934
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0271 0.5265
Onchocerca volvulus 0.0015 0.0096 0.0113
Schistosoma mansoni protein kinase 0.0032 0.0446 0.0446
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0096 0.0681
Echinococcus granulosus pyruvate kinase 0.0034 0.0477 0.0477
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0096 0.05
Entamoeba histolytica protein kinase, putative 0.0032 0.0446 0.1129
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0274 0.1431
Echinococcus granulosus snurportin 1 0.031 0.6068 0.6068
Echinococcus granulosus pyruvate kinase 0.0017 0.0147 0.0147
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0455 0.2374
Brugia malayi Sugar transporter family protein 0.0015 0.0096 0.0113
Plasmodium vivax importin-beta 2, putative 0.0029 0.0385 0.0333
Brugia malayi major facilitator superfamily protein 0.0015 0.0096 0.0113
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0494 0.0494
Onchocerca volvulus 0.0428 0.8459 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0232 0.4502 0.4502
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1916 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0455 0.093
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0205 0.3956 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0433 0.0433
Onchocerca volvulus 0.0015 0.0096 0.0113
Leishmania major hypothetical protein, conserved 0.0025 0.0311 0.0557
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0494 0.07
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0539 0.1147
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0447 0.0404
Schistosoma mansoni hypothetical protein 0.0016 0.0119 0.0119
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0502 0.0502
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0385 0.075
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1916 0.1916
Plasmodium falciparum protein kinase 7 0.0296 0.5781 0.6542
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.023 0.0348
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0147 0.0059
Plasmodium falciparum hexose transporter 0.0105 0.1916 0.2094
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.023 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1099 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0212 0.1109
Toxoplasma gondii protein kinase, putative 0.0296 0.5781 1
Leishmania major hypothetical protein, conserved 0.0035 0.0502 0.1052
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.1099 0.1099
Chlamydia trachomatis pyruvate kinase 0.0034 0.0477 0.9651
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1088 0.1286
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Plasmodium falciparum thioredoxin reductase 0.0034 0.0494 0.0458
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0502 0.0847
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0494 0.1032
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0446 0.0446
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0494 0.07
Entamoeba histolytica hypothetical protein 0.0023 0.0271 0.0684
Schistosoma mansoni hypothetical protein 0.0016 0.0119 0.0119
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0096 0.05
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.322 0.3595
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0502 0.0502
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0502 0.0645
Loa Loa (eye worm) hypothetical protein 0.0034 0.0492 0.0582
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.023 0.0155
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0494 0.438
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0406 0.0406
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0147 0.009
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0502 0.1052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1916 0.1916
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0502 0.262
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0477 0.0564
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0447 0.0404
Schistosoma mansoni hypothetical protein 0.031 0.6068 0.6068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0494 0.1032
Echinococcus multilocularis GPCR, family 2 0.0016 0.0119 0.0119
Schistosoma mansoni pyruvate kinase 0.0017 0.0147 0.0147
Echinococcus multilocularis geminin 0.0504 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0494 0.438
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0232 0.4502 0.5322
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0494 0.1032
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0311 0.0248
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0446 0.0528
Onchocerca volvulus 0.0015 0.0096 0.0113
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0271 0.0271
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0494 0.2578
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0477 0.0989
Onchocerca volvulus 0.0015 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0593
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0492 0.0582
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0271 0.2306
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0502 0.262
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0433 0.0512
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Mycobacterium ulcerans lipase LipD 0.0035 0.0502 0.4455
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.1806 0.1806
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0274 0.1431
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0446 0.0446
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0494 0.083
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0433 0.8478
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0252 0.489 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0477 0.0564
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni ran 0.0021 0.023 0.023
Plasmodium vivax glutathione reductase, putative 0.0099 0.1806 0.1968
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0502 0.0847
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Mycobacterium ulcerans hypothetical protein 0.0035 0.0502 0.4455
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0455 0.2374
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0028
Echinococcus multilocularis transcription factor Dp 1 0.0119 0.2205 0.2205
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 0.8786 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0311 0.0378
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0271 0.0271
Toxoplasma gondii thioredoxin reductase 0.0099 0.1806 0.3009
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0096 0.0096
Trypanosoma cruzi hexose transporter 0.0032 0.0455 0.093
Onchocerca volvulus 0.0015 0.0096 0.0113
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0447 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Echinococcus granulosus GPCR family 2 0.0016 0.0119 0.0119
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0539 0.1147
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0205 0.3956 1
Schistosoma mansoni glucose transport protein 0.0105 0.1916 0.1916
Onchocerca volvulus 0.0035 0.0502 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0271 0.0271
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0502 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0455 0.2374
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.4379 0.8934
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0271 0.0453
Leishmania major glucose transporter, lmgt1 0.0032 0.0455 0.093
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0199 0.0216
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0477 0.0564
Mycobacterium leprae Probable lipase LipE 0.0035 0.0502 0.0645
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0028 0.0028
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0147 0.0059
Schistosoma mansoni sugar transporter 0.0015 0.0096 0.0096
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0271 0.032
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0271 0.0308
Leishmania major pyruvate kinase 0.0034 0.0477 0.0989
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0271 0.0201
Plasmodium falciparum pyruvate kinase 0.0034 0.0477 0.0439
Plasmodium falciparum protein kinase 6 0.0444 0.8786 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1088 0.1286
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.6068 0.7173
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0502 0.0847
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0502 0.4455
Onchocerca volvulus 0.0015 0.0096 0.0113
Echinococcus multilocularis solute carrier family 22 0.0015 0.0096 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Onchocerca volvulus 0.0015 0.0096 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0311 0.0557
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0311 0.0557
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.1806 0.2135
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Brugia malayi hypothetical protein 0.0025 0.0311 0.0367
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.1806 0.1968
Onchocerca volvulus 0.0015 0.0096 0.0113
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.023 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0096 0.05
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1088 0.1088
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0446 0.0446
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0494 0.438
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0119 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0455 0.2374
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0494 0.2578
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0433 0.0433
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0455 0.093
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0059 0.0069
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0272 0.0687
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1088 0.1088
Leishmania major glucose transporter, lmgt2 0.0032 0.0455 0.093
Mycobacterium ulcerans sugar transporter 0.0015 0.0096 0.0681
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0477 0.0796
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0096 0.0096
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0494 0.1032
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0446 0.233
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0502 0.0847
Brugia malayi Sugar transporter family protein 0.0105 0.1916 0.2265
Entamoeba histolytica protein kinase, putative 0.0032 0.0446 0.1129
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0502 0.0847
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0433 0.0433
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0446 0.0446
Echinococcus granulosus pyruvate kinase 0.0017 0.0147 0.0147
Onchocerca volvulus 0.0035 0.0502 0.0593
Onchocerca volvulus 0.0015 0.0096 0.0113
Brugia malayi glutathione reductase 0.0099 0.1806 0.2135
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0252 0.489 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0494 0.1032
Echinococcus granulosus solute carrier family 22 0.0015 0.0096 0.0096
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0096 0.0096
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.1806 0.3568
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0539 0.1147
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0477 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0455 0.2374
Loa Loa (eye worm) hypothetical protein 0.0029 0.0385 0.0455
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0494 0.1032
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0205 0.3956 0.3956
Mycobacterium tuberculosis Probable reductase 0.0226 0.4379 0.8934
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0385 0.075
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0502 0.0467
Brugia malayi hypothetical protein 0.0015 0.0096 0.0113
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0433 0.2262
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0502 0.0502
Leishmania major protein kinase, putative 0.0032 0.0446 0.0909
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1916 0.1916
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0494 0.1032
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0446 0.0446
Onchocerca volvulus 0.0015 0.0096 0.0113
Schistosoma mansoni protein kinase 0.0032 0.0446 0.0446
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0477 0.0989
Giardia lamblia Pyruvate kinase 0.0034 0.0477 0.9586
Schistosoma mansoni glucose transport protein 0.0105 0.1916 0.1916
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni glucose transport protein 0.0105 0.1916 0.1916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.4502 0.4502
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0271 0.0271
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0502 0.0847
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0502 0.4455
Loa Loa (eye worm) hypothetical protein 0.0026 0.0314 0.0371
Loa Loa (eye worm) glutathione reductase 0.0099 0.1806 0.2135
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0477 0.0564
Onchocerca volvulus 0.0015 0.0096 0.0113
Plasmodium falciparum glutathione reductase 0.0034 0.0494 0.0458
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0447 0.0404
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0119 0.0141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0477 0.0564
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0433 0.0433
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0539 0.1147
Brugia malayi beta-lactamase family protein 0.0035 0.0502 0.0593
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.322 0.5495
Plasmodium falciparum importin beta, putative 0.0029 0.0385 0.0333
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0433 0.0512
Loa Loa (eye worm) sugar transporter 0.0015 0.0096 0.0113
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0205 0.3956 0.4676
Loa Loa (eye worm) hypothetical protein 0.0428 0.8459 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0272 0.0321
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0096 0.0113
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0274 0.1431
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0455 0.2374
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0433 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0096 0.05
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0813 0.0962
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.4379 0.8934
Loa Loa (eye worm) sugar transporter 0.0105 0.1916 0.2265
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.1099 1
Loa Loa (eye worm) RNA binding protein 0.0064 0.1088 0.1286
Trichomonas vaginalis ran, putative 0.0021 0.023 0.1202
Brugia malayi RNA, U transporter 1 0.0083 0.1468 0.1736
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0309 0.0365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0232 0.4502 0.4502
Brugia malayi Importin beta-1 subunit 0.0029 0.0385 0.0455
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.1806 0.1806
Toxoplasma gondii ABC1 family protein 0.0035 0.0502 0.0715
Loa Loa (eye worm) hypothetical protein 0.0023 0.0271 0.032
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0494 0.1032
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.4379 0.8934
Mycobacterium tuberculosis Conserved protein 0.0035 0.0502 0.0847
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0096 0.0681
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0406 0.0406
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1916 0.1916
Onchocerca volvulus Putative transporter 0.0015 0.0096 0.0113
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.1011 0.1196
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.322 0.3595
Brugia malayi hypothetical protein 0.0428 0.8459 1
Schistosoma mansoni hypothetical protein 0.0504 1 1
Onchocerca volvulus 0.0015 0.0096 0.0113
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0205 0.3956 0.3956
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.1916 0.3201
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0477 0.4227
Schistosoma mansoni importin beta-1 0.0029 0.0385 0.0385
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0446 0.0446
Echinococcus granulosus pyruvate kinase 0.0034 0.0477 0.0477
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0205 0.3956 0.4676
Leishmania major importin beta-1 subunit, putative 0.0024 0.0274 0.0462
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0455 0.093
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0494 0.0458
Brugia malayi beta-lactamase 0.0035 0.0502 0.0593
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.1806 0.4431
Echinococcus multilocularis solute carrier family 22 0.0015 0.0096 0.0096
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0477 0.0989
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0119 0.0119
Trypanosoma brucei trypanothione reductase 0.0099 0.1806 0.4431
Mycobacterium tuberculosis Conserved protein 0.0035 0.0502 0.0847
Brugia malayi hypothetical protein 0.0015 0.0096 0.0113
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0494 0.0458
Leishmania major pyruvate kinase 0.0034 0.0477 0.0989
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1916 0.1916
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0593
Schistosoma mansoni sugar transporter 0.0015 0.0096 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0096 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Echinococcus granulosus solute carrier family 22 0.0015 0.0096 0.0096
Schistosoma mansoni lozenge 0.0054 0.0884 0.0884
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.1099 0.1299
Giardia lamblia Pyruvate kinase 0.0017 0.0147 0.1281
Brugia malayi Thioredoxin reductase 0.0099 0.1806 0.2135
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0494 0.0458
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0447 0.0404
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0232 0.4502 0.4502
Brugia malayi RNA binding protein 0.0064 0.1088 0.1286
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0477 0.0564
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0232 0.4502 0.4502
Mycobacterium ulcerans beta-lactamase 0.0035 0.0502 0.4455
Trypanosoma brucei glucose transporter 2A 0.0032 0.0455 0.093
Echinococcus granulosus transcription factor Dp 1 0.0119 0.2205 0.2205
Schistosoma mansoni hypothetical protein 0.0105 0.1916 0.1916
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0028 0.0028
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0446 0.0446
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0309 0.0365
Loa Loa (eye worm) hypothetical protein 0.005 0.0813 0.0962
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Entamoeba histolytica hypothetical protein 0.0024 0.0274 0.0693
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0271 0.1413
Brugia malayi hypothetical protein 0.0015 0.0096 0.0113
Schistosoma mansoni ran 0.0021 0.023 0.023
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0813 0.0962
Brugia malayi TAR-binding protein 0.0064 0.1088 0.1286
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0502 0.0847
Echinococcus multilocularis solute carrier family 22 0.0015 0.0096 0.0096
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni sugar transporter 0.0015 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0016 0.0119 0.0119
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0494 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0004 0.0004
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0096 0.0681
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0494 0.1032
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0477 0.0564
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.4379 0.891
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0477 0.2492
Brugia malayi Sugar transporter family protein 0.0015 0.0096 0.0113
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1916 0.1916
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.023 0.0272
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0271 0.0453
Echinococcus multilocularis snurportin 1 0.031 0.6068 0.6068
Echinococcus multilocularis pyruvate kinase 0.0034 0.0477 0.0477
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0446 0.0446
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.023 0.0237
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1088 0.1088
Echinococcus multilocularis pyruvate kinase 0.0017 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0025 0.0311 0.0367
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0271 0.4393
Onchocerca volvulus 0.0035 0.0502 0.0593
Treponema pallidum NADH oxidase 0.0034 0.0494 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0271 0.2306
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0096 0.0113
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0477 0.2492
Loa Loa (eye worm) hypothetical protein 0.0428 0.8459 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0096 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0502 0.262
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0455 0.093
Trypanosoma brucei glucose transporter, putative 0.0032 0.0455 0.093
Leishmania major trypanothione reductase 0.0099 0.1806 0.4431
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1088 0.1088
Leishmania major GTP-binding protein, putative 0.0021 0.023 0.0348
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1916 0.1916
Echinococcus granulosus pyruvate kinase 0.0017 0.0147 0.0147
Schistosoma mansoni pyruvate kinase 0.0034 0.0477 0.0477
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0433 0.0499
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Echinococcus multilocularis General substrate transporter 0.009 0.1618 0.1618
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0205 0.3956 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0311 0.0557
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0502 0.0502
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0252 0.489 1
Schistosoma mansoni protein kinase 0.0032 0.0446 0.0446
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0494 0.0584
Onchocerca volvulus 0.0015 0.0096 0.0113
Onchocerca volvulus 0.0015 0.0096 0.0113
Echinococcus multilocularis pyruvate kinase 0.0026 0.0334 0.0334
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0385 0.0509
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0272 0.0321
Trichomonas vaginalis esterase, putative 0.0035 0.0502 0.262
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0455 0.093
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0502 0.262
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.4296 0.876
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0096 0.0096
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0477 0.0671
Schistosoma mansoni glucose transporter 0.0015 0.0096 0.0096
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0446 0.0528
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1088 0.1088
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.023 0.3378
Brugia malayi hypothetical protein 0.0016 0.0129 0.0153
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0539 0.1147
Onchocerca volvulus 0.0015 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0593
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.023 0.0348
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0477 0.0564
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0593
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0232 0.4502 0.5322
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0447 0.0404
Plasmodium falciparum thioredoxin reductase 0.0099 0.1806 0.1968
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.4379 0.8934
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0494 0.1032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0502 0.0593
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0433 0.0512
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0232 0.4502 0.4502
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0447 0.0404
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0096 0.05
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0477 0.0564
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0205 0.3956 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0096 0.05
Schistosoma mansoni hypothetical protein 0.0504 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0274 0.0462
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0433 0.0512
Loa Loa (eye worm) hypothetical protein 0.0015 0.0096 0.0113
Schistosoma mansoni sugar transporter 0.0015 0.0096 0.0096
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0447 0.0404
Schistosoma mansoni pyruvate kinase 0.0034 0.0477 0.0477

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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