Detailed information for compound 543851

Basic information

Technical information
  • TDR Targets ID: 543851
  • Name: (6S)-N,N-dipropyl-5,6,7,8-tetrahydroindolizin -6-amine
  • MW: 220.354 | Formula: C14H24N2
  • H donors: 0 H acceptors: 0 LogP: 2.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN([C@H]1CCc2n(C1)ccc2)CCC
  • InChi: 1S/C14H24N2/c1-3-9-15(10-4-2)14-8-7-13-6-5-11-16(13)12-14/h5-6,11,14H,3-4,7-10,12H2,1-2H3/t14-/m0/s1
  • InChiKey: JLTVNRULFIBVDV-AWEZNQCLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dipropyl-[(6S)-5,6,7,8-tetrahydroindolizin-6-yl]amine
  • 6-N,N-dipropylamino-5,6,7,8-tetrahydroindolizine
  • 140848-67-5
  • 6-Dip-5,6,7,8-tetind
  • 6-Indolizinamine, 5,6,7,8-tetrahydro-N,N-dipropyl-, (S)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0132 0.0544
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0532 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0799 0.3225
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3681 0.3595
Loa Loa (eye worm) hypothetical protein 0.0036 0.0607 0.2501
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.1933
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0532 0.0404
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0636 0.7564
Brugia malayi Sugar transporter family protein 0.0106 0.22 0.9015
Brugia malayi Sugar transporter family protein 0.0015 0.0134 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Plasmodium falciparum hexose transporter 0.0106 0.22 0.2094
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0577
Toxoplasma gondii sugar transporter ST3 0.0015 0.0134 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0532 0.0404
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0134 0.0008
Brugia malayi hypothetical protein 0.0015 0.0134 0.0007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0594 0.6934
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0532 0.1933
Leishmania major glucose transporter, lmgt3 0.0033 0.0541 0.6136
Trypanosoma brucei glucose transporter 1E 0.0033 0.0541 0.6136
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0332 1
Brugia malayi hypothetical protein 0.0015 0.0134 0.0007
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0799 0.3225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0132 0.057
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0607 0.0977
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Mycobacterium tuberculosis Conserved protein 0.0036 0.0607 0.0977
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Toxoplasma gondii ABC1 family protein 0.0036 0.0607 0.0911
Brugia malayi beta-lactamase family protein 0.0036 0.0607 0.2069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0594 0.2675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0607 0.2501
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Loa Loa (eye worm) hypothetical protein 0.0036 0.0607 0.2501
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0607 0.2295
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0532 0.2192
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0799 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0607 0.2295
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.22 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2426 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0799 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0607 0.2735
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0799 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0517 0.2131
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0134 0.1497
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.005 0.5
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0008
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0134 0.0007
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0799 0.3225
Toxoplasma gondii protein kinase, putative 0.03 0.6589 1
Brugia malayi MH2 domain containing protein 0.0116 0.2426 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Giardia lamblia GTOR 0.0044 0.0799 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0636 0.7564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0389 0.1743
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0332 0.0201
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0134 0.0551
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0029
Mycobacterium leprae Probable lipase LipE 0.0036 0.0607 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.22 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0594 0.2675
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0134 0.5
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0799 1
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0541 0.6136
Leishmania major hypothetical protein, conserved 0.0015 0.0134 0.0024
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0332 0.2985
Loa Loa (eye worm) hypothetical protein 0.0032 0.0517 0.2131
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0132 0.057
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0607 0.2735
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0517 0.1861
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0251 0.0243
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0541 0.2436
Schistosoma mansoni glucose transport protein 0.0106 0.22 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0532 0.0798
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0134 0.0024
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0532 0.0798
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0607 0.2501
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0134 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0607 0.2735
Plasmodium vivax hexose transporter 0.0106 0.22 0.2094
Leishmania major hypothetical protein, conserved 0.0036 0.0607 0.7118
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0266 0.1181
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0532 0.0404
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.1933
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0134 0.0577
Mycobacterium ulcerans beta-lactamase 0.0036 0.0607 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0532 0.1933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0336 0.1503
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.1933
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0541 0.2436
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0336 0.1503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0594 0.2675
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0542 0.2439
Toxoplasma gondii sugar transporter ST2 0.0015 0.0134 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0541 0.2436
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0594 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0594 0.2675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0132 0.057
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0532 0.0404
Loa Loa (eye worm) beta-lactamase 0.0036 0.0607 0.2501
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0517 0.7473
Loa Loa (eye worm) hypothetical protein 0.0026 0.0382 0.1573
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0332 0.0201
Leishmania major glucose transporter, lmgt2 0.0033 0.0541 0.6136
Schistosoma mansoni protein kinase 0.0033 0.0532 0.1933
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0607 0.0479
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0532 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0203 0.1067
Mycobacterium tuberculosis Conserved protein 0.0036 0.0607 0.0977
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.22 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0607 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0577
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0799 0.3293
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0607 0.2735
Loa Loa (eye worm) sugar transporter 0.0015 0.0134 0.0551
Schistosoma mansoni protein kinase 0.0033 0.0532 0.1933
Brugia malayi Sugar transporter family protein 0.0015 0.0134 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Loa Loa (eye worm) hypothetical protein 0.0036 0.0607 0.2501
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0134 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0337 0.1506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0447 0.2006
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0532 0.2192
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Brugia malayi major facilitator superfamily protein 0.0015 0.0134 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0541 0.2436
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0799 0.3611
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0332 0.0968
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0134 0.1497
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Brugia malayi hypothetical protein 0.0015 0.0134 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0395 0.177
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0517 0.5761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0799 0.3611
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.1933
Brugia malayi beta-lactamase family protein 0.0036 0.0607 0.2069
Onchocerca volvulus 0.0036 0.0607 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0395 0.177
Entamoeba histolytica protein kinase, putative 0.0033 0.0532 0.4277
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0541 0.6136
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0607 0.0977
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0332 0.0968
Leishmania major protein kinase, putative 0.0033 0.0532 0.5995
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.1933
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0332 0.0968
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0636 0.7564
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0517 0.1678
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0636 0.7564
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0134 0.0577
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0532 0.0404
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0799 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.22 1
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0134 0.0024
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0332 0.3002
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0636 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0636 0.051
Brugia malayi major facilitator superfamily protein 0.0015 0.0134 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0542 0.2439
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0134 0.0008
Schistosoma mansoni protein kinase 0.0033 0.0532 0.1933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0337 0.1506
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0607 0.2501
Mycobacterium ulcerans sugar transporter 0.0015 0.0134 0.1497
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0541 0.6136
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0134 0.0551
Loa Loa (eye worm) sugar transporter 0.0106 0.22 0.9069
Schistosoma mansoni glucose transporter 0.0015 0.0134 0.0008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0332 0.137
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0607 0.0977
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0799 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0636 0.7564
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.4978 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0607 0.0977
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0542 0.2439
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0008
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0799 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0607 0.7118
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0532 0.0404
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0532 0.5995
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0332 0.0873
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0799 0.3611
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0541 0.2436
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0607 0.2069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0799 0.2907
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0542 0.2439
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0532 0.2192
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0517 0.1678
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2426 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0532 0.1743
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Brugia malayi Cam kinase protein 1 0.0033 0.0532 0.1743
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.22 1
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0008
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0517 0.1861
Onchocerca volvulus 0.0036 0.0607 1
Echinococcus multilocularis General substrate transporter 0.0091 0.1862 0.8365
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3681 0.3595
Loa Loa (eye worm) hypothetical protein 0.0036 0.0607 0.2501
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0332 0.3002
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0541 0.6136
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0332 0.1483
Schistosoma mansoni glucose transport protein 0.0106 0.22 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0332 0.2276
Entamoeba histolytica protein kinase, putative 0.0033 0.0532 0.4277
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.1933
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0542 0.0813
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Mycobacterium ulcerans hypothetical protein 0.0036 0.0607 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0134 0.0008
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0092 0.0378
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trypanosoma brucei sugar transporter, putative 0.0015 0.0134 0.0024
Plasmodium falciparum protein kinase 7 0.03 0.6589 0.6542
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Onchocerca volvulus 0.0036 0.0607 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0132 0.057
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0541 0.6136
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0517 0.1861
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0799 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.22 0.3332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0542 0.2439
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0607 0.0977
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0517 0.2325
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0134 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0132 0.057
Echinococcus multilocularis solute carrier family 22 0.0015 0.0134 0.0008
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0332 0.5067
Schistosoma mansoni hypothetical protein 0.0106 0.22 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0607 0.7118
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0517 0.3957
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0594 0.6934
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0607 0.0977
Mycobacterium tuberculosis Conserved protein 0.0036 0.0607 0.0977
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0134 0.0007
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0532 0.1933
Brugia malayi beta-lactamase 0.0036 0.0607 0.2069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0336 0.1503
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0541 0.2436
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0607 0.2735
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0486 0.1713
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0337 0.1506
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0541 0.2436
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0607 0.0977
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0008
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0251 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0469 0.2105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0542 0.2439
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0532 0.2393
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0652 0.2942
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0541 0.6136
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0636 0.0956
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0517 0.1861
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0607 0.2295
Leishmania major glucose transporter, lmgt1 0.0033 0.0541 0.6136
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0134 0.0192
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0486 0.1713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0594 0.2675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0542 0.2439
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Schistosoma mansoni glucose transport protein 0.0106 0.22 1
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0008
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0134 0.1497
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0134 0.0008
Echinococcus granulosus solute carrier family 22 0.0015 0.0134 0.0008
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0332 0.3002
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.22 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0607 0.2295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0395 0.177
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0134 0.0024
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.22 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0212 0.1204
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0332 0.0968
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0332 0.0494
Echinococcus granulosus General substrate transporter 0.0091 0.1862 0.8365
Plasmodium vivax CDK-related protein kinase 6, putative 0.0451 1 1
Trypanosoma brucei glucose transporter 2A 0.0033 0.0541 0.6136
Schistosoma mansoni sugar transporter 0.0015 0.0134 0.0008
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0541 0.6136
Toxoplasma gondii sugar transporter ST1 0.0015 0.0134 0.0192
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.22 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Trypanosoma brucei glucose transporter, putative 0.0033 0.0541 0.6136
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0134 0.0577
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0607 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0065 0.0263
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0607 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0607 0.7118
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0134 0.0008
Trichomonas vaginalis esterase, putative 0.0036 0.0607 0.2735
Loa Loa (eye worm) hypothetical protein 0.0015 0.0134 0.0551
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3681 0.5582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0337 0.1506
Trypanosoma cruzi hexose transporter 0.0033 0.0541 0.6136
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.027 0.207
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0332 0.5067
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0532 0.0404
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0532 0.0798
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0134 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0389 0.1743

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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