Detailed information for compound 546606

Basic information

Technical information
  • TDR Targets ID: 546606
  • Name: hydroxymethanesulfinic acid
  • MW: 96.1057 | Formula: CH4O3S
  • H donors: 2 H acceptors: 3 LogP: -1.19 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCS(=O)O
  • InChi: 1S/CH4O3S/c2-1-5(3)4/h2H,1H2,(H,3,4)
  • InChiKey: SBGKURINHGJRFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • formaldehydesulfoxylate
  • NCIOpen2_000709
  • EINECS 201-189-4
  • Hydroxymethanesulfinic acid, monosodium salt
  • Hydroxymethanesulphinic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.0761 1 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0146 0.0151
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0027 0.0195 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0045 0.0441 0.0694
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0195 0.0739
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0621 0.0621
Mycobacterium ulcerans putative regultory protein 0.0027 0.0195 1
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0195 1
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0186 0.0293
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0503 0.0503
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0503 0.0503
Loa Loa (eye worm) hypothetical protein 0.0032 0.0258 0.0258
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0186 0.0319
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0215 0.0442
Schistosoma mansoni hypothetical protein 0.034 0.4379 0.6902
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0195 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0195 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0186 0.0186
Plasmodium falciparum heat shock protein 90 0.0027 0.0195 0.5705
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0195 0.5705
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0195
Entamoeba histolytica hypothetical protein 0.0036 0.0316 0.2429
Echinococcus granulosus heat shock protein 90 0.0027 0.0195 0.0195
Onchocerca volvulus Alhambra homolog 0.0029 0.0215 0.0815
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0184 0.2295 0.2295
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0195 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0258 0.0238
Giardia lamblia PHD finger protein 15 0.0029 0.0215 0.1086
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0195 1
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0195 0.5
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0195 0.0195
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1071 0.4063
Brugia malayi RNA, U transporter 1 0.0091 0.1044 0.1044
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0186 0.0186
Schistosoma mansoni hypothetical protein 0.0181 0.2246 0.354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.3731 0.588
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0195 0.5705
Schistosoma mansoni kinase 0.0047 0.0462 0.0728
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0463 0.0463
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0195 0.0358
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1438 0.1438
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0173 0.0173
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0195 0.5705
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0195 0.0136
Echinococcus granulosus expressed conserved protein 0.0103 0.1213 0.1213
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1084 0.1084
Schistosoma mansoni patched 1 0.0047 0.0463 0.073
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Giardia lamblia Pms1-like protein 0.0027 0.0195 0.088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0292 0.3731 0.3731
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0195 0.0358
Echinococcus granulosus snurportin 1 0.034 0.4379 0.4379
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0487 0.6345 0.6345
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0186 0.0293
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0195 0.0195
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0316 0.0316
Onchocerca volvulus 0.021 0.2635 1
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1071 0.4063
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0195 0.0739
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0195 0.5705
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0291 0.0291
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0195 0.0195
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0195 0.0136
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0195 0.0136
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0146 0.0146
Brugia malayi jmjC domain containing protein 0.0094 0.1084 0.1084
Entamoeba histolytica Ran family GTPase 0.0023 0.0146 0.1121
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0195 0.0136
Brugia malayi PHD-finger family protein 0.0029 0.0215 0.0215
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0027 0.0195 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0027 0.0195 0.5
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1438 0.1438
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0195 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1071 0.4063
Brugia malayi Niemann-Pick C1 protein precursor 0.011 0.1302 0.1302
Loa Loa (eye worm) hypothetical protein 0.0761 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.046 0.5983 0.9429
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0445 0.169
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0195 0.0136
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0292 0.3731 0.3731
Leishmania major DNA topoisomerase ii 0.0027 0.0195 0.0136
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0045 0.0045
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1071 0.1071
Schistosoma mansoni ap endonuclease 0.0021 0.011 0.0174
Schistosoma mansoni importin beta-1 0.0032 0.0258 0.0407
Echinococcus multilocularis heat shock protein 0.0027 0.0195 0.0195
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.011 0.0419
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0292 0.3731 0.3731
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0258 0.0627
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0146 0.2408
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0146 0.0057
Leishmania major importin beta-1 subunit, putative 0.0026 0.0178 0.0108
Schistosoma mansoni ran 0.0023 0.0146 0.023
Leishmania major hypothetical protein, conserved 0.0027 0.0195 0.0136
Schistosoma mansoni hypothetical protein 0.0034 0.0291 0.0458
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0292 0.3731 0.3731
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0195 0.0358
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0178 0.0675
Brugia malayi Importin beta-1 subunit 0.0032 0.0258 0.0258
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.1325 0.2088
Loa Loa (eye worm) hypothetical protein 0.0058 0.0605 0.0605
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1071 0.1687
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0195 0.0136
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0146 0.0146
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0197 0.2472 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0215 0.0215
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0295 0.0295
Onchocerca volvulus 0.0151 0.1844 0.6999
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0186 0.0293
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0045
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0195 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1071 0.1071
Echinococcus multilocularis protein dispatched 1 0.0054 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.011 0.1302 0.1302
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0195 0.0136
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0027 0.0195 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0463 0.0463
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.007
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0215 0.7043
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.011 0.011
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0827 0.1303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0186 0.0186
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0195 0.0739
Entamoeba histolytica hypothetical protein 0.0036 0.0316 0.2429
Loa Loa (eye worm) hypothetical protein 0.005 0.0503 0.0503
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.011 0.0847
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.017 0.2109 0.3206
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0195 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1071 0.1071
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0316 0.0316
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0215 0.0215
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0195 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.011 0.011
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0195 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0295 0.0465
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.3731 0.588
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1071 0.4063
Schistosoma mansoni hypothetical protein 0.0045 0.0441 0.0694
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0195 0.0195
Schistosoma mansoni hypothetical protein 0.0045 0.0441 0.0694
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.011 0.011
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0463 0.0463
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0195 0.5705
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0503 0.0503
Schistosoma mansoni heat shock protein 0.0027 0.0195 0.0307
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0195 0.0136
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1071 0.4063
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0146 0.0371
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0215 0.0215
Brugia malayi Endoplasmin precursor 0.0027 0.0195 0.0195
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Echinococcus multilocularis peregrin 0.0029 0.0215 0.0215
Plasmodium vivax importin-beta 2, putative 0.0032 0.0258 1
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.007
Trypanosoma brucei developmentally regulated phosphoprotein 0.0487 0.6345 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.0487 0.6345 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0195 0.0739
Echinococcus multilocularis expressed conserved protein 0.0103 0.1213 0.1213
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1071 0.1071
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0195 1
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0258 0.0258
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0195 0.0136
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0195 0.0136
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.011 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0186 0.0293
Loa Loa (eye worm) endoplasmin 0.0027 0.0195 0.0195
Brugia malayi Pre-SET motif family protein 0.0026 0.0186 0.0186
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0195 0.0136
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0195 0.5705
Echinococcus granulosus GPCR family 2 0.0016 0.0045 0.0045
Brugia malayi hypothetical protein 0.0151 0.1844 0.1844
Echinococcus multilocularis GPCR, family 2 0.0016 0.0045 0.0045
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0195 0.0739
Loa Loa (eye worm) hypothetical protein 0.0047 0.0463 0.0463
Plasmodium falciparum endoplasmin, putative 0.0027 0.0195 0.5705
Loa Loa (eye worm) hypothetical protein 0.0034 0.0291 0.0291
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0146 0.0146
Echinococcus multilocularis snurportin 1 0.034 0.4379 0.4379
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0295 0.0465
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0195 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0295 0.0295
Schistosoma mansoni hypothetical protein 0.0029 0.0215 0.0338
Loa Loa (eye worm) hypothetical protein 0.0029 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0049 0.0488 0.0488
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0364 0.0364
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0316 0.0499
Trichomonas vaginalis sensor histidine kinase, putative 0.0027 0.0195 0.0739
Echinococcus multilocularis muscleblind protein 1 0.0761 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0195 0.0136
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0195 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1071 0.154
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0195 0.0136
Schistosoma mansoni hypothetical protein 0.0036 0.0316 0.0499
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0045 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1071 0.4063
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Echinococcus multilocularis geminin 0.0181 0.2246 0.2246
Echinococcus granulosus peregrin 0.0029 0.0215 0.0215
Brugia malayi hypothetical protein 0.0036 0.0316 0.0316
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0195 0.0136
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0027 0.0195 1
Leishmania major GTP-binding protein, putative 0.0023 0.0146 0.0057
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0146 0.0057
Brugia malayi Pre-SET motif family protein 0.0184 0.2295 0.2295
Echinococcus granulosus Niemann Pick C1 protein 0.0157 0.1933 0.1933
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0027 0.0195 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1071 0.8221
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0027 0.0195 1
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0487 0.6345 0.6345
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0195 0.0195
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0027 0.0195 0.0739
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0487 0.6345 0.6345
Plasmodium vivax endoplasmin, putative 0.0027 0.0195 0.5705
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0195 0.088
Schistosoma mansoni ran 0.0023 0.0146 0.023
Echinococcus granulosus heat shock protein 0.0027 0.0195 0.0195
Echinococcus multilocularis Niemann Pick C1 protein 0.011 0.1302 0.1302
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.011 0.011
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0195 0.1496
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.017 0.2109 0.3206
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0195 1
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0463 0.0463
Schistosoma mansoni hypothetical protein 0.0181 0.2246 0.354
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0195 1
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0195 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1071 0.4063
Brugia malayi jmjC domain containing protein 0.0035 0.0295 0.0295
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0258 0.0238
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1084 0.1084
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0195 1
Plasmodium vivax SET domain protein, putative 0.0026 0.0186 0.5089
Echinococcus multilocularis muscleblind protein 0.0761 1 1
Loa Loa (eye worm) hypothetical protein 0.0487 0.6345 0.6345
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0178 0.0108
Mycobacterium leprae Probable two-component sensor kinase 0.0027 0.0195 0.5
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0195 1
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Trichomonas vaginalis DNA topoisomerase II, putative 0.0027 0.0195 0.0739
Trichomonas vaginalis ran, putative 0.0023 0.0146 0.0554
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0292 0.3731 0.3731
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0295 0.0295
Brugia malayi MH2 domain containing protein 0.012 0.1438 0.1438
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0445 0.169
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0045 0.0045
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0146 0.2408
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0195 1
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0195 0.1496
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1071 0.154
Schistosoma mansoni endoplasmin 0.0027 0.0195 0.0307
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0178 0.0675
Schistosoma mansoni pyruvate dehydrogenase 0.046 0.5983 0.9429
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0195 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0195 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0195 1
Brugia malayi heat shock protein 90 0.0027 0.0195 0.0195
Plasmodium falciparum phd finger protein, putative 0.0029 0.0215 0.7043
Mycobacterium tuberculosis Conserved protein 0.0027 0.0195 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.011 0.1302 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0045 0.0045
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0195 0.0739
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.017 0.2109 0.8466
Mycobacterium leprae Probable two component sensor kinase MprB 0.0027 0.0195 0.5
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.017 0.2109 0.3206
Brugia malayi CHE-14 protein 0.0047 0.0463 0.0463
Entamoeba histolytica hypothetical protein 0.0036 0.0316 0.2429
Echinococcus multilocularis protein patched 0.0047 0.0463 0.0463
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1071 0.4063
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0151 0.1844 0.1844
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0195 0.0739
Brugia malayi Bromodomain containing protein 0.0029 0.0215 0.0215
Echinococcus granulosus geminin 0.0181 0.2246 0.2246
Onchocerca volvulus 0.0026 0.0186 0.0705
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0195 1
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Echinococcus granulosus importin subunit beta 1 0.0032 0.0258 0.0258
Schistosoma mansoni ap endonuclease 0.0021 0.011 0.0174
Trichomonas vaginalis set domain proteins, putative 0.021 0.2635 1
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0195 0.0136
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0195 0.0358
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0027 0.0195 0.0739
Schistosoma mansoni hypothetical protein 0.0045 0.0441 0.0694
Echinococcus granulosus jumonji domain containing protein 0.004 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0761 1 1
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0195 0.0136
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0195 0.0739
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0195 1
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0195 0.0358
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1071 0.154
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0195 0.5
Entamoeba histolytica hypothetical protein 0.0026 0.0178 0.1366
Echinococcus granulosus Niemann Pick C1 protein 0.011 0.1302 0.1302
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0146 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0463 0.1758
Brugia malayi kinase, mitochondrial precursor 0.0487 0.6345 0.6345
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0195 0.0195
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0195 0.0307
Leishmania major heat shock protein 83-1 0.0027 0.0195 0.0136
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0195 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.034 0.4379 0.4379
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0195 0.0739
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0195 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0292 0.3731 0.588
Giardia lamblia Kinase, PLK 0.0093 0.1071 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0487 0.6345 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0146 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0292 0.3731 0.3731
Entamoeba histolytica DNA topoisomerase II, putative 0.0027 0.0195 0.1496
Schistosoma mansoni heat shock protein 0.0027 0.0195 0.0307
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0215 0.0338
Trypanosoma brucei heat shock protein, putative 0.0027 0.0195 0.0136
Plasmodium falciparum importin beta, putative 0.0032 0.0258 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0195 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0157 0.1933 0.1933
Echinococcus multilocularis heat shock protein 90 0.0027 0.0195 0.0195
Entamoeba histolytica hypothetical protein 0.0036 0.0316 0.2429
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0195 0.0195
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0215 0.0442
Trypanosoma brucei polo-like protein kinase 0.0093 0.1071 0.154
Schistosoma mansoni pyruvate dehydrogenase 0.0487 0.6345 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0195 0.0195
Schistosoma mansoni endoplasmin 0.0027 0.0195 0.0307
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0027 0.0195 0.0739
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0195 0.5705
Schistosoma mansoni hypothetical protein 0.0016 0.0045 0.007
Trichomonas vaginalis endoplasmin, putative 0.0027 0.0195 0.0739
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0178 0.0675

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

61 literature references were collected for this gene.

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