Detailed information for compound 551221

Basic information

Technical information
  • TDR Targets ID: 551221
  • Name: 1-(benzotriazol-1-yl)ethanone
  • MW: 161.161 | Formula: C8H7N3O
  • H donors: 0 H acceptors: 3 LogP: 1 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)n1nnc2c1cccc2
  • InChi: 1S/C8H7N3O/c1-6(12)11-8-5-3-2-4-7(8)9-10-11/h2-5H,1H3
  • InChiKey: NIIUIBKEGRPPDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1-benzotriazolyl)ethanone
  • N-acetylbenzotriazole
  • 18773-93-8
  • 1H-Benzotriazole, 1-acetyl-
  • 1-acetyl-1H-1,2,3-benzotriazole
  • 1H-1,2,3-benzotriazole, 1-acetyl-
  • InChI=1/C8H7N3O/c1-6(12)11-8-5-3-2-4-7(8)9-10-11/h2-5H,1H
  • NCGC00165409-01
  • UPCMLD00WGW009:001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0333 0.8052
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0414 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0414 0.5789
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis General substrate transporter 0.0087 0.193 0.851
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 0.8052
Onchocerca volvulus 0.0014 0.0217 0.5
Schistosoma mansoni glucose transport protein 0.0102 0.2266 1
Brugia malayi Cam kinase protein 1 0.0031 0.0611 0.2648
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3734 0.3724
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0016 0.0262
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Entamoeba histolytica protein kinase, putative 0.0031 0.0611 1
Toxoplasma gondii protein kinase, putative 0.0287 0.6617 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0217 0.0894
Giardia lamblia Hexose transporter 0.0014 0.0217 0.346
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 0.9989
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0611 0.2648
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3734 0.5643
Toxoplasma gondii sugar transporter ST2 0.0014 0.0217 0.0327
Loa Loa (eye worm) hypothetical protein 0.0031 0.0611 0.2648
Trypanosoma brucei glucose transporter 1E 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0414 0.0399
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0894
Entamoeba histolytica protein kinase, putative 0.0031 0.0611 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0597 0.2583
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0217 0.0894
Schistosoma mansoni glucose transport protein 0.0102 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0023 0.0414 0.1769
Leishmania major glucose transporter, lmgt3 0.0032 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Trypanosoma brucei glucose transporter 2A 0.0032 0.0621 0.868
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0414 0.1769
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0016 0.0377
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0414 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0414 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0597 0.2583
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0715 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Toxoplasma gondii sugar transporter ST1 0.0014 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0217 0.0894
Leishmania major glucose transporter, lmgt2 0.0032 0.0621 0.868
Echinococcus granulosus General substrate transporter 0.0087 0.193 0.851
Loa Loa (eye worm) sugar transporter 0.0014 0.0217 0.0894
Plasmodium vivax CDK-related protein kinase 6, putative 0.0431 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0715 1
Mycobacterium ulcerans sugar transporter 0.0014 0.0217 0.5234
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0894
Brugia malayi Sugar transporter family protein 0.0102 0.2266 1
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0217 0.303
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0414 0.0399
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0611 0.855
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0217 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0414 0.1828
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3734 0.3724
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.5
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0217 0.5047
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Onchocerca volvulus 0.0014 0.0217 0.5
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Schistosoma mansoni protein kinase 0.0031 0.0611 0.2648
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0611 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0597 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0217 0.5234
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.2583
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0025 0.0463 0.1987
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0612 0.0597
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0414 0.1771
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0715 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0597 1
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0217 0.0894
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0715 0.1081
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Schistosoma mansoni ap endonuclease 0.0023 0.0414 0.1771
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Onchocerca volvulus 0.0014 0.0217 0.5
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0134 0.3239
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0414 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0217 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0621 0.274
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0611 0.2648
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0414 0.6932
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0612 0.0597
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0566 0.2448
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2266 0.3424
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0597 0.2583
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Toxoplasma gondii sugar transporter ST3 0.0014 0.0217 0.0327
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0715 0.0701
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0414 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2266 1
Schistosoma mansoni glucose transport protein 0.0102 0.2266 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Onchocerca volvulus 0.0014 0.0217 0.5
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0621 0.274
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0621 0.868
Plasmodium falciparum protein kinase 7 0.0287 0.6617 0.6612
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2266 1
Schistosoma mansoni hypothetical protein 0.0102 0.2266 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0612 0.0597
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0612 0.0597
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0333 0.5587
Schistosoma mansoni sugar transporter 0.0014 0.0217 0.0894
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0016 0.0377
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0597 0.9752
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0414 0.1769
Brugia malayi major facilitator superfamily protein 0.0014 0.0217 0.0894
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0217 0.5234
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0286 0.3994
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0414 0.0625
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0217 0.303
Loa Loa (eye worm) hypothetical protein 0.0031 0.0597 0.2583
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0217 0.5234
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0414 0.1771
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0597 0.2583
Leishmania major glucose transporter, lmgt1 0.0032 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0175 0.0709
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0016 0.0024
Plasmodium vivax hexose transporter 0.0102 0.2266 0.2253
Plasmodium falciparum hexose transporter 0.0102 0.2266 0.2253
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0414 0.5789
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0414 0.6849
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0566 0.2448
Brugia malayi Sugar transporter family protein 0.0014 0.0217 0.0894
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0217 0.5234
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Onchocerca volvulus 0.0014 0.0217 0.5
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0612 0.0925
Trypanosoma cruzi hexose transporter 0.0032 0.0621 0.868
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0612 0.0597
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0612 0.0925
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0612 0.0597
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Leishmania major protein kinase, putative 0.0031 0.0611 0.855
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0612 0.0597
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0414 0.9989
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0715 1
Plasmodium vivax sugar transporter, putative 0.0014 0.0217 0.0201
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0134 0.2974
Onchocerca volvulus Putative transporter 0.0014 0.0217 0.5
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0217 0.303
Toxoplasma gondii exonuclease III APE 0.0023 0.0414 0.0626
Loa Loa (eye worm) sugar transporter 0.0102 0.2266 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0597 0.2634
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0612 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0611 0.2699
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Entamoeba histolytica hypothetical protein 0.0023 0.0414 0.6679
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Giardia lamblia Sugar-proton symporter 0.0014 0.0217 0.346
Brugia malayi hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0414 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0621 0.868
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0414 0.6857
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0414 0.6687
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Echinococcus granulosus solute carrier family 22 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0217 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0621 0.274
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0134 0.2978
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0414 0.1826
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0621 0.274
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0217 0.5234
Schistosoma mansoni protein kinase 0.0031 0.0611 0.2648
Leishmania major hypothetical protein, conserved 0.0014 0.0217 0.303
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0414 0.1771
Schistosoma mansoni ap endonuclease 0.0023 0.0414 0.1771
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0621 0.274
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0414 0.0399
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0621 0.868
Echinococcus multilocularis solute carrier family 22 0.0014 0.0217 0.0894
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0414 0.5783
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0414 0.5789
Onchocerca volvulus 0.0014 0.0217 0.5
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0016 0.0377
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0414 0.1828
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0414 0.5789
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0217 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0611 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0348 0.1536
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0032 0.0621 0.868
Trypanosoma brucei sugar transporter, putative 0.0014 0.0217 0.303
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Schistosoma mansoni glucose transporter 0.0014 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0597 0.2583
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0016 0.0218
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0612 0.0925
Onchocerca volvulus 0.0014 0.0217 0.5
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0414 0.1769
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0414 0.1771
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0014 0.0217 0.0894
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0597 0.2583
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2266 1
Schistosoma mansoni protein kinase 0.0031 0.0611 0.2648
Onchocerca volvulus 0.0014 0.0217 0.5
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0217 0.303

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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