Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0015 | 0.0336 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0015 | 0.0336 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0172 | 0.9149 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0015 | 0.0336 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0015 | 0.0336 | 0.0367 |
Mycobacterium ulcerans | hypothetical protein | 0.0015 | 0.0336 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0015 | 0.0336 | 0.0367 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0015 | 0.0336 | 0.0367 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0015 | 0.0336 | 0.0367 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0015 | 0.0336 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0015 | 0.0336 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0015 | 0.0336 | 0.0367 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0172 | 0.9149 | 0.9119 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0015 | 0.0336 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0336 | 0.0367 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0187 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0172 | 0.9149 | 0.9119 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0015 | 0.0336 | 0.5 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0015 | 0.0336 | 0.5 |
Onchocerca volvulus | 0.0187 | 1 | 1 | |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0015 | 0.0336 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0015 | 0.0336 | 0.0367 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0015 | 0.0336 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0187 | 1 | 1 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0015 | 0.0336 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0015 | 0.0336 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.0336 | 0.0336 | |
Onchocerca volvulus | 0.0187 | 1 | 1 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0172 | 0.9149 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.0187 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0172 | 0.9149 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0015 | 0.0336 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.0172 | 0.9149 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0015 | 0.0336 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0015 | 0.0336 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0015 | 0.0336 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.8185 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.4864 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.7421 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 24.6338 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.6379 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 61.8773 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.