Detailed information for compound 555986

Basic information

Technical information
  • TDR Targets ID: 555986
  • Name: (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(hydrox ymethyl)-4-methyl-tetrahydrofuran-3-ol
  • MW: 265.269 | Formula: C11H15N5O3
  • H donors: 3 H acceptors: 5 LogP: -1.04 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1C)O)n1cnc2c1ncnc2N
  • InChi: 1S/C11H15N5O3/c1-5-6(2-17)19-11(8(5)18)16-4-15-7-9(12)13-3-14-10(7)16/h3-6,8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,6-,8-,11-/m1/s1
  • InChiKey: IUICAGSHIJKNDR-HUKYDQBMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-methyl-3-tetrahydrofuranol
  • (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-methyl-oxolan-3-ol
  • (2R,3R,4S,5S)-2-adenin-9-yl-4-methyl-5-methylol-tetrahydrofuran-3-ol
  • (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-methyloxolan-3-ol
  • 3-methyl-3'-deoxyadenosine
  • (2R,3R,4S,5S)-2-(6-amino-9-purinyl)-5-(hydroxymethyl)-4-methyl-3-tetrahydrofuranol
  • (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-4-methyl-5-methylol-tetrahydrofuran-3-ol
  • 41094-06-8
  • 3-Methyldeoxyadenosine
  • Adenosine, 3'-deoxy-3'-methyl-
  • NSC 127970
  • 3'-Deoxy-3-methyladenosine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0373 0.088
Echinococcus granulosus microtubule associated protein 2 0.0704 0.4198 0.6359
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0289 1
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0018 0.0034
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0015 0.0527
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0037 0.0223
Brugia malayi hypothetical protein 0.002 0.0014 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0039 0.0739
Leishmania major UDP-galactopyranose mutase 0.0021 0.0015 0.0236
Schistosoma mansoni hypothetical protein 0.0035 0.0103 0.0237
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0103 0.035
Loa Loa (eye worm) hypothetical protein 0.0112 0.0574 0.2024
Brugia malayi CHE-14 protein 0.0043 0.0153 0.0526
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.1677 1
Brugia malayi SWIRM domain containing protein 0.0021 0.0015 0.004
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.002 0.0014 0.0485
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.002 0.0692
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0285 0.067
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0479 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0479 1
Schistosoma mansoni hypothetical protein 0.0042 0.0144 0.0333
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.002 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.03
Brugia malayi MH2 domain containing protein 0.0122 0.0635 0.2226
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0103 0.0364
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.002 0.0014 0.0485
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.1307
Onchocerca volvulus 0.0032 0.0085 0.1491
Loa Loa (eye worm) hypothetical protein 0.0053 0.0213 0.0749
Plasmodium vivax thrombospondin-related anonymous protein 0.002 0.0014 0.0485
Schistosoma mansoni hypothetical protein 0.0035 0.0103 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Schistosoma mansoni hypothetical protein 0.0065 0.0289 0.0679
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0037 0.0118
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0504 1
Entamoeba histolytica hypothetical protein 0.008 0.0376 0.7447
Giardia lamblia PHD finger protein 15 0.0065 0.0289 0.5997
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0014 0.02
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0285 0.1004
Brugia malayi jmjC domain containing protein 0.0021 0.0018 0.0051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0079 0.0373 0.088
Echinococcus multilocularis protein dispatched 1 0.0049 0.019 0.0187
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0214 0.1198 0.181
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0018 0.0065
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0478 0.2817 0.6707
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0004 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0479 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0565 0.1981
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0285 0.0991
Echinococcus granulosus phd:f box containing protein 0.0021 0.0018 0.0022
Schistosoma mansoni hypothetical protein 0.008 0.0376 0.0888
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0376 0.0565
Plasmodium falciparum phd finger protein, putative 0.0065 0.0289 1
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.002 0.0014 0.0049
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0018 0.0034
Treponema pallidum 76K protein 0.002 0.0014 0.5
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0479 0.1677
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0015 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0351 0.1226
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0139 0.2841
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0138
Loa Loa (eye worm) hypothetical protein 0.0075 0.0351 0.1238
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0024
Schistosoma mansoni hypothetical protein 0.0098 0.0491 0.116
Echinococcus granulosus lysine specific demethylase 5A 0.0079 0.0373 0.0559
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0018 0.0014
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.002 0.0014 0.021
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0289 1
Brugia malayi hypothetical protein 0.0024 0.0039 0.0124
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Treponema pallidum hypothetical protein 0.002 0.0014 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0015 0.0098
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0018 0.0014
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0037 0.0223
Echinococcus granulosus GPCR family 2 0.0035 0.0103 0.015
Echinococcus granulosus collagen alpha 1VII chain 0.002 0.0014 0.0015
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0037 0.0668
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0018 0.0302
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0004 0.0024
Brugia malayi jmjC domain containing protein 0.0079 0.0373 0.1302
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0037 0.0668
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0285 0.067
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.007
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Schistosoma mansoni amine oxidase 0.0021 0.0015 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0037 0.0118
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0103 0.035
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0037 0.0703
Brugia malayi PHD-finger family protein 0.0065 0.0289 0.1006
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0015 0.0045
Loa Loa (eye worm) CUTiclin-Like family member 0.002 0.0014 0.0049
Schistosoma mansoni kinase 0.0049 0.0189 0.0441
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Schistosoma mansoni serine-rich repeat protein 0.0258 0.1466 0.3485
Echinococcus multilocularis GPCR, family 2 0.0035 0.0103 0.0099
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0015 1
Mycobacterium ulcerans oxidoreductase 0.0021 0.0015 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0373 0.1315
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0139 0.2841
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0153 0.3139
Echinococcus multilocularis expressed conserved protein 0.0094 0.0467 0.0463
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0015 0.0017
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0768 0.0764
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0021 0.0018 0.0158
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0376 0.0373
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0015 0.0527
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0135 0.0715 0.2518
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0015 0.0527
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.049
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0479 1
Trypanosoma brucei polo-like protein kinase 0.0096 0.0479 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Plasmodium vivax JmjC domain containing protein 0.0021 0.0018 0.0636
Onchocerca volvulus 0.0098 0.0491 1
Schistosoma mansoni hypothetical protein 0.0042 0.0144 0.0333
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0635 0.2237
Brugia malayi PHD-finger family protein 0.0021 0.002 0.0056
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0103 0.015
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0139 0.2622
Echinococcus granulosus chromobox protein 1 0.0073 0.0335 0.0501
Brugia malayi jmjC domain containing protein 0.0021 0.0018 0.0051
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0018 0.0034
Schistosoma mansoni hypothetical protein 0.0042 0.0144 0.0333
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0039 0.0913
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0018 0.0065
Echinococcus granulosus jumonji domain containing protein 0.0091 0.0446 0.0669
Brugia malayi Zona pellucida-like domain containing protein 0.002 0.0014 0.0035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.002 0.0038
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0015 0.0527
Schistosoma mansoni microtubule-associated protein tau 0.0704 0.4198 1
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0499 0.2942 0.2939
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0181 0.3732
Echinococcus multilocularis survival motor neuron protein 1 0.0482 0.2838 0.2835
Brugia malayi von Willebrand Factor 0.002 0.0014 0.0035
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0153 0.0226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0065
Schistosoma mansoni hypothetical protein 0.0035 0.0103 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0479 0.1133
Brugia malayi TAR-binding protein 0.0065 0.0285 0.0991
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.002 0.0014 0.0485
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0565 0.1981
Onchocerca volvulus 0.0021 0.0015 0.0026
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0153 0.054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0037 0.0668
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0768 0.1158
Echinococcus multilocularis jumonji domain containing protein 0.0091 0.0446 0.0442
Loa Loa (eye worm) RNA binding protein 0.0065 0.0285 0.1004
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0214 0.1198 0.1195
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0015 0.0527
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0285 0.0281
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0054
Entamoeba histolytica hypothetical protein 0.002 0.0014 0.02
Loa Loa (eye worm) hypothetical protein 0.0221 0.1241 0.4372
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0285 0.067
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0018 0.0065
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0479 1
Plasmodium vivax hypothetical protein, conserved 0.002 0.0014 0.0485
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0004 0.0014
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0504 0.1765
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0004 0.0026
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0103 0.0099
Mycobacterium ulcerans hypothetical protein 0.0024 0.0037 0.0223
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0018 0.0034
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0004 0.0026
Brugia malayi hypothetical protein 0.0021 0.0015 0.004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0037 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0015 0.0527
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0018 0.0022
Echinococcus multilocularis chromobox protein 1 0.0073 0.0335 0.0331
Echinococcus granulosus chromobox protein 1 0.0073 0.0335 0.0501
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0021 0.0015 0.0045
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0565 0.1992
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0037 0.0118
Echinococcus multilocularis microtubule associated protein 2 0.0704 0.4198 0.4196
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0018 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0479 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0015 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0479 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0514 0.1215
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0054
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0015 0.0091
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.002 0.0218
Echinococcus granulosus expressed conserved protein 0.0094 0.0467 0.0702
Loa Loa (eye worm) hypothetical protein 0.011 0.0565 0.1992
Brugia malayi hypothetical protein 0.0482 0.2838 1
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.002 0.0014 0.0485
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0491 0.1718
Schistosoma mansoni chromobox protein 0.0073 0.0335 0.0788
Brugia malayi chromobox protein homolog 3 0.0041 0.0139 0.0476
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0335 0.118
Echinococcus multilocularis PHD finger protein rhinoceros 0.0065 0.0289 0.0285
Onchocerca volvulus Alhambra homolog 0.0065 0.0289 0.5768
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0479 0.072
Entamoeba histolytica hypothetical protein, conserved 0.002 0.0014 0.02
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0037 0.0241
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0335 0.696
Entamoeba histolytica hypothetical protein 0.008 0.0376 0.7447
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0037 0.0241
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0037 0.0703
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0479 0.9758
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1096 0.66 0.6599
Entamoeba histolytica elongation factor-2 kinase, putative 0.002 0.0014 0.02
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0054
Brugia malayi hypothetical protein 0.008 0.0376 0.1314
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.002 0.0218
Echinococcus multilocularis collagen alpha 1(VII) chain 0.002 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0132
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0015 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0037 0.0223
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.1677 1
Leishmania major hypothetical protein, conserved 0.0021 0.0018 0.0302
Echinococcus granulosus voltage dependent calcium channel subunit 0.0499 0.2942 0.4453
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0018 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0335 0.696
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0271 0.1551 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0153 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0285 0.067
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0015 0.0027
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0479 0.9501
Brugia malayi Bromodomain containing protein 0.0065 0.0289 0.1006
Toxoplasma gondii PHD-finger domain-containing protein 0.0065 0.0289 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0241 0.1365 0.3245
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.002 0.0336
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0037 0.0703
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0479 0.0475
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0479 1
Brugia malayi Zona pellucida-like domain containing protein 0.002 0.0014 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0364
Plasmodium falciparum von Willebrand factor A domain-related protein 0.002 0.0014 0.0485
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0479 0.1689
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0158 0.324
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0285 0.1004
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0065 0.0289 0.0679
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.002 0.0336
Brugia malayi RNA binding protein 0.0065 0.0285 0.0991
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0037 0.0223
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0037 0.0223
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0103 0.0099
Echinococcus multilocularis 0.0021 0.0015 0.0011
Giardia lamblia Kinase, PLK 0.0096 0.0479 1
Brugia malayi jmjC domain containing protein 0.0214 0.1198 0.4214
Onchocerca volvulus 0.0024 0.0037 0.0491
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0037 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0018 0.0302
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0015 0.0091
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0015 0.0236
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0015 0.0236
Mycobacterium ulcerans dehydrogenase 0.0021 0.0015 0.0091
Brugia malayi Heterochromatin protein 1 0.0073 0.0335 0.1167
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0103 0.015
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0015 0.0098
Entamoeba histolytica hypothetical protein 0.008 0.0376 0.7447
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0376 0.0888
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0504 0.0758
Schistosoma mansoni patched 1 0.0043 0.0153 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0066 0.1307
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0373 0.0369
Schistosoma mansoni chromobox protein 0.0073 0.0335 0.0788
Schistosoma mansoni hypothetical protein 0.0258 0.1466 0.3485
Loa Loa (eye worm) hypothetical protein 0.0482 0.2838 1
Schistosoma mansoni hypothetical protein 0.0075 0.0351 0.0828
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0039 0.0739
Echinococcus granulosus PHD finger protein rhinoceros 0.0065 0.0289 0.0432
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0039 0.1354
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Echinococcus granulosus tar DNA binding protein 0.0065 0.0285 0.0426
Brugia malayi Cache domain containing protein 0.0221 0.1241 0.4364
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0504 0.05
Loa Loa (eye worm) hypothetical protein 0.0043 0.0153 0.054
Loa Loa (eye worm) hypothetical protein 0.01 0.0504 0.1777
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0018 0.0014
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0014 0.0035
Brugia malayi AF-10 protein 0.0021 0.002 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0037 0.0223
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0018 0.0022
Loa Loa (eye worm) CUTiclin family member 0.002 0.0014 0.0049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0132
Loa Loa (eye worm) PHD-finger family protein 0.0065 0.0289 0.1018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0132
Brugia malayi jmjC domain containing protein 0.0021 0.0018 0.0051
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0479 1
Entamoeba histolytica hypothetical protein 0.008 0.0376 0.7447
Leishmania major hypothetical protein, conserved 0.0024 0.0039 0.0739
Loa Loa (eye worm) hypothetical protein 0.0065 0.0289 0.1018
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0037 0.0223
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0158 0.324
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0479 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0021 0.0018 0.0636
Schistosoma mansoni hypothetical protein 0.0035 0.0103 0.0237
Echinococcus granulosus voltage dependent calcium channel subunit 0.1096 0.66 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0039 0.1354
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0018 0.0302
Schistosoma mansoni hypothetical protein 0.0042 0.0144 0.0333
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0153 0.0226
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0015 0.0011
Schistosoma mansoni amine oxidase 0.0021 0.0015 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0285 0.067
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0158 0.302
Schistosoma mansoni jumonji domain containing protein 0.017 0.0929 0.2206
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0015 0.0527
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0021 0.0018 0.0158
Echinococcus multilocularis peregrin 0.0065 0.0289 0.0285
Schistosoma mansoni hypothetical protein 0.0021 0.002 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0039 0.0739
Echinococcus granulosus peregrin 0.0065 0.0289 0.0432
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0018 0.0022
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0015 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0039 0.1354
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0018 0.0014
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.002 0.0014 0.0035
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.002 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0181 0.3732
Plasmodium falciparum thrombospondin-related anonymous protein 0.002 0.0014 0.0485
Echinococcus multilocularis protein patched 0.0043 0.0153 0.0149
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0635 0.2237
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0049
Plasmodium vivax hypothetical protein, conserved 0.0021 0.002 0.0692
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0018 0.0034
Echinococcus granulosus survival motor neuron protein 1 0.0482 0.2838 0.4296
Schistosoma mansoni survival motor neuron protein 0.0098 0.0491 0.116
Brugia malayi jmjC domain containing protein 0.0021 0.0018 0.0051
Brugia malayi von Willebrand factor type A domain containing protein 0.002 0.0014 0.0035
Echinococcus multilocularis chromobox protein 1 0.0073 0.0335 0.0331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.