Detailed information for compound 572304

Basic information

Technical information
  • TDR Targets ID: 572304
  • Name: 6-(bromomethyl)pteridine-2,4-diamine
  • MW: 255.075 | Formula: C7H7BrN6
  • H donors: 2 H acceptors: 4 LogP: -0.28 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCc1cnc2c(n1)c(N)nc(n2)N
  • InChi: 1S/C7H7BrN6/c8-1-3-2-11-6-4(12-3)5(9)13-7(10)14-6/h2H,1H2,(H4,9,10,11,13,14)
  • InChiKey: MJRBZALCJHZGKR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-amino-6-(bromomethyl)pteridin-4-yl]amine
  • 6-bromomethyl-2,4-pteridinediamine
  • 59368-16-0
  • 2,4-Pteridinediamine, 6-(bromomethyl)-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major pteridine reductase 1 Curated by TDR Targets References
Leishmania major dihydrofolate reductase-thymidylate synthase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Echinococcus granulosus thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania donovani pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Schistosoma japonicum ko:K00560 thymidylate synthase [EC2.1.1.45], putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Leishmania donovani dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Loa Loa (eye worm) thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium hominis chain A, crystal structure of Dhfr Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma brucei pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Onchocerca volvulus Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Mycobacterium ulcerans thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127385 All targets in OG5_127385
Babesia bovis dihydrofolate reductase/thymidilate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Trypanosoma congolense pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
Echinococcus multilocularis thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Brugia malayi thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Candida albicans Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C) Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Plasmodium yoelii thymidylate synthase, putative Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania infantum dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Get druggable targets OG5_127385 All targets in OG5_127385
Leishmania major pteridine reductase 1 Get druggable targets OG5_133937 All targets in OG5_133937
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase pteridine reductase 1 288 aa 281 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0598 0.1614
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0085 0.0228
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0196 0.1079
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.0529
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.1815 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0013 0.0049
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.2617 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0093 0.0416
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0276 0.1054
Giardia lamblia PHD finger protein 15 0.0028 0.0276 0.5
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0116 0.0314
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0085 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0013 0.0049
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0085 0.0228
Plasmodium falciparum phd finger protein, putative 0.0028 0.0276 0.1054
Onchocerca volvulus 0.013 0.1815 0.7633
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0733 0.1978
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.2617 0.5953
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0529
Brugia malayi Dihydrofolate reductase 0.0053 0.0649 0.1753
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0196 1
Leishmania major pteridine reductase 1 0.0238 0.3453 0.7855
Brugia malayi hypothetical protein 0.0016 0.0086 0.0233
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0745
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2378 0.6419
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3704 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0085 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0793 0.0793
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0487 0.1107
Echinococcus granulosus thymidylate synthase 0.013 0.1815 0.1815
Schistosoma mansoni hypothetical protein 0.0164 0.234 0.234
Echinococcus granulosus dnaJ subfamily B 0.0397 0.5865 0.5865
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0648 0.2474
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.2617 0.5953
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2378 0.6419
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0053 0.0649 0.2895
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.5865 0.5865
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.2 0.4549
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1252 0.1252
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0873
Echinococcus granulosus dihydrofolate reductase 0.0053 0.0649 0.0649
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0196 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2378 0.6419
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0013 0.0047 0.021
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0276 0.0745
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0196 0.0873
Schistosoma mansoni microtubule-associated protein tau 0.0669 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.4396 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0047 0.021
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0793 0.0793
Schistosoma mansoni hypothetical protein 0.0397 0.5865 0.5865
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0873
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.0445
Brugia malayi PHD-finger family protein 0.0011 0.0011 0.003
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.3704 1
Echinococcus granulosus peregrin 0.0028 0.0276 0.0276
Brugia malayi PHD-finger family protein 0.0028 0.0276 0.0745
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.4396 1
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0444 0.0444
Onchocerca volvulus Alhambra homolog 0.0028 0.0276 0.1161
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0085 0.0085
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0793 0.2141
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0793 0.2141
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.0445
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0276 0.1054
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2378 0.6419
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0444 0.0444
Brugia malayi Bromodomain containing protein 0.0028 0.0276 0.0745
Schistosoma mansoni cpg binding protein 0.0029 0.0294 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2378 0.6419
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0108 0.048
Loa Loa (eye worm) dihydrofolate reductase 0.0053 0.0649 0.1753
Echinococcus multilocularis cpg binding protein 0.0029 0.0294 0.0294
Toxoplasma gondii hypothetical protein 0.0048 0.0581 0.2219
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Echinococcus granulosus GPCR family 2 0.0016 0.0085 0.0085
Brugia malayi hypothetical protein 0.0062 0.0783 0.2114
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.2 0.4549
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2617 1
Brugia malayi thymidylate synthase 0.013 0.1815 0.49
Echinococcus granulosus tar DNA binding protein 0.0062 0.0793 0.0793
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0013 0.0013
Trypanosoma brucei pteridine reductase 1 0.0235 0.3406 0.7748
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.0529
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0196 1
Echinococcus multilocularis thymidylate synthase 0.013 0.1815 0.1815
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0783 0.3491
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0793 0.0793
Schistosoma mansoni hypothetical protein 0.0164 0.234 0.234
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.001 0 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.2 0.4549
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0218 0.0832
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.2617 0.5953
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.2617 1
Brugia malayi jmjC domain containing protein 0.0093 0.1252 0.338
Echinococcus multilocularis microtubule associated protein 2 0.0669 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0196 0.0873
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0196 0.0873
Brugia malayi hypothetical protein 0.0024 0.0218 0.0588
Loa Loa (eye worm) hypothetical protein 0.0017 0.0108 0.0291
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0276 0.1054
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0276 0.0276
Leishmania major mitochondrial DNA polymerase beta 0.03 0.4396 1
Trypanosoma brucei oxidoreductase-like protein 0.0013 0.0047 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0783 0.2114
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0793 0.0793
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1252 0.1252
Brugia malayi CXXC zinc finger family protein 0.0028 0.027 0.0728
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0793 0.0793
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0218 0.0832
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.001 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0108 0.0291
Loa Loa (eye worm) thymidylate synthase 0.013 0.1815 0.49
Loa Loa (eye worm) hypothetical protein 0.0016 0.0085 0.0228
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0487 0.1107
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.3704 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.4396 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0487 0.1107
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0013 0.0047 0.018
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.1815 0.1815
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0085 0.0228
Loa Loa (eye worm) RNA binding protein 0.0062 0.0793 0.2141
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1603 0.4329
Onchocerca volvulus 0.0013 0.0047 0.0198
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.001 0.001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0013 0.0013
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0053 0.0649 0.2895
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0196 0.0873
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2378 0.6419
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.039 0.039
Leishmania major hypothetical protein, conserved 0.0024 0.0218 0.0496
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0218 0.0496
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0093 0.0416
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0783 0.1781
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.2243 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.039 0.039
Schistosoma mansoni dihydrofolate reductase 0.0053 0.0649 0.0649
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0196 0.0873
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0196 0.0873
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0598 0.1614
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0108 0.048
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0196 0.1079
Echinococcus granulosus geminin 0.0164 0.234 0.234
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0627 0.1425
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0218 0.0496
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0085 0.0085
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.039 0.039
Brugia malayi TAR-binding protein 0.0062 0.0793 0.2141
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0793 0.2141
Schistosoma mansoni cpg binding protein 0.0028 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0024 0.0218 0.0588
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0108 0.0411
Brugia malayi RNA binding protein 0.0062 0.0793 0.2141
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0218 0.0832
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1603 0.4329
Brugia malayi jmjC domain containing protein 0.0036 0.039 0.1054
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0093 0.0416
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0013 0.0047 0.0107
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.2378 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0529
Onchocerca volvulus 0.0028 0.027 0.1134
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3704 1
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.1815 0.809
Echinococcus granulosus cpg binding protein 0.0029 0.0294 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2514 0.6787
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3704 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0582 0.1572
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0487 0.1107
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0276 0.0276
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.2378 0.6419
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0366 0.0366
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0047 0.021
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0963 0.0963
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Chlamydia trachomatis dihydrofolate reductase 0.0053 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0108 0.0291
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3704 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0598 0.1614
Brugia malayi dihydrofolate reductase family protein 0.0053 0.0649 0.1753
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0108 0.1657
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0218 0.0496
Loa Loa (eye worm) hypothetical protein 0.0034 0.036 0.0973
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0093 0.0416
Leishmania major oxidoreductase-like protein 0.0013 0.0047 0.0107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0196 0.0529
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0108 0.0411
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0013 0.0047 0.021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0108 0.0291
Brugia malayi MH2 domain containing protein 0.0116 0.1603 0.4329
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0793 0.0793
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.039 0.1054
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3704 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.027 0.0728
Onchocerca volvulus 0.0023 0.0196 0.0824
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0276 0.0276
Schistosoma mansoni cpg binding protein 0.0029 0.0294 0.0294
Schistosoma mansoni hypothetical protein 0.0016 0.0085 0.0085
Echinococcus multilocularis GPCR, family 2 0.0016 0.0085 0.0085
Echinococcus multilocularis dihydrofolate reductase 0.0053 0.0649 0.0649
Mycobacterium ulcerans thymidylate synthase 0.013 0.1815 0.809
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0047 0.021
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0196 0.0529
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2514 0.6787
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0743 0.0743
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0196 0.0445
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0196 0.0873
Echinococcus multilocularis geminin 0.0164 0.234 0.234
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0218 0.0832
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.036 0.0973
Echinococcus multilocularis peregrin 0.0028 0.0276 0.0276
Schistosoma mansoni hypothetical protein 0.0034 0.036 0.036
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0053 0.0649 0.3578
Mycobacterium ulcerans hypothetical protein 0.0023 0.0196 0.0873
Loa Loa (eye worm) hypothetical protein 0.005 0.0598 0.1614
Mycobacterium ulcerans hypothetical protein 0.0158 0.2243 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0108 0.0291
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.3704 1
Schistosoma mansoni hypothetical protein 0.0028 0.0276 0.0276

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 25954  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to slow growth of Leishmania sp. in cell assay; References: 9371081 9398595
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major 21977  
Annotator: aaronjr@u.washington.edu Comment: Drug: 700-47-0; Drug: 704-61-0; Drug: 708-74-7; Drug: 945-24-4; Drug: 1026-36-4; Drug: 1597-01-9; Drug: 1899-40-7; Drug: 2432-24-8; Drug: 2440-80-4; Drug: 3977-17-1; Drug: 5774-32-3; Drug: 6954-23-0; Drug: 6973-01-9; Drug: 7319-50-8; Drug: 14684-54-9; Drug: 17005-34-4; Drug: 17005-35-5; Drug: 19152-86-4; Drug: 26398-12-9; Drug: 34244-78-5; Drug: 34244-80-9; Drug: 36804-91-8; Drug: 38713-63-2; Drug: 38713-64-3; Drug: 38713-65-4; Drug: 47066-05-7; Drug: 50691-65-1; Drug: 51395-54-1; Drug: 51583-00-7; Drug: 52128-15-1; Drug: 53219-56-0; Drug: 53274-34-3; Drug: 54798-36-6; Drug: 58091-86-4; Drug: 61267-65-0; Drug: 61267-67-2; Drug: 73978-42-4; Drug: 73978-43-5; Drug: 73978-44-6; Drug: 89977-50-4; Drug: 104422-58-4; Drug: 104422-59-5; Drug: 107174-41-4; Drug: 160602-03-9; Drug: 160602-12-0; Drug: 200127-49-7; Drug: 200127-50-0; Drug: 200127-51-1; Drug: 200127-52-2; Drug: 200127-53-3; Drug: 200127-54-4; Drug: 200127-55-5; Drug: 200127-57-7; Drug: 200127-58-8; Drug: 200127-59-9; Drug: 200127-60-2; Drug: 200127-61-3; Drug: 200127-62-4; Drug: 200127-63-5. chemical inhibition with DHFR and PTR1 inhibitors leads to reduced enzyme activity in vitro; References: 9371081 9398595

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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Bibliographic References

2 literature references were collected for this gene.

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