Detailed information for compound 572663

Basic information

Technical information
  • TDR Targets ID: 572663
  • Name: 6-(dihydroxymethyl)-6-hydroxy-2H-pyran-5-one
  • MW: 160.125 | Formula: C6H8O5
  • H donors: 3 H acceptors: 4 LogP: -1.36 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(C1(O)OCC=CC1=O)O
  • InChi: 1S/C6H8O5/c7-4-2-1-3-11-6(4,10)5(8)9/h1-2,5,8-10H,3H2
  • InChiKey: CCBGJZIXYONESN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • cortalcerone
  • 2-(dihydroxymethyl)-2-hydroxy-6H-pyran-3-one
  • 59896-20-7
  • 2-(Dihydroxymethyl)-2-hydroxy-2H-pyran-3(6H)-one
  • 2H-Pyran-3(6H)-one, 2-(dihydroxymethyl)-2-hydroxy-
  • Cortalceron

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0074 0.0304
Brugia malayi phosphofructokinase 0.0111 0.0479 0.2243
Brugia malayi 6-phosphofructokinase 0.0111 0.0479 0.2243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0129 0.0617
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1868 1 1
Brugia malayi mbt repeat family protein 0.0049 0.014 0.061
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0479 0.2292
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0129 0.0205
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0408 0.2088 1
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0408 0.2088 1
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0408 0.2088 1
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0182 0.0859 0.3853
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0479 0.1953
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0408 0.2088 1
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0275 0.1366 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0129 0.0527
Schistosoma mansoni bromodomain containing protein 0.0065 0.0226 0.1084
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0182 0.0859 0.4075
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0408 0.2088 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0176 0.0722
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0129 0.0558
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0176 0.0722
Loa Loa (eye worm) hypothetical protein 0.0049 0.014 0.0259
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0408 0.2088 1
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0182 0.0859 0.3514
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0133 0.0597 0.286
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0206 0.0845
Brugia malayi Bromodomain containing protein 0.0039 0.0088 0.0358
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0408 0.2088 1
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0408 0.2088 1
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0408 0.2088 1
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.014 0.0572
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0182 0.0859 0.4112
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0129 0.0527
Plasmodium falciparum phenylalanine--tRNA ligase 0.0182 0.0859 0.4003
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0479 0.215
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1868 1 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0176 0.0845
Brugia malayi Bromodomain containing protein 0.0077 0.0291 0.1341
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0597 0.2728
Brugia malayi 6-phosphofructokinase 0.0111 0.0479 0.2243
Loa Loa (eye worm) hypothetical protein 0.0056 0.0176 0.0442
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0919 0.3761
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0919 0.3761
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0408 0.2088 1
Echinococcus granulosus neuropeptide receptor A26 0.0474 0.2444 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0176 0.0722
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.014 0.0669
Brugia malayi mbt repeat family protein 0.0049 0.014 0.061
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0479 0.215
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0408 0.2088 0.8545
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0408 0.2088 1
Onchocerca volvulus 0.0049 0.014 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0479 0.215
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0479 0.215
Loa Loa (eye worm) hypothetical protein 0.0044 0.0112 0.0119
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0133 0.0597 0.2728
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.014 0.0669
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0597 0.2728
Plasmodium falciparum phenylalanine--tRNA ligase 0.0151 0.0693 0.3196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0129 0.0617
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.014 0.0572
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0182 0.0859 0.4003
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0479 0.215
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0479 0.2292
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0408 0.2088 0.8545
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.014 0.0572
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.014 0.0572
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0176 0.0787
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0479 0.1959
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0206 0.0845
Loa Loa (eye worm) hypothetical protein 0.0408 0.2088 1
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0479 0.215
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0479 0.1953
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0176 0.0722
Loa Loa (eye worm) hypothetical protein 0.0072 0.0268 0.0899
Loa Loa (eye worm) MBCTL1 0.0056 0.0176 0.0442
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0129 0.0617
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0408 0.2088 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0129 0.0527
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.014 0.0259
Echinococcus granulosus neuropeptide s receptor 0.0474 0.2444 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0074 0.0304
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0479 0.215
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0479 0.1959
Echinococcus multilocularis neuropeptide s receptor 0.0474 0.2444 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.014 0.5
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0182 0.0859 0.4003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0066
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.014 0.0669
Schistosoma mansoni hypothetical protein 0.0297 0.1486 0.7115
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0182 0.0859 0.3514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0129 0.0527
Echinococcus multilocularis neuropeptide receptor A26 0.0474 0.2444 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0479 0.1953
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1868 1 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0479 0.215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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